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133篇 您的检索式：作者名="Martin CG"

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	题名	作者	年代	出处	被引量
1	Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression.	Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li	2010	World Journal of Gastroenterology2010，16，33：	10
2	The effects ofmorphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog显示文摘	Martin WR Eades CG Thompson JA	1976	J Pharmacol Exp Ther1976，197，3：	1
3	Relationship of homocysteine to markers of platelet and endothelial activation in 'high risk' hypertensives: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial显示文摘	Spencer CG Martin SC Felmeden DC	2004	Int J Cardiol2004，94，23：	1
4	Adenosine A2A receptors in- teract with GABAergic pathways to modulate respiration in neonatal piglets 显示文摘	Wilson CG Martin R J Jaber M	2004	Respir Physiol Neurobio12004，141，2：	1
5	Relationship of homo- cysteine to markers of platelet and endothelial activation in 'high risk' hypertensives: a substudy of the Anglo - Scandinavian Cardiac Out- comes Trial显示文摘	Spencer CG Martin SC Felmeden DC	2004	Int J Cardiol2004，94，23：	1
6	Resuscitation-promofing factors possess a lysozyme-like domain显示文摘	Martin CG Nicholas HK Angharad PD	2004	Trends in biochemical sciences2004，29，1：	1
7	P53 induces apoptosis by caspase activation through mitochondrial cytochrome release显示文摘	Martin S Ella BW Joshua CG	2000	Biochemistry2000，275，：	1
8	显示文摘	MARTIN N BUNZLIJ CG MCKEE V	1998	InorgChem1998，37，3：	1
9	Identification of key tissue type for antler regeneration through pedicle periosteum deletion显示文摘	Li C Mackintosh CG Martin SK Clark DE	2007	Cell Tissue Res2007，328，1：	1
10	Relationship of homocysteine to markers of platelet and endothelial activation in 'high risk' hypertensives:a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial显示文摘	Spencer CG Martin SC Felmeden DC	2004	Int J Cardiol2004，94，23：	1
11	Does breast-feeding influence risk of type 2diabetes in later Life?Aquantitative analysis of published evidence显示文摘	Owen CG Martin RM Whincup PH	2006	Am J ClinNutri2006，84，5：	1
12	Relationship of homocysteine to markers of platelet and endothelial activation in 'high risk' hypertensives:A substudy of the Anglo-Scandinavian Cardiac Outcomes Trial显示文摘	Spencer CG Martin SC Felmeden DC	2004	Int J Cardiol2004，94，23：	1
13	Relationship of hono-cysteine to markers of platelets and endothethefial activation in 'highrisk' hypertensives : a substudy of the anglo-Scand inavian cardi-acoutcomes trial 显示文摘	Spencer CG Martin SC Felmeden DC	2004	Int Cardiol2004，94，：	1
14	Resuscitationpromoting factors possess a lysozyme-like domain显示文摘	Martin CG Nilas HK Angharad PD	2004	Trends Biochemical Sci2004，29，1：	1
15	Studies of an S9-based metabolic activation system used in the mouse lymphoma L5178Y cell mutation assay显示文摘	Mcgregor DB Edwards I Riach CG Cattanach P Martin R Mitchell A	1988	Mutagenesis1988，3，6：	1
16	Resuscitation-promoting factors possess a lysozyme-like domain显示文摘	Martin CG Nicholas HK Angharad PD	2004	Trends in biochemical sciences2004，29，1：	1
17	Relationship of homocyateine to markers of platelet and endothelial activation in'high risk' hypertentives, a substudy of the Anglo - SCandinavian Cardiac Outcomes Trial显示文摘	Spencer CG Martin SC Felmeden DC	2004	Int J Cardiol2004，94，23：	1
18	Small bowel bacterial overgrowth in patients with alcoholic cirrhosis显示文摘	CASAFONT MF DE LAS HERAS CG MARTIN R L	1996	Dig Dis Sci1996，41，：	1
19	Relationship of homocysteine to markers of platelet and endothelial activation in“high risk”hypertensives:a substudy of the Anglo-Scandinavian Cardiac outcomes Trial显示文摘	Spencer CG Martin SC Felmeden DC	2004	Int J Cardiol2004，94，23：	1
20	Resuscitationpromoting factors possess a lysozyme-like domain显示文摘	Martin CG Nicholas HK Angharad PD	2004	Trends in biochemical sciences2004，29，1：	1

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