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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in surface water and sediments from Baiyangdian Lake in North China显示文摘Persistent organochlorine compounds,including hexachlorocyclohexanes (HCHs),dichlorodiphenyltrichloroethanes (DDTs) and polychlorinated biphenyls (PCBs) were analyzed in surface water and sediments from Baiyangdian Lake,North China.Total concentrations of HCHs,DDTs and PCBs in surface water were in the range of 3.13-10.60,4.05-20.59 and 19.46-131.62 ng/L,respectively,and total concentrations of HCHs,DDTs and PCBs in sediments were 1.75-5.70,0.91-6.48 and 5.96-29.61 ng/g dry weight,respectively.Among the groups of HCHs (sum of α-HCH,β-HCH,γ-HCH and δ-HCH) and DDTs (sum of DDT,DDD and DDE),the predominance of β-HCH,DDE and DDD in water and sediment samples was clearly observed.This observation suggested that β-HCH was resistant to biodegradation and the DDTs had been transformed to its metabolites,DDE and DDD.For PCBs,penta-,hexa-and hepta-chlorinated congeners were the most abundant compounds in the both phases.Furthermore,the partitioning of chlorinated compounds between sediment and water was investigated to understand their transport and fates in aquatic ecosystems.The results indicated that average logs of organic carbon-normalized sediment-water partition coefficients (logK'oc) for OCPs varied between 3.20 and 5.53,and for PCBs,logK'oc values ranged from 3.19 to 5.57.The observed logK'oc was lower than their equilibrium logKoc predicted from linear model,which may be attributed to the solubility enhancement effect of colloidal matter in water phase and the disequilibrium between sediment and water. | Guohua Dai Xinhui Liu Gang Liang Xu Han Liu Shi Dengmiao Cheng Wenwen Gong | 2011 | Journal of Environmental Sciences2011，23，10： | 44 |
| 3 | JMJD3 is a histone H3K27 demethylase显示文摘组蛋白甲基化是参予细胞的过程的一个多样的数组的重要 epigenetic 现象并且被发现了与癌症被联系。几的 Recentidentification 嘘一 demethylases 证明了那嘘一甲基化是一个可逆过程。通过一条候选人途径,我们化学上有简历作为 H3K27demethylase 识别了 JMJD3。进 HeLa 房间的 JMJD3 的 Transfection 引起了整齐的乙醇 H3K27 的特定的减小,但是没在 di- 和单音的甲基 H3K27 上有效果,或嘘 H3K4 和 H3K9 上的一离氨酸 methylations。Theenzymatic 活动要求 JmjC 域和被建议了为余因子绑定重要的保存组氨酸。试管内生物化学的实验证明那 JMJD3directly 催化 demethylation。另外,我们发现 JMJD3 起来在前列腺癌症,和它的表示调整了在变形前列腺癌症是更高的。因此,我们作为能够把整齐的乙醇组从移开的 ademethylase 识别了 JMJD3 嘘一 H3 离氨酸 27 并且起来在前列腺癌症调整了。 | Yang Xiang Ziqi Zhu Gang Han Hanqing Lin Longyong Xu Charlie Degui Chen | 2007 | Cell Research2007，17，10： | 37 |
| 4 | Expressions of inducible nitric oxide synthase and matrix metalloproteinase-9 and their effects on angiogenesis and progression of hepatocellular carcinoma显示文摘AIM: To determine the expressions of inducible nitric oxide synthase (iNOS) and matrix metalloproteinase-9 (MMP-9)in hepatocellular carcinoma (HCC) and to investigate the relationship between iNOS and MMP-9 expression and their effects on angiogenesis and progression of HCC.METHODS: Tn this study, we examined iNOS, MMP-9,and CD34 expression in specimens surgically removed from 32 HCC patients and 7 normal liver tissues by immunohistochemical staining. Meanwhile, microvessel density (MVD) was determined as a marker of angiogenesis by counting CD34-positive cells.RESULTS: The positive rates of iNOS and MMP-9expression were 71.88% (23/32) and 78.13% (25/32) in HCC. MMP-g expression was significantly correlated with tumor size, capsule status, TNM stage, and risk of HCC recurrence (P= 0.032, P= 0.033, P= 0.007, and P= 0.001,respectively). There was also a significant relationship between iNOS expression and capsule status and risk of HCC recurrence (P = 0.04g and P = 0.004, respectively),but