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| 1 | Lime and Phosphate Could Reduce Cadmium Uptake by Five Vegetables Commonly Grown in South China显示文摘A pot experiment was conducted in artificially Cd-contaminated (5 mg Cd kg-1) soils to investigate the feasibility of using lime (3 g kg-1) or phosphate (80 mg P kg-1) to mitigate uptake of Cd by vegetables.Five common vegetables in South China,including lettuce (Lactuca sativa L.var.ramosa Hort.),Chinese cabbage [Brassica rapa L.subsp.Chinensis (L.) var.parachinensis (L.H.Bailey) Hanect],Chinese broccoli (Brassica oleracea L.var.albiflora Kuntze),white amaranth (Amaranthus tricolor L.) and purslane (Amaranthus viridis L.),were grown in the soils and harvested after 60 d.The results showed that liming significantly reduced Cd uptake by most vegetables by 40%-50% (or a maximum of 70%),mainly due to immobilization of soil Cd.Increased availability of Ca in the soil might also contribute to the Cd uptake reduction as a result of absorption competition between Ca and Cd.Liming caused biomass reduction in white amaranth and purslane,but did not influence growth of the other vegetables.Phosphate decreased Cd uptake by vegetables by 12%-23%.Compared with lime,phosphate decreased,to a smaller extent,the bioavailability of Cd in most cases.Phosphate markedly promoted growth of vegetables.Changes in soil chemistry by adding lime or phosphate did not markedly influence nutrient uptake of vegetables except that lime increased Ca content and phosphate increased P content in shoots of the vegetables.The results suggested that a proper application of lime could be effective in reducing Cd uptake of vegetables,and phosphate could promote growth of the vegetables as well as alleviate the toxicity of Cd. | TAN Wan-Neng LI Zhi-An QIU Jing ZOU Bi LI Ning-Yu ZHUANG Ping WANG Gang | 2011 | Pedosphere2011，21，2： | 34 |
| 2 | Heavy Metal Contamination in Soil and Soybean near the Dabaoshan Mine, South China显示文摘Concentrations of Pb, Cd, Cu, Zn, Cr and Ni in soybean (Glycine max L.) grown near the Dabaoshan Mine were investigated, and their potential risk to the health of inhabitants was estimated. In the Fandong (FD) and Zhongxin (ZX) villages, which are near the Dabaoshan mineral deposit, concentrations of Pb (0.34 mg kg^(-1) for FD), Cd (0.23 mg kg^(-1) for ZX) and Cr (1.14 and 1.75 mg kg^(-1) for FD and ZX, respectively) in the seeds of soybean exceeded the tolerance limit set by Chinese standards. The estimated daily intakes (EDIs) from consumption of soybean seeds for FD inhabitants were 0.570, 0.170, 38.550, 142.400, 1.910 and 14.530 μg d^(-1) kg^(-1) boby weight for Pb, Cd, Cu, Zn, Cr and Ni, respectively. Our results indicate that soybeans grown in the vicinity of the Dabaoshan Mine accumulate some metals, and the seeds pose a potential health risk to the local inhabitants. | ZHUANG Ping LI Zhi-An ZOU Bi XIA Han-Ping WANG Gang | 2013 | Pedosphere2013，23，3： | 23 |
| 3 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 4 | Three-dimensional morphological characteristics measurement of ankle joint based on computed tomography image post-processing显示文摘脚关节X光线照相术的精确的放不是可能的背景,重复脚关节X光检查电影上的所有 syndesmotic 参数的量的测量可能具有这研究的小 value.The 目的是为由聪明的联合精确地并且可靠地估计脚关节破裂减小的质量提供一套科学、客观的评估标准三维的( 3-D )计算了断层摄影术( CT )测量从2008年6月的 model.Methods 到2011年3月,所有薄片的 CT | CHEN Yan-xi LU Xiao-ling BI Gang YU Xiao HAO Yi-li ZHANG Kun ZOU Li-ling MEI Jiong YU Guang-rong | 2011 | Chinese Medical Journal2011，，23： | 12 |
