|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 超音速火焰喷涂碳化物粒径不同的WC-10Co4Cr涂层在粗细磨粒下的磨损性能显示文摘改进的ASTM G65橡胶轮测试方法可采用220nm二氧化钛颗粒和368μm的砂粒分别在潮湿和干燥条件下使用。在由碳化物粒径不同(传统和亚微米)的两种粉末所制备的WC-CoCr涂层上开展试验,研究碳化物大小和磨损介质特性对涂层磨损性能的影响。采用扫描电镜对同一位置磨损前后的低倍和高倍形貌进行观察,并分析了涂层的磨损机理。结果表明:磨损机理取决于碳化物和磨粒的相对大小。在样品上进行磨损定量分析,通过调整碳化物尺寸可改善磨损性能,测试涂层的一些力学性能用于对比。 | Arash Ghabchi Tommi Varis Erja Turunen Tomi Suhonen S-P Hannula 谢旭霞 | 2010 | 热喷涂技术2010，，4： | 15 |
| 2 | How would Capital Account Liberalization Affect China's Capital Flows and the Renminbi Real Exchange Rates?显示文摘在这份报纸,我们学习粗野大写的流动的决定因素,在 2020 投射中国的国际投资位置的尺寸,并且分析为人民币的含意真实汇率如果中国放宽大写的报道。我们在这锻练假设人民币将大部分在当前的十年底完成大写的帐户可改变,与由人们中国的银行的最近的建议一致的一张时间表。我们的分析证明如果大写的帐户被放宽,中国的粗野国际投资位置将显著地成长,并且流入和流出将变得更平衡。私人部门将把它的网络责任位置变成一个平衡位置,并且正式扇区将显著地减少它的网络财产位置,相对这个国家的 GDP。因为私人部门的增加的重要性外国主张和正式外国储备的减少的重要性,中国将能挣更高的网投资收入从在国外。总的来说,中国将继续是一个网债权人,与网是的外国财产位置整个这十年仍然保持大部分稳定的 GDP 的份额。这些调查结果建议真实汇率不是的人民币对大写的流动被期望两方面的大写的帐户自由化特别地敏感。真实汇率将多半作为中国在中等欣赏的一条路径上的人民币被期望维持与它的做贸易的搭挡一起微分的可观的生长。 | Dong He Lillian Cheung Wenlang Zhang Tommy Wu | 2012 | China & World Economy2012，20，6： | 13 |
| 3 | Boceprevir,GC-376,and calpain inhibitors Ⅱ,Ⅻ inhibit SARS-CoV-2 viral replication by targeting the viral main protease显示文摘A new coronavirus SARS-CoV-2,also called novel coronavirus 2019(2019-nCoV),started to circulate among humans around December 2019,and it is now widespread as a global pandemic.The disease caused by SARS-CoV-2 virus is called COVID-19,which is highly contagious and has an overall mortality rate of 6.35%as of May 26,2020.There is no vaccine or antiviral available for SARS-CoV-2.In this study,we report our discovery of inhibitors targeting the SARS-CoV-2 main protease(Mpro).Using the FRET-based enzymatic assay,several inhibitors including boceprevir,GC-376,and calpain inhibitorsⅡ,andⅫwere identified to have potent activity with single-digit to submicromolar ICs0 values in the enzymatic assay.The mechanism of action of the hits was further characterized using enzyme kinetic studies,thermal shift binding assays,and native mass spectrometry.Significantly,four compounds(boceprevir,GC-376,calpain inhibitorsⅡandⅫ)inhibit SARS-CoV-2 viral replication in cell culture with EC50 values ranging from 0.49 to 3.37μM.Notably,boceprevir,calpain inhibitorsⅡandⅫrepresent novel chemotypes that are distinct from known substrate-based peptidomimetic Mpro inhibitors.A complex crystal structure of SARS-CoV-2 Mpro with GC-376,determined at 2.15(A)resolution with three protomers per asymmetric unit,revealed two unique binding configurations,shedding light on the molecular interactions and protein conformational flexibility underlying substrate and inhibitor binding by Mpro.Overall,the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics. | Chunlong Ma Michael Dominic Sacco Brett Hurst Julia Alma Townsend Yanmei Hu Tommy Szeto Xiujun Zhang Bart Tarbet Michael Thomas Marty Yu Chen Jun Wang | 2020 | Cell Research2020，30，8： | 13 |
