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| 1 | 到用结构化的问询表的口头的抗病毒的肝炎 B 治疗的坚持的评估显示文摘 AIM:To assess adherence rates to nucleos(t)ide analogues(NUCs) therapy in patients with chronic hepatitis B virus infection and determine factors associated with adherence.METHODS:The questionnaire study was conducted in the liver clinics at Concord Repatriation General Hospital.All patients who were currently taking one or more NUCs were asked to complete a structured,selfadministered 32-item questionnaire.Adherence was measured using visual analogue scales.The patient’s treating clinician was also asked to assess their patient’s adherence via a structured questionnaire.RESULTS:A total of 80 patients completed the questionnaire.Sixty six percent of the patients(n = 49) reported optimal adherence whilst 25(33.8%) graded their adherence to NUCs as suboptimal.Thirty four(43%) patients reported to have omitted taking their NUCs sometime in the past.Recent non-adherence was uncommon.Amongst the patients who reported skipping medications,the most common reason cited was 'forgetfulness'(n = 27,56.25%).Other common reasons included:ran out of medications(n = 5,10.42%),being too busy(n = 4,8.33%) and due to a change in daily routine(n = 5,10.42%).Patients who reported low adherence to other prescription pills were also more likely to miss taking NUCs(P = 0.04).Patients who were under the care of a language-discordant clinician were also more likely to report suboptimal adherence to NUCs(P = 0.04).CONCLUSION:Adherence rates were much less than that expected by the physician and has potential adverse affect on long term outcome.Communication and education appear central and strategies need to be implemented to improve ongoing adherence. | Leesa Giang Christian P Selinger Alice Unah Lee | 2012 | World Journal of Hepatology2012，4，2： | 16 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | A Resonant Accel- erometer with Two-Stage Micro-Leverage Mechanisms Fabricated by SOI-MEMS Technology 显示文摘 | Susan X P Su Henry S Yang Alice M Agogino | 2005 | IEEE Sensors Journal2005，5，6： | 1 |
| 5 | Development of a platform tech-nology to generate long-acting protein therapeutics显示文摘 | Heather P Alice T Ian W | 2012 | EndocriAbstr2012，289，2： | 1 |
| 6 | Rennet coagulation of skim milk and curd drainage: effect of pH, casein concentration, ionic strength and heat treatment显示文摘 | C LINA D MARIE-HILtNE F ALICE P | 2000 | Dairy Sciences and Technology2000，80，4： | 1 |
| 7 | Rennet coagulation of skim milk and curd drainage:Effect of pH,casein concentration,ionic strength and heat treatment显示文摘 | Cé1ina D Marie-Hé1ène F Alice P | | 0，，： | 1 |
| 8 | Chemical characterization and ecotoxicity of three soil foaming agents used in mechanized tunneling显示文摘 | Diego B Eleonora L Alice P | 2015 | Journal of Hazardous Materials2015，296，： | 1 |
| 9 | Inhibition of nucleoside transport By new analogues of nitrobenzylthioinosine显示文摘 | Deghati P Y F Alice B | 2003 | Bioorganic and Medicinal Chemistry2003，11，6： | 1 |
| 10 | Role of placenta growth factor in malignancy and evidence that an antagonistic P1GF/Fh - 1 peptide inhibits the growth and metastasis of human breast cancer xenografts 显示文摘 | Alice P Taylor David M | 2007 | Mol Cancer T her2007，6，2： | 1 |
| 11 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 12 | From epoxidized linseed oil to bioresin:An overall approach of epoxy/anhydride crosslinking显示文摘 | Jean Mathieu P Nicolas S Alice M | 2015 | Chem Sus Chem2015，8，7： | 1 |
| 13 | Glucose Inhibition Persistsin Hypothalamic Neurons Lacking Tandem- Pore K_ Channels 显示文摘 | Alice G Magalie P | 2009 | Neuroscience2009，29，8： | 1 |
| 14 | Use of conserved randomly amplified polymorphic DNA (RAPD) fragments and RAPD pattern for characterization of Lactobacillus fermentum in Ghanaian fermented maize dough显示文摘 | Alice EH Anne P Finn KV | 1999 | Applied Environ Microbiol1999，65，： | 1 |
| 15 | Therapeutic use of interleukin-2 in HIV- infected patients 显示文摘 | Alice K P Jorge A T | 2002 | Current Opinion In Pharmacology2002，2，： | 1 |
| 16 | Quality of life among patients with stage Ⅱ and Ⅲ Breast Carcinoma Randomized to Receive High-Dose Chemotherapy with Autologous Bone Marrow support or intermediate-dose chemotherapy显示文摘 | Jeffrey P James H Alice BK | 2005 | Cancer2005，104，8： | 1 |
| 17 | Micromechanics of magnetorheological suspensions显示文摘 | GAST ALICE P | 2000 | Physical Review E:Statistical Physics Plasmas Fluids and Related Interdisciplinary topics2000，61，6： | 1 |
| 18 | Modulation of circulating andadipose tissue adiponectin levels by antidiabetic therapy 显示文摘 | Susan A Theodore P Alice PS | 2003 | Diabetes2003，52，： | 1 |
| 19 | Thyroid Status, Cardiovascular Risk, and Mortality in Older Adults 显示文摘 | Anne R Linda P Alice M | 2006 | JAMA2006，295，： | 1 |
| 20 | Comparison of human and computer performance across face recognition experiments显示文摘 | Jonathon P P and Alice O J | 2014 | Image and Vision Computing2014，32，1： | 1 |
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