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| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B 显示文摘 | Gosling J lay maker S Gu L | 1999 | J Clin Invest1999，103，6： | 1 |
| 3 | Strategies for CT radiation dose optimization显示文摘 | Kalra M K Maker M M Toth T L | 2004 | Radiology2004，230，3： | 1 |
| 4 | Television viewing as a causeof increasing obesity among children in the United States, 1986-1990显示文摘 | Gorr maker SL Must A Sobol AM | 1996 | Arch Pediatr Adolesc Med1996，50，： | 1 |
| 5 | Pancreatic Cyst Fluid and Serum Mucin Levels Predict Dysplasia in Intraductal Papillary Mucinous Neoplasms of the Pancreas显示文摘 | Maker A V 、 Katabi N Gonen M | 2011 | Ann Surg Oncol2011，18，1： | 1 |
| 6 | The use of general primers in the polymerase chain permits the detection of a broad spectrum of human papillomavirus genotypes 显示文摘 | Snijuders pJ Varr Den Brule AJ Schrijne makers HF et 1 | 1990 | J Gen Virol1990，71，1： | 1 |
| 7 | Cytology from pancreatic cysts has marginal utility in surgical decision-making 显示文摘 | Maker AV Lee LS Rant CP | 2008 | Ann Surg Oncol2008，15，11： | 1 |
| 8 | Muscle amino acid metabohsm at rest and during exercise: role in human physiology and metabolism 显示文摘 | Wagen makers A J | 1998 | Exerc Sport Sci Rev1998，，26： | 1 |
| 9 | Cytology from pancreatic cysts has marginal utility in surgical decision-making 显示文摘 | Maker AV Lee LS Raut CP | 2008 | Ann Surg Oncol2008，15，11： | 1 |
| 10 | Intensity dependent changes in the refractive index in liquids 显示文摘 | Maker P D Terhune R W Savage C M | 1964 | Phys Rev Lett1964，12，18： | 1 |
| 11 | Study of optical effects due toan induced polarization third order in electric fieldstrength 显示文摘 | Maker P D Terhune R W | 1965 | Physical Review1965，137，3： | 1 |
| 12 | Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockades and interleukin 2: a phase Ⅰ/Ⅱ study显示文摘 | Maker AV Phan GQ Attia P | 2005 | Ann Surg Oncol2005，12，12： | 1 |
| 13 | Creativity,Intelligence,and Problem Solving:a Definition and Design for Cross-cultural Research and Measurement tkelated to Giftedness显示文摘 | Maker C.J | | 0，，02： | 1 |
| 14 | Resurfacing is comparable to total hip arthroplasty at short-term fol ow-up显示文摘 | Mont MA Maker DR Smith JM | | 0，，01： | 1 |
| 15 | Cyst fluid biomarkers for intraductal papillary mutinous neoplasms of the pancreas: A critical review from the international expert meet- ing on pancreatic branch-duct-intraductal papillary mucinous neoplasms显示文摘 | MAKER A V CARRARA S JAMIESON N B | 2015 | Journal of the American College of Surgeons2015，220，2： | 1 |
| 16 | Annular pancreas in the adult : two case reports and review of more than a century of liter'- ature显示文摘 | Maker V Gerzenshtein J Lerner T | 2003 | Am Surg2003，69，5： | 1 |
| 17 | Is Port Site Resection Necessary in the Surgical Management of Gallbladder Cancer?显示文摘 | Ajay V. Maker Jean M. Butte Jacqueline Oxenberg Deborah Kuk Mithat Gonen Yuman Fong Ronald P. DeMatteo Michael I. D’Angelica Peter J. Allen William R. Jarnagin | 2012 | Annals of Surgical Oncology2012，，2： | 1 |
| 18 | Hydrogen sulfide - producing variants of Escherichia coli 显示文摘 | Maker M D Washington J A | 1974 | Applied Microbiology1974，28，2： | 1 |
| 19 | The Oklahoma City Bombing:Summary and Recommendations for Multihazard Mitigation显示文摘 | Corley W G Maker P F Sozen M A | | 0，，： | 1 |
| 20 | 联合DNA鉴定及有毒物质、重金属检测加强对中药上市后监测显示文摘草药制品包括传统中药在全世界的应用越来越广泛。但是由于缺乏对原料、杂质及活性成分的检测工具,使得对草药制品的监督管理受到一定的限制。本文首次建立了一种多学科联合检测方法,评价了26种中药组成。该方法利用分离技术和质谱(MS)技术,联合新一代的DNA测序,进行药物杂质、重金属筛查及物种鉴定。基因分析显示,50%的样品含有未申报的植物或动物物种DNA,包括濒危动物雪豹。在50%的中药中,检测到未申报的药剂,包括华法林,地塞米松,双氯芬酸,赛庚啶和扑热息痛。质谱显示药物中含有重金属,包括砷,铅和镉。某品种砷含量>可接受极限的10倍。研究显示,92%的被检查的中药被发现有某种形式的污染和/或替代。本研究表明,联合分子方法可以为监测补充和替代药物提供有效的手段。 | 陈影(译) 游云(校) megan l.coghlan garth maker elly crighton | 2017 | 中国药物警戒2017，14，9： | 1 |
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