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| 1 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 2 | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?显示文摘Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease. | Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno Jesús Zacarías Villarreal-Pérez Héctor Jesús Maldonado-Garza | 2016 | World Journal of Gastroenterology2016，22，10： | 12 |
| 3 | Acute effects of physical exercise in type 2 diabetes: A review显示文摘The literature has shown the efficiency of exercise in the control of type 2 diabetes(T2D), being suggested as one of the best kinds of non-pharmacological treatments for its population. Thus, the scientific production related to this phenomenon has growing exponentially. However, despite its advances, still there is a lack of studies that have carried out a review on the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in individuals with T2 D, not to mention that in a related way, these themes have been very little studied today. Therefore, the aim of this study was to organize and analyze the current scientific production about the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in T2 D individuals. For such, a research with the following keywords was performed:-exercise; diabetes and post-exercise hypotension; diabetes and excess post-exercise oxygen consumption; diabetes and acute effects in PUBMED, SCIELO and HIGHWIRE databases. From the analyzed studies, it is possible to conclude that, a single exercise session can promote an increase in the bioavailability of nitric oxide and elicit decreases in postexercise blood pressure. Furthermore, the metabolic stress from physical exercise can increase the oxidation of carbohydrate during the exercise and keep it, in high levels, the post exercise consumption of O2, this phenomenon increases the rate of fat oxidation during recovery periods after exercise, improves glucose tolerance and insulin sensitivity and reduces glycemia between 2-72 h, which seems to be dependent on the exercise intensity and duration of the effort. | Ricardo Yukio Asano Marcelo Magalhes Sales Rodrigo Alberto Vieira Browne José Fernando Vila Nova Moraes Hélio José Coelho Júnior Milton Rocha Moraes Hebert Gustavo Simoes | 2014 | World Journal of Diabetes2014，5，5： | 8 |
| 4 | Liquid-liquid interfacial tension of equilibrated mixtures of ionic liquids and hydrocarbons显示文摘Ionic liquids are possible alternative solvents for the separation of aromatic and aliphatic hydrocarbons by liquid-liquid extrac- tion. Interfacial tension is an important property to consider in the design of liquid-liquid extraction processes. In this work, the liquid-liquid interfacial tension and the mutual solubility at 25 °C have been measured for a series of biphasic, equilibrated mixtures of an ionic liquid and a hydrocarbon. In particular, the ionic liquids 1-alkyl-3-methylimidazolium bis(trifluorome- thanesulfonyl)imide (with the alkyl substituent being ethyl, hexyl or decyl), 1-ethyl-3-methylimidazolium ethylsulfate, and 1-ethyl-3-methylimidazolium methanesulfonate have been selected, as well as the hydrocarbons benzene, hexane, ethylben- zene, and octane. The selected sets of ionic liquids and hydrocarbons allow the analysis of the influence of a series of effects on the interfacial tension. For example, the interfacial tension decreases with an increase in the length of the alkyl substituent chain of the cation or with an increase of the degree of charge delocalisation in the anion of the ionic liquid. Also, the interfa- cial tension with the aromatic hydrocarbons is markedly lower than that with the aliphatic hydrocarbons. A smaller effect is caused by variation of the size of the hydrocarbon. Some of the observed trends can be explained from the mutual solubility of the hydrocarbon and the ionic liquid. | RODRíGUEZ Héctor ARCE Alberto SOTO Ana | 2012 | Science China Chemistry2012，55，8： | 4 |
| 5 | Liver disease in pregnancy显示文摘 | Deepak Joshi Andra James Alberto Quaglia Rachel H Westbrook Michael A Heneghan | 2010 | The Lancet2010，，9714： | 2 |
