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| 1 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 2 | Thermal decomposition and kinetics of plastic bonded explosives based on mixture of HMX and TATB with polymer matrices显示文摘This work describes thermal decomposition behaviour of plastic bonded explosives(PBXs) based on mixture of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX) and 2,4,6-triamino-1,3,5-trinitrobenzene(TATB)with Viton A as polymer binder. Thermal decomposition of PBXs was undertaken by applying simultaneous thermal analysis(STA) and differential scanning calorimetry(DSC) to investigate influence of the HMX amount on thermal behavior and its kinetics. Thermogravimetric analysis(TGA) indicated that the thermal decomposition of PBXs based on mixture of HMX and TATB was occurred in a three-steps. The first step was mainly due to decomposition of HMX. The second step was ascribed due to decomposition of TATB, while the third step was occurred due to decomposition of the polymer matrices. The thermal decomposition % was increased with increasing HMX amount. The kinetics related to thermal decomposition were investigated under non-isothermal for a single heating rate measurement. The variation in the activation energy of PBXs based on mixture of HMX and TATB was observed with varying the HMX amount. The kinetics from the results of TGA data at various heating rates under non-isothermal conditions were also calculated by Flynn—Wall—Ozawa(FWO) and Kissinger-Akahira-Sunose(KAS)methods. The activation energies calculated by employing FWO method were very close to those obtained by KAS method. The mean activation energy calculated by FWO and KAS methods was also a good agreement with the activation energy obtained from single heating rate measurement in the first step decomposition. | Arjun Singh Tirupati C.Sharma Mahesh Kumar Jaspreet Kaur Narang Prateek Kishore Alok Srivastava | 2017 | Defence Technology(防务技术)2017，13，1： | 8 |
| 3 | Computational Identification of Sweet Wormwood (Artemisia annua) microRNA and Their mRNA Targets显示文摘Despite its efficacy against malaria, the relatively low yield (0.01%-0.8%) of artemisinin in Artemisia annua is a serious limitation to the commercialization of the drug. A better understanding of the biosynthetic pathway of artemisinin and its regulation by both exogenous and endogenous factors is essential to improve artemisinin yield. Increasing evidence has shown that microRNAs (miRNAs) play multiple roles in various biological processes. In this study, we used previously known miRNAs from Arabidopsis and rice against expressed sequence tag (EST) database of A. annua to search for potential miRNAs and their targets in A. annua. A total of six potential miRNAs were predicted, which belong to the miR414 and miR1310 families. Furthermore, eight potential target genes were identified in this species. Among them, seven genes encode proteins that play important roles in ar- temisinin biosynthesis, including HMG-CoA reductase (HMGR), amorpha-4,11-diene synthase (ADS), farnesyl pyrophosphate synthase (FPS) and cytochrome P450. In addition, a gene coding for putative AINTEGUMENTA, which is involved in signal transduction and development, was also predicted as one of the targets. This is the first in silico study to indicate that miRNAs target genes encoding enzymes involved in artemisinin biosynthesis, which may help to understand the miRNA-mediated regulation of artemisinin biosynthesis in A. annua. | Alok Pani Rajani Kanta Mahapatra Niranjan Behera Pradeep Kumar Naik | 2011 | Genomics, Proteomics & Bioinformatics2011，9，6： | 7 |