| 4 | 儿童气管、支气管软化的病因和气道管理初步研究显示文摘目的探讨儿童气管、支气管软化的病因和气道管理方法。方法对671例儿童进行支气管镜检查,对发现气管软化和支气管软化的病例进行病因分析,并对他们的治疗加以总结。结果(1)通过支气管镜共发现气管、支气管软化的患儿148例,其中气管软化77例,支气管软化71例。(2)气管软化中:46例为血管环畸形,11例与先天性气道畸形有关,10例合并有先天性食管闭锁伴食管气管瘘,6例与气管切开造口和机械通气相关,4例为孤立性气管软化。(3)支气管软化中:64例患有心血管畸形,6例与先天性气道畸形有关,1例为孤立性支气管软化。(4)10例异常无名动脉患儿行主动脉固定术,12例右位主动脉弓伴迷走左锁骨下动脉和双主动脉弓患儿行血管环松解术,6例肺动脉吊带的患儿行肺动脉吊带纠治术;手术中直接切除严重的气管软化段的4例。38例患儿行机械通气,4例患儿进行气管造口,治疗气管软化和支气管软化,相当程度地缓解了症状。2例在支气管内进行金属支架植入治疗支气管软化,1例获得成功,另1例需要2次植入支架;这2例患儿均在以后进行了支架远端球囊扩张。结论心血管畸形是儿童发生气管、支气管软化的主要原因。对心血管畸形进行纠治后,大多数病例症状在6个月内逐渐改善。对严重的病例,治疗还包括机械通气和气管造口。支气管内支架植入可运用于难治性的病例中,但有一定的局限性。 | 殷勇 Tommy SCHONFELD 陈同辛 | 2009 | 中华儿科杂志2009，47，2： | 12 |
| 5 | 人类皮下和网膜脂肪组织中脂联素基因的表达和调控的研究显示文摘目标:探讨脂联素在人类皮下和网膜脂肪组织中mRNA表达水平,以及糖皮质激素和PPARγ激动剂对脂联素的调控作用。方法:应用real-time摇RT-PCR方法观察了16名成人腹部皮下和网膜脂肪组织中脂联素mRNA表达水平以及与肥胖的关系。通过体外培养,观察地塞米松(dexamethasone,DEX)和/或PPARγ激动剂(troglitazone,TGZ)对不同部位脂肪组织脂联素的表达和分泌的调控作用。结果:皮下和网膜脂肪组织脂联素mRNA表达丰富但无显著部位差异,网膜脂肪组织脂联素mRNA水平与BMI呈显著负相关(r=0.56,P<0.05)。体外培养24h后,TGZ处理组脂肪组织脂联素基因的表达明显增加(皮下:70%;网膜:102%),且网膜脂肪组织脂联素的分泌明显高于对照组(P<0.05);DEX则下调网膜脂肪组织脂联素mRNA的表达水平36%,TGZ可逆转这种抑制作用。结论:网膜脂肪组织中脂联素mRNA的表达随BMI增加而下降,并受到糖皮质激素及PPARγ激动剂调控。脂联素的部位特异性表达和调控可能是内脏型肥胖连接胰岛素抵抗的重要分子机制。 | 李晓南 陈荣华 潘亚 Tommy Olsson Olle Hernell | 2006 | 南京医科大学学报(自然科学版)2006，26，1： | 12 |
| 6 | HyDeploy:The UK’s First Hydrogen Blending Deployment Project显示文摘The HyDeploy project is the UK’s first practical project to demonstrate that hydrogen can be safely blended into the natural-gas distribution system without requiring changes to appliances and the associated disruption.The project is funded under Ofgem’s Network Innovation Competition and is a collaboration between Cadent Gas,Northern Gas Networks,Progressive Energy Ltd,Keele University(Keele),Health&Safety Laboratory and ITM Power.Cadent and Northern Gas Networks are the Gas Distribution Network sponsors of the project.Keele University is the host site,providing the gas-distribution network,which will receive the hydrogen blend.Keele University is the largest campus university in the UK.Health&Safety Laboratory provides the scientific laboratories and experimental expertise.ITM Power provides the electrolyser that produces the hydrogen.Progressive Energy Ltd is the project developer and project manager.HyDeploy is structured into three distinct phases.The first is an extensive technical programme to establish the necessary detailed evidence base in support of an application to the Health&Safety Executive for Exemption to Schedule 3 of the Gas Safety(Management)Regulations(GS(M)R)to permit the injection of hydrogen at 20 mol%.This is required to allow hydrogen to be blended into a natural-gas supply above the current British limit of 0.1 mol%.The second phase comprises the construction of the electrolyser and grid entry unit,along with the necessary piping and valves,to allow hydrogen to be mixed and injected into the Keele University gas-distribution network and to ensure all necessary training of operatives is conducted before injection.The third phase is the trial itself,which is due to start in the summer of 2019 and last around 10 months.The trial phase also provides an opportunity to undertake further experimental activities related to the operational network to support the pathway to full deployment of blended gas.The outcome of HyDeploy is principally developing the initial evidence base that hydrogen can be blended