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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | 气候变化下黄土高原耕作系统演变与适应性管理显示文摘耕作系统主要包括土壤系统、作物系统和区域气候系统等几个相对独立、但又紧密关联的组成部分,涉及作物栽培模式、作物类型、杂草和病虫害及农田水土资源管理等方面,在黄土高原生态系统管理和农业可持续发展中占有重要地位。过去50a(1951-2000年),黄土高原的年平均气温升高了1.1℃,且其变率逐渐增加,降雨和热量资源分布呈现复杂的时空异质性。作物种植区域的变迁、熟制制度的演变和农田灾害的加剧促使农田管理模式不断寻求改变,对当地农业耕作系统产生了深远影响。本文总结了黄土高原过去多年的气候变化(气温、降水量、积温)特征和发展趋势,气候变化下耕作系统(种植区、耕作制度、土壤环境)和作物系统(需水量、物候、品种、产量)的演变规律,作物与土壤互作关系,以及气象灾害对黄土高原耕作系统的影响,并提出气候变化下耕作系统适应性管理途径和策略。旨在为黄土高原耕作技术和田间管理提供新的理论,寻求气候变化下区域农业可持续发展应对策略。 | 邓浩亮 周宏 张恒嘉 莫非 杨通 孔维萍 卢盼盼 杨晓婷 蒙强 赵鸿 王润元 Turner Neil C 吴姗 祝英 张晓峰 Batool Asfa 熊友才 | 2015 | 中国农业气象2015，36，4： | 10 |
| 3 | 气候变化下旱区农业生态系统的可持续性显示文摘农业生产是将自然资源不断转化为农产品的过程。简单的说就是将阳光、空气、水和土壤等无机资源转化为可以供人类消费的有机产物。农业生态系统必须对全球气候变化、市场竞争、自然环境的恶化、经济等政策法规和人民的需求等因素做出灵活的应对策略,同时还要保证自然生态系统的稳定性。在发展中国家, | 李凤民 Kadambot H. M Siddique Neil C Turner 欧阳志云 Guijun Yan 熊友才 | 2011 | 生态学报2011，31，9： | 5 |
| 4 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 5 | 第二届生态系统评估与管理(EAM)国际会议综述显示文摘自2005年联合国《千年生态系统评估》发布以来,旱区农业生态系统评估与管理研究越来越受到世界各国的广泛关注和重视。综述了2010年7月19日至25日在兰州大学举行的第二届生态系统评估与管理(Ecosystem assessment and management,EAM)国际会议28场特邀专家报告,围绕'气候变化与旱区农业生态系统管理'主题,分别从生态系统时空格局、全球变化生态学、植物逆境适应机制、植物与土壤关系和生态系统管理五个方面进行总结,旨在探讨全球气候变化条件下如何提高干旱与半干旱脆弱农业生态系统生产力和可持续性发展的创新理论研究。对生态系统评估与管理的未来发展趋势和目标进行了探讨,并对该会议将来的举办和组织形式提出了建议。 | 李朴芳 赵旭喆 程正国 Kadambot H. M Siddique Neil C Turner 李凤民 Guijun Yan 熊友才 | 2011 | 生态学报2011，31，9： | 3 |
| 6 | 应对全球气候变化的干旱农业生态系统研究--第二届EAM国际会议青年学者论坛综述显示文摘全球气候变暖对干旱农业生态系统管理提出了严峻的挑战,解决方案须从个体到全球不同尺度开展系统研究,并协同考虑与社会经济系统的互作机制。综述了2010年7月24日在兰州大学举行的第二届生态系统评估与管理(EAM)国际会议青年学者论坛的18场青年学者报告,包括全球变化生态学、植物水分生态学、植物营养与土壤生态学、草畜耦合生态学和生态系统设计与管理等5个分支,报告内容从个体尺度到全球尺度、从自然层面到社会层面均有涉及。将会议主题放入Reynolds等人提出的旱地系统发展范式(DDP)、Jianguo Liu等人提出的人与自然耦合系统理论(CHANS)和Thorvald Sφrensen提出的生态区概念(ecotope)及脆弱生态系统差别分层管理理论(SFDM)的视角中开展系统地讨论。总结过去20a在干旱农业生态学方面的研究工作,并融合国际前沿进展,提出在年降水量为300-550 mm的地区如何实施'大面积搞生态、小面积搞生产'和以'提高农业生产力和增加植被覆盖率'为核心的生态系统管理模式。该模式映射了未来几十年高效应对全球变化给干旱农业生态系统管理带来的挑战。 | 赵旭喆 李朴芳 Kadambot H.M Siddique Neil C Turner 李凤民 莫非 熊友才 | 2011 | 生态学报2011，31，9： | 3 |
| 7 | Transanal total mesorectal excision:a valid option for rectal cancer?显示文摘Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended. | Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 8 | Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image显示文摘 | Barbara C Silva William D Leslie Heinrich Resch Olivier Lamy Olga Lesnyak Neil Binkley Eugene V McCloskey John A Kanis John P Bilezikian | 2014 | J Bone Miner Res2014，，3： | 2 |
