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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Sensitivity and inter-observer variability for capsule endoscopy image analysis in a cohort of novice readers显示文摘瞄准:为检测囊内视镜检查法调查结果决定新手阅读器(第 4 个年医学院的学生) 的性能。方法:小肠损害的十个囊内视镜检查法盒子予读者被以。标准答案调查结果被胃的肠学预先规定。十个标准答案“目标”在 10 个盒子之中被识别。读者们被给快速的读者软件的 30-min 概述并且指示标记畸形的任何潜在的区域。一个软件程序用 SAS 被开发分析缩小的调查结果。结果:为检测标准答案调查结果的全面敏感是 80% 。作为一个组,至少 5 从 10 个读者检测了每记录发现的每个标准答案。当读者的结果被联合时,所有标准答案目标被识别。偶然的 finding/false 积极的率每读者在 8.2-59.8 之间变化了。结论:有最小的内视镜的经验的医学院的学生的一块面板能在在囊内视镜检查法上检测损害完成高敏感。一组新手读者能预先屏蔽为进一步的评论缩小小肠损害的潜在的区域的记录。这些指图必须被考察决定临床的关联。进一步的研究是进行中的估计另外的队。 | Gary C Chen Pedram Enayati Tam Tran Mary Lee-Henderson Clifford Quan Gareth Dulai Ian Arnott James Sul Rome Jutabha | 2006 | World Journal of Gastroenterology2006，12，8： | 5 |
| 3 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 4 | Internal nutrient efficiencies of irrigated lowland rice in tropical and subtropical Asia显示文摘 | C Witt A Dobermann S Abdulrachman H.C Gines Wang Guanghuo R Nagarajan S Satawatananont Tran Thuc Son Pham Sy Tan Le Van Tiem G.C Simbahan D.C Olk | 1999 | Field Crops Research1999，，2： | 2 |
| 5 | Marked induction of the IAP family antiapoptosis proteins Survivin and XIAP by VEGF in vascular endothelial cells显示文摘 | Tran J Rak J Sheehan C | 1999 | Biochem Biophys Res Commun1999，264，： | 1 |
| 6 | Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation显示文摘 | Pai R Lin C Tran T | 2005 | Biochem Biophys Res Commun2005，331，： | 1 |
| 7 | Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to an- esthetics 显示文摘 | Bianchi SL Tran T Liu C etal | 2008 | Neurobiol Aging2008，29，7： | 1 |
| 8 | A randomized controlled trial of sequentially bilateral prefrontal cortex repetitive transcranial magnetic stimulation in the treatment of negative symptoms in schizophrenia显示文摘 | Barr M S Farzan F Tran L C | 2012 | Brain Stimul2012，5，3： | 1 |
| 9 | Using GATT,Art XX to Justify Climate Change Measures in Claims under the WTO Agreements显示文摘 | Tran C | 2010 | Environmental and Planning Law Journal2010，27，346： | 1 |
| 10 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 11 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 12 | Identification of galactose-a-1, 3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy 显示文摘 | Hamsten C Starkhammar M Tran TA | 2013 | Allergy2013，68，： | 1 |
| 13 | Characterization of diamond-like carbon by raman spectroscopy,XPS and optical constants 显示文摘 | Mossner C Grant P Tran H | 1998 | Thin Solid Films1998，317，： | 1 |
| 14 | Molecular determinants of resist- ance to antiandregen therapy显示文摘 | Chen CD Welsbie DS Tran C | 2004 | Nature Med2004，10，： | 1 |
| 15 | Two-phase pressure drop of refrigerants during flow boiling in small channels:an experimental investigation and correlation development显示文摘 | Tran T N Chyu M C Wambsganss M W | 2000 | Int J Multiphase Flow2000，26，： | 1 |
| 16 | Semantic Web Services显示文摘 | MCLLRAITH S A TRAN C S | 2001 | IEEE Intelligent Systems2001，3，4： | 1 |
| 17 | Reduction of NOx by plasma-facilitated catalysis over In- doped alumina显示文摘 | Tran D N Aardahl C L Rappe KG | 2004 | Appl Catal B: Environ2004，48，2： | 1 |
| 18 | Marked induction of the IAP fami- ly antiapoptotic proteins Survivin and XIAP by VEGF in vascular endothelial cells显示文摘 | Tran J Rak J Sheehan C | 1999 | Biochem Biophys Res Commun1999，264，5： | 1 |
| 19 | Near-Infrared Spectroscopic Investigation of Inclusion Complexes Between Cyclodextrinsand Aromatic Compounds 显示文摘 | Politi M J’Tran C D Gao G H | 1995 | J Phys Chem1995，99，14： | 1 |
| 20 | Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc显示文摘 | Tran C M Markova D Smith H E | 2010 | Arthritis Rheum2010，62，7： | 1 |
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