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18篇 您的检索式：作者名="VanGundy"

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		题名	作者	年代	出处	被引量
	1	Exercise training versus- propranolol in the treatment of the postural orthostatie tachycardia syndrome显示文摘	Fu Q Vangundy TB Shibata S	2011	Hypertension2011，58，2：	1
	2	Effects of exercise training on arterial-cardiac baroreflex function in POTS 显示文摘	Galbreath MM Shibata S VanGundy TB	2011	Clin Auton Res2011，21，2：	1
	3	Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndrome 显示文摘	Fu Q VanGundy TB Shibata S	2011	Hypertension2011，58，2：	1
	4	Cardiac origins of the postural orthostatic tachycardia syndrome 显示文摘	Fu Q VanGundy TB Galbreath MM	2010	J Am Coil Cardiol2010，55，25：	1
	5	Cardiac origins of the postural orthostatic tachycardia syndrome显示文摘	Fu Q VanGundy TB Galbreath MM	2010	Journal of the Ameri-can College of Cardiology2010，55，25：	1
	6	Exercise training versus pro-pranolol in the treatment of the postural orthostatic tachycardia syn-drome 显示文摘	Fu Q VanGundy TB Shibata S	2011	Hypertension2011，58，2：	1
	7	Effects of exercise training on arterial-cardiac baroreflex function in POTS 显示文摘	Galbreath MM Shibata S VanGundy TB	2011	Clin Auton Res2011，21，2：	1
	8	Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity显示文摘AIM:To understand how interactions between hepatitis C virus(HCV) and the host's immune system might lead to viral persistence or effective elimination of HCV.METHODS:Nucleotides 3519-3935 of the non-structural 3(NS3) region were amplified by using reverse transcription polymerase chain reaction(PCR).PCR products of the HCV NS3 regions were integrated into a PCR T7TOPO TA vector and then sequenced in both directions using an automated DNA sequencer.Relative major histocompatibility complex binding levels of wild-type and variant peptides were performed by fluorescence polarization-based peptide competition assays.Peptides with wild type and variant sequences of NS3 were synthesized locally using F-moc chemistry and purified by high-performance liquid chromatography.Specific cytotoxic T lymphocytes(CTLs) clones toward HCV NS3 wild-type peptides were generated through limiting dilution cloning.The CTL clones specifically recognizing HCV NS3 wild-type peptides were tested by tetramer staining and flow cytometry.Cytolytic activity of CTL clones was measured using target cells labeled with the fluorescence enhancing ligand,DELFIA EuTDA.RESULTS:The pattern of natural variants within three human leukocyte antigen(HLA)-A2-restricted NS3 epitopes has been examined in one patient with chronic HCV infection at 12,28 and 63 mo post-infection.Results obtained may provide convincing evidence of immune selection pressure for all epitopes investigated.Statistical analysis of the extensive sequence variation found within these NS3 epitopes favors a Darwinian selection model of variant viruses.Mutations within the epitopes coincided with the decline of CTL responses,and peptide-binding studies suggested a signif icant impact of the mutation on T cell recognition rather than peptide presentation by HLA molecules.While most variants were either not recognized or elicited low responses,such could antagonize CTL responses to target cells pulsed with wild-type peptides.CONCLUSION:Cross-recognition of CTL epitopes from wild-type and naturally-occurring HCV variants may lead to impaired immune responses and ultimately contribute to viral persistence.	Shuping Wang Rico Buchli Jennifer Schiller Jianen Gao Rodney S VanGundy William H Hildebrand David D Eckels	2010	World Journal of Gastroenterology2010，16，16：	1
	9	Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells显示文摘	VanGundy ZC Guerau-de-Arellano M Baker JD	2014	BMC Immunol2014，15，1：	1
	10	Fixation for iliac fractures显示文摘	VanGundy T E	1990	Vet Med Rep1990，2，：	1
	11	Cardiac origins of the postural orthostatic tachycardia syndrome显示文摘	Fn Q Vangundy TB Galbreath MM	2010	J Am Coll Cardio12010，55，25：	1
	12	Effects of common compo nents on hardness of culture media prepared with GelriteTM显示文摘	Huang L C Kohashi C Vangundy R	1995	In Vitro CeLl Dev Biol Plant1995，31，2：	1
	13	Exercise Training Versus Propranolol in the Treatment of the Postural Orthostatic Tachycardia Syndrome显示文摘	Qi Fu Tiffany B. VanGundy Shigeki Shibata Richard J. Auchus Gordon H. Williams Benjamin D. Levine	2011	Hypertension2011，，2：	1
	14	Effects of exercise training on arterial-cardiac baroreflex function in POTS显示文摘	Galbreath MM Shibata S VanGundy TB	2011	Clin Auton Res2011，21，2：	1
	15	Cardiac origins of the postural orthostatic tachycardia syndrome显示文摘	Fu Q Vangundy TB Galbreath MM		0，，25：	1
	16	Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndrome显示文摘	Fu Q Vangundy TB Shibata S		0，，02：	1
	17	'Zincone' zinc oxide-organic hybrid polymer thin films formed by molecular layer deposition显示文摘	PENG Q GONG B VANGUNDY R M	2009	Chemistry of Materials2009，21，5：	1
	18	Cardiac origins of the postural orthostatic tachycardia syndrome 显示文摘	Fu Q Vangundy TB Galbreath MM	2010	J Am Coil Cardiol2010，55，25：	1

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