| 5 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 6 | Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance显示文摘Background:Osteosarcoma is the most common bone malignancy in children and adolescents,and 20%-30%of the patients suffer from poor prognosis because of individual chemoresistance.The Hippo/yes-associated protein(YAP) signaling pathway has been shown to play a role in tumor chemoresistance,but no previous report has focused on its involvement in osteosarcoma chemoresistance.This study aimed to investigate the role of the Hippo/YAP signaling pathway in osteosarcoma chemoresistance and to determine potential treatment targets.Methods:Using the Cell Titer-Glo Luminescent cell viability assay and flow cytometry analysis,we determined the proliferation and chemosensitivity of YAP-overexpressing and YAP-knockdown osteosarcoma cells.In addition,using western blotting and the real-time polymerase chain reaction technique,we investigated the alteration of the Hippo/YAP signaling pathway in osteosarcoma cells treated with chemotherapeutic agents.Results:Mammalian sterile 20-like kinase 1(MST1) degradation was increased,and large tumor suppressor kinase1/2(LAT51/2) total protein levels were decreased by methotrexate and doxorubicin,which increased activation and nuclear translocation of YAP.Moreover,YAP increased the proliferation and chemoresistance of MG63 cells.Conclusions:The Hippo/YAP signaling pathway plays a role in osteosarcoma chemoresistance,and YAP is a potential target for reducing chemoresistance. | Dong-Yu Wang Ya-Nan Wu Jun-Qi Huang Wei Wang Meng Xu Jin-Peng Jia Gang Han Bei-Bei Mao Wen-Zhi Bi | 2016 | Chinese Journal of Cancer2016，35，7： | 10 |
| 7 | Mitochondrial Modulation of Apoptosis Induced by Low-dose Radiation in Mouse Testicular Cells显示文摘Objective To investigate whether apoptosis induced by low-dose radiation(LDR) is regulated by mitochondrial pathways in testicular cells.Methods Male mice were exposed to whole-body LDR,and changes in mitochondrial function and in expression of apoptotic factors were analyzed in the testicular cells as follows.Total nitric-oxide synthase(T-NOS) and Na+/K+ATPase activities were biochemically assayed.Reactive oxygen species(ROS) and mitochondrial membrane potential(Δψm) were determined by flow cytometry using fluorescent probes.Levels of mRNAs encoding cytochrome c(Cyt c) and apoptosis-inducing factor(AIF) were quantified by real-time reverse-transcription PCR(RT-PCR).Expression of Cyt c,AIF,caspase-9,and caspase-3 at the proteinlevel was assessed by western blotting and immunohistochemistry.Results LDR induced an increase in T-NOS activity and ROS levels,and a decrease in Na+/K+ATPase activity and mitochondrial Δψm,in the testicular cells.The intensity of these effects increased with time after irradiation and with dose.The cells showed remarkable swelling and vacuolization of mitochondria,and displayed a time- and dose-dependent increase in the expression of Cyt c,AIF,procaspase-9,and procaspase-3.Activation of the two procaspases was confirmed by detection of the cleaved caspases.The changes in expression of the four apoptotic factors were mostly limited to spermatogonia and spermatocytes.Conclusion LDR can induce testicular cell apoptosis through mitochondrial signaling pathways. | FANG Fang GONG Ping Sheng ZHAO Hong Guang BI Yu Jing ZHAO Gang GONG Shou Liang WANG Zhi Cheng | 2013 | Biomedical and Environmental Sciences2013，26，10： | 9 |
