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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs显示文摘Objective:To evaluate in ritro antimicrobial activities of selected 58 ethno-medicinal plant extracts with a view to assess their therapeutic potential.Methods:A total of 58 traditional Chinese medicinal plants were carefully selected based on the literature review and their traditional use.The antimicrobial activities of ethanol extracts of these medicinal plants were tested against fungi(Aspergillus funigaius),yeast(Candida albicans),gram-negative(Acirelobacter haumannii and Pseudornnruis aeruginosa)and gram-positive bacteria(Staphglococcus aureus).The activities were tested at three different concentrations of 1.00,0.10 and 0.01 mg/mL.The data was analysed using Gene data Screener program.Results:The measured antimicrobial activities indicated that out of the 58 plant extracts,15 extracts showed anti-fungal activity and 23 extracts exhibited anti-bacterial activity.Eight plant extracts have exhibited both anti-bacterial and anti-fungal activities.For instance,Eucommia ulmoides,Pohgonum cuspidcrtum,Poria cocas and Uncaria rhineophylla showed activity against both bacterial and fungal strains,indicating their broad spectrum of activity.Conclusions:The results revealed that the ethanol extracts of 30 plants out of the selected 58 possess significant antimicrobial activities.It is interesting to note that the findings from the current study are consistent with the traditional use.A clear correlation has also been found between the antimicrobial activity and the flavonoid content of the plant extracts which is in agreement with the literature.Hence.the results presented here can be used to guide the selection of potential plant species for the isolation and structure elucidation of novel antimicrobial compounds in order to establish the structure-activity relationship.This in turn is expected to lead the way to the discovery of novel antimicrobial agents for therapeutic use. | Lin Zhang Anjaneya S.Ravipati Sundar R Koyyalamudi Sang Chul Jeong Narsimha Reddy John Bartlett Paul T.Smith Mercedes de la Cruz Maria Cndida Monteiro ngeles Melguizo Ester Jimnez Francisca Vicente | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 23 |
| 3 | 中德两国屋顶绿化对比 | Peter Küesters | 2004 | 技术与市场(园林工程)2004，0，12： | 9 |
| 4 | 养殖三疣梭子蟹体内哈维氏弧菌的分离与致病性鉴定显示文摘养殖的三疣梭子蟹(Portunus trituberculatus)秋、冬季常发生非典型症状的死亡.本研究取濒死的三疣梭子蟹内脏及体腔液进行细菌分离,经纯化传代获得1株优势菌HY.HY菌的革兰氏染色呈阴性,菌体呈杆状、弧形或逗点状,无荚膜,无芽孢,极生单鞭毛,运动性强.生长特性和生化试验表明该菌生长需盐,最适生长的NaCl含量为30 mg/cm3;28℃下生长旺盛,能利用葡萄糖产酸但不产气,可以利用麦芽糖、蔗糖等糖类.测定了HY菌约930bp的16S rDNA序列,分类进化树显示其与哈维氏弧菌(Vibrio harveyi)XC08001聚为一簇.综合形态、生化和16S rDNA序列分析结果确定HY菌为哈维氏弧菌.以2×106cfu/只(蟹)的HY菌悬液注射健康梭子蟹成蟹(平均体重为400±25 g/只),致死率为35%;菌液浸泡感染梭子蟹仔蟹的半数致死剂量(LC50)为8.25×105cfu/cm3.上述结果表明分离的哈维氏弧菌对三疣梭子蟹具有致病性. | 周永强 李登峰 彭姣 Ester Johanna Shikongo 陈炯 刘联国 顾晓英 | 2013 | 应用海洋学学报2013，32，2： | 7 |
| 5 | Liaison between natural killer cells and dendritic cells in human gestation显示文摘成功的怀孕依靠允许胎儿在子宫成长并且发展的免疫学的改编,尽管有被母亲的有免疫力的房间认出。在在人的母亲 / 胎儿的接口以内在场的几种免疫能力的房间类型之中, DC 签名 + 树枝状的房间(DC ) 和 CD56 + 天赋杀手(NK ) 房间具有为早怀孕维护的主要重要性,不是仅仅产生母亲的免疫学的忍耐而且调整 stromal 房间区别。以前的报告证明 NK-DC 房间的存在在第一三个月人蜕膜结合,建议这些房间可以起在在子宫以内的本地有免疫力的反应的调整的一个作用。当有效免疫是必要的保护母亲免受有害病原体的伤害时,忍耐的某形式必须被激活对胎儿的抗原避免有免疫力的回答。这篇评论文章在人的蜕膜在怀孕和他们的连音有关 DC 和 NK 房间的功能讨论当前的证据。 | Ester Leno-Duran | 2014 | Cellular & Molecular Immunology2014，11，5： | 7 |