| 4 | Machining of circular micro holes by electrochemical micro-machining process显示文摘Machining of micro holes with micro electrochemical machining(micro ECM) process has been carried out with an indigenously developed set up.This paper describes relevant problems and solutions for the circular micro holes machining process on 304 stainless steel sheets with 60 μm thickness using high speed steel cylindrical tool of diameter 500 μm and using dilute H_2SO_4 as electrolyte.The taper angle variation of the machined hole is analyzed and reported for different experimental setting parameters.The minimum value of the taper angle of machined holes is achieved at the parameter setting of0.4 mol/L H_2SO_4,700 kHz,600 ns and 21 V,for stainless steel sheets and HSS tool. | Alok Kumar Das P. Saha AlokKumarDas·ParthaSaha | 2013 | Advances in Manufacturing2013，1，4： | 6 |
| 5 | Herbal antioxidant in clinical practice:A review显示文摘Antioxidant-the word itself is magic.Using the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called'free-radical'reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging compounds.We must acknowledge that such'radicals'have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and folate.Defense strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and carotenoids.This paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall health.It is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell sites.Further evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally | Shashi Alok Sanjay Kumar Jain Amita Verma Mayank Kumar Alok Mahor Monika Sabharwal | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 4 |
| 6 | Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation显示文摘Diabetic peripheral neuropathy(DPN)is a long-term complication associated with nerve dysfunction and uncontrolled hyperglycemia.In spite of new drug discoveries,development of effective therapy is much needed to cure DPN.Here,we have developed a combinatorial approach to provide biochemical and electrical cues,considered to be important for nerve regeneration.Exosomes derived from bone marrow mesenchymal stromal cells(BMSCs)were fused with polypyrrole nanoparticles(PpyNps)containing liposomes to deliver both the cues in a single delivery vehicle.We developed DPN rat model and injected intramuscularly the fused exosomal system to understand its long-term therapeutic effect.We found that the fused system along with electrical stimulation normalized the nerve conduction velocity(57.60±0.45 m/s)and compound muscle action potential(16.96±0.73 mV)similar to healthy control(58.53±1.10 m/s;18.19±1.45 mV).Gastrocnemius muscle morphology,muscle mass,and integrity were recovered after treatment.Interestingly,we also observed paracrine effect of delivered exosomes in controlling hyperglycemia and loss in body weight and also showed attenuation of damage to the tissues such as the pancreas,kidney,and liver.This work provides a promising effective treatment and also contribute cutting edge therapeutic approach for the treatment of DPN. | Anamika Singh Alok Raghav Parvaiz Ahmad Shiekh Ashok Kumar | 2021 | Bioactive Materials2021，6，8： | 4 |
| 7 | 西印度醋栗对四氯化碳引起的大鼠和小鼠急性过氧化肝损伤的保护作用(英文)显示文摘目的:证实西印度醋栗(Phyllanthus acidus(L.)Skeels)的果实在传统医学中作为保肝药使用的药用用途。方法:连续5d分别给予各组大鼠西印度醋栗果实的70%乙醇提取物(100,200和400mg/kg口服)及对照药水飞蓟素(100mg/kg口服)并于第2天及第3天皮下注射四氯化碳(2mL/kg)。测定血清天冬氨酸氨基转移酶(aspartate transaminase,AST)、丙氨酸氨基转移酶(alanine transaminase,ALT)、碱性磷酸酶(alkaline phosphatase,ALP)、总胆红素以及总蛋白并进行肝脏组织病理学检测。检测大鼠肝组织匀浆中的氧化应激标记物如脂质过氧化反应(lipid peroxidation,LPO)、还原型谷胱甘肽(reduced glutathione,GSH)、超氧化物歧化酶(superoxide dismutase,SOD)、过氧化氢酶(catalase,CAT)以及谷胱甘肽过氧化物酶(glutathione peroxidase,GPx)以衡量西印度醋栗的体外抗氧化作用。此外,本实验还记录了伊维巴诱导的给药后小鼠睡眠时间,使用2,2-二苯基-1-苦基肼(2,2-diphenyl-1-picrylhydrazil,DPPH)法测定小鼠服药后的自由基清除率。结果:与对照组相比,西印度醋栗果实的乙醇提取物及水飞蓟素均显著降低了模型大鼠血清AST、ALT和ALP水平及LPO并升高了TP、GSH、SOD、CAT和GPx的水平(P<0.01或P<0.05)。大鼠肝脏组织的组织病理学切片结果也证实了以上实验结果。在小鼠实验中,与对照组相比,西印度醋栗果实的乙醇提取物显著缩短了伊维巴诱导的小鼠睡眠时间(P<0.01),并具有较高的DPPH清除率。结论:本研究的实验结果证实了西印度醋栗果实对四氯化碳引起的大鼠急性过氧化肝损伤的保护作用,机制可能与其抗氧化作用及自由基清除功能有关。 | Nilesh Kumar Jain Santram Lodhi Avijeet Jain Alok Nahata Abhay K.Singhai | 2011 | 中西医结合学报2011，9，1： | 3 |
