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| 1 | 桃果皮毛、果肉颜色对果实糖与酸含量的影响及相关性研究显示文摘对山桃和栽培桃品种杂交后代 10 7个个体 (分成 2 2个毛桃和 85个油桃 ,或 75个白肉桃和 3 2个黄肉桃 )的果实糖酸含量遗传规律进行了研究。结果表明 ,桃果实中的可溶性糖和酸主要是蔗糖和苹果酸 ,分别占总可溶性糖的 65%左右和总酸含量的 50 %。油桃各基因型的蔗糖、果糖、山梨糖醇、总糖、可溶性固形物及奎宁酸平均含量均显著高于毛桃 ,而毛桃和油桃基因型之间的苹果酸、柠檬酸、总酸平均含量及糖酸比没有显著差异。所有毛桃和油桃基因型的莽草酸含量都很低 ,为 0 .0 11~ 0 .0 46meq·10 0g- 1FW。果实内葡萄糖和果糖含量呈正相关 (r =0 .63 ) ,蔗糖、葡萄糖、果糖分别与山梨糖醇呈显著或极显著直线正相关 ,且苹果酸与蔗糖、山梨糖醇、总糖和可溶性固形物呈显著正相关。毛桃的平均单果重显著大于油桃 ,且可溶性固形物和总酸含量与果实的大小呈显著直线负相关。此外 。 | 吴本宏 李绍华 Quilot Bénédicte Génard Michel Kervella Jocelyne | 2003 | 中国农业科学2003，36，12： | 33 |
| 2 | Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations显示文摘AIM To summarize and compare worldwide colorectal cancer(CRC) screening recommendations in order to identify similarities and disparities.METHODS A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website,Google and Google Scholar was performed. RESULTS Fifteen guidelines were identified. Six guidelines were published in North America, four in Europe, four in Asia and one from the World Gastroenterology Organization. The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test(FOBT, mainly the Fecal Immunochemical Test, annually or biennially). Disparities throughout the different guidelines are found relating to the use of colonoscopy, rank order between test, screening intervals and optimal age ranges for screening. CONCLUSION Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none. | Florence Bénard Alan N Barkun Myriam Martel Daniel von Renteln | 2018 | World Journal of Gastroenterology2018，24，1： | 16 |
| 3 | Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease显示文摘AIM To performed a systematic review and meta-analysis to determine any possible differences in terms of effectiveness, safety and tolerability between existing colon-cleansing products in patients with inflammatory bowel disease.METHODS Systematic searches were performed( January 1980-September 2016) using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials assessing preparations with or without adjuvants, given in split and non-split dosing, and in high(> 3 L) or low-volume(2 L or less) regimens. Bowel cleansing quality was the primary outcome. Secondary outcomes included patient willingness-torepeat the procedure and side effects/complications.RESULTS Out of 439 citations, 4 trials fulfilled our inclusion criteria(n = 449 patients). One trial assessed the impact of adding simethicone to polyethylene glycol(PEG) 4 L with no effect on bowel cleansing quality, but a better tolerance. Another trial compared senna to castor oil, again without any differences in term of bowel cleansing. Two trials compared the efficacy of PEG high-volume vs PEG low-volume associated to an adjuvant in split-dose regimens: PEG low-dose efficacy was not different to PEG high-dose; OR = 0.84(0.37-1.92). A higher proportion of patients were willing to repeat low-volume preparations vs high-volume; OR = 5.11(1.31-20.0). CONCLUSION In inflammatory bowel disease population, PEG lowvolume regimen seems not inferior to PEG high-volume to clean the colon, and yields improved willingness-torepeat. Further additional research is urgently required to compare contemporary products in this population. | Sophie Restellini Omar Kherad Talat Bessissow Charles Ménard Myriam Martel Maryam Taheri Tanjani Peter L Lakatos Alan N Barkun | 2017 | World Journal of Gastroenterology2017，23，32： | 16 |
| 4 | 活性炭/沸石层状床氢气纯化穿透曲线热效应显示文摘应用变压吸附技术对氢气混合气进行分离提纯是制取高纯度氢气的有效途径。本文主要研究多组分气体在活性炭/沸石层状床中穿透曲线的热效应影响,基于多物理场仿真平台Comsol,建立了多组分气体在多孔介质中的吸附、传热与传质模型。并将模拟值与实验数据进行验证分析,探索吸附过程伴随的热效应对穿透曲线的影响机理。最后针对变压吸附氢气纯化系统运行参数研究了环境温度、吸附条件和活性炭与沸石层高度比等对穿透曲线的影响。 | 彭育志 明越 肖金生 BNARD Pierre CHAHINE Richard | 2016 | 工程热物理学报2016，37，7： | 5 |
