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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 3 | Methods of Operative Fixation of the Acromio-Clavicular Joint: A Biomechanical Comparison显示文摘 | Alison J McConnell Daniel J Yoo Rad Zdero Emil H Schemitsch Michael D McKee | 2007 | Journal of Orthopaedic Trauma2007，，4： | 2 |
| 4 | Antipsychoti-c-induced weight gain:a comprehensive research synthesis显示文摘 | ALISON DB MENTORE JL MOONSEONG H | | 0，，： | 1 |
| 5 | The natural constituents of historical textile dyes 显示文摘 | FERREIRA Ester S B HULME Alison H MCNAB Hamish | 2004 | Chem Soc Rev2004，，33： | 1 |
| 6 | Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys显示文摘 | Christopher L Coe Marian Kramer Boldizsár Czéh Elizabeth Gould Alison J Reeves Clemens Kirschbaum Eberhard Fuchs | 2003 | Biological Psychiatry2003，，10： | 1 |
| 7 | A point mutation in a Drosophila GABA receptor confers insecticide resistance 显示文摘 | Ffrench-Constant Richard H Rocheleau Thomas A Steichen Jessica C Chalmers Alison E | 1993 | Nature (London)1993，363，： | 1 |
| 8 | Pluripotential liver stem cells: facultative stem cells located in the biliary tree显示文摘 | ALISON M R GOLDIN M H SARRAF C E | 1996 | Cell Prolif1996，29，7： | 1 |
| 9 | Carnitine: a nutritional, biosynthetic, and functional perspective显示文摘 | Alison S Janos K Charles L H | 2004 | Mol Aspects Med2004，25，： | 1 |
| 10 | Com-parative toxicity and carcinogenicity of two chlorinated paraffins in F344N rats and B6C3F1 mice显示文摘 | Bucher J R Alison R H Montgomery C A | | 0，，03： | 1 |
| 11 | The American phytopathological society molecular evidence that the extracellular cutinase PbcIs required for pathogenicity of pyrenopeziza brassicae on oilseed显示文摘 | Li D H Alison M A Johnstone K | 2003 | RapMPMI2003，16，6： | 1 |
| 12 | Nucleotide sequence and analysis and comparison of the structural genes for Shiga-like toxin i and Shiga-like toxin Ⅱ encoded by bacteriophages from Escherichia coli 933显示文摘 | MATTHEW P J ROGER J H ALISON D O | 1987 | FEMS Microbiology Letters1987，44，10： | 1 |
| 13 | Telomere shortening in atherosclerosis显示文摘 | Nilesh J Samani Rachel Boultby Robert Butler John R Thompson Alison H Goodall | 2001 | The Lancet2001，，9280： | 1 |
| 14 | Dissolved organic carbon and nitrogen relationships in forest litter as affected by nitrogen deposition 显示文摘 | Alison H M John D A | 2000 | Soil biology and biochemistry2000，32，： | 1 |
| 15 | The use of willingness-to-pay approaches in mammal conservation显示文摘 | Alison C Emma J V H | 2001 | Mammal Bev2001，31，2： | 1 |
| 16 | Integration of Landscape Fragmentation Analysis into Regional Planning: A Statewide Multi-scale Case Study from California,USA 显示文摘 | Evan H Girvetz Thorne J H Alison M Berry | 2008 | Landscape and Urban Planning2008，86，3： | 1 |
| 17 | Incidence of severe preeclampsia,postpartum haemorrhage and sepsis as a surrogate marker for severe maternal morbidity in a European population-based study:The MOMS-B survey显示文摘 | Zhang W H Sophie A Alison M | 2005 | BJOG:an International Journal of Obstetrics and Gynaecology Iamialy2005，112，： | 1 |
| 18 | Rice yield and nitrogen utilization efficiency under alternative straw management practices显示文摘 | Alison J E Jeffrey A B William R H | 2000 | Agron J2000，92，6： | 1 |
| 19 | Dyeing machine control using inline colour measurement part 2 : On-line control of dye exhaustion rate 显示文摘 | Alison Gilchrist James H Nobbs | 1998 | Journal of the Society of Dyers and Colorists1998，114，9： | 1 |
| 20 | Competition among marine phytoplankton for deferent chelated iron species显示文摘 | David A H Amy E W Alison B | 1999 | Letters to Nature1999，400，6747： | 1 |
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