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| 1 | Influence of environmental factors in the development of inflammatory bowel diseases显示文摘Idiopathic inflammatory bowel diseases(IBD), Crohn's disease(CD) and ulcerative colitis(UC), are multifactorial diseases that are manifested after disruption of a genetic predisposed individual and its intestinal microflora through an environmental stimulus. Urbanization and industrialization are associated with IBD. Epidemiological data, clinical observations and family/immigrants studies indicate the significance of environmental influence in the development of IBD. Some environmental factors have a different effect on the subtypes of IBD. Smoking and appendectomy is negatively associated with UC, but they are aggravating factors for CD. A westernized high fat diet, full of refined carbohydrates is strongly associated with the development of IBD, contrary to a high in fruit, vegetables and polyunsaturated fatty acid-3 diet that is protective against these diseases. High intake of nonsteroidal antiinflammatory drug and oral contraceptive pills as well as the inadequacy of vitamin D leads to an increased risk for IBD and a more malignant course of disease. Moreover, other factors such as air pollution, psychological factors, sleep disturbances and exercise influence the development and the course of IBD. Epigenetic mechanism like DNA methylation, histone modification and altered expression of miR NAS could explain the connection between genes and environmental factors in triggering the development of IBD. | Evangelia Legaki Maria Gazouli | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 15 |
| 2 | 动物消化道上皮屏障在控制肠内环境稳定中的作用显示文摘动物肠道内部与外界环境之间相互作用,而单层上皮细胞将肠道微生物与下层肠组织隔离形成肠道上皮屏障。目前研究发现肠道上皮不仅起屏障作用,对收集体内外信号和协调免疫应答亦至关重要。本文对肠道上皮屏障如何与共生菌、病原微生物及免疫细胞间的相互作用以及调节内环境稳定进行概述,旨在为动物肠道黏膜免疫机制的揭示提供参考。 | 李雨宸 王春凤 杨桂连 | 2015 | 中国兽医学报2015，35，6： | 1 |
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