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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | Hepatoprotective activity of Amorphophallus paeoniifolius tubers against paracetamol-induced liver damage in rats显示文摘 | Pramod J Hurkadale Pournima A Shelar Siddhalingesh G Palled Yuvaraj D Mandavkar Ajay S Khedkar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，，1： | 2 |
| 4 | One stop shop IV: taxonomic update with molecular phylogeny for important phytopathogenic genera: 76-100 (2020)显示文摘This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and fungus-like organisms.This paper focuses on one family:Erysiphaceae and 24 phytopathogenic genera:Armillaria,Barrio-psis,Cercospora,Cladosporium,Clinoconidium,Colletotrichum,Cylindrocladiella,Dothidotthia,,Fomitopsis,Ganoderma,Golovinomyces,Heterobasidium,Meliola,Mucor,Neoerysiphe,Nothophoma,Phellinus,Phytophthora,Pseudoseptoria,Pythium,Rhizopus,Stemphylium,Thyrostroma and Wojnowiciella.Each genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone trees.Species confirmed with pathogenicity studies are denoted when data are available.Six of the genera are updated from previous entries as many new species have been described. | Ruvishika S.Jayawardena Kevin D.Hyde Yi Jyun Chen Viktor Papp Balázs Palla Dávid Papp Chitrabhanu S.Bhunjun Vedprakash G.Hurdeal Chanokned Senwanna Ishara S.Manawasinghe Dulanjalee L.Harischandra Ajay Kumar Gautam Shubhi Avasthi Boontiya Chuankid Ishani D.Goonasekara Sinang Hongsanan XiangYu Zeng Kapila K.Liyanage NingGuo Liu Anuruddha Karunarathna Kalani K.Hapuarachchi Thatsanee Luangharn Olivier Raspé Rashika Brahmanage Mingkwan Doilom Hyang B.Lee Liu Mei Rajesh Jeewon Naruemon Huanraluek Napalai Chaiwan Marc Stadler Yong Wang | 2020 | Fungal Diversity2020，，4： | 2 |
| 5 | Effect of rare earth(Er,Gd,Eu,Nd and La) and bismuth additives on the mechanical and piezoelectric properties of lead zirconate titanate ceramics显示文摘 | AJAI GARG AGRAWAL D C | 2001 | Mater Sci Eng2001，86，： | 1 |
| 6 | Production of biodiesel from waste fryer grease using mixed methand system显示文摘 | TITIPONG I MANGESH G K AJAY K D | 2007 | Fuel Processing Techno2007，88，5： | 1 |
| 7 | Network analysis in the social sciences显示文摘 | Borgatti S P Ajay M Brass D J | 2009 | Science2009，，5916： | 1 |
| 8 | Expression stability of two housekeeping genes (18S rRNA and G3PDH) during in vitro maturation of follicular oocytes in buffalo (Bubalus bubalis)显示文摘 | Ajay P S A Sarvesh R Sachinandan D E | 2008 | Animal Reproduction Science2008，103，12： | 1 |
| 9 | Thermal and catalytic upgrading of a biomass-derived oil in a dual reaction system显示文摘 | SRIMAT T S AJAY K D NARENDRA N B | 2000 | The Canadian Journal of Chemical Engineering2000，78，： | 1 |
| 10 | Recent advance in petroleum microbiology显示文摘 | JONATHAN D VAN H AJAY S | 2003 | Microbiology and Molecular Biology2003，67，4： | 1 |
| 11 | Building Sister Chromatid Cohesion: Smc3 Acetylation Counteracts an Antiestablishment Activity显示文摘 | Benjamin D. Rowland Maurici B. Roig Tatsuya Nishino Alexander Kurze Pelin Uluocak Ajay Mishra Frédéric Beckou?t Philippa Underwood Jean Metson Richard Imre Karl Mechtler Vittorio L. Katis Kim Nasmyth | 2009 | Molecular Cell2009，，6： | 1 |
| 12 | Graphane:A two-dimensional hydrocarbon显示文摘 | Jorge O Sofo Ajay S Chaudhari Greg D Barber | 2007 | Phys Rev B2007，75，15： | 1 |
| 13 | Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy 显示文摘 | Srinivasa P Radha KD Ajay D | 2007 | Hepatology2007，45，3： | 1 |
| 14 | Importance of non -timber forest products in the economic valuation of dry deciduous forests of India 显示文摘 | Ajay Kumar Mahapatra D D Tewari | 2005 | Forest Policy and Economics2005，7，3： | 1 |
| 15 | An aggressive surgical approach leads to improved survival in patients with gal-lbladder cancer:A 12-year study at a north American Center显示文摘 | Charles M Ajay S | 2005 | Ann Surg2005，241，3： | 1 |
| 16 | Effect of pant residues on the size of microbial biomass and nitrogen mineralization in soil incorporation of cowpea and wheat straw显示文摘 | Dharani D P Sukhpal C B Ajay M | 1992 | Soil Sci Plant Nutr1992，38，1： | 1 |
| 17 | A review on natural image denoi-sing u- sing independent component analysis(ICA) technique显示文摘 | Anjalip Ajay S Sappre S D | 2010 | Advances in Computational Research2010，2，1： | 1 |
| 18 | Is Port Site Resection Necessary in the Surgical Management of Gallbladder Cancer?显示文摘 | Ajay V. Maker Jean M. Butte Jacqueline Oxenberg Deborah Kuk Mithat Gonen Yuman Fong Ronald P. DeMatteo Michael I. D’Angelica Peter J. Allen William R. Jarnagin | 2012 | Annals of Surgical Oncology2012，，2： | 1 |
| 19 | Microencapsulation of silicon nitride particles with yttria and yttria-alumina precursors 显示文摘 | Ajay K G Lutgard C D J | 1990 | J Mater Res1990，5，1： | 1 |
| 20 | Recent Advances in Petroleum Microbiology显示文摘 | Jonathan D Van Hamme Ajay Singh Owen P Ward | 2003 | Microbiology and Molecular Biology Reviews2003，，67： | 1 |
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