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| 1 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 2 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 3 | Katrina飓风对新奥尔良市供、排水和污水处理系统的影响显示文摘2005年8月29日,在美国墨西哥湾沿岸登陆的Katrina(卡特里娜)飓风带来的风浪涌入并损坏了新奥尔良市的防波堤,淹没了该市超过80%的面积。着重介绍了卡特里娜飓风对新奥尔良市排水、供水和污水处理系统的影响,并介绍了在飓风过后为恢复这些系统采取的补救措施。还讨论了地表水、地下水和瓶装水等的水质问题,以及在今后的防灾救灾工作中应进行的准备。还提供了在飓风过后几周和几个月内应对市区漫流、地下水渗流和生活污水的措施。 | Hou Ai-xin Benjamin Qi Edward A. Laws Ralph J. Portier 陈超 | 2008 | 中国给水排水2008，24，4： | 3 |
| 4 | Study of the impacts of upstream natural gas market reform in China on infrastructure deployment and social welfare using an SVM-based rolling horizon stochastic game analysis显示文摘Natural gas is expected to play a much more important role in China in future decades, and market reform is crucial for its rapid market penetration. At present, the main gas fields, pipelines and liquefied natural gas(LNG) infrastructure are mainly monopolized by large state-owned companies, and one of the important market reform policies is to open up LNG import rights to smaller private companies and traders. Therefore, in the present study, a game theoretical model is proposed to analyze and compare the impacts of different market structures on infrastructure deployment and social welfare. Moreover, a support vector machine-based rolling horizon stochastic method is adopted in the model to simulate real LNG price fluctuations. Four market reform scenarios are proposed considering different policies such as business separation, third-party access(TPA) and their combinations. The results indicate that, with third-party access(TPA)entrance into the LNG market, the construction of LNG infrastructure will be promoted and more gas will be provided at lower prices, and thus the total social welfare will be improved greatly. | Yan Li Ge Wang Benjamin Mclellan Si-Yuan Chen Qi Zhang | 2018 | Petroleum Science2018，15，4： | 2 |
| 5 | Terahertz quantum-cascade lasers显示文摘 | Benjamin S Williams Sushil Kumar Qi Qin | | 0，，05： | 1 |
| 6 | Molecular characterization of a set of wheat deletion stocks for use in chromosome bin mapping of ESTs显示文摘 | Lili Qi Benjamin Echalier Bernd Friebe Bikram S. Gill | 2003 | Functional & Integrative Genomics (-)2003，，1： | 1 |
| 7 | Review on the petroleum market in China:history,challenges and prospects显示文摘The petroleum industry plays an essential role in driving China's economic development.In the past few decades,severa reforms in the petroleum industry have been implemented;however,there are still some is sues that have not been resolved Moreover,with the new-normal economy,the transition to green energy and international trade disputes,the petroleum marke is also facing emerging challenges.Therefore,the purpose of the present study is to review the historical development o China's petroleum market,identify the current challenges and propose corresponding countermeasures for future prospects As a conclusion,five main challenges are highlighted totally,namely lack of marketization,excess oil refining capacity,hig external dependency,environment pollution and unstable international trading relationship.To address these challenges it is encouraged to deepen petroleum market reform,accelerate the elimination of inefficient refining capacity,diversify of supply sources,as well as improve domestic petroleum enterprises'ability to resist price risks. | Si-Yuan Chen Qi Zhang Benjamin Mclellan Tian-Tian Zhang | 2020 | Petroleum Science2020，17，6： | 1 |
| 8 | Exercise Training Versus Propranolol in the Treatment of the Postural Orthostatic Tachycardia Syndrome显示文摘 | Qi Fu Tiffany B. VanGundy Shigeki Shibata Richard J. Auchus Gordon H. Williams Benjamin D. Levine | 2011 | Hypertension2011，，2： | 1 |
