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| 1 | Liquid-liquid interfacial tension of equilibrated mixtures of ionic liquids and hydrocarbons显示文摘Ionic liquids are possible alternative solvents for the separation of aromatic and aliphatic hydrocarbons by liquid-liquid extrac- tion. Interfacial tension is an important property to consider in the design of liquid-liquid extraction processes. In this work, the liquid-liquid interfacial tension and the mutual solubility at 25 °C have been measured for a series of biphasic, equilibrated mixtures of an ionic liquid and a hydrocarbon. In particular, the ionic liquids 1-alkyl-3-methylimidazolium bis(trifluorome- thanesulfonyl)imide (with the alkyl substituent being ethyl, hexyl or decyl), 1-ethyl-3-methylimidazolium ethylsulfate, and 1-ethyl-3-methylimidazolium methanesulfonate have been selected, as well as the hydrocarbons benzene, hexane, ethylben- zene, and octane. The selected sets of ionic liquids and hydrocarbons allow the analysis of the influence of a series of effects on the interfacial tension. For example, the interfacial tension decreases with an increase in the length of the alkyl substituent chain of the cation or with an increase of the degree of charge delocalisation in the anion of the ionic liquid. Also, the interfa- cial tension with the aromatic hydrocarbons is markedly lower than that with the aliphatic hydrocarbons. A smaller effect is caused by variation of the size of the hydrocarbon. Some of the observed trends can be explained from the mutual solubility of the hydrocarbon and the ionic liquid. | RODRíGUEZ Héctor ARCE Alberto SOTO Ana | 2012 | Science China Chemistry2012，55，8： | 4 |
| 2 | Comparative study of the efficacy and safety of bromfenac, nepafenac and diclofenac sodium for the prevention of cystoid macular edema after phacoemulsification显示文摘● AIM: To compare the efficacy, tolerability and safety of bromfenac 0.09%, nepafenac 0.1% or diclofenac 0.1% for the prophylaxis of the cystoid macular edema(CME) after phacoemulsification.● METHODS: Group sequential observational comparative study. After phacoemulsification, patients received two months for topical treatment of either diclofenac sodium, bromfenac or nepafenac. All patients received concomitant topical tobramycin 0.3% and topical prednisolone 1%. We measured CME using optical coherence tomography(OCT) central foveal thickness, macular thickness and total macular volume.● RESULTS: We enrolled 243 patients from January to June 2015, and 35% received diclofenac, 32.9% bromfenac and 32.1% nepafenac. When we compared pre-operative to three weeks to two months, bromfenac was more effective in reducing foveal volume(21.3 and 35.4 mm3, respectively), compared with the diclofenac(1.3 and 11.5 mm3, respectively), and the nepafenac group, became more edematous 6.4 and 5.3, respectively. Totally 133 patients completed the post-surgical satisfaction questionnaire. Patients complained of eye stickiness in 13.8% whom we gave nepafenac, versus 10.3% whom we gave diclofenac sodium, and in 0 whom we gave bromfenac.● CONCLUSION: Bromfenac is the best tolerated and is more effective than diclofenac and nepafenac in reducing CME after phacoemulsification. | Ana Maria Chinchurreta Capote Mercedes Lorenzo Soto Francisco Rivas Ruiz Enrique Caso Peláez Alicia Garcia Vazquez Group OftaCosta Antonio Ramos Suárez | 2018 | International Journal of Ophthalmology(English edition)2018，11，7： | 2 |
