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| 1 | Trends and outcomes of pancreaticoduodenectomy for periampullary tumors: A 25-year single-center study of 1000 consecutive cases显示文摘AIM To evaluate the evolution, trends in surgical approaches a n d r e c o n s t r u c t i o n t e c h n i q u e s, a n d i m p o r t a n t lessons learned from performing 1000 consecutive pancreaticoduodenectomies(PDs) for periampullary tumors.METHODS This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period(1993-2002), middle period(2003-2012), and late period(2013-2017).RESULTS The frequency showed PD was increasingly performed after the year 2000. With time, elderly, cirrhotic and obese patients, as well as patients with uncinate process carcinoma and borderline tumor were increasingly selected for PD. The median operative time and postoperative hospital stay decreased significantly over the periods. Hospital mortality declined significantly, from 6.6% to 3.1%. Postoperative complications significantly decreased, from 40% to 27.9%. There was significant decrease in postoperative pancreatic fistula in the second 10 years, from 15% to 12.7%. There was a significant improvement in median survival and overall survival among the periods.CONCLUSION Surgical results of PD significantly improved, with mortality rate nearly reaching 3%. Pancreatic reconstruction following PD is still debatable. The survival rate was also improved but the rate of recurrence is still high, at 36.9%. | ayman el nakeeb waleed askar ehab atef ehab el hanafy ahmad m sultan tarek salah ahmed shehta mohamed el sorogy emad hamdy mohamed el hemly ahmed a el-geidi tharwat kandil mohamed el shobari talaat abd allah amgad fouad mostafa abu zeid ahmed abu el eneen nabil gad el-hak gamal el ebidy omar fathy ahmed sultan mohamed abdel wahab | 2017 | World Journal of Gastroenterology2017，23，38： | 15 |
| 2 | 牛支原体TaqMan探针实时荧光定量PCR检测方法的建立及应用显示文摘以牛支原体p80基因为靶基因,设计特异性引物与探针,优化反应体系,建立了牛支原体TaqMan探针实时荧光定量PCR(TaqMan real-time PCR)检测方法,并对该方法进行了特异性、敏感性、重复性评估以及临床样本检测。结果显示,特异性试验中,牛支原体2个菌株Cq值均小于18,其余13个非牛支原体菌株Cq值均大于36;敏感性试验中,最低可检3.89拷贝/μL靶DNA,是普通PCR的10~4倍(普通PCR 3.89×10~4拷贝/μL);重复性试验中,组内、组间重复的变异系数均小于1%;44份牛的临床样品利用TaqMan real time PCR检出6份阳性(阳性率为13.64%),分离培养鉴定检出7份阳性,普通PCR检测全部阴性。本研究建立了一种敏感、特异、稳定的牛支原体TaqMan real time PCR检测方法,可用于牛支原体的快速诊断和核酸定量检测。 | 翟肖辉 王方国 郝华芳 颜新敏 陈胜利 Hussam Askar Mohamad 朱建勋 储岳峰 | 2019 | 畜牧与兽医2019，0，8： | 8 |
| 3 | 牛支原体诱导宿主免疫应答的研究进展显示文摘牛支原体(Mycoplasma bovis)是一种重要的兽医病原体,牛支原体感染给当前世界养牛业造成了重大的经济损失。本文从天然免疫、体液免疫和细胞免疫三个方面,对宿主感染牛支原体后的免疫应答特点进行了概括和讨论,可帮助我们更好地了解牛支原体与宿主的相互作用,也为合理地设计和研发有效的牛支原体感染防控技术提供参考。 | 季文恒 陈胜利 郝华芳 颜新敏 吴娅琴 翟肖辉 Hussam Askar Hamad 马丽娜 储岳峰 | 2020 | 中国兽医科学2020，50，4： | 6 |
| 4 | Biliary leakage following pancreaticoduodenectomy:Prevalence,risk factors and management显示文摘Background: Few studies investigated biliary leakage after pancreaticoduodenectomy(PD) especially when compared to postoperative pancreatic fistula(POPF). This study was to determine the incidence of biliary leakage after PD, predisposing factors of biliary leakage, and its management. Methods: We retrospectively studied all patients who underwent PD from January 2008 to December 2017 at Gastrointestinal Surgery Center, Mansoura University, Egypt. According to occurrence of postoperative biliary leakage, patients were divided into two groups. Group(1) included patients who developed biliary leakage and group(2) included patients without identified biliary leakage. The preoperative data, operative details, and postoperative morbidity and mortality were analyzed. Results: The study included 555 patients. Forty-four patients(7.9%) developed biliary leakage. Ten patients(1.8%) had concomitant POPF. Multivariate analysis identified obesity and time needed for hepaticojejunostomy reconstruction as independent risk factors of biliary leakage, and no history of preoperative endoscopic retrograde cholangiopancreatiography(ERCP) as protective factor. Biliary leakage from hepaticojejunostomy after PD leads to a significant increase in development of delayed gastric emptying, and wound infection. The median hospital stay and time to resume oral intake were significantly greater in the biliary leakage group. Non-surgical management was needed in 40 patients(90.9%). Only 4 patients(9.1%) required