|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 2 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 3 | Salmonella enterica Flagellin Is Recognized via FLS2 and Activates PAMP-Triggered Immunity in Arabidopsis thaliana显示文摘有沙门氏菌 enterica 的感染属于食物中毒和感染的水果的最突出的原因,蔬菜代表重要向量 forsalmonellosis。最近的证据显示植物认出 S。enterica 和加薪防卫回答。尽管如此,控制 S 的相互作用的分子的机制。有植物的 enterica 大部分仍然是不清楚的。这里,我们从 S 显示出那 flagellin。enterica 在 Arabidopsis thaliana 代表一个突出的联系病原体的分子的模式(PAMP ) ,它由受体 kinase FLS2 经由 flg22 领域的识别导致被触发 PAMP 的免疫(PTI ) 。Arabidopsis fls2 异种表演不过减少了没废除的 PTI 激活,显示植物也依靠另外的 S 的识别。enterica PAMP。有趣地, S。enterica 类型 III 分泌物系统(T3SS ) 异种 prgH 在 Arabidopsis 比野类型的细菌导致了更强壮的防卫基因表示,建议 T3SS 受动器涉及防卫抑制。而且,我们观察那 S。enterica 紧张在 flg22 epitope 显示出变化,它与减少的导致 PTI 活动导致蛋白质。总的来说, theseresults 表演那 S。enterica 在 Arabidopsis 激活 PTI 并且建议那,以便完成植物殖民, S。enterica 发展了策略避免或压制 PTI.Key 词: | Ana Victoria Garcia Amelie Charrier Adam Schikora Jean Bigeard Stephanie Pateyron Marie-Ludivine de Tauzia-Moreau Alexandre Evrard Axel Mithofer Marie Laure Martin-Magniette Isabelle Virlogeux-Payant Heribert Hirt | 2014 | Molecular Plant2014，7，4： | 3 |
| 4 | A population-based study of 135 lymphomas after solid organ transplantation: The role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival显示文摘 | Amelie Kinch Eva Baecklund Carin Backlin Tor Ekman Daniel Molin Gunnar Tufveson Pia Fernberg Christer Sundstr? m Karlis Pauksens Gunilla Enblad | 2014 | Acta Oncologica2014，，5： | 2 |
| 5 | New Strigolactone Analogs as Plant Hormones with Low Activities in the Rhizosphere显示文摘Strigolactones (SL ) 为建立共生 andparasitic 相互作用不仅作为植物荷尔蒙,而且作为根围信号被知道。新特定的 SL 类似物的设计是在理解基本植物 biologyand 也是有用的没有赞成寄生植物的开发,控制植物体系结构的一个挑战性的目标。二个不同分子(23 (3-methyl-GR24 ) , 31 (thia-3-methyl-debranone-like 分子)) 已经描述了,并且新的(AR36 ) 它 thesynthesis 被介绍,生物学上与著名 GR24 和最近识别的 CISA-1 相比。这些 differentstructures 强调部分的宽范围属于作为植物荷尔蒙为 bioactivity 搀。这些新 compoundspossess 一个普通 dimethylbutenolide 主题但是他们的结构在分子的 ABC 部分变化:, 23 有象 GR24 的一样的 ABCpart 31 并且 AR36 分别地,带一枚芳香的戒指和非循环的碳链。为在 strigolactone 合成或在感觉异种的如此的衍生物的 bioactivity 的详细信息 isgiven 种(豌豆 rms1 和 rms4, Arabidopsis max2 并且, max4 )为与他们在 arbuscular mycorrhizal 上的根围的行动一起的不同神经质的功能菌丝的生长 andparasitic 杂草 germination.Key 词: | Francois-Didier Boyer Alexandre de Saint Germain Jean-Bernard Pouvreau Guillaume Clave Jean-Paul Pillot Amelie Roux Amanda Rasmussen Stephen Depuydt Dominique Lauresserguesh Nicolas Frei dit Frey Thomas S.A. Heugebaert Christian V. Stevens Danny Geelen Sofie Goormachtig Catherine Rameau | 2014 | Molecular Plant2014，7，4： | 2 |
| 6 | The effect of host plants on genotype variability in fitness and honeydew composition of Aphis fabae显示文摘蚜虫种类能是杂食的,在越过类的多重宿主植物上喂。当主人植物种类能在他们的韧皮部作文有大变化,这能影响蚜虫健康和蜜露作文。以前的研究在黑豆子蚜虫蚜虫属 fabae 的蜜露糖类的作文显示出重要 intraspecific 遗传型变化,与显示出越过不同遗传型的特别大的变化的蚂蚁引诱剂 trisaccharide melezitose。在这研究,如果在 melezitose 和蚜虫蜜露的糖类作文的变化能被连接到特定的蚜虫遗传型的改编到特别主人植物,我们测试。到这个目的, 4 高度和黑豆子蚜虫蚜虫属 fabae 的 5 低 melezitose secreting 遗传型在 4 普通主人植物上被饲养:蚕豆,黎,甜菜,和鸦片。糖类作文,和特别地 melezitose 分泌物,显示出的重要蚜虫遗传型和主人种相互作用,与高的一些遗传型 1 主人植物上然而并非在另外一个上的 melezitose secreting。然而,相互作用效果不是在健康大小的 paralleled,尽管处于越过不同主人植物的平均健康有重要差别。总体上,这研究证明蚜虫蜜露作文被复杂草食动物植物相互作用影响。我们在蚜虫在蚂蚁蚜虫互助论和适应专门化的上下文讨论这些调查结果的关联。 | Sharon Schillewaert Amelie Vantaux Wim Van den Ende Tom Wenseleers | 2017 | Insect Science2017，24，5： | 2 |
