|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficiency and patient experience with propofol vsconventional sedation:A prospective study显示文摘AIM: To determine whether anaesthesiologistadministered sedation with propofol(AAP) or endoscopist-administered conscious sedation(EAC) with fentanyl/midazolam shortens colonoscopy duration/total room time. METHODS: This is a prospective, non-randomized, comparative study that enrolled patients greater than 18 years of age undergoing colonoscopy in a single Canadian academic outpatient endoscopy unit over a three-month consecutive period. Colonoscopies in this unit are performed both with AAP and EAC. Patient demographics, procedure-related data and adverse events were documented. Additionally, the level of procedure difficulty, and whether a staff endoscopist, trainee with assistance, or independent trainee, performed the procedure were documented. A validated modified 4-question, 5-point Likert scale telephone survey was used to assess patient satisfaction with colonoscopy. The telephone patient satisfaction survey was conducted 24-72 h following the procedure.RESULTS: Two hundred and thirty patients were enrolled during the study period with 126 patients in the AAP group and 104 patients in the EAC group. Mean procedure time was 18.3 ± 10.1 min in the AAP group and 14.7 ± 7.1 min in the EAC group(P = 0.002). Mean total room time was 36.8 ± 13.7 with AAP and 30.1 ± 11 min with EAC(P < 0.001). Multivariate analysis revealed the use of AAP(P = 0.002), resident participation(P < 0.001), diagnostic interventions(P = 0.033), therapeutic interventions(P < 0.001), lower body mass index(P = 0.008) and American Society of Anaesthesiologist class(P = 0.016), to be predictors of longer total room time. Patient age and gender were not significant predictors. After excluding cases in which trainees were involved, there was no significant difference in procedure time between the two groups(P = 0.941), however total room time was still prolonged in the AAP group(P = 0.019). The amount of pain experienced was lower with AAP(P = 0.02), with a trend toward overall higher patient satisfaction(P = 0.074). There were 2 sedation-related adverse events, both in the AAP group involving a patient with aspiration requiring hospitalization and a patient with hypoxia managed with bronchodilators.CONCLUSION: EAC results in reduced total room time compared to AAP. Resident participation doubles procedure time regardless of sedation type. | Patrick Thornley Mohammad Al Beshir James Gregor Andreas Antoniou Nitin Khanna | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 2 |
| 2 | On the location and number of expansion centers for the Generalized multipole technique显示文摘 | BESHIR K I RICHIE J E | 1996 | IEEE Trans EMC1996，38，2： | 1 |
| 3 | Synthesis and Structure-activity Relationships of Metal-ligandcom- plexes That Potently Inhibit Cell Migration 显示文摘 | BESHIR A B GUCHHAIT S K GASCON J A | 2008 | Bioorg Med Chem Lett2008，28，： | 1 |
| 4 | CucurbitacinⅠinhibits cell motility by indirectly in-terfering with actin dynamics显示文摘 | Knecht DA LaFleur RA Kahsai AW Argueta CE Beshir AB Fenteany G | 2010 | PLoS One2010，5，14： | 1 |
| 5 | Raf kinase inhibitor protein suppresses nuclear factor-KB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression 显示文摘 | Beshir AB Ren G Magpusao AN | 2010 | Cancer Lett2010，299，2： | 1 |
| 6 | Raf kinase inhibitor protein suppresses nuclear factor-κ B-dependent Cancer cell inva- sion through negative regulation of matrix metalloproteinase expression 显示文摘 | Beshir AB Ren Gang Magpusao AN | 2010 | Cancer Lett2010，299，2： | 1 |
| 7 | Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression显示文摘 | Beshir AB Ren G Magpusao AN | 2010 | Cancer Lett2010，299，2： | 1 |
| 8 | Raf kinase inhibitor protein suppresses nuclear factor-kappaB-de- pendent cancer cell invasion through negative regulation of matrix metalloproteinase expression 显示文摘 | Beshir A B Ren G Magpusao A N | 2010 | Cancer Lett2010，299，2： | 1 |
| 9 | Mo1399 Gastrointestinal Stromal Tumors: a Systematic Review of Diagnostic Yield and Complication Rates of Endoscopic Ultrasound Fine Needle Biopsy显示文摘 | Mohammad AL. Beshir Mohammed Alawamy Malcolm M. Wells ADAM Rahman Marko Mrkobrada Brian Yan | 2014 | Gastrointestinal Endoscopy2014，，5： | 1 |
| 10 | Application of solutions of rhodamine B in dosimetry 显示文摘 | Beshir W B Eid S Gafar S M | 2014 | Applied Radiation and Isotopes2014，，6： | 1 |
| 11 | Knee manipulationafter total knee arthroplasty显示文摘 | Ellis TJ Beshires E Brindley GW | 1999 | J South Orthop Assoc1999，8，： | 1 |