| 8 | D-dimer level and long-term outcome in patients with end-stage heart failure secondary to idiopathic dilated cardiomyopathy显示文摘Background Previous studies had demonstrated hemostatic abnormalities in patients with heart failure (HF) and several studies have shown that abnormal coagulation indices, represented by elevated D-dimer, had prognostic significance in patients with compatible or acute decompensated HF. However, the impact of D-dimer on the outcome in patients with end-stage HF remains unclear. Methods A total of 244 consecutive patients with end-stage HF due to idiopathic dilated cardiomyopathy (DCM) were prospectively enrolled from February 2011 to September 2014. D-dimer levels were measured and its prognostic value was assessed. Primary endpoint was all-cause mortality during the follow-up period. Secondary endpoints were stroke, bleeding, occurrence of sustained ventricular tachycardia or ventricular fibrillation, and major adverse cardiovascular events (MACE). Results D-dimer was significantly elevated in the non-survivors (median: 0.8 vs. 1.1 mg/L, P < 0.001). Traditional markers including B-type natriuretic peptide, troponin I, left ventricular ejection fraction, and left ventricular end-diastolic dimension provided limited prognostic value;but the addition of D-dimer refined the risk stratification. The optimal cut-off value of D-dimer to predict all-cause mortality was 0.84 mg/L by receiver operator characteristic analysis. Elevated D-dimer level was independently associated with increased risk of long-term all-cause mortality (HR = 2.315, 95% CI: 1.570–3.414, P < 0.001) and MACE (HR = 1.256, 95% CI: 1.058–1.490, P = 0.009), and the predictive value was independent of age, sex, atrial fibrillation and anticoagulation status. Conclusions Elevated D-dimer level was independently associated with poor long-term outcome in patients with end-stage HF secondary to idiopathic DCM, and the predictive value was superior to that of traditional prognostic markers. | Bi HUANG Yuan-Jing LI Jian SHEN Yuan YANG Gang LIU Su-Xin LUO | 2019 | Journal of Geriatric Cardiology2019，16，8： | 9 |
| 9 | Adverse Respiratory Events Increase Post-anesthesia Care Unit Stay in China:A 2-year Retrospective Matched Cohort Study显示文摘Despite growing attention to patients,safety worldwide,no data were available on the impact of adverse respiratory events(AREs)on post-anesthesia care and post-operation care in China.This study evaluated the occurrence of AREs,the impact of AREs on length of stay(LOS)in post-anesthesia care unit(PACU)and postoperative time in hospital,and PACU cost and in patient healthcare costs.A retrospective,matched-cohort study was conducted by prospectively collecting the data of 159 AREs in PACU during 2016-2017 in an university hospital in China.Records were reviewed by pre-trained,qualified nurses and/or anesthesiologists.The incidence and the impact of AREs were analyzed.The LOS in PACU and postoperative time in hospital and the costs in PACU and inpatient healthcare costs were also obtained.Results showed that there were 253 AREs involving 156 patients.Hypoxia(n=141,55.73%)and respiratory depression(n=70,27.67%)were the most common AREs.Measurement data including body mass index(BMI)(22.85±4.36 vs.22.32±3.83),duration of procedure(138.47±77.33 min vs.137.44±72.33 min),duration of anesthesia(176.35±82.66 min vs.174.61±78.08 min),LOS(16.53±10.65 days vs.16.57±9.56 days),inpatient healthcare costs($9465.57±9416.33 vs.$8166.51±5762.01),and postoperative LOS(11.26±8.77 days vs.11.9±8.30 days)showed no significant differences between ARE and matched groups(P<0.05).Duration(81.65±54.79 min vs.38.89±26.09 min)and costs($31.99±17.80 vs.$18.72±8.39)in PACU were significantly different in ARE group from those in matched group(P<0.001).Proportion of patients with prolonged stay in PACU was significantly higher in ARE group than in matched group(18.59%vs.1.28%),with an odds ratio(after matching)of 17.58(95%CI=4.11 to 75.10;P<0.001).The AREs that occurred during the immediate postoperative period in PACU increased the incidence rate of prolonged stay,delayed the PACU stay,and increased the costs in PACU,resulting in the need of higher levels of postoperative care than anticipated,but the postoperative LOS and inpatient healthcare costs were unchanged. | Shang-kun LIU Gang CHEN Bi YAN Jiao HUANG Hui XU | 2019 | Current Medical Science2019，39，2： | 7 |
