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| 1 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 2 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 4 |
| 3 | Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management显示文摘Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using 'top-down' care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. | Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 4 |
| 4 | The emergency department length of stay: Is the time running out?显示文摘Purpose: To examine the relationships between emergency department length of stay (EDLOS) with hospital length of stay (HLOS) and clinical outcome in hemodynamically stable trauma patients. Methods: Prospective data collected for 2 years from consecutive trauma patients admitted to the trauma resuscitation bay. Only stable blunt trauma patients with appropriate trauma triage criteria requiring trauma teamactivationwere included in the study. EDLOSwas determined short if patient spent less than 2 h in the emergency department (ER) and long for more than 2 h. Results: A total of 248 patients were enrolled in the study. The mean total EDLOS was 125 min (range 78 e180). Injury severity score (ISS) were significantly higher in the long EDLOS group (17 ± 13 versus 11 ± 9, p < 0.001). However, when leveled according to ISS, there were no differences in mean in diagnostic workup, admission rate to intensive care unit (ICU) or HLOS between the short and long EDLOS groups. Conclusion: EDLOS is not a significant parameter for HLOS in stable trauma patients. | Alexander Becker Gil Segal Yuri Berlin Dan Hershko | 2019 | Chinese Journal of Traumatology2019，22，3： | 2 |
| 5 | Argon Plasma Coagulation of Cervical Heterotopic Gastric Mucosa as an Alternative Treatment for Globus Sensations显示文摘 | Monther Bajbouj Valentin Becker Florian Eckel Stephan Miehlke Oliver Pech Christian Prinz Roland M. Schmid Alexander Meining | 2009 | Gastroenterology2009，，2： | 2 |
| 6 | Dual-source CT cardiac imaging: initial experience显示文摘 | Thorsten R. C. Johnson Konstantin Nikolaou Bernd J. Wintersperger Alexander W. Leber Franz Ziegler Carsten Rist Sonja Buhmann Andreas Knez Maximilian F. Reiser Christoph R. Becker | 2006 | European Radiology2006，，7： | 2 |
| 7 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 2 |
| 8 | Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors显示文摘 | Sarah Schwitalla Paul K. Ziegler David Horst Valentin Becker Irina Kerle Yvonne Begus-Nahrmann André Lechel K. Lenhard Rudolph Rupert Langer Julia Slotta-Huspenina Franz G. Bader Olivia Prazeres da Costa Markus F. Neurath Alexander Meining Thomas Kirchner | 2013 | Cancer Cell2013，，： | 2 |
| 9 | Ephrin-B reverse signaling induces expression of wound healing associated genes in IEC-6 intestinal epithelial cells显示文摘AIM: Eph receptors and ephrin ligands play a pivotal role in development and tissue maintenance. Since previous data have indicated an involvement of ephrin-B2 in epithelial healing, we investigated the gene expression and downstream signaling pathways induced by ephrin-B mediated cell-cell signaling in intestinal epithelial cells.METHODS: Upon stimulation of ephrin-B pathways in IFC-6 cells with recombinant rat EphB1-Fc, gene expression was analyzed by Affymetrix(R) rat genome 230 high density arrays at different time points. Differentially expressed genes were confirmed by real-time RT-PCR. In addition, MAP kinase pathways and focal adhesion kinase (FAK) activation downstream of ephrin-B were investigated by immunoblotting and fluorescence microscopy.RESULTS: Stimulation of the ephrin-B reverse signaling pathway in IEC-6 cells induces predominant expression of genes known to be involved into wound healing/cell migration, antiapoptotic pathways, host defense and inflammation. Cox-2, c-Fos, Egr-1, Egr-2, and MCP-1 were found among the most significantly regulated genes.Furthermore, we show that the expression of repairrelated genes is also accompanied by activation of the ERK1/2 MAP kinase pathway and FAK, two key regulators of epithelial restitution.CONCLUSION: Stimulation of the ephrin-B reverse signaling pathway induces a phenotype characterized by upregulation of repair-related genes, which may partially be mediated by ERK1/2 pathways. | Christian Hafner Stefanie Meyer Ilja Hagen Bernd Becker Alexander Roesch Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，29： | 2 |