re-exploration due to biliary peritonitis and associated POPF. The mortality rate in the biliary leakage group was significantly higher than that of the non-biliary leakage group(6.8% vs 3.9%, P = 0.05). Conclusions: Obesity and time needed for hepaticojejunostomy reconstruction are independent risk factors of biliary leakage, and no history of preoperative ERCP is protective factor. Biliary leakage increases the risk of morbidity and mortality especially if concomitant with POPF. However, biliary leakage can be conservatively managed in majority of cases. | Ayman El Nakeeb Mohamed El Sorogy Hosam Hamed Rami Said Mohamad Elrefai Helmy Ezzat Waleed Askar Ahmed M Elsabbagh | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 4 |
| 5 | T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ显示文摘 | Xuexian O. Yang Bhanu P. Pappu Roza Nurieva Askar Akimzhanov Hong Soon Kang Yeonseok Chung Li Ma Bhavin Shah Athanasia D. Panopoulos Kimberly S. Schluns Stephanie S. Watowich Qiang Tian Anton M. Jetten Chen Dong | 2008 | Immunity2008，，1： | 3 |
| 6 | Experimental investigations of freezing soils at ground conditions of Astana, Kazakhstan显示文摘Kazakhstan regions is seasonal climatic with transient freezing of soil ground during the winter. Roadbed integrity is important to resist the sustained load transmitted by traffic on the road surface. Freezing of soil ground could significantly influence roadbed integrity in the seasonal freezing climate of Kazakhstan. The proper determination magnitude of frost heave and heaving pressure by the influence of freezing temperatures during the winter season are necessary for design and construction of highways. Thus, experimental tests were conducted on specimens obtained from Astana(Kazakhstan) to determine the freezing pressure and magnitude of frost heaving. | Zhussupbekov Askar Shakhmov Zhanbolat | 2015 | Research in Cold and Arid Regions2015，7，4： | 3 |
| 7 | Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target显示文摘 | Ashfaq Shuaib Ken Butcher Askar A Mohammad Maher Saqqur David S Liebeskind | 2011 | Lancet Neurology2011，，10： | 3 |
| 8 | Geotechnical problems on freezing ground soil and experimental investigation in Kazakhstan显示文摘Frost susceptibility should be considered in the design and construction of foundations and retaining-wall structures in regions with the seasonally freezing-soil ground condition.When planning construction that goes deep into this soil,one has to understand the impact of horizontal forces to an underground wall and realize the potential effect of frost heaving upon,deep foundations.This article presents a few soil tests for frost heaving and the results of those tests show dangerous data for retaining structures under the soil conditions in Kazakhstan.The main parameters of the soil include frost penetration and heaving rate and amount.So,in designing underground structures,one must understand and consider that frost heaving occurs in various directions;this factor is very important for predicting on the restriction of deformations of structures in the seasonally freezing-soil ground condition. | Askar Zhussupbekov Zhanbolat Shakhmov Gulshat Tleulenova | 2017 | Research in Cold and Arid Regions2017，9，3： | 3 |
| 9 | Outcomes of pancreaticoduodenectomy in elderly patients显示文摘BACKGROUND: Although the mortality and morbidity of pancreaticoduodenectomy(PD) have improved significantly over the past years, the concerns for elderly patients undergoing PD are still present. Furthermore, the frequency of PD is increasing because of the increasing proportion of elderly patients and the increasing incidence of periampullary tumors. This study aimed to analyze the outcomes of PD in elderly patients.METHODS: We studied all patients who had undergone PD in our center between January 1995 and February 2015. The patients were divided into three groups based on age: group I(patients aged <60 years), group II(those aged 60 to 69 years) and group III(those aged ≥70 years). The primary outcome was the rate of total postoperative complications. Secondary endpoint included total operative time, hospital mortality, length of postoperative hospital stay, delayed gastric emptying, re-exploration, and survival rate.RESULTS: A total of 828 patients who had undergone PD for