| 10 | Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccination显示文摘 | Xiaofeng Liang Shengli Bi Weizhong Yang Longde Wang Gang Cui Fuqiang Cui Yong Zhang Jianhua Liu Xiaohong Gong Yuansheng Chen Fuzhen Wang Hui Zheng Feng Wang Jing Guo Zhiyuan Jia Jingchen Ma Huaqing Wang Huiming Luo Li Li Shuigao Jin Stephen C. Hadler Yu W | 2009 | Vaccine2009，，47： | 7 |
| 11 | Diffusion Bonding of Silicon Carbide Particulate Reinforced 2024 Al Composites显示文摘A study has been made on diffusion bonding of SiCp/2024Al composites by means of pure Al interlayer. In the condition of TB=843 K, PB=16 MPa, tB=60 min, the diffusion bonded joint, with a shear strength of 235 MPa, was obtained when a 15μm thick interlayer was used. The results of the shear testing and SEM indicate that fracture of the joint presented characteristics of ductile rupture. | Mingjiu ZHAO+, Liqing CHEN and Jing BI (Metal Matrix Composites Department, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) Gang ZHANG (Shenyang Institute of Technology, Shenyang 110015, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 6 |
| 12 | Ascorbic acid secretion in the human stomach and the effect of gastrin显示文摘AIM To investigate the changes of gastricmucosal ascorbic acid secretion in patients withnonulcer dyspepsia and the effect of gastrin onit,and to relate any observed changes to H.pylori infection and mucosal histology.METHODS Ascorbic acid secretions in patientswere examined by collecting continuouslygastric juice for one hour after having aspiratedand discarded fasting gastric juice.Using theclearance rate(mL/min)of ascorbic acid fromblood to gastric juice represented ascorbic acidsecretion in the gastric mucosa.Ascorbic acidconcentrations in plasma and juice weremeasured by ferric reduced method.RESULTS Gastric ascorbic acid secretions inH.pylori-positive patients(1.46 mL/min,range0.27-3.78)did not significantly differ fromthose in H.pylori-negative patients(1.25 mL/min,0.47-3.14)(P>0.05).There were nosignificant differences in ascorbic acidsecretions between patients with mild(1.56 mL/min,0.50-3.30),moderate(1.34 mL/min,0.27-2.93)and severe(1.36 mL/min,0.47-3.78)inflammation(P>0.05).There were nosignificant differences in ascorbic acidsecretions between patients without activity(l.45mL/min,0.27-3.14)and with mild(1.32mL/min,0.61-2.93),moderate(1.49mL/min,0.50-3.78)and severe(1.43 mL/min,0.51-3.26)activity of chronic gastritis either(P>0.05).Ascorbic acid secretions in patientswith severe atrophy(0.56 mL/min,0.27-1.20)were markedly lower than those in patientswithout atrophy(1.51 mL/min,0.59-3.30)and with mild(1.43 mL/ min,0.53-3.78)andmoderate(1.31 mL/min,0.47-3.16)atrophy(P<0.005).There was a significant negativecorrelation between ascorbic acid secretion andseverity of atrophy(correlation coefficient=-0.43,P<0.005).After administration ofpentagastrin,ascorbic acid secretions weremarkedly elevated(from 1.39 mL/min,0.36-2.96 to 3.53mL/min,0.84-5.91)(P<0.001).CONCLUSION Ascorbic acid secretion ingastric mucosa is not affected by H.pyloriinfection.Gastric ascorbic acid secretion ismarkedly related to the severity of atrophy,whereas not related to the severity ofinflammation and activity.Gastrin may stimulategastric ascorbic acid secretion.A decreasedascorbic acid secretion may be an importantfactor in the link between atrophic gastritis andgastric carcinogenesis. | Bi Guang Tuo Yong Hui Yan Zheng Long Ge Gang Wei Ou Kui Zhao | 2000 | World Journal of Gastroenterology2000，6，5： | 6 |
