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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting显示文摘 | Christine Esau Scott Davis Susan F. Murray Xing Xian Yu Sanjay K. Pandey Michael Pear Lynnetta Watts Sheri L. Booten Mark Graham Robert McKay Amuthakannan Subramaniam Stephanie Propp Bridget A. Lollo Susan Freier C. Frank Bennett Sanjay Bhanot Brett P. Mo | 2006 | Cell Metabolism2006，，2： | 4 |
| 3 | Association between visual status and mental health status in Thai rural elderly:a community-based study显示文摘AIM:To evaluate the association between visual impairment(VI) and mental health or social engagement in older adults living in rural Thailand.METHODS:Data for this cross-sectional study were drawn from a community survey conducted in 2015 in Saraburi Province,Thailand.Participants were 327 adults aged ≥50 y.VI was assessed using presenting distance visual acuity.Mental health and social engagement were evaluated in face-to-face interviews using validated questionnaires.After determining the prevalence of VI and relevant sociodemographic characteristics,multivariate regression analysis was used to evaluate the impact of VI on mental health and social engagement.RESULTS:The prevalence of VI was 18.3%.Major causes were refractive error(58.3%) and cataract(35%).Factors associated with VI in the crude analysis were:older age [odds ratio(OR) 8.08],unemployment(OR 2.72),widowhood(OR 2.47),being divorced/separated(OR 3.27),smoking(OR 2.09) and disability in activities of daily living(OR 2.35).Protective factors were undergoing eye screening at least once a year(P=0.029) and obesity(P=0.005).VI was significantly associated with low social engagement(adjusted OR 4.13) but not with poor mental health(P>0.05).CONCLUSION:Although VI older adults reported less participation in social activities,there is no significant association between VI and poor mental health.Annual eye examinations may prevent VI in older adults.Information about employment and anti-smoking should be targeted to older adults with VI. | Pear Pongsachareonnont Nopphawan Uramphorn Nuchanad Hounnaklang | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 2 |
| 4 | 用酶技术将畜产品废料变为饲料显示文摘用酶可将家禽和鱼加工过程中的“湿废料”变成蛋白质饲料。根据蛋白质原料的结构选择酶种类酶参与的加工过程的某些步骤是一样的,而有些步骤则需特殊的酶。酶水解过程的第一步是“预处理”。 | Pears Lyons 刘春华 | 1992 | 国外畜牧科技1992，19，5： | 2 |
| 5 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 6 | Char- acterization of surface oxidation carbon and their influenceon dynamic adsorption显示文摘 | N V Beck S E Meech P R Noman L A Pears | 2001 | Carbon2001，40，4： | 1 |
| 7 | Notch and cancer: best to avoid the ups and downs显示文摘 | Maillard 1 Pear WS | 2003 | Cancer Cell2003，3，3： | 1 |
| 8 | The multifaceted role of Notch in cancer显示文摘 | Roy M Pear WS Aster JC | 2007 | Curr Opin Genet Dev2007，17，1： | 1 |
| 9 | miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting显示文摘 | Christine Esau Scott Davis Susan F. Murray Xing Xian Yu Sanjay K. Pandey Michael Pear Lynnetta Watts Sheri L. Booten Mark Graham Robert McKay Amuthakannan Subramaniam Stephanie Propp Bridget A. Lollo Susan Freier C. Frank Bennett Sanjay Bhanot Brett P. Mo | 2006 | Cell Metabolism2006，，2： | 1 |
| 10 | The role of protein kinase C in B cell Transduction and tumor Promotion显示文摘 | Keenan C Pears C Knox K | | Nature0，308，59610： | 1 |
| 11 | A Social Constructivist Approach to Computer-mediated Instruction显示文摘 | Darlene E Crone-Todd | 2002 | Computer & Education2002，，38： | 1 |
| 12 | Efficient and rapid induction of a chronic myelogenous leukemia- like myeloproliferative disease in mice receiving P210 bcr/abl- transduced bone marrow显示文摘 | Pear WS Miller JP Xu L | 1998 | Blood1998，92，10： | 1 |
| 13 | Higher plants contain homologs of the CelA genes that encode the catalytic subunit of the bacterial cellulose synthases显示文摘 | PEAR J R Kawagoe Y Schrechengost W E | 1996 | Proceedings of the National Academy of Science USA1996，93，12： | 1 |
| 14 | Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells显示文摘 | Ivan Maillard Ute Koch Alexis Dumortier Olga Shestova Lanwei Xu Hong Sai Seth E. Pross Jon C. Aster Avinash Bhandoola Freddy Radtke Warren S. Pear | 2008 | Cell Stem Cell2008，，4： | 1 |
| 15 | 美医疗费用支出增长首次放缓显示文摘2007年,美国国民健康支出的增长率达到了9年来的新低。在经济衰退时期,健康支出的增速是一项敏感指标,受到行内外广泛关注。 | Robert Pear Sherry(编译) | 2009 | 中国处方药2009，，1： | 1 |
| 16 | Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells显示文摘 | Ivan Maillard Ute Koch Alexis Dumortier Olga Shestova Lanwei Xu Hong Sai Seth E. Pross Jon C. Aster Avinash Bhandoola Freddy Radtke Warren S. Pear | 2008 | Cell Stem Cell2008，，4： | 1 |
| 17 | Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow 显示文摘 | Pear WS Miller JP Pui JC | 1998 | Blood1998，92，： | 1 |
| 18 | Production of high titer helper-free retroviruses by transient transfection 显示文摘 | Pear W Nolan GP Scott M | 1993 | Proc Natl Acad Sci USA1993，90，18： | 1 |
| 19 | Generation of genomic mini-libraries by Taq DNA polymerase modification of genomic fragments显示文摘 | Huang H J Pears C | 1998 | Biotechniques1998，24，： | 1 |
| 20 | Notch and the immune system 显示文摘 | Maillard I Adler SH Pear WS | 2003 | Immunity2003，19，6： | 1 |
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