no correlation between iNOS expression and tumor size and TNM stage. There was a positive association between MVD and TNM stage and risk of HCC recurrence (P = 0.037 and P = 0.000, respectively). The count of MVD was significantly different in different iNOS and MMP-9 immunoreactivity groups (F= 17.713 and 17.097, P = 0.000 and P = 0.000, respectively). The examination of Spearman's rank correlation coefficient showed that there was a significant positive correlation between MVD and iNOS,MMP-9 immunoreactivity (r= 0.754 and 0.751, P= 0.000 and P=0.000, respectively). There was also a significant association between MMP-9 and iNOS expression in HCC (P = 0.010).CONCLUSION: Nitric oxide (NO) produced by iNOS could modulate MMP-9 production and therefore contribute to tumor cell angiogenesis and invasion and metastasis in HCC. The strong expression of iNOS and MMP-9 in HCC may be helpful in evaluating the recurrence of HCC,predicting poor prognosis. For patients with strong expression of MMP-9 and iNOS, the optimal treatment scheme needs to be selected. | Min-Hua Sun Xi-Chun Han Ming-Ku Jia Wei-Dong Jiang Min Wang Hong Zhang Gang Han Yi Jiang | 2005 | World Journal of Gastroenterology2005，11，38： | 30 |
| 5 | An intriguing RNA species--perspectives of circularized RNA显示文摘圆形的 RNA (circRNAs ) ,一种 covalently 关上的 RNA 分子,被认为拼接 mis 事件的副产品的一种类型并且在早年里由于工艺的限制偶发地被发现。与象高产量的下一代的定序那样的大工艺的进步,众多的 circRNAs 最近在许多种类被检测了。CircRNAs 以一种时间空间地特定的方式被表示,建议他们的规章的功能的潜力以前被俯看。有趣地,某 circRNAs 确实在某些情形与批评生理的功能被发现。CircRNAs 有能抵抗到比作那些线性的 exoribonuclease 的更稳定的分子的结构,并且他们的分子的函数包括 microRNA 海绵,在抄写的规章的角色,与线性拼接竞争的 mRNA 陷井,为翻译并且可能的模板另外的一会儿未知的角色。这里,我们考察 circRNAs,起源和形成机制,生理的功能和分子的角色的发现和描述,与为 circRNAs 的察觉的方法一起。我们进一步调查未来并且建议关键问题为这些魔术的 RNA 分子被回答。 | Ting Shen Miao Han Gang Wei Ting Ni | 2015 | Protein & Cell2015，6，12： | 29 |
| 6 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 7 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 8 | Double role of Fas ligand in the apoptosis of intervertebral disc cells in vitro显示文摘船边交货 ligand (FasL ) 可以在维持 intervertebral 圆盘(IVD ) 的有免疫力的特权起一个重要作用。而且,它是仔细与退化圆盘房间的 apoptosis 有关。现在,大量报告关于 FasL 的矛盾的效果描述了,尽管 IVD 房间上的 FasL 的效果仍然在争论下面。在这研究,我们试着在船边交货表示上并且在原子核 pulposus (NP ) 的 apoptosis 上调查 FasL 的效果在 SpragueDawley 老鼠的房间。结果证明在 NP 房间的船边交货的表示被 recombinant FasL 显著地增加。同时, NP 房间的 apoptosis 以一种 FasL 剂量依赖者方式显著地增加了。有趣地, RNA 干扰结果显示船边交货表示和以前描述的 NP 房间 apoptosis 的增加被船边交货 siRNA 禁止,建议 RNA 干扰可能是阻止 IVD 房间 apoptosis 的新奇策略之一。 | Dunfu Han Yue Ding Shang-Li Liu Gang Wang In-Cheong Si Xinguang Wang Liyang Cui Dongshang Huang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，11： | 14 |
| 9 | Field evaluation of effects of transgenic cry1Ab/cry1Ac,cry1C and cry2A rice on Cnaphalocrocis medinalis and its arthropod predators显示文摘The impacts of transgenic Bt rice on target pests and their predators need to be clarified prior to the commercialization of Bt rice.In this study,the percentages of folded leaves of three transgenic Bt rice lines and non-transgenic parental rice line caused by Cnaphalocrocis medinalis were studied over two successive growing seasons.In addition,the population densities,relative abundance and population dynamics of C.medinalis and four species of its natural arthropod predators were investigated at three sites in China.The results showed that rice line significantly affected the percentages of folded leaves and population densities of C.medinalis larvae.Significantly higher percentages of folded leaves were observed on the non-transgenic rice compared with the three transgenic Bt rice on most sampling dates.Significantly higher densities of C.medinalis larvae and higher relative abundance of C.medinalis within