| 9 | AIWW:a new nutrition-screening tool for the oncologic population显示文摘Malnutrition is a common comorbidity among patients with cancer.However,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is needed.Based on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each category.According to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on PG-SGA.Based on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,respectively.The sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and 0.975.The Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,respectively.The area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,respectively.The IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with cancer.The missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,respectively.AIWW showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool for this population. | Yi-Zhong Ge Zhen-Ming Fu Qi Zhang Meng-Meng Song Guo-Tian Ruan Xi Zhang Xiao-Wei Zhang Xiang-Rui Li Kang-Ping Zhang Meng Tang Xiao-Yue Liu Ming Yang Tong Liu Hai-Lun Xie He-Yang Zhang Zi-Wen Wang Chun-Lei Hu Shi-Qi Lin Rui Zhang Hong-Xia Xu Wei Li Chun-Hua Song Ming Liu Jun-Qiang Chen Kun-Hua Wang Li Bo Ming-Hua Cong Zeng-Ning Li Zeng-Qin Guo Xiao-Bin Wang Bin-Yan Wang Benjamin Xu Xian-Hui Qin Xi-Ping Xu Rocco Barazzoni Qing-Hua Yao Min Weng Xian Shen Han-Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2023 | Science China(Life Sciences)2023，66，8： | 1 |
| 10 | Laster light scattering of poly(acrylamide) in 1 M NaCI aquesous solution 显示文摘 | Qi C Y Guang W W Benjamin Chu | 1996 | Macromolecules1996，29，： | 1 |
| 11 | Epidemic Surveillance of Influenza Infections:A Network-Free Strategy—Hong Kong Special Administrative Region,China,2008–2011显示文摘Introduction:The ease of coronavirus disease 2019(COVID-19)non-pharmacological interventions and the increased susceptibility during the past COVID-19 pandemic could be a precursor for the resurgence of influenza,potentially leading to a severe outbreak in the winter of 2022 and future seasons.The recent increased availability of data on Electronic Health Records(EHR)in public health systems,offers new opportunities to monitor individuals to mitigate outbreaks.Methods:We introduced a new methodology to rank individuals for surveillance in temporal networks,which was more practical than the static networks.By targeting previously infected nodes,this method used readily available EHR data instead of the contactnetwork structure.Results:We validated this method qualitatively in a real-world cohort study and evaluated our approach quantitatively by comparing it to other surveillance methods on three temporal and empirical networks.We found that,despite not explicitly exploiting the contacts’network structure,it remained the best or close to the best strategy.We related the performance of the method to the public health goals,the reproduction number of the disease,and the underlying temporal-network structure(e.g.,burstiness).Discussion:The proposed strategy of using historical records for sentinel surveillance selection can be taken as a practical and robust alternative without the knowledge of individual contact behaviors for public health policymakers. | Zhanwei Du Qi Tan Yuan Bai Lin Wang Benjamin J.Cowling Petter Holme | 2022 | China CDC weekly2022，4，46： | 0 |
| 12 | Ultra-dense planar metallic nanowire arrays with extremely large anisotropic optical and magnetic properties显示文摘为对晶片尺寸可伸缩的极端稠密的平面金属性的 nanowire 数组的生产的一个 nanofabrication 方法被介绍。方法基于一个有效模板免职过程在仅仅二步与极端整齐种多样的金属性的 nanowire 数组。首先, III-V 半导体底层被一根低精力的离子横梁在提高的温度照耀,形成由一个反向的取向附生过程由于的一个高度订的 nanogroove 模式表面空缺自己组装。第二,多样的金属性的 nanowire 穿(Au, Fe, Ni,公司, FeAl 合金) 被免职在一个看一眼的发生角度在这些 III-V 模板上制作。这个方法允许有频率的数组击倒到 45 nm 的金属性的 nanowire 的制造可伸缩直到晶片尺寸制造。作为典型高贵、磁性的金属,这里生产的 Au 和 Fe nanowire 数组展出了大各向异性光并且磁性分别地。Au nanowire 数组的局部性的表面电浆子回声(LSPR ) 的刺激导致了高电场改进,它被用来在散布的提高表面的拉曼(重量的单位) 检测酞毒(CoPc ) 。而且, Fe nanowire 数组显示出一架很高的在里面飞机约 412 mT 的磁性的 anisotropy,它磁性的 anisotropy 还回答的最大的在里面飞机可以被报导那完全在一部薄电影的飞机以内经由形状 anisotropy 被导致。 | Qi Jia Xin Ou Manuel Langer Benjamin Schreiber Jorg Grenzer Pablo F. Siles Raul D. Rodriguez Kai Huang Ye Yuan Alireza Heidarian Rene Hubner Tiangui You Wenjie Yu Kilian Lenz Jurgen Lindner Xi Wang Stefan Facsko | 2018 | Nano Research2018，11，7： | 0 |
| 13 | Characterizing Human Collective Behaviors During COVID-19 — Hong Kong SAR, China, 2020显示文摘Summary What is already known about this topic?People are likely to engage in collective behaviors online during extreme events,such as the coronavirus disease 2019(COVID-19)crisis,to express awareness,take action,and work through concerns. | Zhanwei Du Xiao Zhang Lin Wang Sidan Yao Yuan Bai Qi Tan Xiaoke Xu Sen Pei Jingyi Xiao Tim K.Tsang Qiuyan Liao Eric H.YLau Peng Wu Chao Gao Benjamin J.Cowling | 2023 | China CDC weekly2023，5，4： | 0 |
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