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| 1 | Efficacy and safety of vildagliptin in clinical practice-results of the PROVIL-study显示文摘AIM:To investigate efficacy and safety of vildagliptin compared to other oral antidiabetics in clinical practice in Germany.METHODS:In this prospective,open,observational study,patients with type 2 diabetes mellitus(T2DM) previously on oral monotherapy were selected by their treating physician to receive either vildagliptin addon to metformin(cohort 1),vildagliptin+metformin single-pill combination(SPC)(cohort 2)or another dual combination therapy with oral antidiabetic drugs(OADs)(cohort 3).According to routine clinical practice,interim examinations occurred every 3 mo:at baseline,after approximately 3 mo and after approximately 6 mo.Parameters documented in the study included demographic and diagnostic data,history of T2DM,data on diabetes control,vital signs,relevant prior and concomitant medication and disease history.Efficacy was assessed by changes in HbA1c and fasting plasma glucose(FPG)3 mo and 6 mo after initiation of dual combination therapy.Safety was assessed by adverseevent reporting and measurement of specific laboratory values(serum creatinine,total bilirubin,alanine aminotransferase,aspartate aminotransferase,creatine kinase).RESULTS:Between October 2009 and January 2011,a total of 3881 patients were enrolled in this study.Since 47 patients were withdrawn due to protocol violations,3834 patients were included in the statistical analysis.There were no relevant differences between the three cohorts concerning age,body weight and body mass index.Average diabetes duration was approximately 6 years and mean HbA1c was between 7.6%and 7.9% at baseline.Antidiabetic treatment was recorded in 3648 patients.Patients were treated with vildagliptin add-on to metformin(n=603),vildagliptin+metformin(SPC)(n =2198),and other oral OADs including combinations of metformin with sulfonylurea(n=370),with glitazones(n =123),other dipeptidyl peptidase-4 inhibitors(n=99).After 6 mo of treatment,the absolute decrease in HbA1c(mean±SE)was significantly more pronounced in patients receiving vildagliptin add-on to metformin(-0.9% ±0.04%)and vildagliptin+metformin(SPC)(-0.9%± 0.03%)than in patients receiving other OADs(-0.6% ±0.04%;P<0.0001).In addition,significant cohort differences were observed for the improvement in FPG after 6 mo treatment(vildagliptin add-on to metformin:-291 mg/L±18.3 mg/L;vildagliptin+metformin(SPC):-305 mg/L±9.6 mg/L;other antidiabetic drugs:-209 mg/L±14.0 mg/L for(P<0.0001).Moderate decreases in body weight(absolute difference between last control and baseline:mean±SE)were observed for patients in all cohorts(vildagliptin add-on to metformin:-1.4 kg ±0.17 kg;vildagliptin+metformin(SPC):-1.7 kg± 0.09 kg;other OADs:?0.8 kg±0.13 kg).No significant differences in adverse events(AEs)and other safety measures were observed between the cohorts.When performing an additional analysis by age(patients<65 years vs patients≥65 years),there was no relevant difference in the most common AEs between the two age groups and the AE profile was similar to that of the overall patient population.CONCLUSION:Clinical practice confirms that vildagliptin is an effective and well-tolerated treatment in combination with metformin in T2DM patients. | Matthias Blüher Ira Kurz Simone Dannenmaier Markus Dworak | 2012 | World Journal of Diabetes2012，3，9： | 9 |
| 2 | 天然气增压站经济优化:压缩机运行显示文摘对于外输管道的天然气增压站,其全周期运行经济性很大程度上取决于压缩机组的运行情况。概述了影响压气站经济运行的基本要素,着重描述了管道与压气站的相互影响。通过多个典型方案的描述,指明了管道经济运行必须着重考虑负荷变化的事实。为明确管线运维中离心式压缩机的控制与运行,描述了压缩机与管道系统的内在联系,指出了影响压缩机运行点的方法。稳态运行及瞬态运行均被纳入考虑。根据给定曲线,讨论了管线输量波动情况下机组的优化,强调了驱动机选型和数量选择的重要性。 | Rainer Kurz Matt Lubomirsky | 2015 | 天然气与石油2015，33，2： | 6 |