| 6 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 7 | Update on the treatment of focal segmental glomerulosclerosis in renal transplantation显示文摘Focal segmental glomerulosclerosis(FSGS) represents one of the most severe glomerular diseases, with frequent progression to end-stage renal disease and a high rate of recurrence in renal allografts(30%-50%). Recurrent FSGS portends a negative outcome, with the hazard ratio of graft failure being two-fold higher then that of other glomerulonephritis. Two patterns of clinical presentations are observed: Early recurrence, which is characterized by massive proteinuria within hours to days after implantation of the renal graft, and late recurrence, which occurs several months or years after the transplantation. Many clinical conditions have been recognized as risk factors for recurrence, including younger age, rapid progression of the disease to end-stage renal disease on native kidneys, and loss of previous renal allografts due to recurrence. However, much less is known about the incidence and risk factors of the so-called 'de novo ' type of FSGS, for which sufferers are transplanted patients without disease on native kidneys; but, rapid development of allograft failure is frequently observed. Management of both forms is challenging, and none of the approaches proposed to date have been demonstrated as consistently beneficial or effective. In the present review we report an update on the available therapeutic strategies for FSGS in renal transplantation within the context of a critical overview of the current literature. | Maria Messina Ester Gallo Alberto Mella Fabiola Pagani Luigi Biancone | 2016 | World Journal of Transplantation2016，6，1： | 5 |
| 8 | Ternary Ni-Co-Fe oxyhydroxide oxygen evolution catalysts:Intrinsic activity trends,electrical conductivity,and electronic band structure显示文摘Nickel-,cobalt-,and iron-based(oxy)hydroxides comprise the most-commonly studied electrocatalysts for the oxygen-evolution reaction(OER)in alkaline solution.A fundamental understanding of composition-structure-activity relationships for mixed-metal Ni-Co and Ni-Co-Fe(oxy)hydroxides is important to guide the design of advanced OER catalysts.Here we use cyclic voltammetry,chronopotentiometry,inductively-coupled plasma-optical emission spectroscopy,and in situ electrical conductivity measurements to characterize the properties and activity of various compositions of Ni-Co-Fe(oxy)hydroxides prepared by cathodic co-electrodeposition.Consistent with previous studies,we find Fe is essential for the mixed-metal(oxy)hydroxides to achieve high OER activity.In the rigorous absence of Fe(achieved by using specially cleaned electrolytes),the most-active Ni-Co(oxy)hydroxide composition has an OER turn-over frequency only twice that ofpure Co(oxy)hydroxide,suggesting minimal synergism between the two metals.The addition of Co to Ni-Fe(oxy)hydroxides shifts the onset of electrical conductivity to lower potentials,but has little effect on the intrinsic OER activity,with the most-active Ni-Co-Fe(oxy)hydroxide having an OER turn-over frequency only -1.5 times that of the Ni-Fe(oxy)hydroxides.The magnitudes of the electrical conductivities are similar for all the compositions measured.Density-functional-theory-calculated projected density of states show a significant contribution of all chemical elements at the valence band edge of the mixed-metal oxyhydroxide electronic structure,demonstrating significant electronic hybridization between the elements.The calculations suggest the involvement of all the elements in modulating the electronic structure at putative Fe-based active sites that are probably located at edges or defects in the two-dimensional oxyhydroxide sheets. | Michaela Burke Stevens Lisa J. Enman Ester Hamal Korkus Jeremie Zaffran Christina D. M. Trang James Asbury Matthew G. Kast Maytal Caspary Toroker Shannon W. Boettcher | 2019 | Nano Research2019，12，9： | 5 |