| 3 | Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement显示文摘 | Evanthia Diamanti-Kandarakis Jean-Pierre Bourguignon Linda C. Giudice Russ Hauser Gail S. Prins Ana M. Soto R Thomas Zoeller Andrea C. Gore | 2009 | Endocrine Reviews2009，，4： | 1 |
| 4 | Bacterial Translocation in HIV-Infected Patients With HCV Cirrhosis: Implication in Hemodynamic Alterations and Mortality显示文摘 | Montserrat Montes de Oca Arjona Mercedes Marquez Maria Jose Soto Claudio Rodriguez-Ramos Alberto Terron Antonio Vergara Ana Arizcorreta Clotilde Fernandez-Gutierrez Jose Antonio Giron-González | 2011 | JAIDS Journal of Acquired Immune Deficiency Syndromes2011，，5： | 1 |
| 5 | Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption显示文摘 | Laura N. Vandenberg Maricel V. Maffini Carlos Sonnenschein Beverly S. Rubin Ana M. Soto | 2009 | Endocrine Reviews2009，，1： | 1 |
| 6 | Performance of α- sulfo fatty methyl ester sulfonate versus linear alkylbenzene sulfon- ate, secondary alkane sulfonate and α-Sulfo fatty methyl ester sul- fonate 显示文摘 | Leon Cohen Fernando Soto Ana Melgarejo | 2008 | J Surfact Deterg2008，11，： | 1 |
| 7 | Lugar de la cirugía local en el adenocarcinoma de recto T 2 N 0 M 0显示文摘 | Xavier Serra Aracil Jordi Bombardó Juncá Laura Mora López Manuel Alcantara Moral Isidro Ayguavives Garnica Ana Darnell Marti Alex Casalots Casado Carles Pericay Pijaume Rafael Campo Fernández de Los Ríos Salvador Navarro Soto | 2008 | Cirugia Espanola2008，，2： | 1 |
| 8 | Ionic liquids on desul- ftnization of fuel oils显示文摘 | Maria Francisco Alberto Arce Ana Soto | 2010 | Fluid Ptme Equilibris2010，294，12： | 1 |
| 9 | Kinetics of the reactions of Cl atoms with 2-buten-1-ol, 2-methyl-2-propen-1-ol, and 3-methyl-2-buten-1-ol as a function of temperature显示文摘 | Diana Rodriguez Ana Rodriguez Amparo Soto Alfonso Aranda Yolanda Diaz-de-Mera Alberto Notario | 2008 | Journal of Atmospheric Chemistry2008，，3： | 1 |
| 10 | Pancreatic adenosquamous carcinoma and intraductal papillary mucinous neoplasm in a CDKN2A germline mutation carrier显示文摘A 69-year-old woman from a kindred with familial atypical multiple mole melanoma and carrier of a germline mutation in CDKN2A, presented with abdominal pain caused by a solid-cystic pancreatic mass. The patient had an abdominal computed tomography three years before in which there was no evidence of pancreatic lesion. The endoscopic ultrasound guided fine needle aspiration showed adenocarcinoma with squamous component. After surgical resection the final diagnosis was adenosquamous pancreatic carcinoma(ASPC) arising in an intraductal papillar mucinous neoplasm(IPMN). Adenosquamous carcinomas are uncommon in the pancreas and have rarely been described in association with IPMNs. It has worse prognosis than the ordinary pancreatic ductal adenocarcinoma and some distinct features. We review the clinical, imaging, pathologic and molecular aspects of ASPC. Differential diagnosis with contamination, squamous metaplasia and pancreatic metastases from a distant squamous carcinoma is discussed. Besides, the case is an accelerated model of the adenoma(IPMN)-carcinoma sequence probably due to the CDKN2A ger-mline mutation. Somatic CDKN2A mutations are commonevents in the early steps of sporadic pancreatic cancer, but germline mutation carriers have a significantly higher risk of pancreatic carcinoma. | Fernando Martínez de Juan María Reolid Escribano Carmen Martínez Lapiedra Fernanda Maia de Alcantara María Caballero Soto Ana Calatrava Fons Isidro Machado | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 1 |
| 11 | Physical and excess properties for binary mixtures of 1-methy1-3-octylimidazolium tetrafluoroborate,,ionic liquid with different alcohols显示文摘 | Alberto Awe Eva Rodil Ana Soto | 2006 | Journal of Solution Chemistry2006，35，： | 1 |