into a UK operational natural-gas network without disruption to customers and without prejudicing the safety of end users.If deployed at scale,hydrogen blending at 20 mol%would unlock 29 TWh pa of decarbonized heat and provide a route map for deeper savings.The equivalent carbon savings of a national roll-out of a 20-mol%hydrogen blend would be to remove 2.5 million cars from the road.HyDeploy is a seminal UK project for the decarbonization of the gas grid via hydrogen deployment and will provide the first stepping stone for setting technical,operational and regulatory precedents of the hydrogen vector. | Tommy Isaac | 2019 | Clean Energy2019，3，2： | 10 |
| 7 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 8 | 异丙酚复合静脉麻醉用于儿童纤维支气管镜检查临床观察显示文摘 | 钱娟 Tommy SCHEONFELD 王莹 殷勇 肖洁 | 2006 | 中国当代儿科杂志2006，8，6： | 10 |
| 9 | 支气管镜在儿童气管食管瘘全程手术管理中的应用研究显示文摘目的探讨支气管镜在儿童气管食管瘘术前、术中和术后的临床应用价值。方法对14例疑似气管食管瘘患儿(其中1例支气管食管瘘)尝试应用支气管镜进行手术全程管理。结果术前对4例患儿应用支气管镜检查明确诊断为气管食管瘘;运用相同方法确诊1例患儿为气管窦道,排除了气管食管瘘;利用支气管镜引导下气管插管技术,成功封堵1例因误食烧碱造成左主支气管-食管瘘。在术中应用'支气管镜透射照明'法和'导丝环'法精确定位3例气管食管瘘,减少了手术创伤和探查瘘管的时间。在术后应用支气管镜发现2例气管食管瘘复发和2例存在气管软化;支气管镜还充当了一次'超细胃镜',将导丝引入食道,然后进行食管狭窄的球囊扩张。结论支气管镜在儿童气管食管瘘诊治中有很大的临床应用价值,可应用于气管食管瘘的全程管理。 | 殷勇 蒋丽蓉 严志龙 Tommy Schonfeld 张磊 张静 | 2009 | 临床儿科杂志2009，27，1： | 9 |
| 10 | Nitrite,a novel method to decrease ischemia/reperfusion injury in the rat liver显示文摘AIM:To investigate whether nitrite administered prior to ischemia/reperfusion(I/R)reduces liver injury.METHODS:Thirty-six male Sprague-Dawley rats were randomized to 3 groups,including sham operated(n=8),45-min segmental ischemia of the left liver lobe(IR,n=14)and ischemia/reperfusion(I/R)preceded by the administration of 480 nmol of nitrite(n=14).Serum transaminases were measured after 4 h of reperfusion.Liver microdialysate(MD)was sampled in 30-min intervals and analyzed for glucose,lactate,pyruvate and glycerol as well as the total nitrite and nitrate(NOx).The NOx was measured in serum.RESULTS:Aspartate aminotransferase(AST)at the end of reperfusion was higher in the IR group than in the nitrite group(40±6.8μkat/L vs 22±2.6μkat/L,P=0.022).Similarly,alanine aminotransferase(ALT)was also higher in the I/R group than in the nitrite group(34±6μkat vs 14±1.5μkat,P=0.0045).The NOx in MD was significantly higher in the nitrite group than in the I/R group(10.1±2.9μmol/L vs 3.2±0.9μmol/L,P=0.031)after the administration of nitrite.During ischemia,the levels decreased in both groups and then increased again during reperfusion.At the end of reperfusion,there was a tendency towards a higher NOx in the I/R group than in the nitrite group(11.6±0.7μmol/L vs 9.2±1.1μmol/L,P=0.067).Lactate in MD was significantly higher in the IR group than in the nitrite group(3.37±0.18 mmol/L vs 2.8±0.12 mmol/L,P=0.01)during ischemia and the first 30 min of reperfusion.During the same period,glycerol was also higher in the IRI group than in the nitrite group(464±38μmol/L vs 367±31μmol/L,P=0.049).With respect to histology,there were more signs of tissue damage in the I/R group than in the nitrite group,and29%of the animals in the I/R group exhibited necrosis compared with none in the nitrite group.Inducible nitric oxide synthase transcription increased between early ischemia(t=15)and the end of reperfusion in both groups.CONCLUSION:Nitrite administered before liver ischemia in the rat liver reduces anaerobic metabolism and cell necrosis,which could be important in the clinical setting. | Bergthor Bjrnsson Linda Bojmar Hans Olsson Tommy Sundqvist Per Sandstrm | 2015 | World Journal of Gastroenterology2015，21，6： | 8 |