phytophages were found on non-transgenic rice compared with three transgenic Bt rice at different sites across the study period.The population dynamics of C.medinalis larvae were significantly affected by rice line,rice line×sampling date,rice line×year,rice line×sampling date×year.However,there was little,if any,significant difference in the relative abundance,population density and population dynamics of the four arthropod predators between the three Bt rice lines and non-transgenic rice.The results of this study indicate that the Bt toxin in transgenic Bt rice can effectively suppress the occurrence of C.medinalis,but has no significant effects on the occurrence of the four predatory arthropod species. | XU XueLiang HAN Yu WU Gang CAI WanLun YUAN BenQi WANG Hui LIU FangZhou WANG ManQun HUA HongXia | 2011 | Science China(Life Sciences)2011，54，11： | 14 |
| 10 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 11 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 12 | PPARy agonists inhibit TGF-β-PKA signaling in glomeru Iosclerosis显示文摘 | Rong ZOU Gang XU Xiao-cheng LIU Min HAN Jing-jing JIANG Qian HUANG Yong HE Ying YAO | 2010 | Acta Pharmacologica Sinica2010，31，1： | 12 |
| 13 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 14 | Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population显示文摘The effects of genetic factors on the noise-induced hearing loss(NIHL)are still unclear.In the present study,eight single-nucleotide polymorphisms(SNPs)included rs1227049 and rs3802711(CDH23),rs1695(GSTP1),rs137852540(GJB2),rs2289274(PMCA2),rs4880(SOD2),rs7943316,and rs769214 within CAT that might associated with NIHL were further validated | WANG Sheng Li YU Lu Gang LIU Ren Ping ZHU Wan Zhan GAO Wei Min XUE Li Ping JIANG Xu ZHANG Ya Han YI Ding CHEN Dong ZHANG Yong Hong | 2014 | Biomedical and Environmental Sciences2014，27，12： | 12 |
| 15 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 16 | Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota显示文摘Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. | Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 12 |
| 17 | Intra-continental back-arc basin inversion and Late Carboniferous magmatism in Eastern Tianshan,NW China:Constraints from the Shaquanzi magmatic suite显示文摘The Yamansu belt,an important tectonic component of Eastern Tianshan Mountains,of the Central Asian Orogenic Belt,NW China hosts many Fe-(Cu)deposit.In this study,we present new zircon U-Pb geochronology and geochemical data of the volcanic rocks of Shaquanzi Formation and diorite intrusions in the Yamansu belt.The Shaquanzi Formation comprises mainly basalt,andesite/andesitic tuff,rhyolite and sub-volcanic diabase with local diorite intrusions.The volcanic rocks and diorites contain ca.315-305 Ma and ca.298 Ma zircons respectively.These rocks show calc-alkaline affinity with enrichment in large-ion lithophile elements(LILEs),light rare-earth elements(LREEs),and depletion in high field strength elements(HFSEs)in primitive mantle normalized multi-element diagrams,which resemble typical back-arc basin rocks.They show depleted mantle signature with ε_(Nd)(t)ranging from+3.1 to +5.6 for basalt;+2.1 to+4.7 for andesite;-0.2 to+1.5 for rhyolite and the ε_(Hf)(t)ranges from-0.1 to +13.0 for andesites;+5.8 to +10.7 for andesitic tuffs.We suggest that the Shaquanzi Formation basalt might have originated from a depleted,metasomatized lithospheric mantle source mixed with minor(3-5%)subduction-derived materials,whereas the andesite and rhyolite could be fractional crystallization products of the basaltic magma.The Shaquanzi Formation volcanic rocks could have formed in an intracontinental back-arc basin setting,probably via the southward subduction of the Kangguer Ocean beneath the Middle Tianshan Massif.The Yamansu mineralization belt might have undergone a continental arc to back-arc basin transition during the Late Carboniferous and the intra-continental back-arc basin might have closed in the Early Permian,marked by the emplacement of dioritic magma in the Shaquanzi belt. | Hongjun Jiang Jinsheng Han Huayong Chen Yi Zheng Wanjian Lu Gang Deng Zhixiong Tan | 2017 | Geoscience Frontiers2017，8，6： | 11 |
