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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Colon cancer and the epidermal growth factor receptor:Current treatment paradigms,the importance of diet,and the role of chemoprevention显示文摘Colorectal cancer represents the third most common and the second deadliest type of cancer for both men and women in the United States claiming over 50000 lives in 2014. The 5-year survival rate for patients diagnosed with metastatic colon and rectal cancer is < 15%. Early detection and more effective treatments are urgently needed to reduce morbidity and mortality of patients afflicted with this disease. Here we will review the risk factors and current treatment paradigms for colorectal cancer, with an emphasis on the role of chemoprevention as they relate to epidermal growth factor receptor(EGFR) blockade. We will discuss how various EGFR ligands are upregulated in the presence of Western diets high in saturated and N-6 polyunsaturated fats. We will also outline the various mechanisms of EGFR inhibition that are induced by naturally occurring chemopreventative agents such as ginseng, green tea, and curcumin. Finally, we will discuss the current role of targeted chemotherapy in colon cancer and outline the limitations of our current treatment options, describing mechanisms of resistance and escape. | Baldeep Pabla Marc Bissonnette Vani J Konda | 2015 | World Journal of Clinical Oncology2015，6，5： | 7 |
| 3 | Chitinase 3-Like-1 Expression in Colonic Epithelial Cells as a Potentially Novel Marker for Colitis-Associated Neoplasia显示文摘 | Chun-Chuan Chen Joel Pekow Victoria Llado Manasa Kanneganti Cindy W. Lau Atsushi Mizoguchi Mari Mino-Kenudson Marc Bissonnette Emiko Mizoguchi | 2011 | The American Journal of Pathology2011，，3： | 3 |
| 4 | Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas显示文摘 | Bissonnette RP McGahon A Mahboubi A | 1994 | J Exp Med1994，180，6： | 2 |
| 5 | Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: An international consensus显示文摘 | Lasse R. Braathen Rolf-Markus Szeimies Nicole Basset-Seguin Robert Bissonnette Peter Foley David Pariser Rik Roelandts Ann-Marie Wennberg Colin A. Morton | 2007 | Journal of the American Academy of Dermatology2007，，： | 2 |
| 6 | Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis显示文摘 | Liu Weicheng Chen Yunzi Golan Maya Aharoni Annunziata Maria L Du Jie Dougherty Urszula Kong Juan Musch Mark Huang Yong Pekow Joel Zheng Changqing Bissonnette Marc Hanauer Stephen B Li Yan Chun | 2013 | Journal of Clinical Investigation2013，，9： | 2 |
| 7 | Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis显示文摘Background:Mastitis caused by different pathogens including Streptococcus uberis(S.uberis)is responsible for huge economic losses to the dairy industry.In order to investigate the potential genetic and epigenetic regulatory mecha‑nisms of subclinical mastitis due to S.uberis,the DNA methylome(whole genome DNA methylation sequencing)and transcriptome(RNA sequencing)of milk somatic cells from cows with naturally occurring S.uberis subclinical mastitis and healthy control cows(n=3/group)were studied.Results:Globally,the DNA methylation levels of CpG sites were low in the promoters and first exons but high in inner exons and introns.The DNA methylation levels at the promoter,first exon and first intron regions were nega‑tively correlated with the expression level of genes at a whole‑genome‑wide scale.In general,DNA methylation level was lower in S.uberis‑positive group(SUG)than in the control group(CTG).A total of 174,342 differentially methylated cytosines(DMCs)(FDR<0.05)were identified between SUG and CTG,including 132,237,7412 and 34,693 DMCs in the context of