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| 1 | Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties显示文摘 | Monica Bostad Kristian Berg Anders H?gset Ellen Skarpen Harald Stenmark P?l K. Selbo | 2013 | Journal of Controlled Release2013，，3： | 4 |
| 2 | Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial显示文摘 | John Willy Haukeland Zbigniew Konopski Heidi Beate Eggesb? Hilde L?land von Volkmann Gabriele Raschpichler Kristian Bj?ro Terese Haaland Else Marit L?berg K?re Birkeland | 2009 | Scandinavian Journal of Gastroenterology2009，，7： | 3 |
| 3 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 4 | Acute surgical emergencies in inflammatory bowel disease显示文摘 | Dale F Berg Anil M Bahadursingh Donald L Kaminski Walter E Longo | 2002 | The American Journal of Surgery2002，，： | 2 |
| 5 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 6 | 计算机技术与临床工作平静地等待戈多显示文摘信息技术(information technology,IT)的流程支持已经被人称为改善卫生保健质量和安全性的重要障碍。有2个方面特别引起人们的注意和投资。第一个是临床决策支持系统,亦即为改善临床医生做出决定而设计的信息系统。第二个则是一种为减少用药错误而采用的计算机医嘱输入(Computerized Physician Order Entry,CPOE)系统。该领域的文献以频繁的成功报告为特征,并且经常预言一个光明的新(近期的)未来;然而,这个未来似乎永远不会到来。在统治会议进程的欢呼和高度期望的背后,在自动贩卖信息和大量科学文献的背后,其现实情况是,目前各地所用系统虽然拥有满意的使用者,但是对医疗质量和安全性做出有效贡献者罕见。 | Robert L Wears Marc Berg 苗峥(译) | 2005 | 美国医学会杂志(中文版)2005，24，5： | 2 |
| 7 | Monodisperse polymer particles-a step forword for chromatography显示文摘 | Ugelstad J Soderberg L Berge A | 1983 | Nature1983，303，： | 2 |
| 8 | Combining transient elastography with FIB4 enhances sensitivity in detecting advanced fibrosis of the liver显示文摘 | Hans Lannerstedt Zbigniew Konopski Leiv Sandvik Terese Haaland Else Marit Lø berg John Willy Haukeland | 2013 | Scandinavian Journal of Gastroenterology2013，，1： | 2 |
| 9 | Unfrozen water contents of undisturbed and remolded Alaskan 显示文摘 | Tice A R Black P B Berg R L | 1989 | Cold Regions Science and Technology1989，17，： | 2 |
| 10 | Breakup and Fusion of Self- Guide Femtosecond Light Pulses in Air 显示文摘 | TZORTZAKIS S BERGE L | 2002 | Physical Review Letters2002，，86： | 1 |
| 11 | Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer 显示文摘 | Berg WA Gutierrez L NessAiver MS | 2004 | Radiology2004，233，： | 1 |
| 12 | Protection of experimentally infected pigs by suil- ysin, the thiol-activated haemolysin of Streptococcus suis 显示文摘 | JACOBS A A VAN DEN BERG A J LOEFFEN P L | 1996 | Vet Rec1996，139，10： | 1 |
| 13 | Evidence for the forma- tion of disulfide radicals in protein crystals upon X-ray irra- diation显示文摘 | Weik M Berges J Raves M L | 2002 | J Synchrotron Radiat2002，9，6： | 1 |
| 14 | A new clinical scale for the staging of dementia显示文摘 | Hughes CP Berg L Danziger WL | 1982 | Br J Psychiatry1982，140，： | 1 |
| 15 | Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife显示文摘 | VAN den Berg BIRNBAUM M BOSVELD L | 1998 | Environ Health Persp1998，106，： | 1 |
| 16 | Motivation and satisfaction among polyclinic volunteers at the 2002 Winter Olympic and Paralympie Games 显示文摘 | Recscr J C Berg R L Rhea D | 2005 | British Journal of Sports Medicine2005，39，4： | 1 |
| 17 | Long-term siol nitrogen and vegetation change on sandhill rangeland显示文摘 | Berg W A Bradford J A Smis P L | 1997 | Journal of Range Management1997，50，5： | 1 |
| 18 | Convenient route to monocyclopentadienylzirconium (IV) complexes 显示文摘 | Erker G Berg K Treschanke L | 1982 | Inorg Chem1982，，21： | 1 |
| 19 | Identification, purification, and characterization of a thiol-activated hemolysin(suilysin) of Streptococcus suis 显示文摘 | JACOBS A A C LOEFFEN P L W BERG A J G | 1994 | Infect Immun1994，62，5： | 1 |
| 20 | Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy显示文摘 | Berge K E Ose L Leren T P | 2006 | Arterioscler Thromb Vase Biol2006，26，5： | 1 |
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