| 6 | Effective use of FibroTest to generate decision trees in hepatitis C显示文摘AIM:To assess the usefulness of FibroTest to forecast scores by constructing decision trees in patients with chronic hepatitis C.METHODS:We used the C4.5 classification algorithm to construct decision trees with data from 261 patients with chronic hepatitis C without a liver biopsy.The FibroTest attributes of age,gender,bilirubin,apolipoprotein,haptoglobin,α2 macroglobulin,and γ-glutamyl transpeptidase were used as predictors,and the FibroTest score as the target.For testing,a 10-fold cross validation was used.RESULTS:The overall classification error was 14.9%(accuracy 85.1%).FibroTest's cases with true scores of F0 and F4 were classified with very high accuracy(18/20 for F0,9/9 for F0-1 and 92/96 for F4) and the largest confusion centered on F3.The algorithm produced a set of compound rules out of the ten classification trees and was used to classify the 261 patients.The rules for the classification of patients in F0 and F4 were effective in more than 75% of the cases in which they were tested.CONCLUSION:The recognition of clinical subgroups should help to enhance our ability to assess differences in fibrosis scores in clinical studies and improve our understanding of fibrosis progression. | Dana Lau-Corona Luís Alberto Pineda Héctor Hugo Avilés Gabriela Gutiérrez-Reyes Blanca Eugenia Farfan-Labonne Rafael Núez-Nateras Alan Bonder Rosalinda Martínez-García Clara Corona-Lau Marco Antonio Olivera-Martínez Maria Concepción Gutiérrez-Ruiz Guillermo Robles-Díaz David Kershenobich | 2009 | World Journal of Gastroenterology2009，15，21： | 2 |
| 7 | Mechanism of degradation of wool wax in the anaerobic treatment of woolscouring wastewater显示文摘 | SOLE DAD C ALBERTO H MARIA V | 1999 | Water Sci Tech1999，40，8： | 1 |
| 8 | Cold tolerance ofmaize seedlings as determined by root morphology and photosynthetic traits显示文摘 | Andreas H Yvan F Alberto S | 2008 | European Journal of Agronomy2008，28，： | 1 |
| 9 | Predicting Systemic Disease in Patients With Esophageal Cancer After Esophagectomy: A Multinational Study on the Significance of the Number of Involved Lymph Nodes显示文摘 | Christian G. Peyre Jeffrey A. Hagen Steven R. DeMeester Jan J. B. Van Lanschot Arnulf H?lscher Simon Law Alberto Ruol Ermanno Ancona S Michael Griffin Nasser K. Altorki Thomas W. Rice John Wong Toni Lerut Tom R. DeMeester | 2008 | Annals of Surgery2008，，6： | 1 |
| 10 | Docetaxel for treatment of solid tumours: a systematic review of clinical data 显示文摘 | Alberto M Frank F Gabriel H | 2005 | Lancet Oncot2005，6，7： | 1 |
| 11 | Possible anxiolytic effect of two extracts of Passiflora quadrangularis L in experimental models显示文摘 | Pollyanna C Alberto H Jair C | 2007 | Phytother Res2007，21，： | 1 |
| 12 | Hybrid model predictive control based on ireless sensor feedback:An experimental study显示文摘 | Alberto B Stefano D C Erik H | 2010 | International Journal of Robust and Nonlinear Control2010，20，2： | 1 |
| 13 | Characterization of different water/powder ratios of dental gypsum using fiber Bragg grating sensors 显示文摘 | Alberto N Carvalho L Lima H | 2011 | Dent Mater J2011，30，5： | 1 |
| 14 | Prevention and control of cystic echinococcosis显示文摘 | Philip S Craig Donald P McManus Marshall W Lightowlers Jose A Chabalgoity Hector H Garcia Cesar M Gavidia Robert H Gilman Armando E Gonzalez Myriam Lorca Cesar Naquira Alberto Nieto Peter M Schantz | 2007 | The Lancet Infectious Diseases2007，，6： | 1 |
| 15 | Microstructure and Wear Resistance of Pearlitic Rails Steels 显示文摘 | ALBERTO J Perez-Unzueta JOHN H Beynon | 1993 | Wear1993，162，： | 1 |
| 16 | Endoscopic foraminotormy using MED system in eadaverlc specimens显示文摘 | Sun WR Danid H Alberto C | 2000 | $pine2000，25，： | 1 |
| 17 | A description of the ICU liaison nurse role in Argentina显示文摘 | Alberto L Zotdrez H Cafiete AA | 2014 | Intensive Crit Care Nurs2014，30，1： | 1 |
| 18 | Rheological properties of aerated cement pastes with fly ash, metaka- olin and sepiolite additions 显示文摘 | Javier P M Alberto S A Francisco H O | 2014 | Construction and Build- ing Materials2014，65，： | 1 |
| 19 | Docetaxel for treatment of solid tumours:a systematic review of clinical data显示文摘 | Alberto M Frank F Gabriel H | 2005 | Lancet Oncol2005，6，4： | 1 |
| 20 | Mechanism of Degradation of Wool Wax in the Anaerobic Treatment of Woolscouring Wastewater显示文摘 | Soledad C Alberto H Maria V | 1999 | Water Sci Tech1999，40，8： | 1 |
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