| 5 | Large endoscopic mucosal resection for colorectal tumors exceeding 4 cm显示文摘AIM:To evaluate the feasibility and the outcome of endoscopic mucosal resection(EMR)for large colorectal tumors exceeding 4 cm(LCRT)undergoing piecemeal resection. METHODS:From January 2005 to April 2008,146 digestive tumors larger than 2 cm were removed with the EMR technique in our department.Of these,34 tumors were larger than 4 cm and piecemeal resection was carried out on 26 colorectal tumors.The mean age of the patients was 71 years.The mean follow-up duration was 12 mo. RESULTS:LCRTs were located in the rectum,left colon,transverse colon and right colon in 58%,15%, 4%and 23%of cases,respectively.All were sessile tumors larger than 4 cm with a mean size of 4.9 cm (4-10 cm).According to the Paris classification,34%of the tumors were typeⅠs,58%typeⅡa,4%typeⅡb and 4%typeⅡc.Pathological examination showed tubulous adenoma in 31%,tubulo-villous adenoma in 27%,villous adenoma in 42%,high-grade dysplasia in38%,in situ carcinoma in 19%of the cases and mucosal carcinoma(m2)in 8%of the cases.The two cases(7.7%)of procedural bleeding that occurred were managed endoscopically and one small perforation was treated with clips.During follow-up,recurrence of the tumor occurred in three patients(12%),three of whom received endoscopic treatment. CONCLUSION:EMR for tumors larger than 4 cm is a safe and effective procedure that could compete with endoscopic submucosal dissection,despite providing incomplete histological assessment. | Philippe Ah Soune Charles Ménard Ezzedine Salah Ariadne Desjeux Jean-Charles Grimaud Marc Barthet | 2010 | World Journal of Gastroenterology2010，16，5： | 4 |
| 6 | 序列地震图:核幔边界区域的散射全景图显示文摘了解核幔边界区域的各向异性对于了解俯冲板块的命运、热点火山成因和原始地球化学储集层的性质均具有重要意义。传统上,地球物理学家通过对地震图的人工解读,从高信噪比的信号中获取核幔边界区域的结构信息。但是,传统的方法在采样欠佳区域中的实用性受到限制,并且没有利用跨越不同路径的波形数据集的全部统计能力。 | 夏群科(编译) Kim D Lekic V Ménard B Baron D Taghizadeh-Pop M | 2020 | 矿物岩石地球化学通报2020，39，4： | 3 |
| 7 | 三种被动式采集方法对甲虫收集效果的比较研究:以香港城门样地为例显示文摘标本标准化采集是昆虫多样性研究的根本。昆虫种类繁多、习性复杂、分布广泛,基于不同的研究目标,昆虫学家会选用不同的采集方法。由于主动式采集方法存在较多干扰因素和重现性差等问题,以飞行阻隔器(flight interception trap,FIT)、马氏网(Malaise trap,MT)和罐诱(pitfall trap,PT)为代表的被动式采集方法被广泛应用,并在昆虫多样性研究中展现独特的优势。然而关于这些被动式采集方法的收集特点和采集效果等还缺乏系统性研究。本研究选取香港城门13个样点,利用上述3种被动式采集方法共156个采集装备开展为期24天的鞘翅目昆虫采集工作,并通过多样性指数分析、多度分析、体型与食性相关分析、相似性分析以及物种累积曲线分析评估了不同采集方法对甲虫的收集效果。本研究共采集甲虫6,380头,涉及40科197种,分析结果显示:(1)采用不同采集方法获得的物种数量和组成存在差异。从科级和种级的数量来看,FIT(36科,149种)>MT(24科,79种)>PT(17科,60种);在物种组成方面,FIT与PT之间、MT与PT之间区别较大,FIT与MT对应的物种相似度稍高于前两组。(2)多样性指数和物种多度分布分析显示:丰富度指数为FIT>MT>PT,优势度指数为FIT>PT>MT,多样性指数为MT>FIT>PT,均匀度指数为MT>PT>FIT。3种方法采集到的甲虫个体数为1头的种较多,个体数超过1头的种在时间和空间方面的分布较广,优势科的种类较少,但其个体数占总个体数的比例较高。(3)FIT和PT均采集到了6类食性的甲虫,其中藻食性的缨甲科甲虫仅见于FIT和PT采集方法。(4)物种累积曲线的结果表明3种采集方法效果均较好。3种采集方法各有特点,但FIT采集的综合效果最优。FIT和MT两种方法的结合提升了采集甲虫的种类、食性和体型等方面的覆盖度,更利于对甲虫多样性及类群与生态环境功能互作的研究。3种方法所收集到的甲虫存在一定差异,因此可以针对不同研究目的选取适宜的采集方式。 | 滕备 杨海东 佟一杰 梁敏轩 张嘉康 李英铭 Benoit Guénard 白明 | 2021 | 生物多样性2021，29，10： | 3 |
| 8 | Risk of hepatitis B virus reactivation in rheumatoid arthritis patients undergoing biologic treatment: Extending perspective from old to newer drugs显示文摘Hepatitis B virus(HBV) reactivation in rheumatoid arthritis(RA) patients undergoing biological therapy is not infrequent. This condition can occur in patients with chronic hepatitis B as well as in patients with resolved HBV infection. Current recommendations are mainlyfocused on prevention and management strategies of viral reactivation under tumor necrosis factor-α inhibitors or chimeric monoclonal antibody rituximab. In recent years, growing data concerning HBV reactivation in RA patients treated