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| 1 | Early chronic obstructive pulmonary disease: Beyond spirometry显示文摘The significant healthcare burden associated with chronic obstructive pulmonary disease(COPD) is driving us to improve our understanding of the natural history of this disease. Historically, the focus has been largely centred on diagnosing and treating individuals with moderate and severe disease. However, it is now recognised that the speed of decline in lung function as measured by forced expiratory volume in 1 s occurs faster in the earlier stages of the disease process. As a result, a clearer understanding of the potential benefits of treatment in early COPD is needed. It is recognised that many patients with COPD remain undiagnosed in the community which has prompted global case-finding initiatives. In this review we discuss the difficulties in diagnosing COPD in its early stages, examine the roleof case-finding and look at the evidence for early intervention with therapeutic agents. There is a growing interest in the phenotypic variation amongst patients with COPD and we explore the role of phenotyping in early COPD and its potential benefits in providing a more individualised approach to COPD management. The majority of patients with COPD are known to die from non-respiratory causes such as cardiovascular disease. The mechanistic link is thought to relate to systemic inflammation, causing us to question whether earlier interventions could have a beneficial impact on the burden of co-morbidities for patients with COPD. | Judith A Brebner Alice M Turner | 2013 | World Journal of Respirology2013，3，3： | 5 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | 应用超短波治疗COVID-19患者需考虑的风险显示文摘2020年初,新型冠状病毒疾病(COVID-19)占据了全球政府公共卫生防控最重要的位置。我国正在做出巨大的努力以应对COVID-19构成的公共卫生威胁,并积极探索治疗该疾病的方法。康复同仁为此也付出了辛苦的工作,并提议使用超短波疗法(USWD)为患者提供康复治疗。回顾了国内外相关超短波疗法的研究报道,拟阐明将其用于干预急性期COVID-19患者可能潜在的风险。在管理COVID-19患者时,必须首先考虑避免医务人员和患者之间的交叉感染风险;此外,在应用任何电疗为患者提供治疗之前,必须评估电疗仪器输出量的可靠性和进行患者正常皮肤感觉的测试程序。由于COVID-19患者的心脏功能可能会受病毒影响,必须考虑电流靠近心脏区域的风险。并通过检索已有的国内外关于USWD的研究发现,在过去的20年中,物理因子的可用性和使用量呈急剧下降趋势;也没有证据表明物理因子疗法可以治疗肺部疾病。英语文献中完全没有关于USWD治疗肺炎的临床试验报告。尽管在中国有一些关于使用USWD治疗肺炎的报道,但仍缺乏描述适当的随机化方法、详细的治疗过程以及安全防范措施程序,或考虑对肺功能的长期影响的报道。所以,在使用USWD对COVID-19患者进行康复治疗建议前,需要系统化的数据收集及研究USWD对急性和慢性肺损伤的作用机制和安全性。 | 喻鹏铭 ALICE Y M Jones E-LIISA Laakso | 2020 | 康复学报2020，30，2： | 3 |
| 4 | Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease显示文摘AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their perspectives.METHODS: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans. | Alice L Bennett David Moore Peter A Bampton Robert V Bryant Jane M Andrews | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 5 | 中国大陆居民对中风的危险因素、征兆、应急处理及信息获取等相关认知的调查研究(英文)显示文摘目的:以中国大陆居民为受访对象,就中风的认知和预防进行问卷调查,以推进预防中风的健康教育活动。方法:选择大陆两个主要城市(武汉和成都)公园、商场及其他公共场所的居民为对象,进行一项有关中风知识标准化的横截面问卷调查,内容包括风险因素、征兆、应急救援和信息获取。结果:846人参与问卷调查,其中55%为男性,45%为女性,平均年龄45.7岁。收集数据表明,28%的受调查居民认为高血压是主要的危险因素,头晕(29%)和麻木(20.2%)是中风常见的征兆。所有数据都显示,当中风时人们采取急救措施是有必要的。家庭/朋友(21%)及媒体(电视占19.5%,报纸占17.7%)是中风信息传播的主要途径。结论:应重视推广中国大陆地区有关中风预防的低成本高效率的教育项目,尤其是中风危险因素、征兆、应急处理和信息获取途径的相关项目。开拓多元化的途径,包括开展促进公众健康的活动,通过医疗专家和医疗设施开展健康教育活动向广大民众宣传中风常识和预防措施。 | Zhenyi LI Peng WANG Alice Y M JONES Elizabeth DEAN | 2015 | 康复学报2015，0，2： | 3 |
| 6 | 通过模拟学习最大限度地提高物理治疗的临床实习成效(英文)显示文摘本文描述物理治疗专业和物理治疗入门级教育在中国康复医学教育中的演变,提倡以模拟学习技术(simulation-based learning,SBL)为临床实习生积累经验。与医学专业的学生一样,物理治疗专业学生的教育需要一个结构化的临床教育方案,以确保毕业时具备一定的临床专业能力。SBL多年以来一直是医学、工程以及航空专业的首选教学模式。在物理治疗专业培养方案中,SBL培养临床技能的教学模式已经出现。本文亦论述SBL在物理治疗专业入门级教育中的优势,尤其是使用模拟标准化患者作为核心临床教育内容,为学生进入临床实习做好准备。我们建议中国可以将SBL应用在物理治疗专业人才培养方案中,这能够最大限度地提高学生的临床实习经验。 | Alice Y M JONES Margot A SKINNER Elizabeth DEAN | 2015 | 康复学报2015，25，1： | 2 |
| 7 | Histopathological regression grading matches excellently with local and regional spread after neoadjuvant therapy of rectal cancer显示文摘 | Sefer Elezkurtaj Lutz Moser Jan Budczies Alice Josephine Müller Hendrik Bl?ker Heinz Johannes Buhr Manfred Dietel Martin Kruschewski | 2013 | Pathology - Research and Practice2013，，7： | 2 |
