|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 2 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 3 | Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia显示文摘AIM:To determine the expression of neurokinin-1receptor(NK-1R),phosphorylated epidermal growth factor receptor(p EGFR),cyclooxygenase-2(Cox-2),and vitamin D receptor(VDR)in normal,inflammatory bowel disease(IBD),and colorectal neoplasia tissues from Puerto Ricans.METHODS:Tissues from patients with IBD,colitisassociated colorectal cancer(CAC),sporadic dysplasia,and sporadic colorectal cancer(CRC),as well as normal controls,were identified at several centers in Puerto Rico.Archival formalin-fixed,paraffin-embedded tissues were de-identified and processed by immunohistochemistry for NK-1R,p EGFR,Cox-2,and VDR.Pictures of representative areas of each tissues diagnosis were taken and scored by three observers using a4-point scale that assessed intensity of staining.Tissues with CAC were further analyzed by photographing representative areas of IBD and the different grades of dysplasia,in addition to the areas of cancer,within each tissue.Differences in the average age between the five patient groups were assessed with one-way analysis of variance and Tukey-Kramer multiple comparisons test.The mean scores for normal tissues and tissues with IBD,dysplasia,CRC,and CAC were calculatedand statistically compared using one-way analysis of variance and Dunnett’s multiple comparisons test.Correlations between protein expression patterns were analyzed with the Pearson’s product-moment correlation coefficient.Data are presented as mean±SE.RESULTS:On average,patients with IBD were younger(34.60±5.81)than normal(63.20±6.13,P<0.01),sporadic dysplasia(68.80±4.42,P<0.01),sporadic cancer(74.80±4.91,P<0.001),and CAC(57.50±5.11,P<0.05)patients.NK-1R in cancer tissue(sporadic CRC,1.73±0.34;CAC,1.57±0.53)and sporadic dysplasia(2.00±0.45)were higher than in normal tissues(0.73±0.19).p EGFR was significantly increased in sporadic CRC(1.53±0.43)and CAC(2.25±0.47)when compared to normal tissue(0.07±0.25,P<0.05,P<0.001,respectively).Cox-2 was significantly increased in sporadic colorectal cancer(2.20±0.23 vs 0.80±0.37 for normal tissues,P<0.05).In comparison to normal(2.80±0.13)and CAC(2.50±0.33)tissues,VDR was significantly decreased in sporadic dysplasia(0.00±0.00,P<0.001 vs normal,P<0.001 vs CAC)and sporadic CRC(0.47±0.23,P<0.001 vs normal,P<0.001 vs CAC).VDR levels negatively correlated with NK-1R(r=-0.48)and p EGFR(r=-0.56)in normal,IBD,sporadic dysplasia and sporadic CRC tissue,but not in CAC.CONCLUSION:Immunohistochemical NK-1R and p EGFR positivity with VDR negativity can be used to identify areas of sporadic colorectal neoplasia.VDR immunoreactivity can distinguish CAC from sporadic cancer. | Raymond A Isidro Myrella L Cruz Angel A Isidro Axel Baez Axel Arroyo William A González-Marqués Carmen González-Keelan Esther A Torres Caroline B Appleyard | 2015 | World Journal of Gastroenterology2015，21，6： | 7 |
| 4 | Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury显示文摘 | Caudrillier Axelle Kessenbrock Kai Gilliss Brian M Nguyen John X Marques Marisa B Monestier Marc Toy Pearl Werb Zena Looney Mark R | 2012 | EN2012，，7： | 2 |
| 5 | Correlation coefficient of the heart rate turbulence slope: an independent risk stralifier in post-infarction patients 显示文摘 | Petra B Raphael S Axel B | 2001 | Circulation2001，104，17： | 1 |
| 6 | Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘 | Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch** Eckhart Dühmke** Hans-Konrad Müller-Hermelink? Klaus Wilms§ | 2000 | Gastroenterology2000，，5： | 1 |
| 7 | Dehiscence and fenestration in pa- tients with class I and Class II Division 1 malocclusion assessed with cone-beam computed tomography显示文摘 | Karine E Karla FV Axel B | 2010 | American Journal of Orthodon- tics and Dentofacial Orthopedics2010，138，2： | 1 |
| 8 | Genetic diversity within a range of cultivars and landraces of flax as revealed by RAPDs显示文摘 | Ong B Axel D Richards K | 2002 | Genetic Resources and Crop Volution2002，49，2： | 1 |
| 9 | Cyclodextrin rotaxanes and polyrotaxanes显示文摘 | Gerhard W Han B H Axel M | 2006 | Chemical Reviews2006，106，： | 1 |
| 10 | Upgrading of waste derived solid fuel by steam gasification 显示文摘 | Colette B Axelle D | 1998 | Fuel1998，77，12： | 1 |
| 11 | Dry eyes or mouth-an epidemiological study in Swedish adults,with special reference to primary Sjogren's syndrome显示文摘 | Jacobsson L T Axell T E Hansen B U | 1989 | J Autoimmun1989，2，4： | 1 |
| 12 | Hyperbranched polymers: modification with flexiblechains 显示文摘 | Axel R B Brigittel V | 1995 | polym Mater Sci Eng1995，7，： | 1 |
| 13 | Tubules and donuts:a type Ⅵ secretion story显示文摘 | B(o)emann G Aleksandra P Axel M | 2010 | Molecular Microbiology2010，76，4： | 1 |
| 14 | Decleration capacity of heart rate as a prelictor of mortality after myocardial infarction~ cohort study 显示文摘 | Axel B Jan W K Petra B | 2006 | Lancet2006，367，9523： | 1 |
| 15 | C a n cer testisantigens and N Y - B R - 1 expression in p r i m a r breast cancer:prognostic and therapeutic implications 显示文摘 | Dimitrios B Axel Z H Sebastian M | | B M CCancer0，13，： | 1 |
| 16 | EAU Guidelines on Renal Cell Carcinoma: The 2010 Update显示文摘 | B?rje Ljungberg Nigel C. Cowan Damian C. Hanbury Milan Hora Markus A. Kuczyk Axel S. Merseburger Jean-Jacques Patard Peter F.A. Mulders Ioanel C. Sinescu | 2010 | European Urology2010，，3： | 1 |
| 17 | Hyperbranched polymers: modification with flexi ble chains显示文摘 | Axel R B Brigitte I V | 1995 | Polym Mater Sci Eng1995，73，： | 1 |
| 18 | An equilibrium model of search employment显示文摘 | ALBRECHT J W AXELL B | 1984 | Journal of Political Economy1984，92，： | 1 |
| 19 | Geographic differences in tooth loss and denture-wearing among the elderly in Norway 显示文摘 | Henriksen B M Axell T Laake K | 2003 | Commundent & Oral Epidemi2003，31，6： | 1 |
| 20 | Efficacy of Caspofungin against invasive candida or invasive aspergillus infections in nertropenic patients显示文摘 | ROBERT B AXEL G JOHAN M | 2006 | Cancer2006，106，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员