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| 1 | Identification and expression profiling of Vigna mungo microRNAs from leaf small RNA transcriptome by deep sequencing显示文摘MicroRNAs(miRNAs) represent a class of small non-coding RNA molecules that play a crucial role in post-transcriptional gene regulation. Several conserved and species-specific miRNAs have been characterized to date, predominantly from the plant species whose genome is well characterized. However, information on the variability of these regulatory RNAs in economically important but genetically less characterized crop species are limited. Vigna mungo is an important grain legume, which is grown primarily for its protein-rich edible seeds. miRNAs from this species have not been identified to date due to lack of genome sequence information. To identify miRNAs from V. mungo, a small RNA library was constructed from young leaves. High-throughput Illumina sequencing technology and bioinformatic analysis of the small RNA reads led to the identification of 66 miRNA loci represented by 45 conserved miRNAs belonging to 19 families and eight non-conserved miRNAs belonging to seven families. Besides, 13 novel miRNAcandidates in V. mungo were also identified. Expression patterns of selected conserved, non-conserved, and novel miRNA candidates have been demonstrated in leaf, stem, and root tissues by quantitative polymerase chain reaction, and potential target genes were predicted for most of the conserved miRNAs. This information offers genomic resources for better understanding of miRNA mediated post-transcriptional gene regulation. | Sujay Paul Anirban Kundu Amita Pal | 2014 | Journal of Integrative Plant Biology2014，56，1： | 5 |
| 2 | Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer显示文摘AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma(HNSCC). METHODS: In this retrospective study,19 HNSCC patients underwent pre- and intra-treatment DCEMRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images,generating maps of volume transfer rate(Ktrans) and volume fraction of the extravascular extracellular space(ve). Image texture analysis was then employed on maps of Ktrans and ve,generating two texture measures: Energy(E) and homogeneity.RESULTS: No significant changes were found for the mean and standard deviation for Ktrans and ve between pre- and intra-treatment(P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans,relative to pretreatment scans(P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors. | Jacobus FA Jansen Yonggang Lu Gaorav Gupta Nancy Y Lee Hilda E Stambuk Yousef Mazaheri Joseph O Deasy Amita Shukla-Dave | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 3 | Demographic determinants of risk,colon distribution and density scores of diverticular disease显示文摘AIM:To investigate associations between ethnicity,age and sex and the risk,colon distribution and density scores of diverticular disease(DD).METHODS:Barium enemas were examined in 1000 patients:410 male,590 female;760 whites,62 Asians,44 black africans(BAs),and 134 other blacks(OBs).Risks and diverticula density of left-sided DD(LSDD) and rightsided-component DD(RSCDD = right-sided DD + right and left DD + Pan-DD) were compared using logistic regression.RESULTS:Four hundred and forty-seven patients had DD(322 LSDD and 125 RSCDD).Adjusted risks:(1) LSDD:each year increase in age increased the odds by 6%(95% CI:5-8,SE:0.8%,P < 0.001);Asians:odds ratio(OR):0.23(95% CI:0.10-0.53,SE:0.1,P ≤ 0.001) and OBs:OR:0.25(95% CI:0.14-0.43,SE:0.07,P ≤ 0.001) appeared protected vs Whites;(2) RSCDD:each year increase in age increased the odds by 4%(95% CI:2-6,SE:1%,P < 0.001);females were 0.60 times(95% CI:0.40-0.90,SE:0.12,P = 0.01) less likely than males to have RSCDD;BAs were 3.51 times(95% CI:1.70-7.24,SE:1.30,P < 0.001) more likely than Whites to have RSCDD;and(3) DD density scores:each year increase in age increased the odds of highdensity scores by 4%(95% CI:1-6,SE:1%,P < 0.001);RSCDD was 2.77 times(95% CI:1.39-3.32,SE:0.67,P < 0.001) more likely to be of high density than LSDD.No further signif icant differences were found in the adjusted models.CONCLUSION:Right colonic DD might be more common and has higher diverticula density in the west than previously reported.BAs appear predisposed to DD,whereas other ethnic differences appear conserved following migration. | Mark Golder Irina Chis Ster Pratusha Babu Amita Sharma Muhammad Bayat Abdulkadir Farah | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 4 | And-hyperglycemic activity of leaves extract of Hyptis suavcolens L.Poit in streptozotocin induced diabetic