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| 1 | Role of Reactive Oxygen Species in Triptolide-induced Apoptosis of Renal Tubular Cells and Renal Injury in Rats显示文摘This study investigated the role of reactive oxygen species(ROS) in the pathogenesis of triptolide-induced renal injury in vivo.Rats were randomly divided into 4 groups(n=5 in each):triptolide group in which the rats were intraperitoneally injected with triptolide solution at a dose of 1 mg/kg of body weight on day 8;control group in which the rats received a single intraperitoneal injection of 0.9% physiological saline on day 8;vitamin C group in which the rats were pretreated with vitamin C by gavage at a dose of 250 mg/kg of body weight per day for 7 days before the same treatment as the control group on day 8;triptolide+vitamin C group in which the rats were first subjected to an oral administration of vitamin C at a dose of 250 mg/kg of body weight per day for 7 days,and then to the same treatment as the triptolide group on day 8.All the rats were sacrificed on day 10.Blood samples were collected for detection of plasma creatinine(Pcr) and plasma urea nitrogen(PUN) concentrations.Both kidneys were removed.The histological changes were measured by haematoxylin-eosin(HE) staining.The production of ROS was determined by detecting the fluorescent intensity of the oxida-tion-sensitive probe rhodamine 123 in renal tissue.Renal malondialdehyde(MDA) content was meas-ured to evaluate lipid peroxidation level in renal tissue.TUNEL staining was performed to assess apop-tosis of renal tubular cells.Renal expression of apoptosis-related proteins Bcl-2,Bax,Bid,Bad,Fas and FasL,as well as corresponding encoding genes were assessed by Western Blotting and real-time PCR.The results showed that triptolide treatment promoted the generation of a great amount of ROS,up-regulated the expression of Bax,Bid,Bad,Fas and FasL at both protein and mRNA levels,as well as the ratio of Bax to Bcl-2,and caused the apoptosis of renal tubular cells and renal injury.However,pretreatment with an antioxidant,vitamin C,significantly reduced the generation of ROS and effectively inhibited the triptolide-induced apoptosis of renal tubular cells and renal injury.It was concluded that ROS plays a critical role in triptolide-induced apoptosis of renal tubular cells and renal injury.The protective administration of vitamin C may help alleviate triptolide-induced renal injury and nephrotoxicity. | 杨帆 卓荦 Sunnassee Ananda 孙婷怡 李上勋 刘良 | 2011 | Journal of Huazhong University of Science and Technology(Medical Sciences)2011，31，3： | 15 |
| 2 | Effect of Biophytum sensitivum on streptozotocin and nicotinamideinduced diabetic rats显示文摘Objective:To investigate the effect of aqueous solution of Biophytum sensUiuum leaf extract(BSEt)on normal and strcptozotocin(STZ)-nicotinamide-induced diabetic rats.Methods:Diabetes was induced in adult male Wislar rata by the administration of STZ-nicotinamide(40,110 mg/kg b.w.,respectively)intraperitoneally.BSEt(200 mg/kg)was administered to diabetic rats for 28 days.The effect of extract on blood glucose,plasma insulin,total haemoglobin,glycosylated haemoglobin,liver glycogen and carbohydrate melatxilism regulating enzymes of liver was studied in diabetic rats.Results:BSEt significantly reduced the blood glucose and glycosylated haemoglobin levels and significantly increased the total haemoglobin,plasma insulin and liver glycogen levels in diabetic rats.It also increased the hexokinase activity and decreased glucose-6-phosphatase,fructose-1,6-bisphosphatase activities in diabetic rats.Conclusions:The results of our study suggest that BSEt possesses a promising effecl on STZ-nicotinamide-induced diabetes. | Ananda Prabu K Kumarappan CT Sunil Christudas Kalaichelvan VK | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 5 |
| 3 | Transfer Learning for Multi-Crop Leaf Disease Image Classification using Convolutional Neural Network VGG显示文摘In recent times,the use of artificial intelligence(AI)in agriculture has become the most important.The technology adoption in agriculture if creatively approached.Controlling on the diseased leaves during the growing stages of crops is a crucial step.The disease detection,classification,and analysis of diseased leaves at an early stage,as well as possible solutions,are always helpful in agricultural progress.The disease detection and classification of different crops,especially tomatoes and grapes,is a major emphasis of our proposed research.The important objective is to forecast the sort of illness that would affect grapes and tomato leaves at an early stage.The Convolutional Neural Network(CNN)methods are used for detecting Multi-Crops Leaf Disease(MCLD).The features extraction of images using a deep learning-based model classified the sick and healthy leaves.The CNN based Visual Geometry Group(VGG)model is used for improved performance measures.The crops leaves images dataset is considered for training and testing the model.The performance measure parameters,i.e.,accuracy,sensitivity,specificity precision,recall and F1-score were calculated and monitored.The main objective of research with the proposed model is to make on-going improvements in the performance.The designed model classifies disease-affected leaves with greater accuracy.In the experiment proposed research has achieved an accuracy of 98.40%of grapes and 95.71%of tomatoes.The proposed research directly supports increasing food production in agriculture. | Ananda S.Paymode Vandana B.Malode | 2022 | Artificial Intelligence in Agriculture2022，，1： | 4 |
