|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells显示文摘 | Ivan Maillard Ute Koch Alexis Dumortier Olga Shestova Lanwei Xu Hong Sai Seth E. Pross Jon C. Aster Avinash Bhandoola Freddy Radtke Warren S. Pear | 2008 | Cell Stem Cell2008，，4： | 1 |
| 2 | Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells显示文摘 | Ivan Maillard Ute Koch Alexis Dumortier Olga Shestova Lanwei Xu Hong Sai Seth E. Pross Jon C. Aster Avinash Bhandoola Freddy Radtke Warren S. Pear | 2008 | Cell Stem Cell2008，，4： | 1 |
| 3 | Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX显示文摘 | Chen HT Bhandoola A Difilippantonio M J | 2000 | Scienee2000，290，4598： | 1 |
| 4 | From stem cell to T cell:one route or many?显示文摘 | Bhandoola A Sambandam A | 2006 | Nat Rev Immunol2006，6，2： | 1 |
| 5 | The earliest thymic progenitors for T cells possess mycloid lineage potential 显示文摘 | Bell JJ Bhandoola A | 2008 | Nature2008，452，7188： | 1 |
| 6 | The earliest thymic progenitors for T cells possess myeloid lineage potential 显示文摘 | Bell JJ Bhandoola A | 2008 | Nature2008，452，7188： | 1 |
| 7 | CD8 coreceptor extinction in signaled CD4^+ CD8^+ thymocytes:Coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes显示文摘 | CIBOTTI R BHANDOOLA A | 2000 | Molecular and Cellular Biology2000，20，： | 1 |
| 8 | The earliest thymic progenitors for T cells possess myeloid lineage potential显示文摘 | Bell JJ Bhandoola A | 2008 | Nature2008，452，： | 1 |
| 9 | Circulating hematopoietic progenitors with T lineage potential显示文摘 | Schwarz BA Bhandoola A | 2004 | Nat Immunol2004，5，9： | 1 |
| 10 | Closer to the source:notch and the nature of thymus-settling cells显示文摘 | Zediak V P Maillard I Bhandoola A | 2005 | Immunity2005，23，3： | 1 |
| 11 | IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells显示文摘 | Steven A. Saenz Mark C. Siracusa Laurel A. Monticelli Carly G.K. Ziegler Brian S. Kim Jonathan R. Brestoff Lance W. Peterson E. John Wherry Ananda W. Goldrath Avinash Bhandoola David Artis | 2013 | Journal of Experimental Medicine2013，，9： | 1 |
| 12 | Signal integration and crosstalk during thymocyte migration and emigration 显示文摘 | Love PE Bhandoola A | 2011 | Nat Rev Immunol2011，11，7： | 1 |
| 13 | Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells显示文摘 | Bhandoola A Cibotti R | 2000 | Immunity2000，13，： | 1 |
| 14 | From stem cell to T cell: one route or many? 显示文摘 | Bhandoola A Sambandam A | 2006 | Nat Rev Immunol2006，6，2： | 1 |
| 15 | The earliest thymic progenitors for T cells possess myeloid lineage potential 显示文摘 | Bell JJ Bhandoola A | 2008 | Nature2008，452，： | 1 |
| 16 | In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells 显示文摘 | Yu Q Erman B Bhandoola A | 2003 | J Exp Med2003，197，4： | 1 |
| 17 | Response to RAG-mediated VDJ deavage by NBS1 and gamma-H2AX显示文摘 | Chen HT Bhandoola A Difilippantonio MJ Zhu J Brown MJ Tai X | 2000 | Science2000，290，5498： | 1 |
| 18 | Building early defenses显示文摘Innate lymphoid cells(ILCs)are considered as innate equivalents of T cells.Liu et al.used single-cell RNA sequencing to determine the proportions of ILCs in human fetal tissues,and additionally identified novel progenitor subsets undergoing ILC lineage specification in fetal liver. | Yi Ding Avinash Bhandoola | 2021 | Cell Research2021，31，10： | 0 |
| 19 | 小鼠LSK及DN原代细胞中基因编辑方法的建立显示文摘小鼠(Mus musculus)免疫系统包含种类众多、功能各异的细胞群体。为了研究小鼠免疫系统的发育机制,需要建立高效的遗传操作技术方法。首先选择Cas9敲入小鼠的DN细胞(CD4-~CD8^-double negative thymocytes)为研究对象,针对GFP和CD4表面抗原基因设计构建了sgRNA(single guide RNA),使用小鼠逆转录病毒(Murine stem cell virus,MSCV)为载体实施了基因编辑。通过流式细胞仪分析,检测到GFP和CD4被成功敲除。在此基础上,选取Cas9敲入小鼠的LSK细胞(Lin^-Sca1^+Kit^+)为研究对象,使用同样的方法针对Tcf7基因设计构建了sgRNA并实施基因编辑。基因编辑后,LSK细胞不能正常分化为下游T细胞,但其分化为髓系细胞能力不受影响。这些结果表明,针对小鼠LSK和DN原代细胞实施的基因编辑取得成功。 | 王跃强 Avinash Bhandoola | 2018 | 生物技术通报2018，34，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员