CpG,CHG and CHH(H=A or T or C),respectively.Besides,101,612 methylation haplotype blocks(MHBs)were identified,including 451 MHBs that were significantly different(dMHB)between the two groups.A total of 2130 differentially expressed(DE)genes(1378 with up‑regulated and 752 with down‑regulated expression)were found in SUG.Integration of methylome and transcriptome data with MethGET program revealed 1623 genes with signifi‑cant changes in their methylation levels and/or gene expression changes(MetGDE genes,MethGET P‑value<0.001).Functional enrichment of genes harboring≥15 DMCs,DE genes and MetGDE genes suggest significant involvement of DNA methylation changes in the regulation of the host immune response to S.uberis infection,especially cytokine activities.Furthermore,discriminant correlation analysis with DIABLO method identified 26 candidate biomarkers,including 6 DE genes,15 CpG‑DMCs and 5 dMHBs that discriminated between SUG and CTG.Conclusion:The integration of methylome and transcriptome of milk somatic cells suggests the possible involve‑ment of DNA methylation changes in the regulation of the host immune response to subclinical mastitis due to S.uberis.The presented genetic and epigenetic biomarkers could contribute to the design of management strategies of subclinical mastitis and breeding for mastitis resistance. | Mengqi Wang Nathalie Bissonnette Mario Laterriere Pier‑Luc Dudemaine David Gagne Jean‑Philippe Roy Xin Zhao Marc‑Andre Sirard Eveline M.Ibeagha‑Awemu | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 2 |
| 8 | Usefulness of endoscopic ultrasonography in hepatology显示文摘 | Bissonnette J Paquin S Sahai A | | 0，，11： | 1 |
| 9 | Influence of key parameters on drying shrinkage of cementitious materials显示文摘 | Benoit Bissonnette Pascale Pierre Michel Pigeon | 1999 | Cement and Concrete Research1999，29，10： | 1 |
| 10 | Microvascular decompression for glossopharyngeal neuralgia 显示文摘 | Resnick DK Jannetta PJ Bissonnette K | 1995 | Neurosurgery1995，36，1： | 1 |
| 11 | Microvascular decompression for glossopharyngcal neuralgia显示文摘 | Resnick DK Jannetta PJ Bissonnette D | 1995 | Neurosurgery1995，36，1： | 1 |
| 12 | Capnometry and the paediatric laryngeal mask airway 显示文摘 | Spahr-Schopfer I A Bissonnette B Hartley E J | 1993 | Can J Anesth1993，40，5： | 1 |
| 13 | Lack of association between smoking and DNA fragmentation in the sper- matozoa of normal men显示文摘 | SERGERIE M OUHILAL S BISSONNETTE F | 2000 | Hum Reprod2000，15，6： | 1 |
| 14 | The treatment of moderate to severe psori asis with a new anti-CD11a monoclonalantibody显示文摘 | Papp K Bissonnette R Krueger JG | | 0，，： | 1 |
| 15 | Cone-beamcomputed to- mographic image guidance for lung cancer radiation therapy 显示文摘 | Bissonnette JP Purdie TG Hiqqins JA | 2009 | Int J Radiat Oncol Biol Phys2009，73，： | 1 |
| 16 | Peroperative risks in cerebral aneurysm surgery 显示文摘 | Mustaki JP Bissonnette B Archer D | 1996 | Ann Fr Anesth Reanim1996，15，3： | 1 |
| 17 | The long-term outcome of microvascular decompression for trigeminal neuralgia 显示文摘 | Barker F Jannetta P Bissonnette D | 1996 | N Engl J Med1996，334，： | 1 |
| 18 | Influence of key parameters on drying shrinkage of cementitious materials显示文摘 | Beno?t Bissonnette Pascale Pierre Michel Pigeon | 1999 | Cement and Concrete Research1999，29，： | 1 |
| 19 | Influence of key parameters on drying shrinkage of cementitious mate- rials显示文摘 | Bissonnette B Pierre P Pigeon M | 2003 | Cement and Structure2003，29，10： | 1 |
| 20 | Quality assurance for image-guided radiation therapy utilizing CT-based technologies:A report of the AAPM TG-179显示文摘 | Bissonnette J P Baiter P A Dong L | 2012 | Med Phys2012，39，4： | 1 |
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