| 13 | Preparation and Characterization of Hydrophobic Nano Silver Film on Butterfly Wings as Bio-template显示文摘 | FANG Yan SUN Gang BI Yuhan | 2014 | Chemical Research in Chinese Universities2014，30，5： | 4 |
| 14 | Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer:a multicenter,randomized,double-blinded,placebo-controlled,phaseⅡclinical trial显示文摘Background: Metastatic colorectal cancer(mCRC) patients with progressive disease after all available standard therapies need new medication for further treatment. Famitinib is a small-molecule multikinase inhibitor, with promising anticancer activities. This multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial was designed to evaluate the safety and efficacy of famitinib in mCRC.Methods: Famitinib or placebo was administered orally once daily. The primary endpoint was progression-free survival(PFS). Secondary endpoints included objective response rate(ORR), disease control rate(DCR), overall survival(OS), quality-of-life(QoL), and safety.Results: Between July 18,2012 and Jan 22,2014, a total of 167 patients were screened, and 154 patients were randomized in a 2:1 ratio to receive either famitinib(n = 99) or placebo(n = 55). The median PFS was 2.8 and 1.5 months in the famitinib and placebo groups(hazard ratio = 0.60,95% confidence interval = 0.41-0.86, P = 0.004). The DCR was 59.8% and 31.4%(P = 0.002) and the ORR was 2.2% and 0.0%(P = 0.540) in the famitinib and placebo groups,respectively. The most frequent grade 3-4 adverse events were hypertension(11.1%), hand-foot syndrome(10.1%),thrombocytopenia(10.1%) and neutropenia(9.1%). Serious adverse events occurred in 11(11.1%) patients in the famitinib group and 5(9.1%) in the placebo group(P = 0.788). The median OS of the famitinib and placebo groups was 7.4 and 7.2 months(P = 0.657).Conclusion: Famitinib prolonged PFS in refractory mCRC patients with acceptable tolerability.Trial registration This study was registered on ClinicalTrials.gov(NCT01762293) and was orally presented in the 2015 ASCO-Gastrointestinal | Rui-Hua Xu Lin Shen Ke-Ming Wang Gang Wu Chun-Mei Shi Ke-Feng Ding Li-Zhu Lin Jin-Wan Wang Jian-Ping Xiong Chang-Ping Wu Jin Li Yun-Peng Liu Dong Wang Yi Ba Jue-Ping Feng Yu-Xian Bai Jing-Wang Bi Li-Wen Ma Jian Lei Qing Yang Hao Yu | 2017 | Chinese Journal of Cancer2017，36，12： | 4 |
| 15 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 16 | Effect of algal flocculation on dissolved organic matters using cationic starch modified soils显示文摘Modified soils(MSs) are being increasingly used as geo-engineering materials for the sedimentation removal of cyanobacterial blooms. Cationic starch(CS) has been tested as an effective soil modifier, but little is known about its potential impacts on the treated water.This study investigated dissolved organic matters in the bloom water after algal removal using cationic starch modified soils(CS-MSs). Results showed that the dissolved organic carbon(DOC) could be decreased by CS-MS flocculation and the use of higher charge density CS yielded a greater DOC reduction. When CS with the charge density of 0.052, 0.102 and0.293 meq/g were used, DOC was decreased from 3.4 to 3.0, 2.3 and 1.7 mg/L, respectively.The excitation–emission matrix fluorescence spectroscopy and UV254 analysis indicated that CS-MS exhibits an ability to remove some soluble organics, which contributed to the DOC reduction. However, the use of low charge density CS posed a potential risk of DOC increase due to the high CS loading for effective algal removal. When CS with the charge density of 0.044 meq/g was used, DOC was increased from 3.4 to 3.9 mg/L. This study suggested, when CS-MS is used for cyanobacterial bloom removal, the content of dissolved organic matters in the treated water can be controlled by optimizing the charge density of CS. For the settled organic matters, other measures(e.g., capping treatments using oxygen loaded materials) should be jointly applied after algal flocculation. | Wenqing Shi Lei Bi Gang Pan | 2016 | Journal of Environmental Sciences2016，28，7： | 3 |