| 4 | New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer显示文摘 | Rahul Pannala Ananda Basu Gloria M Petersen Suresh T Chari | 2009 | Lancet Oncology2009，，1： | 3 |
| 5 | 深圳水围柠盟人才公寓显示文摘在深圳,城中村一直都是一个热门的话题,多种观点相互碰撞。在过去的一二十年里,城中村的改造就意味着大规模的拆迁,彻底推倒重建,拆迁改善了生活环境,创造了财富,但导致了城市空间匀质化,同时,造成了一些社会问题,更割断了城市的历史。目前深圳市新出台的政策是通过综合整治,让城中村全面进入柔性改造的通道,鼓励在原来的用地上开展城中村的综合整治。然而新政策出台不久之后,却又发生了原住民反对综合整治,要求城市更新的情况。说明政策的转变对城中村的居民和开发企业都产生了很大的影响,“综合整治”和“拆除重建”的投入产出模型完全不同,两种模式的转变,意味着居民的诉求和企业的战略都应当做出相应的调整,在新形势下共同努力,继续探索。为此,我们选登了通过综合整治获得比较成功的水围村项目,该项目保留了城市的肌理、文脉和集体记忆,同时,也提升了消防、市政配套,及改善了生活设施。并增加空中连廊、电梯,创造出了一个符合现代标准的宜居空间立体的社区。该项目改造后,由政府返租补贴,并以低于市场的价格出租,以确保改造后的房源租金在可负担的范围内。水围村项目为城中村的改造提供了一种可能,并引发了社会各界对城中村改造的再思考,这也反映出有关城中村的争论还在继续,城中村的改造还需要不断的探索…… | Chris Lai Jasmine M.Y.Tsoi Kwan Yee Wong Cindy Yan David Wen Demi Han Zachary Bao Jack Ou Nita Lin Red Liu Ann Hu Morning Dong Ananda de Vos Helene Pohl Arnound Stavenuiter Bert Oostdijk 王晓勇 | 2019 | 世界建筑导报2019，34，1： | 2 |
| 6 | Synthesis of 4-acylpyrazolone Schiff base ligand grafted silica and selectivity in adsorption of lanthanides from aqueous solutions显示文摘The Schiff base form of the 4-acylpyrazolone ligand was immobilized on the silica surface by reaction of 3-aminopropyl silica with 4-acetyl-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one in 97% yield, producing grafted silica with 0.77 mmol/g ligand loading. This surface modified silica was shown to be selective in the adsorption of Yb3+ ions from dilute aqueous solutions, for which 98% adsorption was observed from a 1.0×10-5 mol/L aq. solution at pH 6.7, after 24 h at room temperature. Six other lanthanides studied Eu3+, Gd3+, Nd3+, Tb3+, Sm3+ and La3+ showed moderate to weaker adsorptions of 39%, 28%, 16%, 12%, 11% and 5% respectively under similar conditions. | Ananda S.Amarasekara Onome S.Owereh Sukesh K.Aghara | 2009 | Journal of Rare Earths2009，27，5： | 2 |
| 7 | Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes Mellitus显示文摘 | Rahul Pannala Jeffery B. Leirness William R. Bamlet Ananda Basu Gloria M. Petersen Suresh T. Chari | 2008 | Gastroenterology2008，，： | 2 |
| 8 | ECG Noise Removal and QRS Complex Detection U- sing UWT 显示文摘 | Naregalkar Akshay Naga Ananda Vamsee Jonnabhotla Nikita Sadam | 2010 | ICEIE2010，，2： | 1 |
| 9 | Tubular bacterial cellulose gel oriented fibrils on the curved surface显示文摘 | Ananda P Akira K Hidemitsu F | 2008 | Polymer2008，49，4： | 1 |
| 10 | Mechanical Thermal and Morphological Behavior of Bismaleimide Modified Polyurethane-epoxy IPN Matrices显示文摘 | Maheshk P O Alagar M Ananda K S | 2003 | Polymers for Advanced Technologies2003，14，2： | 1 |
| 11 | TCP Vegas- A: Improving the performance of TCP Vegas 显示文摘 | SRIJITH K N LILLYKUTTY JACOB ANANDA A L | 2005 | Computer Communications2005，28，4： | 1 |
| 12 | TCP Vegas-A: Improving the Performance of TCP Vegas 显示文摘 | K N Srijith Lillykutty Jacob A L Ananda | 2005 | Computer Communications (S0140-3664)2005，28，4： | 1 |
| 13 | Development of dimethylsiloxane based tetraglycidyl epoxy nanocomposites for high performance, aerospace and advanced engineering applications显示文摘 | Shree MK Pradeep JSE Ananda KS and Umapathy MJ | 2012 | Frog Org Coat2012，74，： | 1 |
| 14 | A mi- croparticle swarm optimizer for the reconstruction of microwave images显示文摘 | Tony Huang Ananda Sanagavarapu Mohan | 2007 | IEEE Transactions on Anten- nas and Propagation2007，55，3： | 1 |
| 15 | Modeling actuarial data with a composite lognormal-pareto model显示文摘 | Cooray K Ananda M M A | 2005 | Scandinavian Actuarial Journal2005，5，： | 1 |
| 16 | TCP Vegas-A: improving the performance of TCP Vegas 显示文摘 | SRIJITH K N JACOB L ANANDA A L | 2005 | Computer Communications2005，28，6： | 1 |
| 17 | Cordierite glass-ceramics for multiplayer ceramic packaging显示文摘 | SARAH H K ANANDA H K HERRON L Wynn | 1993 | Am Ceram Soc Bull1993，72，1： | 1 |
| 18 | Synthesis and Thermal Characterization of Phosphorus Containing Sili conized Epoxy Resins 显示文摘 | Ananda Kumar S Denchev Z Alagarm | 2006 | Eur Polym J2006，42，10： | 1 |
| 19 | Genetics of fertility restoration in hybrid rice显示文摘 | Ananda Kumar C R Subramanian S | 1992 | Theor Appl Genet1992，83，： | 1 |
| 20 | Cordierite glass-ceramics for multiplayer ceramic packaging显示文摘 | Sarah H K Ananda H K Herron W | 1993 | Am Ceram Soc Bull1993，72，1： | 1 |
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