| 11 | 青藏高原上发现世界最老的岩面艺术显示文摘青藏高原高寒、缺氧,属于地球上居住条件极端恶劣的环境.人类在什么时候克服生理和生存的重重困难去征服高原是人类演化历史中至关重要的科学问题.在第二次青藏高原综合科学考察过程中,研究团队在西藏邱桑温泉附近发现了一组由古人类有意留下的手印和脚印(简称手脚印).通过对这些手脚印进行详细的3D扫描,解剖学和沉积学分析,以及铀系法测年,发现这些手脚印是由古人类在泉华软泥上用其手脚压制而成,随后这些留有印记的软泥迅速脱水并固结成岩,得以长期保留.这些手脚印形成于距今16.9~22.6万年,是人类占据高原已知最早的记录.由于这些有意压制的手脚印排列有序并富于创造性,研究团队认为这是世界上最古老的岩面艺术,其中的手印也是世界上目前已知最古老有意创作的手印.该研究显示邱桑古人类比智人走出非洲的时间更早,但与最近在青藏高原边缘发现的丹尼索瓦人的年代相近.手脚印的创作者究底是丹尼索瓦人还是其他直立人?这给考古学家们留下了新的挑战. | 章典 Matthew R.Bennett 程海 王蕾彬 张海伟 Sally C.Reynolds 张盛达 王晓晴 李腾 Tommy Urban 裴卿 吴志峰 张普 刘春茹 汪亚峰 王聪 张冬菊 R.Lawrence Edwards | 2021 | Science Bulletin2021，66，24： | 7 |
| 12 | Human-driven topographic effects on the distribution of forest in a flat, lowland agricultural region显示文摘复杂地形学在多山的区域对采伐森林缓冲森林。然而,如果地面也在人的影响是可能的是地面抑制的更少的低地塑造森林分发,它是未知的。在如此的区域,如果重要根本,地志的效果将取决于文化历史的因素并且因此人驱动(人为) 而非自然,除了在一般气候或极端玷污的区域,限制森林的出现。我们使用了空间回归当模特儿估计地志的因素向解释森林分发的程度(存在缺席在一 48 ? | Mette V. ODGAARD Peder K. BOCHER Tommy DALGAARD Jesper E. MOESLUND Jens-Christian SVENNING | 2014 | Journal of Geographical Sciences2014，24，1： | 6 |
| 13 | Multicell power allocation method based on game theory for inter-cell interference coordination显示文摘As a new technology, coordinated multipoint (CoMP) transmission is included in LTE-Advanced study item. Moreover, the network architecture in LTE-Advanced system is modified to take into account coordinated transmission. Under this background, a novel power allocation game model is established to mitigate inter-cell interference with cellular coordination. In the light of cellular cooperation relationship and centralized control in eNodeB, the power allocation in each served antenna unit aims to make signal to interference plus noise ratio (SINR) balanced among inter-cells. Through the proposed power allocation game algorithm, the users' SINR can reach the Nash equilibrium, making it feasible to reduce the co-frequency interference by decreasing the transmitted power. Numerical results show that the proposed power allocation algorithm improves the throughput both in cell-center and cell-edge. Moreover, the blocking rate in cell-edge is reduced too. | ZHANG Hui XU XiaoDong LI JingYa TAO XiaoFeng ZHANG Ping SVENSSON Tommy BOTELLA Carmen | 2009 | Science in China(Series F)2009，52，12： | 5 |
| 14 | 人类皮下和网膜脂肪组织脂肪细胞因子的表达显示文摘目的探讨脂肪细胞因子在成人皮下和网膜脂肪组织中的表达水平。方法应用即刻定量PCR方法测定16例成人皮下和网膜脂肪组织中瘦素、脂联素、肿瘤坏死因子α(TNF-α)和抵抗素的表达水平。结果正常体重组和超重组皮下脂肪组织瘦素mRNA水平均明显高于网膜组织(P<0.01);正常组网膜脂肪组织脂联素mRNA水平较皮下组织有升高趋势(P=0.07);TNF-α和抵抗素mRNA表达水平低下且无显著部位差异。无论皮下或网膜脂肪组织瘦素表达水平均与体重指数(BMI)成正相关(皮下:r=0.68,P<0.01;网膜:r=0.71,P<0.01)),而网膜脂肪组织脂联素表达与BMI呈明显负相关(r=-0.60,P<0.05)。结论基因编码的一些细胞因子在脂肪组织中的表达呈部位特征,肥胖时皮下和网膜脂肪组织瘦素过度表达,而内脏脂肪组织脂联素表达下调,这可能是肥胖相关的胰岛素抵抗发生的潜在危险因素。 | 李晓南 陈荣华 Tommy Olsson Olle Hernell | 2005 | 江苏医药2005，31，12： | 5 |