| 10 | Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT显示文摘 | Christoph R. Becker Konstantin Nikolaou Michael Muders Gregor Babaryka Alexander Crispin U. Joseph Schoepf Udo Loehrs Maximilian F. Reiser | 2003 | European Radiology2003，，9： | 1 |
| 11 | Antithrombotic therapy in heparin-induced thrombocytopenia: guidelines translated for the clinician显示文摘 | Hess CN Becker RC Alexander JH | 2012 | J Thromb Thrombolysis2012，34，4： | 1 |
| 12 | Transient bone resorption following finger replantation: a report of 3 cases显示文摘在发生跟随成功的手指种植园的矿物质内容, osteopaenia 或破坏神经病由改变组成的 X 光线照相术的变化已经被描述了。我们报导我们在骨头改变谁的三个个人的大约四根手指与完全的归还广告 integrum 手术后地在开始的三个月内开发了的经验。三个病人, 21-49 岁(一般水准 36 年) 支撑了四根手指的轮廓鲜明的切断。第一个病人在戒指手指的近似方阵的底在食指和第二个病人的中间的方阵的底有切断。第三在五手指切断在第一根掌部的骨头和小手指的近似方阵的底有切断。在第一个案例中,二根背面的静脉和二根手掌的数字动脉和神经被修理。在第二个案例中,一根手掌的动脉和一根背面的静脉被重新吻合。在在姆指的第三个案例中,二根背面的静脉和二根手掌的数字动脉和神经被重建。在小手指,一根背面的静脉,一根手掌的数字动脉和二根数字神经被重建。骨头固定与二和三根 K 电线或紧张乐队配线被完成。种植园在所有情况中是成功的。在种植园以后的三个星期, X 光在 juxtaarticular 区域和骨头的 metaphyses 显示出 osteopaenia 的快速的开发。这些变化被 subperiosteal, intracortical 和位於骨内的骨头再吞跟随。没有进一步外科的过程或 splintage 被需要,手治疗没被中止。手术后地,在 10-13 星期(一般水准 12 星期) , X 光与新 periosteal 骨头形成显示出完全的恢复。我们建议在手指种植园以后的 X 光线照相术的变化是短暂的,第一明显 subperiosteally 并且集中地进行。他们可以反映小容器的妥协和 microinfarction 和对神经与血管的损坏或到同情的进步恢复第二等的短暂 hyperemia。 | Stefano Lucchina Hillary A. Becker Cesare Fusetti Alexander Y. Shin | 2011 | Chinese Journal of Traumatology2011，14，3： | 1 |
| 13 | Accura2 cy ofmultidetector spiral computed tomography in identifying and differentiating the composition ofcoronary atherosclerotic plaques,a comparative study with intracoronary ultrasound显示文摘 | Andreas Knez Alexander Becker | 2004 | J Am Col l Cardiol2004，43，7： | 1 |
| 14 | An- tithrombotic therapy in heparin-induced thrombocytope- nia: guidelines translated for the clinician 显示文摘 | Hess C N Becker R C Alexander J H | 2012 | J Thromb Thrombolysis2012，34，4： | 1 |
| 15 | Antithrombotie therapy in heparin-induced thromboeytopenia: guidelines translated for the elinieian显示文摘 | Hess CN Becker RC Alexander JH | 2012 | J Thromb Thrombolysis2012，34，4： | 1 |
| 16 | Apixaban,an oral,direct,selective factor Xa inhibitor,in combination with antiplatelet therapy after acute coronary syndrome:results of the Apixaban for Prevention of Acute Ischemic and Safety Events(APPRAISE)trial显示文摘 | Alexander JH Becker RC Bhatt DL | 2009 | Circulation2009，119，22： | 1 |
| 17 | Heritability of Platelet Responsiveness to Aspirin in Activation Pathways Directly and Indirectly Related to Cyclooxygenase-1显示文摘 | Nauder Faraday Lisa R. Yanek Rasika Mathias J Enrique Herrera-Galeano Dhananjay Vaidya Taryn F. Moy M Daniele Fallin Alexander F. Wilson Paul F. Bray Lewis C. Becker Diane M. Becker | 2007 | Circulation2007，，19： | 1 |
| 18 | Antithrombotic therapy in heparin-induced thrombocytopenia:guidelines translated for the clinician显示文摘 | Hess CN Becker RC Alexander JH | 2012 | J Thromb Thrombolysis2012，34，4： | 1 |
| 19 | Cloud filling of ocean colour and sea surface temperature remote sensing products over the Southern North Sea by the Data Interpolating Empirical Orthogonal Functions methodology显示文摘 | Damien Sirjacobs Aida Alvera-Azcárate Alexander Barth Geneviève Lacroix YoungJe Park Bouchra Nechad Kevin Ruddick Jean-Marie Beckers | 2010 | Journal of Sea Research2010，，1： | 1 |
| 20 | Composition-dependent band gap in ZnS x Se 1? x : a combined experimental and theoretical study显示文摘 | Thorsten Homann Urte Hotje Michael Binnewies Alexander B?rger Klaus-Dieter Becker Thomas Bredow | 2005 | Solid State Sciences2005，，1： | 1 |
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