with newer biological drugs like tocilizumab and abatacept have cumulated. In this review, epidemiology, pathogenesis and natural history of HBV infection have been revised first, mainly focusing on the role that specific therapeutic targets of current biotechnological drugs play in HBV pathobiology; finally we have summarized current evidences from scientific literature, including either observational studies and case reports as well, concerning HBV reactivation under different classes of biological drugs in RA patients. Taking all these evidences into account, some practical guidelines for screening, vaccination, prophylaxis and treatment of HBV reactivation have been proposed. | Francesca De Nard Monica Todoerti Vittorio Grosso Sara Monti Silvia Breda Silvia Rossi Carlomaurizio Montecucco Roberto Caporali | 2015 | World Journal of Hepatology2015，7，3： | 3 |
| 9 | Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study显示文摘AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. | Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 10 | 新双重内皮素受体拮抗剂aprocitentan在高血压患者中应用的随机剂量-反应研究显示文摘本研究探讨内皮素A/内皮素B受体双重拮抗剂aprocitentan应用于原发性高血压患者的剂量-反应特点。研究者进行一个随机双盲平行研究,坐位舒张压为90~109mm Hg(1mm Hg=0.133kPa)的患者分别服用aprocitentan 5、10、25或50mg,安慰剂或作为阳性对照的赖诺普利20mg/d,共8周。在基线、第2、4、8周时多次获取患者静息时无人值守的自动诊室血压数据。在基线和第8周时监测24h动态血压。 | 赵狄(摘译) 刘莉(审校) Verweij P Danaietash P Flamion B Ménard J Bellet M | 2020 | 中华高血压杂志2020，28，4： | 3 |
| 11 | Development of a Direct Competitive Enzyme-Linked Immunosorbent Assay for the Detection of Fluoroquinolone Residues in Shrimp显示文摘 | Sheryl A. Tittlemier Jean-Marc Gélinas Guy Dufresne Mehul Haria Jessica Querry Chantal Cleroux Cathie Ménard Philippe Delahaut Gurmit Singh Nathalie Fischer-Durand Samuel Benrejeb Godefroy | 2008 | Food Analytical Methods2008，，1： | 2 |
| 12 | Innate immune recognition on the intestinal mucosa显示文摘 | Michael Lotz Sandrine Ménard Mathias Hornef | 2007 | International Journal of Medical Microbiology2007，，5： | 2 |
| 13 | Intrarectal Amifostine During External Beam Radiation Therapy for Prostate Cancer Produces Significant Improvements in Quality of Life Measured by EPIC Score显示文摘 | Nicole L. Simone Cynthia Ménard Benjamin P. Soule Paul S. Albert Peter Guion Sharon Smith Denise Godette Nancy S. Crouse Linda C. Sciuto Theresa Cooley-Zgela Kevin Camphausen C. Norman Coleman Anurag K. Singh | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，1： | 2 |
| 14 | Temperament and character dimensions and their relationship to major depression and panic disorder显示文摘 | MOCHCOVITCH MD NARD| AE CARDOSO A | 2012 | Rev Bras Psiquiatr2012，34，3： | 1 |
| 15 | Thermal separation of soot carbon显示文摘 | Cachier H P Bremond M P Buat-Ménard P | 1989 | Aerosol Science and Technology1989，10，2： | 1 |
| 16 | Identification and mapping on chromosome 9 of RAPD markers linked to Sw-5 in tomato by bulked segregant analysis 显示文摘 | Chagúe V Mercier J C Gue' nard M | 1996 | Rep Tomato Genet Coop1996，92，： | 1 |
| 17 | Determination of atmospheric soot carbon by a simple thermal method显示文摘 | Cachier H P Bremond M P Buat-Ménard P | 1989 | Tellus1989，41，： | 1 |
| 18 | Delta opioid receptors mediatechemotaxis in bone marrow-derived dendritic cells显示文摘 | Bénard A BouéJ Chapey E | 2008 | J Neuroim-munol2008，197，1： | 1 |
| 19 | Predictive visual outcome after macula-off retinal detachment surgery using optical coherence tomography显示文摘 | Lecleire-Collet A Muraine M Ménard JF | 2005 | Retina2005，25，1： | 1 |
| 20 | Immunoregulatory properties of clinical grade mesenchymal stromal cells:evidence,uncertainties,and clinical application显示文摘 | Ménard C Tarte K | | 0，，03： | 1 |
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