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| 1 | Itopride for gastric volume,gastric emptying and drinking capacity in functional dyspepsia显示文摘AIM To study the effect of itopride on gastric accommodation, gastric emptying and drinking capacity in functional dyspepsia(FD). METHODS Randomized controlled trial was conducted to check the effect of itopride on gastric accommodation, gastric emptying, capacity of tolerating nutrient liquid and symptoms of FD. We recruited a total of 31 patients having FD on the basis of ROME III criteria. After randomization, itopride was received by 15 patients while 16 patients received placebo. Gastric accommodation was determined using Gastric Scintigraphy. ^(13) C labeled octanoic breadth test was performed to assess gastric emptying. Capacity of tolerating nutrient liquid drink was checked using satiety drinking capacity test. Theintervention group comprised of 150 mg itopride. Patients in both arms were followed for 4 wk. RESULTS Mean age of the recruited participant 33 years(SD = 7.6) and most of the recruited individuals, i.e., 21(67.7%) were males. We found that there was no effect of itopride on gastric accommodation as measured at different in volumes in the itopride and control group with the empty stomach(P = 0.14), at 20 min(P = 0.38), 30 min(P = 0.30), 40 min(P = 0.43), 50 min(P = 0.50), 60 min(P = 0.81), 90 min(P = 0.25) and 120 min(P = 0.67). Gastric emptying done on a sub sample(n = 11) showed no significant difference(P = 0.58) between itopride and placebo group. There was no significant improvement in the capacity to tolerate liquid in the itopride group as compared to placebo(P = 0.51). Similarly there was no significant improvement of symptoms as assessed through a composite symptom score(P = 0.74). The change in QT interval in itopride group was not significantly different from placebo(0.10). CONCLUSION Our study found no effect of itopride on gastric accommodation, gastric emptying and maximum tolerated volume in patients with FD. | Shahab Abid Wasim Jafri Maseeh Uz Zaman Rakhshanda Bilal Safia Awan Aamir Abbas | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 6 |
| 2 | Value of multi-disciplinary input into laparoscopic management of rectal cancer-An observational study显示文摘AIM To assess the impact of multi-disciplinary teams(MDTs)management in optimising the outcome for rectal cancers.METHODS We undertook a retrospective review of a prospectively maintained database of patients with rectal cancers(defined as tumours≤15 cm from anal verge)discussed at our MDT between Jan 2008 and Jan 2011.The data was validated against the national database to ensure completeness of dataset.The clinical course and follow-up data was validated using the institution’s electronic patient records.The data was analysed in terms of frequencies and percentages.Significance of any differences were analysed usingχ2 test.A Kaplan-Meier analysis was performed for overall survival and disease free survival.RESULTS Following appropriate staging,one hundred and thirtythree patients were suitable for potentially curative resections.Seventy two(54%)were upper rectal cancer(URC)-tumour was>6 cm from the anal verge and 61(46%)were lower rectal cancers(LRC)-lower extent of the tumour was palpable≤6 cm.Circumferential resection margin(CRM)appeared threatened on preoperative MRI in 19/61(31%)patients with LRC requiring neo-adjuvant therapy(NAT).Of the 133 resections,118(89%)were attempted laparoscopically(5%conversion rate).CRM was positive in 9(6.7%)patients;Median lymph node harvest was 12(2-37).Major complications occurred in 8(6%)patients.Median follow-up was 53 mo(0-82).The 90-d mortality was 2(1.5%).Over the followup period,disease related mortality was 11(8.2%)and overall mortality was 39(29.3%).Four(3%)patients had local recurrence and 22(16.5%)patients had distant metastases.CONCLUSION Management of rectal cancers can be optimized with multidisciplinary input to attain acceptable long-term oncological outcomes even when incorporating a laparoscopic approach to rectal cancer resection. | Pawan Kumar Dhruva Rao Sooriyaratchige Pradeep Manjula Peiris Seema Safia Arif Rhodri A Davies Ashraf Gergies Masoud Puthucode Narayanan Haray | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 2 |