| 3 | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases显示文摘AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein expression by immunohistochemistry (IHC) in 294 paraffin-embedded liver specimens comprising all stages of hepatocellular carcinogenesis. In addition, in cell culture experiments HBV-positive (HepG2.2.15 and HB611) and HBV-negative (HepG2) hepatoma cell lines were tested for the Nup88 expression by Western-immunoblotting to test data obtained by IHC.RESULTS: Specific Nup88 expression was found in chronic HCV hepatitis and unspecific chronic hepatitis, whereas no or very weak Nup88 expression was detected in normal liver. The Nup88 expression was markedly reduced or missing in mild chronic HBV infection and inversely correlated with HBcAg expression. Irrespective of the HBV- or HCV-status, increasing Nup88 expression was observed in cirrhosis and dysplastic nodules, and Nup88 was highly expressed in hepatocellular carcinomas. The intensity of Nup88 expression significantly increased during carcinogenesis (P < 0.0001) and correlated with dedifferentiation (P < 0.0001). Interestingly, Nup88 protein expression was significantly downregulated in HBV-positive HepG2.2.15 (P < 0.002) and HB611 (P < 0.001) cell lines as compared to HBV-negative HepG2 cells. CONCLUSION: Based on our immunohistochemical data, HBV and HCV are unlikely to influence the expression of Nup88 in cirrhotic and neoplastic liver tissue, but point to an interaction of HBV with the nuclear pore in chronic hepatitis. The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 4 | ICE3的新设计思想显示文摘介绍了德国联邦铁路最新旗舰产品ICE3的运营及其发展情况,着重阐述了ICE3列车编组的车辆配置、车辆内部设备、牵引设备、制动系统、供电系统和诊断系统等,并对ICE系列产品进行了比较。 | Heinz Kurz 陈砚 | 2004 | 国外铁道车辆2004，41，1： | 3 |
| 5 | Current concepts in mild cognitive impairment显示文摘 | Petersen RC Doody R Kurz A | | Archives of Neurology0，，： | 3 |
| 6 | Cosmic ray exposure dating with in situ produced cosmogenic 3He:resluts from young Hawaiian lava flows 显示文摘 | Kurz M D Colodner D | 1990 | Earth Planet Sci Lett1990，97，： | 2 |
| 7 | Immunohistochemical detection of estrogen receptor α in articular chondrocytes from cows, pigs and humans: in situ and in vitro results显示文摘 | Horst Claassen Joachim Hassenpflug Michael Schünke Walter Sierralta Hubert Thole Bodo Kurz | 2001 | Annals of Anatomy2001，，3： | 2 |
| 8 | Intraoperative hypothermia: pathophysiology and clinical sequence显示文摘 | Kurz A | 1997 | Wien Klin Wochenschr1997，109，： | 2 |
| 9 | 为德国联邦铁路制造的新一代电动车组——ICE3和ICE-T显示文摘详细介绍了 ICE 3和 ICE- T的研制方案、编组方式、结构组成和主要设备。 | Heinz Kurz 阎锋 李国平 | 2001 | 国外铁道车辆2001，38，3： | 2 |
| 10 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Juan P. Cata Maria Bauer Telemate Sokari María F. Ramirez David Mason Gregory Plautz Andrea Kurz | 2013 | Journal of Clinical Anesthesia2013，，： | 2 |
| 11 | Single-crystal laser deposition of superalloys: processing–microstructure maps显示文摘 | M. G?umann C. Bezen?on P. Canalis W. Kurz | 2001 | Acta Materialia2001，，6： | 2 |
| 12 | 天然气增压站经济优化:管道与增压站选型显示文摘对于外输管道的天然气增压站,其全周期运行经济性很大程度上取决于压缩机组的运行情况。讨论了管道和增压站选型的部分概念,如利用管道水力学优化管线上增压站的数量及增压站中压缩机组数量等。这些设计原理应在燃料消耗、维护及大修等设计标准上予以考虑。结合每个增压站和每个系统中机组数量的考虑,对增压站与系统的可用率进行了探讨。 | Rainer Kurz Matt Lubomirsky | 2015 | 天然气与石油2015，33，3： | 2 |
| 13 | 拉·维莱特公园显示文摘1983年,伯纳德·屈米建筑师事务所从470支团队里脱颖而出,赢得了巴黎拉。维莱特公园国际设计竞赛。该项目同新法国国家图书馆、卢浮宫金字塔、拉德芳斯新凯旋门和阿拉伯世界研究中心等项目一样,是当时法国政府主持的几大工程之一。那次设计竞赛的目标是表达时代愿景,推动项目所处的巴黎关键区域未来经济和文化的发展。 | bernard tschumi luca merlini alexandra villegas luca pagnamenta jon olsen jean-franCois erhel ursula kurz christian biecher marie-line luquet neil porter steve mcadam jean-pierre nourry didier pasquier renzo bader | 2016 | 城市环境设计2016，0，1： | 2 |
| 14 | The effects of S( - ) - , R ( + ) - , and racemic bupivacaine on lysophosphatidate-induced priming of human neutrophils 显示文摘 | Hollmann MW Kurz K Herroeder S | 2003 | Anesth Analg2003，97，4： | 1 |
| 15 | Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization显示文摘 | Kurz A Sessler DI Lenhardt R | 1996 | New Engl J Med1996，334，： | 1 |
| 16 | Experience with the use of palivizumab together with infection control measures to prevent respiratory syncytial virus outbreaks in neonatal intensive care units 显示文摘 | Kurz H Herbich K Janata O | 2008 | J Hosp Infect2008，70，3： | 1 |
| 17 | Efficacy of galantamine improbable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial显示文摘 | Erkinjuntti Kurz A Gauthier S | 2002 | Lancet2002，359，9314： | 1 |
| 18 | The effect of melt composition on solidification cracking of steel, with particular reference to continuous casting显示文摘 | Wolf M Kurz W | 1982 | Metallurgical and Materials Transactions B1982，13，： | 1 |
| 19 | Multilocus haplotype analyses reveal amociatlon between 5 novel IL-15 polymorphisms and asthms显示文摘 | Kurz T Strauch K Dietrich H | 2004 | J Allergy Clin Immunol2004，113，5： | 1 |
| 20 | Improved mitochondrial function in brain aging and Alzheimer disease-the new mechanism of action of the old metabolic enhancer piracetam显示文摘 | Leuner K Kurz C Guidetti G | 2010 | Front Neurosci2010，4，44： | 1 |
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