resection of periampullary tumor were included in this study. There were 579(69.9%) patients in group I, 201(24.3%) in group II, and 48(5.8%) in group III. The overall incidence of complications was higher in elderly patients(25.9% in group I, 36.8% in group II, and 37.5% in group III; P=0.006). There were more patients complicated with delayed gastric emptying in group II compared with the other two groups. There was no significant difference in the incidence of postoperative pancreatic fistula, biliary leakage, pancreatitis, pulmonary complications and hospital mortality.CONCLUSIONS: PD can be performed safely in selected elderly patients. Advanced age alone should not be a contraindication for PD. The outcome of elderly patients who have undergone PD is similar to that of younger patients, and the increased rate of complications is due to the presence of associated comorbidities. | Ayman El Nakeeb Ehab Atef Ehab El Hanafy Ali Salem Waleed Askar Helmy Ezzat Ahmed Shehta Mohamed Abdel Wahab | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，4： | 2 |
| 10 | Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection显示文摘AIM:To analyze the correlation between CD14 rs2569190/C-159T single nucleotide polymorphism (SNP) and disease progression in chronic hepatitis C.METHODS: Liver biopsy specimens from a total of 137 and 349 patients with chronic hepatitis C were separately evaluated with respect to necroinflammatory activity (grading) and architectural changes (staging). In one group, further histological lesions characteristic for hepatitis C, hepatitis C virus subtypes, and biochemical parameters of liver disease were also investigated. Samples of genomic DNA were genotyped for the respective SNP by 5'-nuclease assays using fluorescent dye-labeled allele-specif ic probes.RESULTS: Genotype distribution did not deviate from the Hardy-Weinberg equilibrium. In the first group, patients homozygous for the variant allele T were found to be younger than C allele carriers (39.6±12.5 vs 45.7±11.5, P=0.008). Among the histological lesions studied, portal lymphoid aggregates were more frequently observed among TT homozygotes than among C carriers (21/37 vs 32/100, P=0.008). The presence of portal lymphoid aggregates was closely correlated with hepatic inflammation (P=0.003) and with bile duct damage (P<0.001). The degree of fibrosis, in contrast, was not found to be related to the CD14 gene C-159T polymorphism.CONCLUSION: The data suggest a possible relationship between CD14 C-159T polymorphism and the formation of portal lymphoid aggregates, but not liver fibrosis progression in chronic hepatitis C. | Eva Askar Giuliano Ramadori Sabine Mihm | 2009 | World Journal of Gastroenterology2009，15，31： | 2 |
| 11 | A ligamentum flarum-preserving approach to the lumbar spinal canal显示文摘 | Askar Z Wardlaw D Choudhary S | 2003 | Spine2003，28，19： | 1 |
| 12 | Outcome and complications in peritoneal dialysis patients:a five-year single center experience显示文摘 | Alwakeel JS Alsuwaida A Askar A | 2011 | Saudi J Kidney Dis Transpl2011，22，2： | 1 |
| 13 | Application of bit-level pipelining to delay insensitive null convention adders 显示文摘 | ISMAILOGLU A N ASKAR M | 2007 | Circuits and Systems2007，6，25： | 1 |
| 14 | Scott wiring for direct repair of lumbar spondylolysis显示文摘 | Wardlaw D Koti M | 2003 | Spine2003，28，4： | 1 |
| 15 | Effects of heparin fractions on theprevention ofskin necrosis resulting from adriamycin extravasation: An experimental study显示文摘 | Askar I Erbas MK Gurlek A | 2002 | Ann Plast Surg2002，49，3： | 1 |
| 16 | Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case ~port 显示文摘 | Askar S Kilinc N Aytekin S | 2002 | Acta Chir Plast2002，44，4： | 1 |
| 17 | Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid:a case report显示文摘 | Askar S Kilinc N Aytekin S | 2002 | Acta Chir Plast2002，44，4： | 1 |
| 18 | Button battery foreign bodies in children:hazards, management, and recommendations显示文摘 | ThabetMH BashaWM AskarS | 2013 | Biomed Res Int2013，2013，： | 1 |
| 19 | Scott wiring for direct repair of lumbar spondylolysis 显示文摘 | Askar Z Wardlaw D Koti M | 2003 | Spine ( Phila Pa 1976 )2003，25，4： | 1 |
| 20 | 显示文摘 | DEY B K ASKAR A RABITZ H A | 1999 | J Chem Phys1999，109，20： | 1 |
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