| 15 | Resource pooling for frameless network architecture with adaptive resource allocation显示文摘The system capacity for future mobile communication needs to be increased to fulfill the emerging requirements of mobile services and innumerable applications. The cellular topology has for long been regarded as the most promising way to provide the required increase in capacity. However with the emerging densification of cell deployments, the traditional cellular structure limits the efficiency of the resource, and the coordination between different types of base stations is more complicated and entails heavy cost. Consequently, this study proposes frameless network architecture (FNA) to release the cell boundaries, enabling the topology needed to implement the FNA resource allocation strategy. This strategy is based on resource pooling incorporating a new resource dimension-antenna/antenna array. Within this architecture, an adaptive resource allocation method based on genetic algorithm is proposed to find the optimal solution for the multi-dimensional resource allocation problem. Maximum throughput and proportional fair resource allocation criteria are considered. The simulation results show that the proposed architecture and resource allocation method can achieve performance gains for both criteria with a relatively low complexity compared to existing schemes. | XU XiaoDong WANG Da TAO XiaoFeng SVENSSON Tommy | 2013 | Science China(Information Sciences)2013，56，2： | 5 |
| 16 | Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion显示文摘AIM:To study the effects of preconditioning on inducible nitric oxide synthase(iNOS)and interleukin 1(IL-1)receptor transcription in rat liver ischemia/reperfusion injury(IRI).METHODS:Seventy-two male rats were randomized into 3 groups:the one-hour segmental ischemia(IRI,n=24)group,the ischemic preconditioning(IPC,n=24)group or the remote ischemic preconditioning(RIPC,n=24)group.The IPC and R-IPC were performed as 10 min of ischemia and 10 min of reperfusion.The iNOS and the IL-1 receptor mRNA in the liver tissue was analyzed with real time PCR.The total Nitrite and Nitrate(NOx)in continuously sampled microdialysate(MD)from the liver was analyzed.In addition,the NOx levels in the serum were analyzed.RESULTS:After 4 h of reperfusion,the iNOS mRNA was significantly higher in the R-IPC(ΔCt:3.44±0.57)group than in the IPC(ΔCt:5.86±0.82)group(P=0.025).The IL-1 receptor transcription activity was reduced in the IPC group(ΔCt:1.88±0.53 to 4.81±0.21),but not in the R-IPC group,during reperfusion(P=0.027).In the MD,a significant drop in the NOx levels was noted in the R-IPC group(12.3±2.2 to 4.7±1.2μmol/L)at the end of ischemia compared with the levels in early ischemia(P=0.008).A similar trend was observed in the IPC group(11.8±2.1 to 6.4±1.5μmol/L),although this difference was not statistically significant.The levels of NOx rose quickly during reperfusion in both groups.CONCLUSION:IPC,but not R-IPC,reduces iNOS and IL-1 receptor transcription during early reperfusion,indicating a lower inflammatory reaction.NOx is consumed in the ischemic liver lobe. | Bergthor Bjornsson Anders Winbladh Linda Bojmar Tommy Sundqvist Per Gullstrand Per Sandstrom | 2014 | World Journal of Gastroenterology2014，20，28： | 5 |