| 17 | Impact of parameter fluctuations on the performance of ethanol precipitation in production of Re Du Ning Injections, based on HPLC fingerprints and principal component analysis显示文摘The present study was designed to determine the relationships between the performance of ethanol precipitation and seven process parameters in the ethanol precipitation process of Re Du Ning Injections,including concentrate density,concentrate temperature,ethanol content,flow rate and stir rate in the addition of ethanol,precipitation time,and precipitation temperature.Under the experimental and simulated production conditions,a series of precipitated resultants were prepared by changing these variables one by one,and then examined by HPLC fingerprint analyses.Different from the traditional evaluation model based on single or a few constituents,the fingerprint data of every parameter fluctuation test was processed with Principal Component Analysis(PCA)to comprehensively assess the performance of ethanol precipitation.Our results showed that concentrate density,ethanol content,and precipitation time were the most important parameters that influence the recovery of active compounds in precipitation resultants.The present study would provide some reference for pharmaceutical scientists engaged in research on pharmaceutical process optimization and help pharmaceutical enterprises adapt a scientific and reasonable cost-effective approach to ensure the batch-to-batch quality consistency of the final products. | SUN Li-Qiong WANG Shu-Yao LI Yan-Jing WANG Yong-Xiang WANG Zhen-Zhong HUANG Wen-Zhe WANG Yue-Sheng BI Yu-An DING Gang XIAO Wei | 2016 | Chinese Journal of Natural Medicines2016，14，1： | 3 |
| 18 | Late Glacial glacier-climate modeling in two valleys on the eastern slope of Samdainkangsang Peak, Nyaiqentanggulha Mountains显示文摘Well-preserved Late Glacial moraines in the Barenduo and Yuqiongqu valleys on the eastern slope of the Samdainkangsang Peak present an opportunity to reconstruct glacier extents and examine the character of the climate during the Late Glacial stage in the Nyaiqentanggulha Mountains.This study employs a coupled mass-balance and ice-flow model to reconstruct the glacier extents in the two valleys and assess the magnitudes of temperature and precipitation change during the Late Glacial period.Model results indicate that during the Late Glacial,the Barenduo valley contained an ice volume of 1.67×10~8m^3,with the equilibrium-line altitude(ELA)being^5500 m asl;and the Yuqiongqu valley had an ice volume of 5.56×10~8 m^3,with the ELA being^5470 m asl.A climate scenario,temperature depression of 2.6-2.8℃and 60-70%,percent of modern(1981-2010)precipitation,can sustain both of the Late Glacial glacier extents in the two valleys.A 50%increase or decrease from modern precipitation would have been coupled with the respective Late Glacial temperature depressions of 1.6 and 3.0℃in the Barenduo valley,and 2.1 and 2.8℃in the Yuqiongqu valley. | XU XiangKe DONG GuoCheng PAN BaoLin HU Gang BI WeiLi LIU JinHua YI ChaoLu | 2017 | Science China Earth Sciences2017，60，1： | 3 |
| 19 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 20 | Microstructure evolution of electroless Ni-B film during its depostiting process 显示文摘 | Rao Qunli Bi Gang Lu Qinghua | 2005 | Appl Surf Sci2005，，240： | 1 |
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