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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Awakening concentration of desflurane is decreased in patients with obstructive jaundice显示文摘 | Song JG Cao YF Yang LQ Yu WF Li Q Song JC Fu XY Fu Q | 2005 | 第二军医大学学报2005，26，8： | 15 |
| 3 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 4 | A novel therapeutic approach to 6-OHDA-induced Parkinson's disease in rats via supplementation of PTD-conjugated tyrosine hydroxylase显示文摘 | Wu SP Fu AL Wang YX Yu LP Jia PY Li Q Jin GZ Sun MJ | 2006 | 中国生物学文摘2006，20，10： | 9 |
| 5 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 6 | 帕劳国预应力连续箱梁长期下挠分析显示文摘帕劳共和国科罗尔岛-巴伦尔图阿普岛桥(简称KB桥)为主跨241 m的预应力混凝土箱梁,通车后KB桥发生长期下挠,严重影响其正常运营,最后垮塌,其教训值得反思。该桥于1977竣工,运营18年后挠度达到1.61 m,1996年对该桥进行了体外预应力加固,却在加固后3个月发生垮塌。挠度分析结果表明:传统的梁理论与三维空间分析相比,误差高达20%,且宽跨比越大,误差越大。三维有限元空间分析采用多种徐变收缩计算模型:美国ACI模型、日本JSCE模型、CEB-FIP模型和GL模型,其挠度计算值要比(18年后)实测值低50%~70%,预测的变形也与实测不符;预应力损失计算值为22%~24%,远低于实测值50%。唯一基于理论的B3模型,采用经验值参数计算得到预应力损失40%,18年后挠度计算值比实测值低42%。如果根据长期实测值调整输入参数,结果可与实际更符合。对于早期挠度及其预测,B3模型能够合理地考虑因截面厚度差异产生的收缩和干燥徐变的速率差异。此外,B3模型还可考虑温度差异和顶板可能发生的开裂。 | 叶华文 王力武 曲浩博 Bazant Z P Yu Q Li G H | 2017 | 中外公路2017，37，5： | 5 |
| 7 | Exploring in vitro roles of siRNA in cardiovascular disease显示文摘RNA 干扰( RNAi )是通过 搁浅whichdouble 的 RNA 沉默的适应防卫机制在顺序特定的 manner.It 的血缘的基因被采用了在功能的 genomics 的一个强大的工具学习的 widelyas ,目标确认并且治疗学 productdevelopment.Similarly ,到涉及心血管的疾病的 引起thedisease 基因的 silencing 的小介入的 RNA ( siRNA )的申请使大 progress.In 成为了 thisoverview 。 | Yu TANG Yu-zhi GE James Q YIN | 2007 | Acta Pharmacologica Sinica2007，28，1： | 3 |
| 8 | The genetic heterozygosity and fitness of tetraploid embryos and embryonic stem cells are crucial parameters influencing survival of mice derived from embryonic stem cells by tetraploid embryo aggregation显示文摘 | Li X Wei W Yong J Jia Q Yu Y Di K | 2006 | 中国生物学文摘2006，20，7： | 3 |
| 9 | On-line measurement of the straightness of seamless steel pipe using machine vision technique显示文摘 | lU R S LI Y F YU Q | 2001 | Sensor and Actutors A-Physical2001，94，1： | 2 |
| 10 | Properties of lead-free solder alloys with rare earth element additions显示文摘 | WU C M L YU D Q LAW C M T WANG L | 2004 | Materials Science and Engineering2004，44，1： | 2 |
| 11 | Biosorption removal of cadmium from aqueous solution by using pretreated fungal biomass cultured from starch waste water显示文摘 | Yin P H Yu Q M Jin B | 1999 | Wat Res1999，33，8： | 2 |
| 12 | Determinants of foreign direct investment across China 显示文摘 | Sun Q Tong W Yu Q | 2002 | Journal of International Money and Finance2002，，21： | 1 |
| 13 | 显示文摘 | Tong B Y Xu H Y Yu Q | 2003 | Chinese Journal of Synthetic Chemistry2003，12，3： | 1 |
| 14 | Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor显示文摘 | Chuang P Y Yu Q Fang W | 2007 | Kidney Int2007，72，8： | 1 |
| 15 | High prevalence of left ventricular systolic and diastolic asynchreny in patients with congestive heart failure and normal QRS duration显示文摘 | Yu CM Lin H Zhang Q | 2003 | Heart2003，89，1： | 1 |
| 16 | Enhanced high-potential and elevated-temperature cycling stability of LiMn2O4 cathode by TiO2 modification for Li-ion battery 显示文摘 | Yu L Qiu x xi J Zhu W T Chen L Q | 2006 | Eleetrochimica Acta2006，51，： | 1 |
| 17 | Improvement of atrial function and atrial reverse remodeling after cardiac resynchronization therapy for heart failure 显示文摘 | Yu CM Fang F Zhang Q | 2007 | J Am Coll Cardiol2007，50，8： | 1 |
| 18 | Determination of the composition of Chinese Ligustrum lucidum polysaeeharide by capillary zone electrophoresis with amperometrie detection显示文摘 | Wang Q J Yu H Zong J | 2003 | J Pharm Biomed Anal2003，31，： | 1 |
| 19 | Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people显示文摘 | Qi Q Yu Z Ye x | 2007 | Clin Endocrinol Metab2007，92，12： | 1 |
| 20 | Large-scale fabrication of single-Crystalline Mn3O4 nanowires via vapor phase growth显示文摘 | D P Yu Y Long | 2005 | Journal of Crystal Growth2005，279，： | 1 |
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