| 9 | Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome显示文摘 | Giulio Marchesini Elisabetta Bugianesi Gabriele Forlani Fernanda Cerrelli Marco Lenzi Rita Manini Stefania Natale Ester Vanni Nicola Villanova Nazario Melchionda Mario Rizzetto | 2003 | Hepatology2003，，4： | 5 |
| 10 | Water gas shift activity of Co-Mo/MgO-Al_2O_3 catalysts presulfided with ammonium sulfide显示文摘Co-Mo/MgO-Al2O3 catalyst was presulfided with ammonium sulfide in aqueous solution and activated with synthesis gas for water gas shift reaction. The assay results indicate that the presulfided Co-Mo/MgO-Al2O3 catalyst exhibits an excellent catalytic activity and stability. XRD and EPR characterization results show that the O-S exchange might occur during the impregnation, leading to the formation of (NH4)2MoS4 (or (NH4)2MoxSy) precursor, which was then thermally decomposed and reduced to MoS2. The higher catalytic performance is attributed to an optimization formation of active Co-Mo sulfides, consisting of well dispersed MoS2 and Co-Mo-S phase due to the redispersion of Co sulfide particles over the edges of newly formed MoS2 crystallites. | Yixin Lian, Huifang Wang, Weiping Fang, Yiquan Yang Department of Chemistry, College of Chemistry and Chemical Engineering, National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, Xiamen University, Xiamen 361005, Fujian, China | 2010 | Journal of Natural Gas Chemistry2010，19，1： | 4 |
| 11 | Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment显示文摘AIM:To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth(SIBO) in patients with inactive Crohn's disease(CD).METHODS:This was a prospective study in patients with CD in remission and without corticosteroid treatment,included consecutively from 2004 to 2010.SIBO was investigated using the hydrogen glucose breath test.RESULTS:One hundred and seven patients with CD in remission were included.Almost 58%of patients used maintenance immunosuppressant therapy and 19.6%used biological therapy.The prevalence of SIBO was16.8%.No association was observed between SIBO and the use of thiopurine Immunosuppressant(12/62patients),administration of biological drugs(2/21 patients),or with double treatment with an anti-tumor necrosis factor drugs plus thiopurine(1/13 patients).Half of the patients had symptoms that were suggestive of SIBO,though meteorism was the only symptom that was significantly associated with the presence of SIBO on univariate analysis(P<0.05).Multivariate analysis revealed that the presence of meteorism and a fistulizing pattern were associated with the presence of SIBO(P<0.05).CONCLUSION:Immunosuppressants and/or biological drugs do not induce SIBO in inactive CD.Fistulizing disease pattern and meteorism are associated with SIBO. | Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues Julio Ponce Pilar Nos | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 12 | Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia:A prospective study显示文摘瞄准:评估兰伯氏贾第虫的流行(G。兰氏鞭毛虫属) 在有急躁的肠症候群(IBS ) 和消化不良并且到的病人的感染证实哪个是最精确的测试在这个背景诊断感染。方法:连续地由于 IBS 或消化不良的症状在 2002 年 1 月和 2003 年 12 月之间第一次出席了门诊病人肠胃病学诊所的 137 个病人被招募。所有病人经历了临床的评估,第一步的 haematology 和化学测试,为乳糜泻的血清学试金, lactose-H (2 ) 呼吸测试,腹的 ultrasonography,和 esophagogastroduodenoscopy。Helicobacter pylori 地位被评估。