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| 1 | Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis显示文摘BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients' progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption. | Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 26 |
| 2 | Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。 | Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd | 2018 | Protein & Cell2018，9，1： | 2 |
| 3 | Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family显示文摘AIM: To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer (HNPCC) family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers. METHODS: The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the pro-band. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced. RESULTS: The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining. CONCLUSION: The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor. The primary tumor localizations were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria. | Tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky | 2006 | World Journal of Gastroenterology2006，12，48： | 2 |
| 4 | Structural Aspects of Multistep Phosphorelay- Mediated Signaling in Plants显示文摘multistep phosphorelay (MSP ) 是在集成大量神经质、环境的输入并且控制众多的发展改编的植物的一条中央发信号小径。为位于调停 MSP 的信号识别和 transduction 下面的分子的机制的彻底的理解,小径的单个成员的详细结构的描述是批评的。在我们描述并且讨论的这评论,最近已知的水晶和原子磁性的回声在在更高的植物发信号的 MSP 行动的蛋白质组织,特别地集中于在 Arabidopsis thaliana 发信号的细胞激动素和乙烯。我们通过 phosphorelay 包括 ligand 特性,经由它的 autophosphorylation 的受体的激活,和下游的信号 transduction 的决心讨论可得到的结构的信息的功能的方面的范围。我们把植物结构与他们的细菌的对应物作比较并且证明尽管全面类似高,在结构的细节的差别经常、机能上地重要。最后,我们在 MSP 在分子的识别机制上讨论新兴的知识,并且关于在能在所有更高的植物担任这条小径的一个一般模型的 Arabidopsis MSP 表明特性的结构的决定因素提及最近的调查结果。 | Blanka Pekarova Agnieszka Szmitkowska Radka Dopitova Oksana Degtjarik Lukas Zidek Jan Hejatko | 2016 | Molecular Plant2016，9，1： | 2 |
| 5 | Modulation of MHC class Ⅱ expression in human cells by dexamethasone显示文摘 | Schwiebert LM Schleimer RP Radka SF | 1995 | Cell Immunol1995，165，5： | 1 |
| 6 | Chlorophyll a self-assembly in polar solventwater mixtures 显示文摘 | Radka V | 2000 | Photochemistry and photobiology2000，71，1： | 1 |
| 7 | Beyond national networking: International re-search and teaching activities in Biotechnology atthe University of Applied Sciences Wadenswil显示文摘 | Kovar Karin Stmadova Radka Bell Maggi Lus-si | 2007 | CHIMIA2007，，61： | 1 |
| 8 | The Origin of Human Mesenchymal Stromal Cells Dictates Their Reparative Properties显示文摘 | Nili Naftali‐Shani Ayelet Itzhaki‐Alfia Natalie Landa‐Rouben David Kain Radka Holbova Shimrit Adutler‐Lieber Natali Molotski Elad Asher Avishay Grupper Eran Millet Ariel Tessone Eyal Winkler Jens Kastrup Micha S. Feinberg Dov Zipori Meirav Pevsner‐Fischer | 2013 | Journal of the American Heart Association2013，，5： | 1 |
| 9 | Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses 显示文摘 | Jakub Sire Sarka Kubinova Radka Hobzova | 2012 | International Journal of Nanomedicine2012，，7： | 1 |
| 10 | Determination of isoflavones in soy bits by fast column highperformance liquid chromatography coupled with UV-visible diode-array detection显示文摘 | Borivoj Klejdus Radka Mikelova Jitka Petrlova | 2005 | J Chromatogr A2005，1084，： | 1 |
| 11 | Occurrence of hydrogen sulfide in wine and in fermentation influence of yeast strain and supple- mentation of yeast available nitrogen显示文摘 | UGLIANO M RADKA K HENSCHKE P A | 2011 | J Ind Mierobiol Blot2011，38，3： | 1 |
| 12 | 霉菌毒素的经济影响显示文摘霉菌毒素是一个世界性的重大问题,给众多国家造成了巨大的直接或间接经济损失。让料仓中谷物的温度和水分含量保持在较低的水平并定期通风,可以防止霉菌毒素(如赭曲霉毒素和黄曲霉毒素)的蓄积。 | 付亚楠(译) 张配配(审) Radka Borutova | 2020 | 国外畜牧学(猪与禽)2020，40，5： | 1 |
| 13 | Bioactive natural products with anti‐herpes simplex virus properties显示文摘 | Sherif T. S. Hassan Radka Masar?íková Kate?ina Berchová | 2015 | J Pharm Pharmacol2015，，10： | 1 |
| 14 | Detection of the antimicrobial peptide gene in different Amaranthus species 显示文摘 | Radka Pribylova Petr Kralik Bohumila Pisarikova | 2008 | Biologia2008，63，2： | 1 |
| 15 | Investigation of thermal stabilization of poly(vinyl chloride) by lead stearate and its combination with synthetic hydrotalcite显示文摘 | Radka Kalouskova Miroslava Novotna Zdenek Vymazal | 2004 | Polymer Degradation and Stability2004，，： | 1 |
| 16 | Influence of arbuscular mycorrhizal fungi and simulated acid rain on the growth and coexistence of the grasses Calamagrostis villosa and Deschampsia flexuosa显示文摘 | RADKA MALCOVA MIROSLAV VASATKA | 1999 | Plant and Soil1999，207，： | 1 |
| 17 | Anaerobic inhibition and biodegradation of antibiotics in ISO test schemes 显示文摘 | Stefan G Elke U Radka A | 2007 | Chemosphere2007，66，10： | 1 |
| 18 | Zn(11)-Chlorido complexes of phytohormone kinetin and its derivatives modulate expression of inflammatory mediators in THP-1 cells显示文摘 | JAN H RADKA N PETR B | 2013 | PLo S one2013，8，65： | 1 |
| 19 | Modulation of MHC class II expression in human cells by dexamethasone显示文摘 | Schwiebert LM Schleimer RP Radka SF | 1995 | Cell Immunol1995，165，1： | 1 |
| 20 | 免疫系统受抑制是否影响家禽的生长显示文摘许多因素可以影响动物在应激条件下的免疫反应。要降低现代家禽生产中的死亡率,应用有效的疫苗接种计划被认为是非常必要的。然而,免疫接种有时过于频繁且接种剂量过大。不恰当的免疫接种可能会导致动物免疫系统发生应激。多项研究表明,应激不仅会影响动物肠道的功能,也影响营养物质的吸收。 | 唐彩琰 邵建忠 Radka Borutova DVM | 2017 | 国外畜牧学(猪与禽)2017，37，11： | 1 |
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