rats显示文摘Objective:To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin model.Mothods:Hyptis suaveolens extract(HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes,once daily for 21 days.Results:A significant reduction in blood glucose was observed in diabetic animals treated with HSE at different doses when compared with diabetic rats.Levels of triglyceride,total cholesterol,low density lipoprolein.very low density lipoprotein were decreased while administering HSE at different doses,compared with their control values in diabetic animals.Conclusions:Our results show that HSE possesses significant antihyperglycemic activity which might be attributed to stimulating effects on glucose utilization and antioxidant enzyme. | Shanti Bhushan Mishra Amita Verma Alok Mukerjee Vijayakumar M | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 5 | Herbal antioxidant in clinical practice:A review显示文摘Antioxidant-the word itself is magic.Using the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called'free-radical'reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging compounds.We must acknowledge that such'radicals'have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and folate.Defense strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and carotenoids.This paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall health.It is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell sites.Further evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally | Shashi Alok Sanjay Kumar Jain Amita Verma Mayank Kumar Alok Mahor Monika Sabharwal | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 4 |
| 6 | Metastatic clear cell variant of hepatocellular carcinoma with an occult hepatic primary显示文摘Metastatic clear cell carcinomas are commonly seen in the kidney and lung. Clear cell variant of hepatocellular carci- noma is an uncommon tumour. Diagnosis is usually made by correlation of histopathology. tumour markers and im- munohistochemistry, especially HepPar 1. In this unusual case of metastatic clear cell carcinoma presenting as Sister Mary Joseph’s nodule, no primary evidence was observed radiologically in the liver, but the level of alfa fetoprotein was markedly elevated. Metastatic clear cell carcinoma of the liver with an occult hepatic primary was diagnosed by immunohistochemical profile of the tumour. | Samir ShahSamir Shah Sudeep Gupta Tanuja Shet Amita Maheshwari Rekha Wuntkal and Kunisshery Mallath Mohandas | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，2： | 3 |
| 7 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 8 | Radiofrequency ablation for treatment of medically inoperable stage I non–small cell lung cancer显示文摘 | Michael Lanuti Amita Sharma Subba R. Digumarthy Cameron D. Wright Dean M. Donahue John C. Wain Douglas J. Mathisen Jo-Anne O. Shepard | 2009 | The Journal of Thoracic and Cardiovascular Surgery2009，，1： | 2 |
| 9 | Structure of Comparative Advantage of China and India: Global and Regional Dynamics显示文摘这份报纸在世界和 ASEAN 市场上调查在中国和印度之间的竞争的程度。分析用揭示比较优点,相对市场份额,长期的趋势分析和集中的统计测试的概念被承担。在 ASEAN 市场的上下文,在印度和中国之间的竞争的评估相对 ASEAN 印度自由贸易区域与 ASEAN 中国自由贸易区域的优先的实现的特殊参考被承担了。尽管竞争威胁的紧张越过产品变化,结果建议在产品水平的威胁感觉可能当前在两个市场越过所有部门从对方为两经济占优势。然而,比较级的模式印度和中国有利的长期的趋势分析表演沿着分叉的路径并且,因此正在演变在二经济之间的竞争可能不是一个主要问题。 | Amita Batra | 2007 | China & World Economy2007，15，6： | 2 |
| 10 | Role of leptin and adiponectin in insulin resistance显示文摘 | Amita Yadav Megha A. Kataria Vandana Saini Anil Yadav | 2012 | Clinica Chimica Acta2012，，： | 2 |
| 11 | Role of intracellular events in the pathogenesis of dengue; An overview显示文摘 | Bhawana Jain Umesh C. Chaturvedi Amita Jain | 2014 | Microbial Pathogenesis2014，，： | 2 |
| 12 | Role of eIF4E on epithelial-mesenchymal transition,invasion,and chemoresistance of prostate cancer cells显示文摘Dear Editor,Prostate cancer(PCa)is the most common cancer and second leading cause of cancer death for men in the United States[1].PCa with similar Gleason score has been reported to show substantial interpatient heterogeneity and differential prostate cancer-specific mortality rate[2].Such heterogeneity in PCa often results in different therapeutic responses among patients,including therapy resistance,therapeutic failure,relapse,and metastasis[3].Numerous oncogenes,such as eukaryotic translation initiation factor 4E(eIF4E),have been reported to be involved in epithelial-mesenchymal transition(EMT)and/or drug resistance in PCa[4].We previously demonstrated that eIF4E overexpression was involved in chemoresistance of triple-negative breast cancer and silencing eIF4E significantly inhibited cancer cell proliferation and sensitized cancer cells to chemotherapy