| 3 | Evaluation of adsorption capacities of humic acids extracted from Algerian soil on polyaniline for application to remove pollutants such as Cd(Ⅱ), Zn(Ⅱ) and Ni(Ⅱ) and characterization with cavity microelectrode显示文摘The adsorption capacities of new humic acids isolated from Yakouren forest (YHA) and Sahara (Tamenrasset: THA) soils (Algeria) and commercial humic acid (PFHA) on polyaniline emeraldine base (PEB) were studied at pH 6.6. Also the adsorption of heavy metals such as Cd 2+ , Zn 2+ and Ni 2+ on humic acid-polyaniline systems (HA-PEB) was investigated at the same conditions. HA-PEB compounds were characterized by scanning electron microscopy (SEM), infrared spectrometry and cavity microelectrode. In addition, batch adsorption and cavity microelectrode were used in the adsorption study of Cd 2+ , Zn 2+ and Ni 2+ on HA-PEB. To develop biocaptors of polluting metals using a cavity microelectrode modified by HA-PEB systems, the adsorption kinetic and adsorption capacity were investigated. The SEM analysis showed that the presence of humic acid affected the PEB surface and caused the formation of a granular morphology. The maximum adsorption capacities (q max ) of PFHA, THA and YHA determined by adsorption isotherms were 91.31, 132.1 and 151.0 mg/g, respectively. Batch adsorption results showed that q max of Cd 2+ , Zn 2+ and Ni 2+ on HA-PEB followed the order: THA-PEB > YHA-PEB > PFHA-PEB. The voltammograms obtained with HA-PEB modified cavity microelectrode showed the appearance of new redox couples reflecting the adsorption of HA on PEB. Metal-humic acid-polyaniline voltammograms were characterized by appearance of oxidation-reduction couples or reduction wave corresponding to metal. Finally, the result may be exploited to develop a biocaptor based on the cavity microelectrode amended by THA-PEB and YHA-PEB. | Achour Terbouche Chafia Ait Ramdane-Terbouche Didier Hauchard Safia Djebbar | 2011 | Journal of Environmental Sciences2011，23，7： | 2 |
| 4 | Impact of sepsis and non-communicable diseases on prognostic models to predict the outcome of hospitalized chronic liver disease patients显示文摘AIM To evaluate the impact of sepsis and non-communicable diseases(NCDs) on the outcome of decompensated chronic liver disease(CLD) patients.METHODSIn this cross-sectional study, medical records of patients with CLD admitted to the Gastroenterology unit at the Aga Khan University Hospital were reviewed.Patients older than 18 years with decompensation of CLD(i.e., jaundice, ascites,encephalopathy, and/or upper gastrointestinal bleed) as the primary reason for admission were included, while those who were admitted for reasons other than decompensation of CLD were excluded. Each patient was followed for 6 wk after index admission to assess mortality, prolonged hospital stay(> 5 d), and early readmission(within 7 d).RESULTS A total of 399 patients were enrolled. The mean age was 54.3 ± 11.7 years and64.6%(n = 258) were male. Six-week mortality was 13%(n = 52). Prolonged hospital stay and readmission were present in 18%(n = 72) and 7%(n = 28) of patients, respectively. NCDs were found in 47.4%(n = 189) of patients. Acute kidney injury, sepsis, and non-ST elevation myocardial infarction were found in41%(n = 165), 17.5%(n = 70), and 1.75%(n = 7) of patients, respectively. Upon multivariate analysis, acute kidney injury, non-ST elevation myocardial infarction, sepsis, and coagulopathy were found to be statistically significant predictors of mortality. While chronic kidney disease(CKD), low albumin, and high Model for End-Stage Liver Disease(MELD)-Na score were found to be statistically significant predictors of morbidity. Addition of sepsis in conventionalMELD score predicted mortality even better than MELD-Na(area under receiver operating characteristic: 0.735 vs 0.686; P < 0.001). Among NCDs, CKD was found to increase morbidity independently.CONCLUSION Addition of sepsis improved the predictability of MELD score as a prognostic marker for mortality in patients with CLD. Presence of CKD increases the morbidity of patients with CLD. | Fakhar Ali Qazi Arisar Shahab Abid Preet Ayoub Shaikh Safia Awan | 2018 | World Journal of Hepatology2018，10，12： | 2 |