| 17 | Non-alcoholic fatty liver disease-a chronic disease of the 21^(st) century显示文摘Non-alcoholic fatty liver disease(NAFLD) comprises a spectrum of metabolic states ranging from simple steatosis to inflammation with associated fibrosis to cirrhosis. Though accumulation of hepatic fat is not associated with a significant increase in mortality rates, hepatic inflammation is, as this augments the risk of terminal liver disease, i.e.,cirrhosis, hepatic decompensation(liver failure) and/or hepatocellular carcinoma. Disease progression is usually slow, over a decade or more and, for the most part, remains asymptomatic. Recent estimates suggest that the global prevalence of NAFLD is high, about one in four. In most cases, NAFLD overlaps with overweight, obesity,cardiovascular disease and the metabolic syndrome with numerous contributing parameters including a dysregulation of adipose tissue, insulin resistance, type 2 diabetes, changes in the gut microbiome, neuronal and hormonal dysregulation and metabolic stress. NAFLD is diagnosed incidentally, despite its high prevalence. Non-invasive imaging techniques have emerged, making it possible to determine degree of steatosis as well asfibrosis. Despite this,the benefit of routine diagnostics remains uncertain. A better understanding of the(molecular) pathogenesis of NAFLD is needed combined with long-term studies where benefits of treatment can be assessed to determine costbenefit ratios. This review summarizes the current state of knowledge and possible areas of treatment. | Peter Metrakos Tommy Nilsson | 2018 | The Journal of Biomedical Research2018，32，5： | 4 |
| 18 | Utility-based bandwidth allocation algorithm for heterogeneous wireless networks显示文摘In next generation wireless network (NGWN), mobile users are capable of connecting to the core network through various heterogeneous wireless access networks, such as cellular network, wireless metropolitan area network (WMAN), wireless local area network (WLAN), and ad hoc network. NGWN is expected to provide high-bandwidth connectivity with guaranteed quality-of-service to mobile users in a seamless manner; however, this desired function demands seamless coordination of the heterogeneous radio access network (RAN) technologies. In recent years, some researches have been conducted to design radio resource management (RRM) architectures and algorithms for NGWN; however, few studies stress the problem of joint network performance optimization, which is an essential goal for a cooperative service providing scenario. Furthermore, while some authors consider the competition among the service providers, the QoS requirements of users and the resource competition within access networks are not fully considered. In this paper, we present an interworking integrated network architecture, which is responsible for monitoring the status information of different radio access technologies (RATs) and executing the resource allocation algorithm. Within this architecture, the problem of joint bandwidth allocation for