in a patient-derived xenograft mouse model[5].In addition,eIF4E phosphorylation is known to stimulate the translation of matrix metalloproteinase 3(MMP3)and Snail mRNAs to promote EMT in PCa[6].Furthermore,the complexity and dynamic nature of EMT contributes to the heterogeneity of aggressive cancer cells[7].The precise role of eIF4E in EMT,invasion,and chemoresistance in PCa is still to be established with consideration of different subpopulations in order to develop precision medicine for PCa.In this work,we aimed to explore the role of eIF4E in EMT,invasion,and chemoresistance in PCa for establishing a promising new therapeutic strategy by regulating eIF4E expression using(1-aminoethyl)iminobis[Noleicylcysteinyl-1-aminoethyl)propionamide](ECO)/small interfering RNA(siRNA)nanoparticles previously developed in our lab[8-10]for PCa therapy in the context of tumor heterogeneity. | Xujie Liu Amita M Vaidya Da Sun Yan Zhang Nadia Ayat Andrew Schilb Zheng-Rong Lu | 2020 | Cancer Communications2020，40，2： | 2 |
| 13 | Radiofrequency Ablation for Stage I Non-Small Cell Lung Cancer: Management of Locoregional Recurrence显示文摘 | Michael Lanuti Amita Sharma Henning Willers Subba R. Digumarthy Douglas J. Mathisen Jo-Anne O. Shepard | 2012 | The Annals of Thoracic Surgery2012，，3： | 2 |
| 14 | Integrated lignocellulosic biorefinery:Gateway for production of second generation ethanol and value added products显示文摘An increasing demand for energy and depleting petroleum sources has elevated the need for producing alternative renewable resources.Owing to the prominence of lignocellulosic biomass as bio-renewable and the most abundant resource on Earth,this critical review provides perceptions into the potential of lignocellulosic biomass for production of second generation(2G)ethanol and value added products in a biorefinery manner.The efficient utilization of all three components of lignocellulosic biomass(i.e.,cellulose,hemicellulose and lignin)would play a significant role in the economic viability of cellulosic ethanol.The pretreatment method is the key to the success of bioconversion processes and greatly influences the economics of biorefinery process.Biotechnology tools and process engineering play pivotal roles in development of integrated processes for production of biofuels,biochemicals and biomaterials from lignocellulosic biomass.Although,lignocellulosic biorefinery has ample scopes,commercial production of biofuels and chemicals is still challenging.In this context,this review entails concept of lignocellulose biorefinery,latest developments in 2G ethanol production process,importance and market potential of 2G ethanol as renewable fuel and value added chemicals,integration of processes,challenges for integrated production of fuel together with value added chemicals and future directions. | Amisha Patel Amita R.Shah | 2021 | Journal of Bioresources and Bioproducts2021，6，2： | 2 |
| 15 | Phase Ⅰ study of pivaloyloxymethyl butyrate,a prodrug of the differentiating agent butyric acid, in patients with advanced solid malignancies显示文摘 | Amita P Eric KR Miguel AA | 2002 | Clin Cancer Res2002，8，7： | 1 |
| 16 | Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Predictor of Outcome in Head-and-Neck Squamous Cell Carcinoma Patients With Nodal Metastases显示文摘 | Amita Shukla-Dave Nancy Y. Lee Jacobus F.A. Jansen Howard T. Thaler Hilda E. Stambuk Matthew G. Fury Snehal G. Patel Andre L. Moreira Eric Sherman Sasan Karimi Ya Wang Dennis Kraus Jatin P. Shah David G. Pfister Jason A. Koutcher | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 17 | Detection of Prostate Cancer with MR Spectroscopic Imaging: An Expanded Paradigm Incorporating Polyamines 显示文摘 | Amita SD Hedvig Hricak Chaya Moskowitz | 2007 | Radiology2007，245，： | 1 |
| 18 | A novel compound heterozygous ROMK mutation presenting as late onset Bartter syndrome associated with nephrocalcinosis and elevated 1,25 (OH)2 vitamin D levels 显示文摘 | Amita S Micheal A Linshaw | 2011 | Clin Exp Nephrol2011，15，4： | 1 |
| 19 | Correlation of a priori DCE-MRI and 1 H-MRS data with molecular markers in neck nodal metastases: Initial analysis显示文摘 | Jacobus F.A. Jansen Diane L. Carlson Yonggang Lu Hilda E. Stambuk Andre L. Moreira Bhuvanesh Singh Snehal G. Patel Dennis H. Kraus Richard J. Wong Ashok R. Shaha Jatin P. Shah Amita Shukla-Dave | 2012 | Oral Oncology2012，，： | 1 |
| 20 | Molecular mechanism of the inhibition of Estradiol - Induced endometrial epithelial cell proliferation by clomiphene citrate 显示文摘 | AMITA M TAKAHASHI T TSUTSUMI S | 2010 | Endocrinology2010，151，1： | 1 |
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