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| 1 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 2 | The efficacyof hypertonic solutions sailne nasal irrigation for chronic sinonasal symptoms显示文摘 | David R Thomas P Aleksandra Z | 2005 | Otolaryngology-Head and Neck Surgery2005，133，1： | 1 |
| 3 | The application of Scanning Electronic Microscopy:The study of the surface of the upper layers of dyed polyester fibre samples in the ostacet yellow E-LSR显示文摘 | MILENA N M MILOVAN M P ALEKSANDRA R Z | 2004 | FACTA Universitis ( Physics Chemistry and Technology )2004，3，1： | 1 |
| 4 | The efficacy of hypertonic solutions sailne nasal irri-gationfor chronic sinonasal symptoms显示文摘 | DAVLD R THOMAS P ALEKSANDRA Z | 2005 | Otolaryngol Head Neck Surg2005，133，： | 1 |
| 5 | Mean myocardial velocity mapping in quantifying regional myocardial contractile reserve in patients with impaired left ventricular systolic function: Doppler myocardial imaging study 显示文摘 | Przemyslaw P Aleksandra L Colin F | | J Am Soc Echocardiog0，20，： | 1 |
| 6 | Influence of narrowband imaging (NBI) videobronchoscopy on the assessment ofcentral lung cancer extension and therapeutic decision 显示文摘 | Bojan Z Branislav P Aleksandra J | 2009 | Cancer Invest2009，27，9： | 1 |
| 7 | Trilineage myelodysplasia and hemophagocytosis associated with systemic upus erythematosus 显示文摘 | Aleksandra P Nasim S Carol G | 2012 | Am J Hematol2012，87，： | 1 |
| 8 | Late- onset systemic lupus erythematosus: clinical features, course, and prognosis显示文摘 | Aleksandra TL Radmila P Marija RP | 2013 | Clin Rheumatoi2013，32，： | 1 |
| 9 | Tubules and donuts:a type Ⅵ secretion story显示文摘 | B(o)emann G Aleksandra P Axel M | 2010 | Molecular Microbiology2010，76，4： | 1 |
| 10 | The efficacy of hypertonic solutions saline nasal irrigationfor chronic sinonasal symptoms 显示文摘 | David R Thomas P Aleksandra Z | 2005 | Otolaryngology-Head and Neck Surgely2005，133，1： | 1 |
| 11 | Treatment of acute lower respiratory tract in- fections in children 显示文摘 | Ronvir-Babin Nevenka P Popadi6 Jelena Stojadinovi6 Aleksandra | 2010 | Medicinski Pregled2010，55，78： | 1 |
| 12 | The efficacy of hypertonic solutions sailne nasal irrigationf or chronic sinonasal symptoms显示文摘 | David R Thomas P Aleksandra Z | 2005 | Otolaryngology-Head and Neck Surgely2005，133，1： | 1 |
| 13 | Content of blood cell components,inflammatory cytokines and growth factors in autologous platelet-rich plasma obtained by various methods显示文摘BACKGROUND The evaluation of the efficacy of platelet-rich plasma(PRP) in clinical practice yields conflicting results and raises numerous controversies. This may be due to different concentrations of biologically active components in PRP obtained with the use of different methods of gravity separation.AIM To compare the content, repeatability and correlations between biologically active components in PRP obtained with four different commercial systems.METHODS From a whole blood sample of each of 12 healthy male volunteers, 4 PRP samples were prepared using 4 different commercial kits [Arthrex Autologous Conditioned Plasma(ACP), Mini GPS Ⅲ, Xerthra, Dr. PRP] in accordance with the instructions provided by the manufacturers. A comparative analysis of blood cell components-13 selected inflammatory cytokines and 7 growth factors-in the obtained PRP samples was performed using the Kruskal-Wallis test by ranks. The repeatability of results in each method was evaluated by the estimation of the coefficient of variation. The Spearman correlation was used to estimate the relationship between blood cell content and cytokines.RESULTS Significantly higher concentrations of platelets(PLT), white blood cells(WBC) and red blood cells(RBC) were found in PRP obtained with the use of Mini GPS Ⅲ than in PRP obtained using other systems. Significant differences in the content of growth factors and cytokines in PRP were found. A positive correlation of the amount of PLT, RBC and WBC with the concentration of most of the growth factors was found but in only three inflammatory cytokines. The obtained correlations between blood cell components and cytokines differed between the systems in terms of statistical significance, which may be due to insufficient sample size. The repeatability of the obtained PLT concentration also varied between protocols with the lowest in Xerthra and the highest in Arthrex ACP.CONCLUSION Significant differences in the content of biologically active components and their repeatability were found in PRP obtained by various methods, providing new data for further research. | Maciej Dejnek Jarosław Witkowski Helena Moreira Sylwia Płaczkowska Piotr Morasiewicz PawełReichert Aleksandra Królikowska | 2022 | World Journal of Orthopedics2022，13，6： | 1 |
| 14 | The efficacy ofhypertonic solutions saline nasal irrigation for chronic si-nonasal symptoms 显示文摘 | DavldR Thomas P? Aleksandra Z et aZ | 2005 | Otolaryngol Head Neck Surg2005，133，： | 1 |
| 15 | The application of Scanning Electronic Microscopy:The study of the surface of the upper layers of dyed polyester fibre samples in the ostacet yellow E-L5R,FACTA Universities显示文摘 | Milena N M Milovan M P Aleksandra R Z | 2004 | Physics Chemistry and Technology2004，3，1： | 1 |
| 16 | Influence of narrow band imaging (NBI) videobronchoscopy on the assessment of central lung cancer extension and therapeutic decision显示文摘 | Bojan Z Branislav P Aleksandra J | 2009 | Caneer Invest2009，27，： | 1 |
| 17 | Synthesis and aqueous solution properties of functionalized and thermoresponsive poly (D,L-lactide)/polyether block copolymers显示文摘 | Aleksandra P Philip D Ivaylo D | 2004 | Macromol Symp2004，210，： | 1 |
| 18 | Mean myocardial velocity mapping in quantifying regional myocardial contractile reserve in patients with impaired left ventricular systolic function:doppler myocardial imaging study显示文摘 | Przmyslow P Aleksandra L Colin F | 2000 | J Am Soc Echocardiogr2000，13，： | 1 |
| 19 | The efficacy of hypertonic solutions saline nasal irrigationfor chronic sinonasal syrnptorrks 显示文摘 | David R Thomas P Aleksandra Z | 2005 | Otolaryngology - head and Neck Surgely2005，133，1： | 1 |
| 20 | Loneliness in older persons:A theoretical model and empirical findings 显示文摘 | Jiska C M Aleksandra P G | 2007 | International Psychogenatrics2007，19，2： | 1 |
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