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| 1 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 2 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 3 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 4 | Sperling任务中刺激呈现方式对注意分配的影响显示文摘以全部报告法和部分报告法为任务,在Kosslyn瞬时记忆模型框架下,探讨当刺激呈现和报告的方式按列进行时,被试注意窗的放置策略及其对瞬时记忆的影响。结果发现,部分报告优势在这种条件下也是存在的;因为长期的学习而导致的阅读习惯对注意窗放置策略的影响是稳定的;同时发现这种策略使得被试在按列进行的报告方式时,全部报告法和部分报告法的成绩都低于按行报告方式。文章还对上述实验发现作出了进一步的讨论。 | 陈国鹏 王晓丽 方芸秋 Uta Lass Song Yan Dietrich Becker Gerd Lüer | 2004 | 心理科学2004，27，3： | 2 |
| 5 | Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor- alpha显示文摘 | Bryant D Becker L Richardson J | 1998 | Circulation1998，97，14： | 2 |
| 6 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 7 | Feasibility of land surface temperature and emissivity determination from AVHRR data显示文摘 | Becker F | 1993 | Remote Sensing of Environment1993，，43： | 1 |
| 8 | Ruptureand hemorrhage of hepatic focal nodular hyperplasia 显示文摘 | BECKER Y T RAIFORD D S WEBB L | 1995 | Am Surg1995，61，： | 1 |
| 9 | Impact event at the Permian-Triassic boundary:Evidence from extraterrestrial noble gases in fullerenes显示文摘 | Becker L Poreda R J Hunt A G | 2001 | Science2001，291，： | 1 |
| 10 | Nuclear translocation of papillomavirus minor capsid protein L2 requires Hsc70显示文摘 | Florin L Becker K A Sapp C | 2004 | J Virol2004，78，11： | 1 |
| 11 | Inhibition of human brain and RBC acetylcholinesterase (ACHE) by heptylphysostigmine (HPTL)显示文摘 | Moriearty P L Becker R E | 1992 | Methods Find Exp Clin Pharmacol1992，14，8： | 1 |
| 12 | Procalcitonin assay in sys- temic inflammation, infection, and sepsis: clinical utility and limitations显示文摘 | Becker K L Snider R Nylen E S | 2008 | Crit Care Med2008，36，3： | 1 |
| 13 | Evolutionary efficiency and happiness显示文摘 | Rayo L Becker G | 2007 | Journal of Political Economy2007，115，2： | 1 |
| 14 | Ticagrelor versus clopidogrel in patients with acute coronary syndromes显示文摘 | Wallentin L Becker RC Budaj A | 2009 | N EnglJ Med2009，361，： | 1 |
| 15 | 查看详情显示文摘 | Becker L Lenoir D Matuschek G | | 0，，： | 1 |
| 16 | Feasibility of land surface temperature and emissivi- ty determination from AVHRR data显示文摘 | Li Z L Becker F | 1993 | Remote Sensing of Environ- ment1993，43，1： | 1 |
| 17 | Potential versus Actual Faking of a Biodata Form: An Analysis along Several Dimensions of Item Type显示文摘 | Becker T E Colquitt A L | 1992 | Personnel Psychology1992，45，2： | 1 |
| 18 | 显示文摘 | Barnes L Becker K H | 1992 | Atmos Environ1992，26，5： | 1 |
| 19 | 显示文摘 | Jaffe E A Nachman R L Becker C G | 1973 | J Clin Invest1973，52，： | 1 |
| 20 | Insertion/deletion polymorphism in the promoter of NFKB1 as a potential molecular marker for the risk of recurrence in superficial bladder cancer显示文摘 | Riemann K Becker L Struwe H | 2007 | Int J Clin Pharmacol Ther2007，45，8： | 1 |
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