| 18 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 19 | Study on seepage and deformation characteristics of coal microstructure by 3D reconstruction of CT images at high temperatures显示文摘To study the seepage and deformation characteristics of coal at high temperatures,coal samples from six different regions were selected and subjected to computed tomography(CT)scanning studies.In conjunction with ANSYS software,3 D reconstruction of CT images was used for the establishment of fluidsolid conjugate heat transfer model and coal thermal deformation model based on the microstructures of coal.In addition,the structure of coal was studied in 2 D and 3 D perspectives,followed by the analysis of seepage and deformation characteristics of coal at high temperatures.The results of this study indicated that porosity positively correlated with the fractal dimension,and the connectivity and seepage performances were roughly identical from 2 D and 3 D perspectives.As the porosity increased,the fractal dimension of coal samples became larger and the pore-fracture structures became more complex.As a result,the permeability of coal samples decreased.In the meantime,fluid was fully heated,generating high-temperature water at outlet.However,when the porosity was low,the outlet temperature was very high.The average deformation of coal skeleton with different pore-fracture structures at high temperatures showed a trend of initial increase and subsequent decrease with the increase of porosity and fractal dimension.The maximum deformation of coal skeleton positively correlated with connectivity but negatively correlated with the fractal dimension. | Gang Wang Xiangjie Qin Dongyang Han Zhiyuan Liu | 2021 | International Journal of Mining Science and Technology2021，31，2： | 11 |
| 20 | FLOW STRUCTURE IN PARTIALLY VEGETATED RECTANGULAR CHANNELS显示文摘This article discusses the transverse distributions of the depth averaged velocity and the Reynolds stress in a steady uniform flow in partially vegetated rectangular channels.The momentum equation is expressed in dimensionless form and solved to obtain the depth averaged velocity.The analytical solution of the velocity in dimensionless form shows that the depth-averaged velocity is determined by gravity and its distribution is mainly determined by the frictions due to water or vegetations.The analytical solution of the Reynolds stress is also obtained.A relationship between the second flow and the inertia is established and it is assumed that the former is proportional to the square of the depth averaged velocity.The Acoustic Doppler Velocimeter(Micro ADV) was used to measure the steady uniform flow with emergent artificial rigid vegetation.Comparisons between the measured data and the computed results show that our method does well in predicting the transverse distributions of the stream-wise velocity and the Reynolds stress in rectangular channels with partially vegetations. | CHEN Gang HUAI Wen-xin HAN Jie ZHAO Ming-deng | 2010 | Journal of Hydrodynamics2010，22，4： | 11 |
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