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| 1 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 2 | c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1显示文摘AIM: To investigate the effect of stable c-Fos overexpression on immortalized human hepatocyte (IHH) proliferation. METHODS: IHHs stably transfected with c-Fos (IHH-Fos) or an empty vector (IHH-C) were grown in medium supplemented with 1% serum or stimulated with 10% serum. Cell proliferation was assessed by cell counts, 3H-thymidine uptake and fl ow cytometry analyses. The levels of cell cycle regulatory proteins (Cyclin D1, E, A) cyclin dependent kinases (cdk) cdk2, cdk4, cdk6, and their inhibitors p15, p16, p21, p27, to- tal and phosphorylated GSK-3β and epidermal growth factor receptor (EGF-R) were assayed by Western blot- ting. Analysis of Cyclin D1 mRNA levels was performed by reverse transcription-polymerase chain reaction and real-time polymerase chain reaction (PCR) analysis. Stability of Cyclin D1 was studied by cycloheximide blockade experiments. RESULTS: Stable c-Fos overexpression increased cell proliferation under low serum conditions and resulted in a two-fold increase in [3H]-thymidine incorpora- tion following serum addition. Cell cycle analysis by fl ow cytometry showed that c-Fos accelerated the cell cycle kinetics. Following serum stimulation, Cyclin D1 was more abundantly expressed in c-Fos overexpressing cells. Cyclin D1 accumulation did not result from increased transcriptional activation, but from nuclear stabilization. Overexpression of c-Fos correlated with higher nuclear levels of inactive phosphorylated GSK- 3β, a kinase involved in Cyclin D1 degradation and higher levels of EGF-R mRNA, and EGF-R protein compared to IHH-C both in serum starved, and in serum stimulated cells. Abrogation of EGF-R signalling in IHH- Fos by treatment with AG1478, a specif ic EGF-R tyrosine kinase inhibitor, prevented the phosphorylation of GSK-3β induced by serum stimulation and decreased Cyclin D1 stability in the nucleus. CONCLUSION: Our results clearly indicate a positive role for c-Fos in cell cycle regulation in hepatocytes. Importantly, we delineate a new mechanism by which c-Fos could contribute to hepatocarcinogenesis through stabilization of Cyclin D1 within the nucleus, evoking a new feature to c-Fos implication in hepatocellular carcinoma. | Meryem Güller Kahina Toualbi-Abed Agnès Legrand Laurence Michel Alain Mauviel Dominique Bernuau Fanny Daniel | 2008 | World Journal of Gastroenterology2008，14，41： | 6 |
| 3 | Adaptive response surface method based on a double weighted regression technique显示文摘 | Xuan Son Nguyen Alain Sellier Frédéric Duprat Gérard Pons | 2008 | Probabilistic Engineering Mechanics2008，，2： | 2 |
| 4 | Talc grinding in an opposed air jet mill:start-up,product qulity and production rate optimization显示文摘 | Laurence G Alain C John D | 2002 | Powder Technology2002，128，： | 1 |
| 5 | Genetic algorithms using multi -objectives in a multi -agent system显示文摘 | ALAIN C THIERRY G | 2000 | Robotics and Autonomous Systems2000，33，23： | 1 |
| 6 | ESC guidelines for thediagnosis and treatm ent of acute and chron ic heart failure 2008显示文摘 | Kenneth D Alain CS G erasimos F | 2008 | EurHeart J2008，29，19： | 1 |
| 7 | Spinal deformity and instability aft multilevel cervical laminectomy forspondylotic myelopathy 显示文摘 | Pierre G Michel B Alain D | 1998 | Spine1998，23，： | 1 |
| 8 | Failure of methotrexate and internaliliac balloon catherization to manage placenta percreta显示文摘 | Kimberly B Alain G Marie FD | 2002 | Obstet Gynecol2002，99，： | 1 |
| 9 | A Low-Noise Fixed-Tuned 300-360GHz Sub-Harmonic Mixer Using Planar Schottky Diodes显示文摘 | Bertrand Thomas Alain Maestrini Gérard Beaudin | | 0，，12： | 1 |
| 10 | Early and lateonset ventilator associated pneumonia acquired in the intensive careunit:comparison of risk factors显示文摘 | Marine G Alain L Bernard A | | 0，，01： | 1 |
| 11 | Plasmon-Enhanced Photoluminescence of SiC Quantum Dots for Cell Imaging Applications显示文摘 | Yuriy Zakharko Tetiana Serdiuk Tetyana Nychyporuk Alain Gélo?n Mustapha Lemiti Vladimir Lysenko | 2012 | Plasmonics2012，，4： | 1 |
| 12 | Partitioning of ethoxylated alkylphenol surfactants in microemulsion-oil-water Systems显示文摘 | Nelson M Raquel A Alain G | 1995 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1995，100，25： | 1 |
| 13 | Oral fluid testing for driving under the influenceof drugs:history,recent progress and remaining challenges显示文摘 | Alain G V | 2005 | Forensic Sci Int2005，150，23： | 1 |
| 14 | Making the heart resistant to infarction: how can we further decrease infarct size显示文摘 | Renand T Alain B Bijian G | 2008 | Front Biosci2008，13，： | 1 |
| 15 | Knowledge man- agement in supply chain: An empirical study from France显示文摘 | KARINE E S MARIE L ANGAPPA G ALAIN S | 2011 | The Journal of Strategic Information Systems2011，20，3： | 1 |
| 16 | On the nonlinear deformations of thin unsymmetric 0/90 composite plates under hygrothermal loads 显示文摘 | Marco G Jerome M Frederic J Alain V | 2006 | Composites Part A2006，37，4： | 1 |
| 17 | Hybrid organic-inorga- nic membranes显示文摘 | Christian G Alain B Mihail B | 2001 | Sep Purif Techn2001，25，： | 1 |
| 18 | Early and late-onset ventilator-associated pneumonia acquired in the intensive care unit:comparison of risk factors显示文摘 | Marine G Alain L Bernard A | | 0，，01： | 1 |
| 19 | Photochemical bleaching of chemical pulps catalyzed by Photochemistry and Photobiology A显示文摘 | Alain C Stephane G | 1998 | Chemistry Titanium Dioxide1998，，115： | 1 |
| 20 | Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1显示文摘 | Cagatay G Serge L Alain P | 2000 | Cancer Res2000，60，： | 1 |
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