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| 1 | Allogenic banking of dental pulp stem cells for innovative therapeutics显示文摘Medical research in regenerative medicine and cellbased therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells(DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products(ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen(HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues(dental pulps) as a source of mesenchymal stem cells to produce and store, in good manufacturing practice(GMP) conditions, DPSC therapeutic batches. In this review, we discuss about the challenges to transfer biological samples from a donor to HLA-typed DPSC therapeutic lots, following regulations, GMP guidelines and ethical principles. We also present some clinical applications, for which there is no efficient therapeutics so far, but that DPSCs-based ATMP could potentially treat. | Pierre-Yves Collart-Dutilleul Franck Chaubron John De Vos Frederic J Cuisinier | 2015 | World Journal of Stem Cells2015，7，7： | 7 |
| 2 | Transanal total mesorectal excision:a valid option for rectal cancer?显示文摘Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended. | Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 3 | Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care显示文摘 | Katharine Bushby Richard Finkel David J Birnkrant Laura E Case Paula R Clemens Linda Cripe Ajay Kaul Kathi Kinnett Craig McDonald Shree Pandya James Poysky Frederic Shapiro Jean Tomezsko Carolyn Constantin | 2010 | Lancet Neurology2010，，2： | 1 |
| 4 | Fragrance heritability in Hybrid Tea roses显示文摘 | Magali C M Frederic J Philippe H | 2007 | Scientia Horficulturae2007，113，2： | 1 |
| 5 | Chemical Weapons:Documented Use and Compounds on the Horizon显示文摘 | CHANTAL B STEPHEN W B FREDERIC J B | 2004 | Toxicology Letters2004，149，： | 1 |
| 6 | On the nonlinear deformations of thin unsymmetric 0/90 composite plates under hygrothermal loads 显示文摘 | Marco G Jerome M Frederic J Alain V | 2006 | Composites Part A2006，37，4： | 1 |
| 7 | Quantitative measurements with X-ray microscope in laser-tusion experiments显示文摘 | Frederic J M Su Oichang | 1995 | Rev Sci Instrum1995，66，1： | 1 |
| 8 | A systematic investigation of thioxanthen9-ones and analogs as potential antitumor agents 显示文摘 | Frederic A | 1963 | J Med Chem1963，6，： | 1 |
| 9 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 10 | Improvement of the Output Power in TWTs by Harmonic Injection 显示文摘 | Juliette P Marcel R J Andre Frederic | 2005 | IEEE Trans Electron Devices2005，52，5： | 1 |
| 11 | Arbitrary dispersion control of ultrashort optical pulses with acoustic waves显示文摘 | Frederic V Vincent L Huignard J P | 2000 | J Opt Soc Am B2000，17，： | 1 |
| 12 | IFN-γ-receptor deficiency in an infant with fatal bacille calmette-guerin infection显示文摘 | Emmanuelle J Frederic A Salma L | 1996 | N Engl J Med1996，335，26： | 1 |
| 13 | Metal organic frameworks for electrochemical applications 显示文摘 | Adina M Frederic J | 2012 | Energy & environmental science2012，5，11： | 1 |
| 14 | Solubilization of aromatic solutes in block copolymers显示文摘 | Frederic G Willian J K Robert S S | 1995 | Macromolecule1995，28，： | 1 |
| 15 | Highly oxygenated flavones from Mentha piperita显示文摘 | Frederic J Bernard V Jacques B | 1984 | Phytochemistry1984，23，12： | 1 |
| 16 | Intercalibration of vegetation indices from different sensor systems显示文摘 | Michael D S Timothy J M Frederic B Hui X Mark J C | 2003 | Remote Sensing of Environment2003，，88： | 1 |
| 17 | Heterogeneity and collective action for effort regulation: lesson from the senegalese amall-scale fisheries 显示文摘 | FREDERIC GASPART J EAN - PHILIPPE PLATTEAU | 2002 | Journal of Economic Behavior & Organization2002，，57： | 1 |
| 18 | Isomer-specific degradation and endocrine disrupting activity of nonylphenols显示文摘 | Frederic L P Routledge J Rentsch D | 2008 | Environmental Science and Technology2008，42，： | 1 |
| 19 | The effect of adding a minidose of clonidine to intrathecal sufentanail for labor analgesia 显示文摘 | FREDERIC J MOKHTAR D HERVE B | 1998 | Anesthesiology1998，89，： | 1 |
| 20 | Improvement of the Output Power in TWTs by Harmonic Injection 显示文摘 | Juliette P Marcel R J Frederic A | 2005 | IEEE Trans Electron Devices2005，52，5： | 1 |
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