| 8 | Two-warehouse inventory model for deteriorating items with demand influenced by innovation criterion in growing technology market显示文摘One of the major concerns for the technology market is the demand volatility andits impact on inventory policies. Demand volatility in the technology sector mayarise due to many factors namely customer choices, competition, growingmarket size, and so on. Often companies use rented warehouses to absorb anyfluctuations in demand. Unfortunately, warehouse and inventory researchesignore the phenomenon of growing market size to formulate policy decisions. Inthis paper, we proposed a two-warehouse inventory model with deterioration fortechnology products with linearly increasing market size where demand followsinnovation diffusion criterion. The model is based on the assumption that theholding costs in the rented warehouse are more than the own warehouse. Asimple solution procedure also discussed to solve nonlinear cost function.Numerical example and sensitivity analysis are also used to describe the utilityof the model. | Alok Kumar Udayan Chandab | 2018 | Journal of Management Analytics2018，5，3： | 3 |
| 9 | myocardial 以后梗塞巨人让室的 pseudoaneurysm 与严重的心失败介绍显示文摘 Left ventricle(LV) pseudoaneurysm is a late mechanical complication of myocardial infarction.A giant LV pseudoaneurysm is a rare presentation.We report a case of giant LV pseudoaneurysm in a post-MI patient who presented with gross congestive heart failure.The patient had a successful surgical repair of the aneurysm and had a favorable 3-mo outcome.The imaging modality and surgical treatment of the pseudoaneurysm are discussed. | Rajesh Vijayvergiya Alok Kumar Sandeep S Rana Harkant Singh Goverdhan D Puri Manphool Singhal | 2012 | World Journal of Cardiology2012，4，11： | 3 |
| 10 | Frameworks of Non-Orthogonal Multiple Access Techniques in Cognitive Radio Communication Systems显示文摘Recently,the increasing demand of radio spectrum for the next generation communication systems due to the explosive growth of applications appetite for bandwidths has led to the problem of spectrum scarcity.The potential approaches among the proposed solutions to resolve this issue are well explored cognitive radio(CR)technology and recently introduced non-orthogonal multiple access(NOMA)techniques.Both the techniques are employed for efficient spectrum utilization and assure the significant improvement in the spectral efficiency.Further,the significant improvement in spectral efficiency can be achieved by combining both the techniques.Since the CR is well-explored technique as compared to that of the NOMA in the field of communication,therefore it is worth and wise to implement this technique over the CR.In this article,we have presented the frameworks of NOMA implementation over CR as well as the feasibility of proposed frameworks.Further,the differences between proposed CR-NOMA and conventional CR frameworks are discussed.Finally,the potential issues regarding the implementation of CR-NOMA are explored. | Prabhat Thakur Alok Kumar S Pandit G Singh S N Satashia | 2019 | China Communications2019，16，6： | 3 |
| 11 | Synthesis of Co3O4 Nanoparticles Wrapped Within Full Carbon Matrix as an Anode Material for Lithium Ion Batteries显示文摘A facile polyol-assisted pyro-synthesis method was used to synthesize Co_3O_4 nanoparticles embedded into carbon matrix without using any conventional carbon source. The surface analysis by scanning electron microscopy showed that the Co_3O_4 nanoparticles(~20 ± 5 nm) are tightly enwrapped within the carbon matrix. CHN analysis determined the carbon content was only 0.11% in the final annealed sample. The Co_3O_4@carbon exhibited high capacities and excellent cycling performance as an anode at various current rates(such as 914.4 and 515.5 mAh g^(-1) at 0.25 and1.0 C, respectively, after 50 cycles; 318.2 