| 12 | Partitioning ofantibiotics in a two-liquid phase system formed by waterand a room temperature ionic liquid显示文摘 | Ana Soto Alberto Arce MohammadK | 2005 | Separation andPurification Technology2005，44，3： | 1 |
| 13 | Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure显示文摘 | Tessa J. Murray Maricel V. Maffini Angelo A. Ucci Carlos Sonnenschein Ana M. Soto | 2006 | Reproductive Toxicology2006，，3： | 1 |
| 14 | Nanofluid based on 1-dodecylpyridinium chloride for enhanced oil recovery显示文摘The use of nanoparticles is considered promising for enhanced oil recovery(EOR),especially when they are combined with surfactants.However,the combination of nano-sized material with surface-active ionic liquids(SAILs)is an unexplored EOR method.In this work,the advantages of mixing Al2O3 nanoparticles with the SAIL 1-dodecylpyridinium chloride were investigated.Stable nanofluids in brine could only be achieved using the polymer polyvinylpyrrolidone(PVP)as a stabilizing agent.It was found that the addition of nanoparticles(and PVP)to the surfactant formulation helped to:slightly increase its viscosity,enhance its water-oil interfacial tension(IFT)reduction capacity,and reduce the adsorption on carbonate rocks(adsorption on sandstone was found to be excessive).IFT was selected as target property to minimize for the design of EOR formulations.Core flooding tests were carried out with surfactant(0.5 wt%[C_(12)py]Cl),surfactant-polymer(0.5 wt%[C_(12)py]Cl,1.0 wt%PVP)and nanofluid(0.05 wt%Al_(2)O_(3),1.0 wt%PVP,0.5 wt%[C12py]Cl)formulations in brine(0.5 wt%NaCl).Additional oil recoveries of 3.4%,7.4%and 12.0%OOIP were achieved,respectively,the nanofluid formulation being the most promising for the application.Moreover,it was found capable of changing the wettability of carbonate rocks from oilwet to intermediate-wet.The significance of this work lies in showing the new possibilities resulting from the combination of SAILs and nanoparticles for EOR,specifically the combination of[C_(12)py]Cl with Al_(2)O_(3). | Akram Al-Asadi Alba Somoza Alberto Arce Eva Rodil Ana Soto | 2023 | Petroleum Science2023，20，1： | 0 |
| 15 | Co-occurrence of germline pathogenic variants for different hereditary cancer syndromes in patients with Lynch syndrome显示文摘Background:Lynch syndrome(LS)is a hereditary condition characterized by a high risk of colorectal cancer,endometrial cancer,and other neoplasia associated with germline alterations in DNA mismatch repair genes.The classical genetic diagnostic strategy for LS consists of the Sanger sequencing of genes associated with the suspected syndrome.Next-generation sequencing(NGS)enables the simultaneous sequencing of a large number of hereditary cancer genes.Here,we aimed to study whether other germline pathogenic variants of hereditary cancer genes are present in patients with LS.Methods:A cohort of 84 probands with a previous genetic diagnosis of LS by Sanger sequencing was reanalyzed using NGS via a commercial panel of 94 hereditary cancer genes by hybrid capture.The American College of Medical Genetics and Genomics criteria were used to classify the clinical significance of the variants.The findings of NGS were confirmed by Sanger sequencing.When possible,genetic analyses of the new findings in the proband’s relativeswere also performed by Sanger sequencing.Results:We identified five families(6%),out of 84,with at least two germline pathogenic variants conferring to high or moderate risk in different dominant cancer-predisposing