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| 1 | Rhabdomyolysis after midazolam administration in a cirrhotic patient treated with atorvastatin显示文摘The administration of statins in patients with liver disease is not an absolute contraindication. Hepatotoxicity is a rare and often dose-related event and in the literature there are only a few described cases of fatal rhab-domyolysis in patients with chronic liver disease after statin administration. During treatment with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors,the factors responsible for myopathy may either be related to the patient,or due to interactions with other medications that are metabolic substrates of the same isozymes and therefore able to increase blood statin concentration. The most important side effects consist of increased transaminase levels,abdominal pain or muscle weakness,increased serum levels of creatine kinase and rhabdomyolysis. In this article we report a case of fatal rhabdomyolysis with acute renal failure after gastric endoscopy,where midazolam was used as a sedation agent in a patient with chronic liver disease treated with a high dose of atorvastatin. Therefore,we suggest paying particular attention to the potential risks of associating atorvastatin and midazolam in patients with chronic liver disease who need to undergo gastric endoscopy. | Antonietta Gigante Gianluca Di Lazzaro Giraldi Maria Ludovica Gasperini Biagio Barbano Marta Liberatori Liborio Sardo Francesca Di Mario Antonella Giorgi Filippo Rossi-Fanelli Antonio Amoroso | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 6 |
| 2 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 3 | Influence of Screw Speeds of the Mixer at Low Temperature on Characteristics of Moz zarella Cheese显示文摘 | RENDA A BARBANO D M YUN J J | 1997 | Journal of Dairy Science1997，80，9： | 1 |
| 4 | Whole milk reverse osmosis retentates for Cheddar cheese manufacture: Chemical changes during aging显示文摘 | Bynum D G Barbano D M | 1985 | J Dairy Sci1985，68，1： | 1 |
| 5 | Tumor necrosis factor-alpha induced adhesion molecule serum concentrations in Henoch -Schonlein purpura and pediatric systemic lupus erythematosus显示文摘 | Gattorno M Vignola S Barbano G | 2000 | J Rheumatol2000，27，9： | 1 |
| 6 | Effect of CO2 Addition to Raw Milk on Proteolysis and Lipolysis at 4℃显示文摘 | MA Y BARBANO D M SANTOS M V | 2003 | J Dairy Sci2003，86，： | 1 |
| 7 | Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia显示文摘 | Saleh MN Mori PG | 1989 | Blood1989，73，： | 1 |
| 8 | Variability in True Protein,Casein,Nonprotein Nitrogen,and Proteolysis in High and Low Somatic Cell Milks显示文摘 | VERDI R J BARBANO D M DELLAVALLE M E | 1987 | Journal of Dairy Science1987，70，2： | 1 |
| 9 | Proteolysis in Milk Associated with Increasing Somatic Cell Counts显示文摘 | SENYK G G BARBANO D M SHIPE W F | 1985 | J Dairy Sci1985，68，： | 1 |
| 10 | Influence of fatty acid chain length and unsaturation on mid-infrared milk analysis 1显示文摘 | K.E. Kaylegian J.M. Lynch J.R. Fleming D.M. Barbano | 2009 | Journal of Dairy Science2009，，6： | 1 |
| 11 | ADSA FOUNDATION SYMPOSIUM:Feed and animal factors influencing milk fat composition显示文摘 | Palmquist DL Denise Beanlieu A Barbano DM | 1993 | J Dairy Sci1993，76，： | 1 |
| 12 | Influence of milk somatic cell count and milk age on cheese yield显示文摘 | Barbano D M Rasmussen R R Lynch J M | 1991 | Journal of Dairy Science1991，74，2： | 1 |
| 13 | Whole milk reverse osmosis retentates for Cheddar cheese manufacture:Chemical changes during aging显示文摘 | BYNUM D G BARBANO D M | 1985 | J Dairy Sci1985，68，1： | 1 |
| 14 | Comparison of composition,sensory,and volatile components of thirty-four percent whey protein and milk serum protein concentrates显示文摘 | EVANS J NEWBOLD M BARBANO D M | 2009 | J Dairy Sci2009，92，10： | 1 |
| 15 | Effects of Somatic CellCount on Quality and Shelf-Life of Pasteurized Fluid Milk显示文摘 | Ma Y Ryan C Barbano D M | 2000 | J Dairy Sci2000，83，： | 1 |
| 16 | Effect of somatac cell count on proteolysis and lipolysis in pasteurized fluid milk during shelf-life storage 显示文摘 | SANTOS M V MA Y BARBANO D M | 2003 | J Dairy Sci2003，86，： | 1 |
| 17 | Effect of preservatives on the accuracy of mid-infrared milk component testing1 显示文摘 | BARBANO D M WOJCIECHOWSKI K L LYNCH J M | 2010 | Journal of Dairy Science2010，93，12： | 1 |
| 18 | Effects of Somatic Cell Count on Quality and Shelf-Life of Pasteurized Fluid Milk 显示文摘 | Ma Y Ryan C Barbano D M | 2000 | J Dairy Sci2000，83，： | 1 |
| 19 | Impact of Milk Preacidification with CO2 on the Aging and Proteolysis of Cheddar Cheese显示文摘 | NELSON B K LYNCH J M BARBANO D M | 2004 | J Dairy Sci2004，87，： | 1 |
| 20 | Mozzarella Cheese Making by a Stirred Curd, No Brine Procedure显示文摘 | David M Barbano | 1994 | J Dairy Sci1994，77，： | 1 |
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