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| 1 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 2 | Bortezomib Provides Effective Therapy for Antibody- and Cell-Mediated Acute Rejection显示文摘 | Matthew J. Everly Jason J. Everly Brian Susskind Paul Brailey Lois J. Arend Rita R. Alloway Prabir Roy-Chaudhury Amit Govil Gautham Mogilishetty Adele H. Rike Michael Cardi George Wadih Amit Tevar E Steve Woodle | 2008 | Transplantation2008，，12： | 2 |
| 3 | Axin-mediated CKI phosphorylation of beta -catenin at Set 45:a molecular switch for the Wnt pathway显示文摘 | Amit S Hatzubai A Birman Y Andersen J S Ben Shushan E Mann M | 2002 | Genes Dev2002，16，： | 1 |
| 4 | Does venture capital foster the most promising entrepreneurial firms 显示文摘 | Amit R Glosten L Muller E | 1990 | CaliforniaManagement Review1990，，32： | 1 |
| 5 | Preparation and crystal structures of some compounds of A3BX5 type (A=Cs,Tl,NH4,B=Mn,Fe,Co,X=Cl,Br)显示文摘 | Amit M Horowitz A Ron E | 1973 | Israel Journal of Chemistry1973，11，6： | 1 |
| 6 | Entrepreneurial ability, venture investments and risk sharing 显示文摘 | Amit R Glosten L Muller E | 1990 | Management Science1990，36，： | 1 |
| 7 | Challenges to theory de- velopment in entrepreneurship research 显示文摘 | Amit R L Glosten Muller E | 1994 | Journal of Management Studies1994，30，5： | 1 |
| 8 | Recent advances in sentinel lymph node biopsy for breast cancer显示文摘 | Amit Goyal Robert E Mansel | 2008 | Current Opinion in Oncology2008，，6： | 1 |
| 9 | Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy显示文摘 | 0MOALEM G LEIBOWITZ AMIT R YOLES E | 1999 | Nature Medicine1999，5，1： | 1 |
| 10 | Entrepreneurial ability,venture investments and risk sharing显示文摘 | GLOSTEN L MULLER E | 1990 | Management Science1990，36，： | 1 |
| 11 | Entrepreneurial Ability, Venture Investments, and Risk Sharing 显示文摘 | Amit R Glosten L Muller E | 1990 | Management Sci- ence1990，36，10： | 1 |
| 12 | Prednisone and aspirin improve pregnancy rate in patients with reproductive failure and autoimmune antibodies: a prospective study 显示文摘 | Geva E Amit A Lemer-Geva L | 2000 | Am J Reprod Immunol2000，47，1： | 1 |
| 13 | Does venture capital foster the most promising entrepreneurial firms显示文摘 | Amit R Glosten L Muller E | | 0，，03： | 1 |
| 14 | Cat scratch disease during pregnancy显示文摘 | Bilavsky E Amit S Avidor B | 2012 | Obstet Gynecol2012，119，3： | 1 |
| 15 | Entrepreneurial Ability, Venture Investments and Risk Sharing显示文摘 | Amit R Glosten L Muller E | 1990 | Management Science1990，，20： | 1 |
| 16 | PGC-1[alpha] promotes recovery after acute kidney injury during systemic inflammation in mice显示文摘 | Tran Mei Tam Denise Bardia Amit Bhasin Manoj Rowe Glenn C Kher Ajay Zsengeller Zsuzsanna K Akhavan-Sharif M Reza Khankin Eliyahu V Saintgeniez Magali David Sascha Burstein Deborah Karumanchi S Ananth Stillman Isaac E Arany Zoltan Parikh Sa | 2011 | Journal of Clinical Investigation2011，，10： | 1 |
| 17 | Entrepreneurial ability, venture investments, and risk sharing 显示文摘 | Amit R Glosten L Muller E | 1990 | Management Science1990，36，10： | 1 |
| 18 | Characteriza- tion of Aggregate Surface Energy Using the Uni- versal Sorption Device 显示文摘 | Amit Bhasin Dallas N Little P E | 2007 | Journal of Materials in Civil Engineering2007，19，8： | 1 |
| 19 | Distance -dependent processing of pictures and words 显示文摘 | Amit E Algom D Trope Y | 2009 | Journal of Experimental Psychology:General2009，138，3： | 1 |
| 20 | Challenges to Theory Development in Entrepreneurship Research显示文摘 | R Amit L Glosten E Muller | 1993 | Journal of Mnangement Studies1993，，9： | 1 |
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