mAh g^(-1) at a high current rate of 5.0 C after 25 cycles). This superior electrochemical performance of the electrode can be attributed to the various aspects, such as,(1) the existence of carbon matrix, which acts as a flexible buffer to accommodate the volume changes during Li^+ion insertion/deinsertion and facilitates the fast Li^+and electron transfer and(2) the anchoring of Co_3O_4 nanoparticles within the carbon matrix prevents particles agglomeration. | Subhalaxmi Mohapatra Shantikumar V.Nair Alok Kumar Rai | 2018 | Acta Metallurgica Sinica(English Letters)2018，31，2： | 3 |
| 12 | Dual-Core Photonic Crystal Fiber Plasmonic Refractive Index Sensor: A Numerical Analysis显示文摘A numerical analysis on dual core photonic crystal fiber (DC-PCF) based surface plasmon resonance (SPR) refractive index sensor is presented. The guiding parameters and required sensing performances are examined with finite element method (FEM) based software under MATLAB environment. According to simulation, it is warranted that the proposed refractive index sensor offers the maximum amplitude sensitivity of 554.9 refractive index unit (RIU-1) and 636.5 RIU 1 with the maximum wavelength sensitivity of 5800nm/RIU and 11 500nm/RIU, and the sensor resolutions of 1.72 ×10^-5RIU and 8.7× 10^-6 RIU, at analyte refractive index (RI) of 1.40 for x- and y-polarized modes, respectively. As the sensing performance in different wavelength ranges is quite high, the proposed sensor can be used in simultaneous detection for different wavelength ranges. Therefore, the proposed device is of a suitable platform for detecting biological, chemical, biochemical, and organic chemical analytes. | Alok Kumar PAUL Ajay Krishno SARKAR | 2019 | Photonic Sensors2019，9，2： | 3 |
| 13 | Optimal ordering policy for short life-cycle products under credit financing with dynamic adoption in supply chain显示文摘Traditional inventory models are mostly ignorant of the life cycle dynamics of a technology product;hence,they often fail to identify different dimensions of inventory research.This paper attempts to investigate the relationship between adoption behavior of customers using life cycle dynamics and associated trade credit policies in order to optimize the total inventory cost.The demand model used in this paper treats sales as a function of awareness diffusion and adoption.Awareness is considered as a function of feedback effects from users/customers.Retailer’s optimal strategies for short life cycle product under credit financing were determined analytically.Finally,numerical examples have been used to support the theoretical results.Theoretical results have further been used to gain some managerial insights. | Udayan Chanda Alok Kumar | 2019 | Journal of Management Analytics2019，6，3： | 2 |
| 14 | 提高认知能力的印度传统草药土丁桂(英文)显示文摘土丁桂属草药是作用于中枢神经系统的印度传统药物,特别是对促进记忆和改善智力有较好疗效。从印度传统医学和梵语文献中提取的大量信息提示,冠以土丁桂属草药名称的植物类别共4种:旋花科田旋花、旋花科土丁桂、蝶形花科蝴蝶花豆和龙胆科穿心草。这些草药名称均在古代文献中有所记载,可单独使用或与其他药材组合成各种草药处方。本文就现有的科学信息,如土丁桂属不同植物来源物种的生药学特征、化学成分、药理作用、临床前及临床应用等方面进行述评,以期为科学地应用土丁桂提供依据。此外,还可根据不同植物来源土丁桂属草药的不同功效进行鉴别应用。 | Neeraj Kumar SETHIYA Alok NAHATA Sri Hari MISHRA Vinod Kumar DIXIT | 2009 | 中西医结合学报2009，7，11： | 2 |
| 15 | Status of groundwater arsenic contamination in all 17 blocks of Nadia district in the state of West Bengal, India: A 23-year study report显示文摘 | Mohammad Mahmudur Rahman Debapriya Mondal Bhaskar Das Mrinal Kumar Sengupta Sad Ahamed M. Amir Hossain Alok Chandra Samal Kshitish Chandra Saha Subhash Chandra Mukherjee Rathindra Nath Dutta Dipankar Chakraborti | 2013 | Journal of Hydrology2013，，： | 2 |
| 16 | Skin dose estimation for various beam modifiers and source-to-sudace distances for 6MV photons 显示文摘 | Girisesh Yadav RS Yadav Alok Kumar | 2009 | J Med Phys2009，34，： | 1 |