heterogeneous integrated networks is formulated based on utility function theory and bankruptcy game theory. The proposed bandwidth allocation scheme comprises two successive stages, i.e., service bandwidth allocation and user bandwidth allocation. At the service bandwidth allocation stage, the optimal amount of bandwidth for different types of services in each network is allocated based on the criterion of joint utility maximization. At the user bandwidth allocation stage, the service bandwidth in each network is optimally allocated among users in the network according to bankruptcy game theory. Numerical results demonstrate the efficiency of the proposed algorithm. | CHAI Rong WANG XiuJuan CHEN QianBin SVENSSON Tommy | 2013 | Science China(Information Sciences)2013，56，2： | 4 |
| 19 | IgG and fibrinogen driven nanoparticle aggregation显示文摘蛋白质怎么导致 nanoparticle (NP ) 的彻底的理解当在 vitro 并且在 vivo 试金设计并且解释试验性的结果时,聚集是关键的。当为药交货系统开发 nano 申请和明确的表达时,这知识也是关键的。在这研究,我们在更低的聚苯乙烯 NP 聚集从奶牛浆液结果发现了免疫球蛋白 G (IgG ) 的那抽取。而且,到胎儿的奶牛浆液的孤立的 IgG 或纤维蛋白原的增加提高了这聚集,因此证明这些因素是在浆液的 NP 聚集的主要司机。阻止直觉地, NP 聚集相反地依赖于蛋白质集中;即,低蛋白质集中导致了大总数,而高蛋白质集中导致了小总数。导致蛋白质的 NP 聚集和总数尺寸被吸收度在分别地散布的 400 nm 和动态光监视。这里,我们在蛋白质集中依赖者聚集后面建议机制;这机制在另外的浆液蛋白质的 NP 表面,表面区域限制,聚集动力学,和影响上包含多重蛋白质相互作用的效果。 | Risto Cukalevski Silvia A. Ferreira Christopher J. Dunning Tord Berggard Tommy Cedervall | 2015 | Nano Research2015，8，8： | 3 |
| 20 | Intelligent modelling of clay compressibility using hybrid meta-heuristic and machine learning algorithms显示文摘Compression index Ccis an essential parameter in geotechnical design for which the effectiveness of correlation is still a challenge.This paper suggests a novel modelling approach using machine learning(ML)technique.The performance of five commonly used machine learning(ML)algorithms,i.e.back-propagation neural network(BPNN),extreme learning machine(ELM),support vector machine(SVM),random forest(RF)and evolutionary polynomial regression(EPR)in predicting Cc is comprehensively investigated.A database with a total number of 311 datasets including three input variables,i.e.initial void ratio e0,liquid limit water content wL,plasticity index Ip,and one output variable Cc is first established.Genetic algorithm(GA)is used to optimize the hyper-parameters in five ML algorithms,and the average prediction error for the 10-fold cross-validation(CV)sets is set as thefitness function in the GA for enhancing the robustness of ML models.The results indicate that ML models outperform empirical prediction formulations with lower prediction error.RF yields the lowest error followed by BPNN,ELM,EPR and SVM.If the ranges of input variables in the database are large enough,BPNN and RF models are recommended to predict Cc.Furthermore,if the distribution of input variables is continuous,RF model is the best one.Otherwise,EPR model is recommended if the ranges of input variables are small.The predicted correlations between input and output variables using five ML models show great agreement with the physical explanation. | Pin Zhang Zhen-Yu Yin Yin-Fu Jin Tommy HTChan Fu-Ping Gao | 2021 | Geoscience Frontiers2021，12，1： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员