| 8 | Trends and outcomes of transarterial chemoembolization in hepatocellular carcinoma:a national survey显示文摘BACKGROUND:Transarterial chemoembolization(TACE) is a palliative procedure frequently used in patients with advanced hepatocellular carcinoma(HCC). We examined the national inpatient trends of TACE and related outcomes in the United States over the last decade.METHODS:We utilized the National Inpatient Sample(2002 to 2012) and performed trend analyses of TACE for HCC in all adult patients(age >18 years). Multivariate analyses for the outcomes of in-hospital 'procedure-related complications'(PRCs) and 'post-procedure complications'(PPCs) were performed. We also compared early(2002 to 2006) and late(2007 to 2012) eras by multivariate analyses to identify predictors of complications, healthcare resource utilization and mortality.RESULTS:Overall, 19058 patients underwent TACE for HCC where PRCs and PPCs were seen in 24.2% and 17.6% of patients, respectively. The overall trends in the use of TACE(P<0.001) and associated PRCs(P=0.006) were observed to be increasing. There was less mortality [adjusted Odds ratio(a OR):0.58; 95% CI:0.41, 0.82], reduced length of hospital stay(-1.87 days; 95% CI:-2.77,-0.97) and increased hospital charges($19232; 95% CI:11013, 27451) in the late era. Additionally, there was increased mortality(a OR:4.07; 95% CI:2.96, 5.59), PRCs(a OR:3.21; 95% CI:2.56, 4.02), and PPCs(a OR:2.70; 95% CI:2.11, 3.46) among patients with coagulopathy.CONCLUSIONS:There is an increasing trend of TACE utilization in HCC. However, the outcomes are worse in patients with coagulopathy. Although PRCs have increased, mortality has decreased in recent years. These findings should be considered during TACE evaluation in patients with HCC. | Khalid Mumtaz Nishi Patel Rohan M Modi Vihang Patel Alice Hinton James Hanje Sylvester M Black Somashaker Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 2 |
| 9 | A Resonant Accel- erometer with Two-Stage Micro-Leverage Mechanisms Fabricated by SOI-MEMS Technology 显示文摘 | Susan X P Su Henry S Yang Alice M Agogino | 2005 | IEEE Sensors Journal2005，5，6： | 1 |
| 10 | Molecular biology of the lignin-degrading Basidiomycete Phanerochate chrysosporium显示文摘 | Michael H G Alic M | 1993 | Microbiol Rev1993，57，3： | 1 |
| 11 | Acquisition of Mands,Tacts, and Intraverbals through Sign Exposure in an Individual with Autism 显示文摘 | Valentino Amber L Shillingsburg M Alice | 2011 | Analysis of Verbal Behavior2011，，1： | 1 |
| 12 | Reverse transcription-PCR analysis of the regulation of the manganese peroxidase gene family显示文摘 | GETTEMY M Jessiea MA Biao ALIC Margaret | 1998 | Applied and Environmental Microbiology1998，64，2： | 1 |
| 13 | Reverse transcription-PCR analysis of the regulation of the manganese peroxidase gene family显示文摘 | GETTEMY JM MA B ALIC M | 1998 | Appl Environ Microbiol1998，64，2： | 1 |
| 14 | Short- Versus Long-Term Duration of Dual-Antiplatelet Therapy After Coronary Stenting: A Randomized Multicenter Trial显示文摘 | Marco Valgimigli Gianluca Campo Monia Monti Pascal Vranckx Gianfranco Percoco Carlo Tumscitz Fausto Castriota Federico Colombo Matteo Tebaldi Giuseppe Fucà Moh?d Kubbajeh Elisa Cangiano Monica Minarelli Antonella Scalone Caterina Cavazza Alice Frangione M | 2012 | Circulation2012，，16： | 1 |
| 15 | When will a brand scan- dal spill over, and how should competitors respond? 显示文摘 | Michelle L Roehm Alice M Tybout | 2006 | Jour- nal of Marketing Research2006，43，3： | 1 |
| 16 | Prediction of optimal height by anthropometric parameters显示文摘 | Pei-Te Huang Alice M K | | 0，，15： | 1 |
| 17 | Molecular Biology of Lignin-Degrading Basidiomycete Phanerochaete chrysosporium 显示文摘 | Gold M H Alic M | 1993 | Microbiological Reviews1993，57，： | 1 |
| 18 | Effect of the partial replacement of Fe by Ni and/or Mn on the electrocatalytic activity for oxygen evolution of the CoFe2O4 spinel oxide elecprode 显示文摘 | Isabel G M Alice C M Da Silva Pereira M I | 2002 | Electrochem Acta2002，，47： | 1 |
| 19 | Incidelice, manifestations, and predictors of worsening white matter on serial cranial magnetic reasonance imaging in the elderly: the cardiovascular health study 显示文摘 | Longmrenth WT Alice M Norman J | 2005 | Stroke2005，36，1： | 1 |
| 20 | Role of placenta growth factor in malignancy and evidence that an antagonistic P1GF/Fh - 1 peptide inhibits the growth and metastasis of human breast cancer xenografts 显示文摘 | Alice P Taylor David M | 2007 | Mol Cancer T her2007，6，2： | 1 |
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