| 9 | Cardiovascular effects of marine omega-3 fatty acids显示文摘 | Palaniappan Saravanan Neil C Davidson Erik B Schmidt Philip C Calder | 2010 | The Lancet2010，，9740： | 2 |
| 10 | Marketing Productivity, Marketing Audits and Systems for Marketing Performance Assessment显示文摘 | NEIL A M BRUCE H C | 2002 | Journal of Business Research2002，，55： | 1 |
| 11 | A comparison of the digestibility of a range of lupin and soybean protein products when fed to Atlantic salmon (Salmo salar) or rainbow trout ( Oncorhynchus mykiss) 显示文摘 | Brett D G Chris G C Neil D | 2004 | Aquaculture2004，237，14： | 1 |
| 12 | Catalase HPII from Escherichia coli Exhibits Enhanced Resistance to Denaturation显示文摘 | Switala J O'Neil J O Loewen P C | 1999 | Biochemistry1999，38，13： | 1 |
| 13 | Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-Cell acute lymphoblastic leukemia cells显示文摘 | RAO S S O'NEIL J LIBERATOR C D | 2009 | Cancer Res2009，69，： | 1 |
| 14 | Chlamydia pneumoniae exposure and inflammatory markers in acaute coronary syndrome (CIMACS) 显示文摘 | Chandra HR CHoudhary N O' Neil C | 2001 | Am J Cardiol2001，88，3： | 1 |
| 15 | Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine显示文摘 | O'NEIL M M KENNEDY C A BARTON R W | 2001 | Gene Therapy2001，，8： | 1 |
| 16 | Oxygen iso- tope fractionation between synthetic aragonite and water: in-fluence of temperature and Mgz+ concentration显示文摘 | Kim S-T O'Neil J R Hillaire-Mareel C | 2007 | Geochimica et Cosmochimica Acta2007，71，： | 1 |
| 17 | Hydroch|orina tion of acetylene using carbon-supported gold cata- lysts:A study of catalyst reactivation显示文摘 | Bongani N Adams M D Neil ] C | 1991 | Journal of Catalysis1991，，37： | 1 |
| 18 | Comparative study of variable size perturbation and observation maximum power point trackers for PV systems显示文摘 | Neil S D Luiz A C Liu Xuejun | 2010 | Eleclric Power Systems Research2010，，80： | 1 |
| 19 | Extension of human cell lifespan by nicotinamide phosphoribosyltransferase显示文摘 | van der Veer E Ho C O'Neil C | 2007 | J Biol Chem2007，282，10： | 1 |
| 20 | Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation显示文摘 | van der Veer E Nong Z O′Neil C | 2005 | Circ Res2005，97，1： | 1 |
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