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| 1 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 2 | Viral hepatitis in 2021:The challenges remaining and how we should tackle them显示文摘Viral hepatitis results in 1.4 million deaths annually.The World Health Organization(WHO)set an ambitious target to eliminate viral hepatitis by 2030,but significant challenges remain.These include inequalities in access to healthcare,reaching at risk populations and providing access to screening and effective treatment.Stigma around viral hepatitis persists and must be addressed.The WHO goal of global elimination by 2030 is a worthy aim,but remains ambitious and the coronavirus 2019 pandemic undoubtedly has set back progress.This review article will focus on hepatitis A to E,highlighting problems that have been resolved in the field over the past decade,those that remain to be resolved and suggest directions for future problem solving and research. | Rebecca Dunn Aaron Wetten Stuart McPherson Mhairi C Donnelly | 2022 | World Journal of Gastroenterology2022，28，1： | 4 |
| 3 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 4 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 5 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 2 |
| 6 | Keratoconus in a patient with Alport syndrome: A case report显示文摘BACKGROUND Known ocular manifestations of Alport syndrome include features such as anterior lenticonus and fleck retinopathy. Reports of keratoconus in such patients are limited. We report tomographic findings consistent with keratoconus in a patient with Alport syndrome.CASE SUMMARY A 52-year-old female was referred to our ophthalmology clinic with decreased vision and increased tearing. She was diagnosed with stage Ⅲ Alport syndrome two years prior. Upon examination she was found to have average keratometries of 48D bilaterally with tomographic evidence of keratoconus.CONCLUSION Although a rare presentation, concurrent Alport syndrome and keratoconus should be considered when reviewing the ocular health of Alport syndrome patients and appropriate management steps should be taken upon the diagnosis. | Majid Moshirfar David F Skanchy Aaron T Gomez Yasmyne C Ronquillo Benjamin Buckner Phillip C Hoopes | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 7 | Ubiquitin-mediated degradation of cellular proteins in health and disease显示文摘 | Aaron C Schwartz AL | 2002 | Hepatology2002，35，1： | 1 |
| 8 | Interactive story: from corn to cupcakes 显示文摘 | Aaron J Hand C McCarthy | 2000 | Photonics Spectra2000，34，3： | 1 |
| 9 | The ubiquitin system显示文摘 | Avram H Aaron C Alexander V | 2000 | Nat Med2000，6，： | 1 |
| 10 | Evidence-based practice and social work 显示文摘 | AARON C BRUCE A | 2004 | J Evidence Based Social Work2004，1，1： | 1 |
| 11 | Learning physics-based motion style with nonlinear inverse optimization显示文摘 | Liu C Karen Hertzmann Aaron Popovi(c) Zoran | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 12 | Zika virus 显示文摘 | Basarab M Bowman C Aarons E J | 2016 | BMJ2016，，11： | 1 |
| 13 | On the Growth Kineties of Grain Boundary Ferrite Allotriomorphs 显示文摘 | Atkinson C Aaron H B Kinsman K R | 1973 | Metall Trans1973，4，： | 1 |
| 14 | Neurophysiology of spectrotemporal cue organization of spoken language in auditory memory显示文摘 | AARON C M JYOTI B BRADLEY D W | 2014 | Brain Lang2014，130，： | 1 |
| 15 | Polychlorinated biphenyl profiles in ringed seals (Pusa Hispida) reveal historical contamination by a military radar station in Labrador, Canada显示文摘 | Tanya M B Aaron T F Caren C H | 2014 | Environmental Toxicology and Chemistry2014，33，3： | 1 |
| 16 | An efficient palladium- catalyzed negishicross -coupling reaction with arylvinyl iodides: facile regioselective synthesis of E -stilbenes and their analogues显示文摘 | SHAHJAHAN K AARON M JAMES M C | 2007 | Tetrahedron Lett2007，48，41： | 1 |
| 17 | Brand personality in a membership-based organization显示文摘 | Aaron C T | 2006 | International Journal of Nonprofit Voluntary Sector Marketing2006，11，3： | 1 |
| 18 | Inhibition of constitutive aryl hydrocarbon receptor ( AhR ) signaling attenuates androgen independent signaling and growth in ( C4-2 ) prostate cancer cells显示文摘 | Tran C Richmond O Aaron L | 2013 | Biochemical Pharmacology2013，85，6： | 1 |
| 19 | The influence of hook size, type, and location on hook retention and survival of angled bonefish 显示文摘 | Jeffrey A S Aaron D S Steven J C | 2012 | Fisheries Research2012，113，1： | 1 |
| 20 | C-reactive protein and incident coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) study显示文摘 | Nena A Diane C | 2002 | Am Heart J2002，144，： | 1 |
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