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| 1 | The proprotein convertase subtilisin/kexin type 9 geneE670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations显示文摘Background The association of E670G polymorphism in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and serum lipid profiles is inconsistent in dif- ferent ethnic groups.Bai Ku Yao is a special subgroup of the Yao minority in China.The present study was undertaken association of PCSK9 E670G polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Methods A total of 649 subjects of Bai Ku Yao and 646 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples.Genotyping of the PCSK9 E670G polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing. Results The levels of serum total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C) and apolipoprotein(Apo) AI were lower in Bai Ku Yao than in Han(P<0.01 for all).The frequency of A and G alleles was 98.00%and 2.00%in Bai Ku Yao,and 95.20%and 4.80%in Han(P<0.01);respectively. The frequency of AA,AG and GG genotypes was 95.99%,4.01%and 0%in Bai Ku Yao,and 91.02%, 8.36%and 0.62%in Han(P<0.01);respectively.There were also significant differences in the genotypic and allelic frequencies between n and the ratio of ApoAI to ApoB in Han Chinese but not in Bai Ku Yao were different between the AA and AG/GG genotypes(P<0.05 for all).The G allele carriers had higher serum HDL-C and higher ApoAI to ApoB ratio than the G allele noncarriers.When serum lipid parameters in Han were analyzed according to sex,the G allele carriers had higher serum HDL and ApoAI levels in males (P<0.05),and lower ApoB level and higher ApoAI to ApoB ratio in females(P<0.05 for all).Multiple linear regression analysis showed that serum HDL-C levels were correlated with genotypes in both ethnic groups(P<0.05 each).Serum lipid parameters were also correlated with sex,age,body massindex,alcohol consumption,cigarette smoking,and blood pressure in both ethnic groups(P<0.05-0.001).Conclusions These results suggest that the PCSK9 E670G polymorphism is mainly associated with some serum lipid parameters in the Han population,both gender show different relations to different serum lipid parameters.The G allele carriers might have higher serum lipid profiles than the G allele noncarriers. ormal LDL-C(≤3.20 mmol/L) and high LDL-C subgroups (> 3.20 mmol/L,P<0.01;respectively) in Bai Ku Yao, and between normal ApoB(≤1.14 g/L) and high ApoB subgroups(> 1.14 g/L,P < 0.01;respectively) in Han. | Lynn Htet Aung,YIN Rui-xing,MIAO Lin,HU Xi-jiang, YAN Ting-ting,CAO Xiao-li,WU Dong-feng,LI Qing,PAN Shang-ling,WU Jin-zhen (Department of Cardiology,Institute of Cardiovascular Diseases, The First Affiliated Hospital,Guangxi Medical University, Nanning 530021,China) | 2011 | 岭南心血管病杂志2011，17，S1： | 9 |
| 2 | Fabrication and laser performance of polycrystal and single crystal Nd : YAG by advanced ceramic processing 显示文摘 | Ikesue Yan Lin Aung Yoda T | 2007 | Opt Mater2007，29，： | 1 |
| 3 | Fabrication and laser performance of polycrystal and single crystal Nd:YAG by advanced ceramic processing显示文摘 | Ikesue Akio Yan Lin Aung Yoda T | 2007 | Opt Mater2007，29，10： | 1 |
| 4 | Progress in ceramic lasers 显示文摘 | Ikesue A Yan Lin Aung Takunori Taira | 2006 | Ann Rev Mater Res2006，36，： | 1 |
| 5 | PROGRESS IN CERAMIC LASERS显示文摘 | Akio Ikesue Yan Lin Aung Takunori Taira Tomosumi Kamimura Kunio Yoshida Gary L. Messing | 2006 | Annual Review of Materials Research2006，，： | 1 |
| 6 | Ceramic laser materials显示文摘 | IKESUE A AUNG Yan Lin | 2008 | Nat Photonics2008，2，： | 1 |
| 7 | Fabrication and laser performance of polycrystal and single crystal Nd:YAG by advanced ceramic processing显示文摘 | A. Ikesue Yan Lin Aung T. Yoda S. Nakayama T. Kamimura | 2006 | Optical Materials2006，，10： | 1 |
| 8 | Preparations of perovskite-type oxides LaCoO3 from three different methods and their evaluation by homogeneity, sinterability and conductivity显示文摘 | Susumu Nakayama Masahiro Okazaki Yan Lin Aung Masatomi Sakamoto | 2003 | Solid State Ionics2003，，158： | 1 |
| 9 | Synthesis and performance of advanced ceramic lasers显示文摘 | Ikesuew A Yan Lin Aung | 2006 | J Am Ceram Soc2006，89，6： | 1 |
| 10 | Anisotropic alumina ceramics with isotropic optical properties显示文摘Excellent mechanical and isotropic optical properties are achieved simultaneously from fully dense polycrystalline advanced alumina ceramics with a hexagonal crystal structure,which are optically anisotropic.A small amount(240 ppm)of ZrO_(2) additive is used to synthesize the transparent alumina ceramics with an average grain size of 0.7µm,and locally detected optical distortion(birefringence)is extremely minimized,less than 20 nm/pass.Total transmittance(86%)of the alumina ceramics(thickness=0.3 mm)in ultraviolet(UV)to infrared(IR)regions is similar to that of commercial c-axis sapphire single crystals produced by Czochralski(CZ)method,while the extinction ratio in the visible wavelength area is over 25 dB.Like glass and the c-axis sapphire single crystals,the alumina ceramics can clearly display texts and images on liquid crystal display(LCD)screens.A grain boundary phase of nano-sized Al_(2)O_(3)-ZrO_(2) composition(amorphous)is formed at the grain boundary of the advanced alumina ceramics,which enhances four-point bending strength and fracture toughness(KIC)simultaneously to 921 MPa and 6.8 MPa·m^(0.5),respectively,and hence the mechanical properties are superior to those of the sapphire single crystals. | Akio IKESUE Yan Lin AUNG | 2023 | Journal of Advanced Ceramics2023，12，1： | 0 |
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