| 12 | Barrier to asymmetric internal rotation,conformational stability,vibrational spectra and assignments,and ab initio calculations of n-butane-d0,d5 and d10显示文摘 | DURIG J R WANG Aiying BESHIR W | 1991 | J Raman Spectrosc1991，22，： | 1 |
| 13 | Effect of Occupational Exposure to Aflatoxins on Some Liver Tumor Markers in Textile Workers显示文摘 | Amal Saad‐Hussein Safia Beshir Gehan Moubarz Safaa Elserougy Mohamed I.M. Ibrahim | 2013 | Am. J. Ind. Med2013，，7： | 1 |
| 14 | Raf kinase inhibitor proteinsuppresses nuclear factor-KB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression显示文摘 | Beshir AB Ren G Magpusao AN | 2010 | Cancer Letters2010，299，2： | 1 |
| 15 | Amodiaquine re- sistance in Plasmodiumfalciparum malaria in Afghanistan is asso- ciated with the pfcrt SVMNT allele at codons 72 to 76 显示文摘 | Beshir K Suthedand CJ Merinopoulos I | 2010 | Antimi- erob Agents Chemother2010，54，9： | 1 |
| 16 | Formyl violet cyanide liquid dosimetry system 显示文摘 | Ebraheem S Abdel-Fattah Beshir W B | 2007 | Radiation Physics and Chemistry2007，76，： | 1 |
| 17 | Application of solutions of Rhodamine B in dosimetry 显示文摘 | Beshir W B Eid S Gafar S M | 2014 | Applied Radiation and Isotopes2014，89，： | 1 |
| 18 | Role of endoscopic ultrasound and cyst fluid tumor markers in diagnosis of pancreatic cystic lesions显示文摘BACKGROUND Pancreatic cystic lesions(PCLs) are common in clinical practice. The accurate classification and diagnosis of these lesions are crucial to avoid unnecessary treatment of benign lesions and missed opportunities for early treatment of potentially malignant lesions.AIM To evaluate the role of cyst fluid analysis of different tumor markers such as cancer antigens [e.g., cancer antigen(CA)19-9, CA72-4], carcinoembryonic antigen(CEA), serine protease inhibitor Kazal-type 1(SPINK1), interleukin 1 beta(IL1-β), vascular endothelial growth factor A(VEGF-A), and prostaglandin E2(PGE2)], amylase, and mucin stain in diagnosing pancreatic cysts and differentiating malignant from benign lesions.METHODS This study included 76 patients diagnosed with PCLs using different imaging modalities. All patients underwent endoscopic ultrasound(EUS) and EUS-fine needle aspiration(EUS-FNA) for characterization and sampling of different PCLs.RESULTS The mean age of studied patients was 47.4 ± 11.4 years, with a slight female predominance(59.2%). Mucin stain showed high statistical significance in predicting malignancy with a sensitivity of 87.1% and specificity of 95.56%. It also showed a positive predictive value and negative predictive value of 93.1% and 91.49%, respectively(P < 0.001). We found that positive mucin stain, cyst fluid glucose, SPINK1, amylase, and CEA levels had high statistical significance(P < 0.0001). In contrast, IL-1β, CA 72-4, VEGF-A, VEGFR2, and PGE2 did not show any statistical significance. Univariate regression analysis for prediction of malignancy in PCLs showed a statistically significant positive correlation with mural nodules, lymph nodes, cyst diameter, mucin stain, and cyst fluid CEA. Meanwhile, logistic multivariable regression analysis proved that mural nodules, mucin stain, and SPINK1 were independent predictors of malignancy in cystic pancreatic lesions.CONCLUSION EUS examination of cyst morphology with cytopathological analysis and cyst fluid analysis could improve the differentiation between malignant and benign pancreatic cysts. Also, CEA, glucose, and SPINK1 could be used as promising markers to predict malignant pancreatic cysts. | Hussein Hassan Okasha Abeer Abdellatef Shaimaa Elkholy Mohamad-Sherif Mogawer Ayman Yosry Magdy Elserafy Eman Medhat Hanaa Khalaf Magdy Fouad Tamer Elbaz Ahmed Ramadan Mervat E Behiry Kerolis Y William Ghada Habib Mona Kaddah Haitham Abdel-Hamid Amr Abou-Elmagd Ahmed Galal Wael A Abbas Ahmed Youssef Altonbary Mahmoud El-Ansary Aml E Abdou Hani Haggag Tarek Ali Abdellah Mohamed A Elfeki Heba Ahmed Faheem Hani M Khattab Mervat El-Ansary Safia Beshir Mohamed El-Nady | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，6： | 1 |
| 19 | Outcomes of patients with cirrhosis and hepatorenal syndrome type 1 treated with liver transplantation显示文摘 | Florence Wong Wesley Leung Mohammed Al Beshir Max Marquez Eberhard L. Renner | 2015 | Liver Transpl2015，，3： | 1 |
| 20 | Raf kinase inhibitor pro- tein suppresses nuclear factor-kappaB dependent cancer cell in- vasion through negative regulation of matrix metalloproteinase expression显示文摘 | Beshir AB Ren G Magpusao AN | 2010 | Cancer Lett2010，299，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员