genes:[MLH1-BRCA2-NBN],[MLH1-BRCA1],[MSH2-ATM],[MSH6-NF1],and[MLH1-FANCA].Interestingly,only one out of these five families exhibited a clinical phenotype associated with the new pathogenic variants.The family with three pathogenic variants of the[MLH1-BRCA2-NBN]genes showed a high aggregation of tumors associated with LS and breast and ovarian cancer syndrome.Conclusions:Our results showed that the co-occurrence of more than one pathogenic variant in cancer-predisposing genes was remarkable among cases of LS.Inmost cases,no clinicial manifestations were associated with the secondary pathogenic variants.Further studies are needed to confirm these findings and elucidate their clinical impact.Reanalysis of LS families should be considered only in families with mixed clinical phenotypes. | Rosario Ferrer-Avargues Maria Isabel Castillejo Estela Damaso Virginia Diez-Obrero Noemi Garrigos Tatiana Molina Alan Codoner-Alejos Angel Segura Ana Beatriz Sanchez-Heras Adela Castillejo Jose Luis Soto | 2021 | Cancer Communications2021，41，3： | 0 |
| 16 | Oil recovery tests with ionic liquids: A review and evaluation of 1-decyl-3-methylimidazolium triflate显示文摘The main advantages of the use of ionic liquids in enhanced oil recovery are their tunability and stability in harsh environmental conditions. In this work, a comprehensive review of ionic liquids proposed to improve current chemical oil recovery methods has been presented, focusing on core flooding experiments. With an almost infinite number of possible ionic liquids, the amount of experiments carried out up to now has been very limited. However, results are promising, with additional recovery after secondary flooding of up to 32% of the original oil in place. Most formulations with ionic liquids have been proposed for sandstone reservoirs, the number of studies with carbonate cores being very scarce. The possibilities of a new room temperature surface active ionic liquid, 1-decyl-3-methylimidazolium triflate,for this application were analyzed. It was shown that it is able to drastically reduce the water/oil interfacial tension. An optimized formulation was proposed for carbonate reservoirs. After secondary flooding with brine, an additional recovery of 10.5% of original oil in place was achieved at room conditions. A combination of the proposed method followed by a polymer flooding step with polyacrylamide led to a lesser but still significant recovery, reducing the costs associated to the ionic liquid. | Alba Somoza Alberto Arce Ana Soto | 2022 | Petroleum Science2022，19，4： | 0 |
| 17 | 林奇综合征患者中同时具有不同遗传性肿瘤综合征的种系变异显示文摘背景与目的林奇综合征(lynch syndrome,LS)是一种遗传性疾病,LS患者罹患结直肠癌、子宫内膜癌和其他与DNA错配修复基因发生种系突变相关肿瘤的风险较高。LS的传统遗传诊断方法为对与疑似综合征相关的基因进行桑格测序。二代测序技术(next-generation sequencing,NGS)可同时对大量遗传性癌基因进行测序。本研究旨在探究林奇综合征患者中是否存在其他遗传性种系病理癌基因变异。方法我们选取先前已利用桑格测序遗传诊断法确诊的84例LS先证者作为研究对象,通过杂交捕获一组94个商业化的遗传癌基因,随后对这些捕获的样本进行NGS测序。按照美国医学遗传学和基因组学标准,对这些变异的临床意义进行分类。利用桑格测序验证NGS的结果。在可能的情况下,利用桑格测序进一步在先证者的亲属中进行新发现种系变异基因的遗传分析。结果我们从84个家族中鉴定出5(6%)个至少含有2个种系致病变异的家族,这些变异具有高或中等的诱发不同显性癌症的风险,这些家族的种系致病变异如下:[MLH1-BRCA2-NBN]、[MLH1-BRCA1]、[MSH2-ATM]、[MSH6-NF1]和[MLH1-FANCA]。有趣的是,这5个家族中只有1个家族表现出与新的致病变异相关的临床表型。含有3个致病变异基因[MLH1-BRCA2-NBN]的家族显示出LS、乳腺和卵巢癌综合征相关肿瘤的高度聚集特性。结论我们的研究表明,癌症易感基因中,同时发生多个致病变异是LS病例的显著特点。在大部分的病例中,继发性致病变异与临床表型不相关。将来需要进一步验证这些结论并阐明其临床影响。只有表现出复杂的临床表型家族才有必要重新对LS进行分析。 | Rosario Ferrer-Avargues María Isabel Castillejo Estela Dámaso Virginia Díez-Obrero NoemíGarrigos Tatiana Molina Alan Codoñer-Alejos Ángel Segura Ana Beatriz Sánchez-Heras Adela Castillejo JoséLuis Soto | 2022 | 癌症2022，41，5： | 0 |
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