| 17 | Deep-BERT:Transfer Learning for Classifying Multilingual Offensive Texts on Social Media显示文摘Offensive messages on social media,have recently been frequently used to harass and criticize people.In recent studies,many promising algorithms have been developed to identify offensive texts.Most algorithms analyze text in a unidirectional manner,where a bidirectional method can maximize performance results and capture semantic and contextual information in sentences.In addition,there are many separate models for identifying offensive texts based on monolin-gual and multilingual,but there are a few models that can detect both monolingual and multilingual-based offensive texts.In this study,a detection system has been developed for both monolingual and multilingual offensive texts by combining deep convolutional neural network and bidirectional encoder representations from transformers(Deep-BERT)to identify offensive posts on social media that are used to harass others.This paper explores a variety of ways to deal with multilin-gualism,including collaborative multilingual and translation-based approaches.Then,the Deep-BERT is tested on the Bengali and English datasets,including the different bidirectional encoder representations from transformers(BERT)pre-trained word-embedding techniques,and found that the proposed Deep-BERT’s efficacy outperformed all existing offensive text classification algorithms reaching an accuracy of 91.83%.The proposed model is a state-of-the-art model that can classify both monolingual-based and multilingual-based offensive texts. | Md.Anwar Hussen Wadud M.F.Mridha Jungpil Shin Kamruddin Nur Aloke Kumar Saha | 2023 | Computer Systems Science & Engineering2023，44，2： | 1 |
| 18 | Transvenous defibrillator implantation in a patient with persistent left superior vena cava显示文摘Persistent left superior vena cava(LSVC) can be incidentally detected during pacemaker implantation through left pectoral side.There is technical difficulty of optimal site pacing and lead stability for right ventricle lead in such situation.We hereby report a case of successful single-chamber implantable cardioverter defibrillator(ICD) implantation in a 50 years-old male with LSVC.The practical issues related with right ventricle lead implantation and pacing/defibrillation parameters for ICD device are discussed. | Rajesh Vijayvergiya Smit Shrivastava Alok Kumar Parminder S Otaal | 2013 | World Journal of Cardiology2013，5，4： | 1 |
| 19 | INITIATION OF SHELL MOTION ON SAND BEDS: AN EXPERIMENTAL STUDY显示文摘Experimental study on initiation of bivalve shell motion on a horizontal sand bed, under a unidirectional flow of water, is presented. Experiments were carried out in a flume with three types of bivalve shells, namely Coquina Clam, Cross-barred Chione and Ponderous Ark, to test the condition for initiation of motion. The shape parameters of bivalve shells are defined appropriately. Experiments were conducted in a flume with a horizontal bed, and the critical shear stresses were estimated using Vanoni’s side-wall correction. The characteristic parameters affecting the initiation of shell motion on a horizontal bed in rough-turbulent regime identified based on the physical reasoning and dimensional analysis are the Shields parameter (nondimensional critical shear stress), nondimensional competent mean velocity, nondimensional sand roughness, nondimensional flow depth and shape parameter. Equations of Shields parameter and nondimensional competent mean velocity for the initial movement of shells on a horizontal sand bed with convex upward and downward conditions are obtained using experimental data. | Subhasish DEY Alok KUMAR | 2002 | International Journal of Sediment Research2002，17，4： | 1 |
| 20 | Separation of lignosulfonate from its aqueous solution using supported liquid membrane 显示文摘 | Kabita Chakrabarty Prabirkumar Saha Aloke Kumar Ghoshal | 2009 | Journal of Membrane Science2009，340，12： | 1 |
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