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| 1 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 2 | 局灶节段透明变性及硬化在判断IgA肾病预后中的意义显示文摘目的 探讨IgA肾病 (IgAN)进展为慢性肾功能不全 (CRI)的病理学危险因素。方法 对 6 40例经肾活检确诊的IgAN病人进行平均 5 3个月的追踪观察。用病例对照法研究所有病人的病理学资料 ,同时还对其中 2 0 4例活检当时肾功能正常 ,5年后发展为CRI或终末期肾功能衰竭(ESRF) (n =18)以及 5年后肾功能仍保持正常 (n =186 )的病例进行了比较。结果 弥漫性系膜增生型 (DMP)为最常见的病理型 ,占 5 0 %。 / 间质纤维化 ,>40 %硬化肾小球 , / 血管病变 ,局灶节段透明变性及硬化 (FSHS)的均为预测肾功能恶化的危险因素 ,其中FSHS的意义更大 (P <0 0 0 0 1)。结论 FSHS的存在是IgAN病人正常肾功能进展恶化的显著指标。 | 严海东 Packham D Kincaid Smith P Becker G 周希静 | 1999 | 中华肾脏病杂志1999，15，5： | 20 |
| 3 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 4 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 5 | 白蚁的室内饲养和室内试验方法显示文摘Ⅰ.白蚁的饲养、繁殖和试验的一般先决条件 A.生物学和繁殖 B.食物 C.通风、湿度和温度 D.有毒因子、病毒、寄生菌和天敌 E.容器、防止逃跑和观察 F.采集和搬运Ⅱ.饲养和繁殖 A.成虫和早期群体的饲养 B.木白蚁科的白蚁群体(干木白蚁) C.原白蚁科的白蚁群体(湿木白蚁) D.鼻白蚁科的白蚁群体(土木两栖性白蚁) E.白蚁科的白蚁群体(营巢性白蚁) Ⅲ. | Günther Becker 宋晓钢 | 1992 | 白蚁科技1992，9，1： | 4 |
| 6 | Vulnerability of the nigrostriatal system as detected by transcranial ultrasound显示文摘 | Berg D Becker G Zeiler B | 1999 | Neurology1999，53，： | 2 |
| 7 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 8 | Methods for the early diagnosis of Parkinson's disease显示文摘 | Becker G | 2003 | Nervenarzt2003，74，1： | 2 |
| 9 | Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography显示文摘 | Becker G Seufert J Bogdahn U | 1995 | Neurol1995，45，： | 2 |
| 10 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 11 | Coordination 2 Costs and Knowledge 显示文摘 | Becker G S Murphy K The Division of Labor | 1992 | Quarterly Journal of Economics1992，107，4： | 1 |
| 12 | Early diagnosis of Parkinson's disease显示文摘 | Muller A Brawnes S | 2002 | Newrol2002，249，： | 1 |
| 13 | Risk stratification and outcomes of transluminal endografting for abdominal aortic aneurysm: 72-year experience and long-term follow-up显示文摘 | BECKER G J KOVACS M MATHISON M N | 2001 | J Vase Interv Radiol2001，12，9： | 1 |
| 14 | Combined treatment effects after embolisation and radiosurgery in high-grade arterioven- ous malformations Case report and review of the literature 显示文摘 | uffner F freudenstein D Becker G etal | 2000 | Stereotact Funct Neurosurg2000，75，： | 1 |
| 15 | Impact event at the Permian-Triassic boundary:Evidence from extraterrestrial noble gases in fullerenes显示文摘 | Becker L Poreda R J Hunt A G | 2001 | Science2001，291，： | 1 |
| 16 | Fertility Choice in a Model of Economic Growth 显示文摘 | Barro R J Becker G S | 1989 | Econometric1989，2，： | 1 |
| 17 | A Theory of Competition Among Pressure Groups for Political Influence显示文摘 | Becker G S | 1983 | The Quarterly Jour- nal of Economics1983，98，3： | 1 |
| 18 | Comparison of ab- sorbable with nonabsorbable sutures in closure of facial skin wounds显示文摘 | Parell G J Becker GD | 2003 | Arch Facial Plast Surg2003，5，6： | 1 |
| 19 | Evolutionary efficiency and happiness显示文摘 | Rayo L Becker G | 2007 | Journal of Political Economy2007，115，2： | 1 |
| 20 | Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-anal- ysis 显示文摘 | Chu S G Becker R C Berger P B | 2010 | J Thromb Haemost2010，8，1： | 1 |
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