| 7 | Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy显示文摘 | Pierre Hainaut Amelie Plymoth | 2013 | Current Opinion in Oncology2013，，1： | 2 |
| 8 | Identification of osteopontin as a novel marker for early hepatocellular carcinoma显示文摘 | Sufen Shang Amelie Plymoth Shaokui Ge Ziding Feng Hugo R. Rosen Suleeporn Sangrajrang Pierre Hainaut Jorge A. Marrero Laura Beretta | 2012 | Hepatology2012，，2： | 2 |
| 9 | Analytical Calculation of Internal Forces in Orthotropic Plated Bridge Decks Based on the Slope-Deflection Method显示文摘 | Hans De Backer Amelie Outtier Philippe Van Bogaert | 2008 | Journal of Constructional Steel Research2008，，64： | 1 |
| 10 | Thernal ablation balloon in patients with multiple morbidity:3 year up显示文摘 | Dusan T Amelie G Daniel K | 2004 | J AM Assoc Gynecol Laparosc2004，11，： | 1 |
| 11 | Intravitreal Administration of Antisense Oligonucleotides:Potential of Liposomal Delivery显示文摘 | Amelie Bochot Bochot Couvreur Elias Fattal | 2000 | Progress in Retinal and Eye Research2000，19，2： | 1 |
| 12 | The relationships between awareness of consequences, environmental concern, and value orientations显示文摘 | André Hansla Amelie Gamble Asgeir Juliusson Tommy G?rling | 2007 | Journal of Environmental Psychology2007，，1： | 1 |
| 13 | Predictive vis-ual outcome after macula-off retinal detachment surgery u-sing optical coherence tomography显示文摘 | AMELIE LC MURAINE M JEAN-FRANOIS M | 2005 | Retina2005，25，1： | 1 |
| 14 | Cytotoxicity and cbll cycle effects of the plant alkaloids eryptolepine and neocryptolepine: relation to drug induced apoptosis 显示文摘 | Laurent D Amelie L Aurelie W | 2000 | Europ J Pharmacol2000，409，1： | 1 |
| 15 | Rhythms and alternating patterns in plants as emergent properties of a model of interaction between development and functioning显示文摘 | Amelie M | 2008 | Annals of Botany 1012008，101，8： | 1 |
| 16 | Interaction effects of mood induction and nominal representation of price on consumer choice显示文摘 | AMELIE GAMBLE TOMMY GA' RLING DANIEL VA'STFJA' LL AGNETA MARELL | | 0，，： | 1 |
| 17 | Analytical calculation of internal forces in orthotropic plated bridge decks based on the slope-deflection method显示文摘 | Hans D B Amelie O Philippe V B | 2008 | Journal of Constructional Steel Research2008，64，12： | 1 |
| 18 | Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032显示文摘 | Amelie B Tina C Greg H E | 2009 | Cancer Prey Res (Phila)2009，2，9： | 1 |
| 19 | Amphiphilic beta-cyclodextrins modified on the primary face:synthesis, characterization, and evaluation of their potential as novel excipients in the preparation of nanocapsules显示文摘 | Erem Memisoglu Amelie Bochot Murat Sen | 2002 | J Pharm Sci2002，91，5： | 1 |
| 20 | Intravitreal administration of antisense oligonucleotides: potential of liposomal delivery显示文摘 | Amelie B Patrick C Elias F | 2000 | Prog Retin Eye Rese2000，19，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员