| 5 | Biological degradation of plastics:A comprehensive review显示文摘 | Aamer Ali Shah Fariha Hasan Abdul Hameed Safia Ahmed | | 0，，： | 1 |
| 6 | Adsorption of phosphate and nitrate anions on ammonium-functionalized MCM-48: Effects of experimental conditions 显示文摘 | Rabih Saad Khaled Belkacemi Safia Hamoudi | 2007 | Journal of Colloid and Interface Science2007，311，2： | 1 |
| 7 | Isolation,characterization and decolorization of textile dyes by a mixed bacterial consortium JW-2显示文摘 | Safia M Xama K Datta M | 2007 | Dyes and Pigments2007，74，3： | 1 |
| 8 | Occurrence and distribution of hydrocarbons in surface sediments from Marseille Bay (France)显示文摘 | Laurence Asia Safia Mazouz Michel Guiliano Pierre Doumenq Gilbert Mille | 2008 | Marine Pollution Bulletin2008，，3： | 1 |
| 9 | Catalytic oxidation of aqueous phenol solutions catalyst deactivation and kinetics显示文摘 | Safia H | 1999 | Chemical Engineering Science1999，54，2： | 1 |
| 10 | Decolorization of structurally different textile dyes by Aspergillus niger SA1显示文摘 | Naeem Ali Abdul Hameed Safia Ahmed Abdul G. Khan | | 0，2008，： | 1 |
| 11 | Biological degradation of plastics: A comprehensive review显示文摘 | Aamer Ali Shah Fariha Hasan Abdul Hameed Safia Ahmed | 2008 | Biotechnology Advances2008，，3： | 1 |
| 12 | Isolation,characterization and decolorization of textile dyes by a mixed bacterial consortium JW-2显示文摘 | Safia Moosvi Xama Kher Datta Madamwar | 2006 | Dyes and Pigments2006，01，： | 1 |
| 13 | Biological degradation of plastics: A comprehensive review显示文摘 | Aamer Ali Shah Fariha Hasan Abdul Hameed Safia Ahmed | 2008 | Biotechnology Advances2008，，3： | 1 |
| 14 | Detection of pseudomonas syringae pathovars by thiol - linked DNA - Gold nanoparticle probes 显示文摘 | VASEGHI A SAFIAE N SADEGHIZASEDH M | 2013 | Sens Actuators B ChUm2013，，181： | 1 |
| 15 | Prevalence of hepatitis C virus infection among thalassemia patients: a perspective from a multi-ethnic population of Pakistan显示文摘 | Ghufranud Din Sajid Malik Ihsan Ali Safia Ahmed Javid Iqbal Dasti | 2014 | Asian Pacific Journal of Tropical Medicine2014，，： | 1 |
| 16 | Preferential recognition of epitopes on AGE-IgG by the autoantibodies in rheumatoid arthritis patients 显示文摘 | Saman Ahmed Safia Habib Moinuddin N | 2013 | Hum Immunol2013，74，1： | 1 |
| 17 | Magnetohydrodynamic peristaltic flow of a hyperbolic tangent fluid in a vertical asymmetric channel with heat transfer显示文摘In the present paper we discuss the magnetohydrodynamic (MHD) peristaltic flow of a hyperbolic tangent fluid model in a vertical asymmetric channel under a zero Reynolds number and long wavelength approximation. Exact solution of the temperature equation in the absence of dissipation term has been computed and the analytical ex- pression for stream function and axial pressure gradient are established. The flow is analyzed in a wave frame of reference moving with the velocity of wave. The expression for pressure rise has been computed numerically. The physical features of pertinent parameters are analyzed by plotting graphs and discussed in detail. | Sohail Nadeem Safia Akram | 2011 | Acta Mechanica Sinica2011，27，2： | 1 |
| 18 | Wet oxidation of phenol catalyzed by unpromoted and platinum-promoted manganese/cerium oxide显示文摘 | Hamoudi Safia Larachi Faical | 1998 | Industrial Engineering and Chemical Research1998，37，： | 1 |
| 19 | Cardiovascular involvement in Kawasaki disease显示文摘 | Narayanan SN Ahamed MZ Safia M | 2005 | Indian Pediatr2005，42，9： | 1 |
| 20 | Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA 显示文摘 | Alain RT Florent M Safia EM | 2014 | Nat Med2014，20，4： | 1 |
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