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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation显示文摘Lateral optical forces induced by linearly polarized laser beams have been predicted to deflect dipolar particles with opposite chiralities toward opposite transversal directions.These“chirality-dependent”forces can offer new possibilities for passive all-optical enantioselective sorting of chiral particles,which is essential to the nanoscience and drug industries.However,previous chiral sorting experiments focused on large particles with diameters in the geometrical-optics regime.Here,we demonstrate,for the first time,the robust sorting of Mie(size~wavelength)chiral particles with different handedness at an air–water interface using optical lateral forces induced by a single linearly polarized laser beam.The nontrivial physical interactions underlying these chirality-dependent forces distinctly differ from those predicted for dipolar or geometrical-optics particles.The lateral forces emerge from a complex interplay between the light polarization,lateral momentum enhancement,and out-of-plane light refraction at the particle-water interface.The sign of the lateral force could be reversed by changing the particle size,incident angle,and polarization of the obliquely incident light. | Yuzhi Shi Tongtong Zhu Tianhang Zhang Alfredo Mazzulla Din Ping Tsai Weiqiang Ding Ai Qun Liu Gabriella Cipparrone Juan Jose Saenz Cheng-Wei Qiu | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 3 | Antimicrobial activity and phytochemical studies of some lichens from south of Spain显示文摘 | SAENZ M T GARCIA M D ROWE J G | 2006 | Fitoterapia2006，77，： | 1 |
| 4 | Mod- eling and control of a wind turbine driven doubly fed induction generator 显示文摘 | TAPIA A TAPIA G OSTOLAZA J X SAENZ J R | 2003 | IEEE Transactions on Energy Conversion2003，18，2： | 1 |
| 5 | Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation显示文摘 | SIRACUSA M C SAENZ S A WOJNO E D | 2013 | Immunity2013，39，： | 1 |
| 6 | Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activation显示文摘 | Saenz L Lozano J J Valdor R | 2008 | BMC Genomics2008，9，171： | 1 |
| 7 | Discussion of equation for the stress-strain curve of concrete by Desayi and Krishnan显示文摘 | Saenz L P | 1964 | Journal of ACI1964，61，9： | 1 |
| 8 | Susceptibility of Helicobact- er pylori to mupirocin, oxazolidinones, quinupristin/dalfopristln and new quinolones显示文摘 | Sanchez JE Saenz NG Rincon MR | 2000 | J Antimicrob Chemother2000，46，2： | 1 |
| 9 | Human influenza virus NS1 protein enhances viral patho- genicity and acts as an RNA silencing suppressor in plants 显示文摘 | DELGADILLO M O SAENZ P SALVADOR B | 2004 | The Journal of General Virology2004，85，4： | 1 |
| 10 | Factor analysis of forced swimming test, sucrose preference test and open field test on enriched, social and isolated reared rats 显示文摘 | Brenes Saenz JC Villagra OR Fornaguera Trias J | 2006 | Behav Brain Res2006，169，1： | 1 |
| 11 | Thoracoscopic splanchnicectomy for pain control in patients with unresectable carcinoma of the pancreas显示文摘 | Saenz A Kuriansky J Salvador L | 2000 | Surg Endosc2000，14，： | 1 |
| 12 | Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle显示文摘 | Azadzoi K M Saenz de Tejada I | 1991 | J Urol1991，146，： | 1 |
| 13 | Equivalent models of wind farms by using aggregated wind turbines and equivalent winds显示文摘 | Fernandez L M Garcia C A Saenz J R | 2009 | Energy Conversion and Management2009，50，3： | 1 |
| 14 | QSARs for aromatic hydrocarbons at seyeral tropic levels 显示文摘 | MarzioW D Saenz M E | 2006 | Environmental Toxicology2006，21，2： | 1 |
| 15 | Knowledge sharing and innovation performance 显示文摘 | Josune Saenz | 2009 | Journal of intelligence capital2009，10，1： | 1 |
| 16 | Aggregated dynamic model for wind farms with doubly fed induction generator wind turbines显示文摘 | Fernandez Luis M Jurado Francisco Saenz Jose Ramon | 2008 | Renewable Energy2008，33，1： | 1 |
| 17 | Discussion of equation for the stress strain curve of concrete 显示文摘 | Saenz L P | 1964 | Journal of the American Concrete Institute1964，61，9： | 1 |
| 18 | Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence显示文摘 | Saenz de Tejada I Goldstein I Azadzoi K | 1989 | N Engl J Med1989，320，： | 1 |
| 19 | Dynamic models of wind farms with fixed peed wind turbines显示文摘 | Fernandez L M Saenz J R Jurado F | 2006 | Renewable Energy2006，31，8： | 1 |
| 20 | Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a report of 3 cases 显示文摘 | Koreishi AF Saenz A J Fleming SE | 2009 | Int J Surg Pathol2009，17，5： | 1 |
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