在有比 45 年旧的 IBS 的症状的病人,结肠镜检查也被执行。在所有病人,十二指肠的活体检视和凳子样品为 G 的 trophozoites 和包囊被检验。由几个方法的兰氏鞭毛虫属。结果:G。兰氏鞭毛虫属在 9 个病人被识别。下列诊断也被做:IBS (100/137, 73%) ,机能性消化不良(62/137, 45%) ,器官的消化不良(33/137, 24%) ,并且乳糖不耐(75/137, 55%) 。一个重要协会在贾第虫病和 H pylori 感染之间被发现(c2=6.632, OR=12.4, CI=1.5-68.1 ) 。没有症状,可靠地允许贾第虫病的识别。当十二指肠的活体检视的组织学的检查显示了低敏感时,在十二指肠的活体检视和凳子样品考试的寄生虫的直接搜索在所有情况中给了一致结果(例如, 22.2%) 。结论:在这个连续系列, G 的诊断。兰氏鞭毛虫属感染与 IBS 和消化不良说明了 6.5% 病人。如果凳子样品检查被执行,为贾第虫病的诊断的十二指肠的活体检视可能是不必要的。 | Barbara Grazioli Giovanni Matera Costanza Laratta Giuseppina Schipani Giovanni Guarnieri Ester Spiniello Maria Imeneo Andrea Amorosi Alfredo Focà Francesco Luzza | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 13 | Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation: long-term outcomes显示文摘学习的目的是评估骨盆的地板肌肉(PFM ) 的长期的结果在有终生的早泄(PE ) 的男性的康复,用 intravaginal 射精的潜伏时间(IELT ) 和自我报告早泄诊断工具(PEDT ) 同样主要的结果。154 个参加者的一个总数回顾地在这研究被考察,与 122 完成训练协议。在基线,所有参加者有一个 IELT 60 s 和 PEDT 分数 > 11。参加者完成了 PFM 康复的一个 12 星期的节目,包括 physio-kinesiotherapy 处理, electrostimulation,和生物反馈,与每星期的三个会议,与为在每个会议完成的每个部件的 20 min。干预的有效性被在 IELT 和 PEDT 价值的几何平均数比较变化评估,从基线,在在干预期间的 3 , 6 ,和 12 个月,并且在 24 和 36 月 postintervention ,用配对的样品2尾巴t测试,包括联系了95%信心间隔。 122 个参加者完成了 PFM 康复, 111 获得了他们的射精反射的控制与 161.6 s 的吝啬的 IELT 和在干预的12星期的端点的 2.3 的 PEDT 分数,分别地,从 40.4 s 和 17.0 个分数的基线代表增加为 IELT 和 PEDT ( P < 0.0001 )。95 个参加者完成了 36 月的后续,在 24 和 36 月 postintervention 的 64% 和 56% 维持的令人满意的射精控制分别地。 | Antonio Luigi Pastore Giovanni Palleschi Andrea Fuschi Yazan AI Salhi Alessandro Zucchi Giorgio Bozzini Ester Illiano Elisabetta Costantini Antonio Carbone | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 14 | HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Luca Valenti Anna Ludovica Fracanzani Elisabetta Bugianesi Paola Dongiovanni Enrico Galmozzi Ester Vanni Elena Canavesi Ezio Lattuada Giancarlo Roviaro Giulio Marchesini Silvia Fargion | 2010 | Gastroenterology2010，，3： | 4 |
| 15 | Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma显示文摘 | Elisabetta Bugianesi Nicola Leone Ester Vanni Giulio Marchesini Franco Brunello Patrizia Carucci Alessandro Musso Paolo De Paolis Lorenzo Capussotti Mauro Salizzoni Mario Rizzetto | 2002 | Gastroenterology2002，，1： | 4 |
| 16 | Selective suspension of single layer graphene mechanochemically exfoliated from carbon nanofibres显示文摘 | Antonio Esau Del Rio-CastilloI Cesar Merino Enrique Diez-Barra Ester Vazquez | 2014 | Nano Research2014，7，7： | 4 |
| 17 | Catalytic selective oxidation or oxidative functionalization of methane and ethane to organic oxygenates显示文摘Selective oxidation or oxidative functionalization of methane and ethane by both homogeneous and heterogeneous catalysis is presented concerning: (1) selective oxidation of methane and ethane to organic oxygenates by hydrogen peroxide in a water medium in the presence of homogeneous osmium catalysts, (2) selective oxidation of methane to formaldehyde over highly dispersed iron and copper heterogeneous catalysts, (3) selective oxidation of ethane to acetaldehyde and formaldehyde over supported molybdenum catalysts, and (4) oxidative carbonylation of methane to methyl acetate over heterogeneous catalysts containing dual sites of rhodium and iron. | WANG Ye*, AN DongLi & ZHANG QingHong State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China | 2010 | Science China Chemistry2010，53，2： | 4 |
| 18 | From the metabolic syndrome to NAFLD or vice versa ?显示文摘 | Ester Vanni Elisabetta Bugianesi Anna Kotronen Samuele De Minicis Hannele Yki-J?rvinen Gianluca Svegliati-Baroni | 2010 | Digestive and Liver Disease2010，，5： | 3 |
| 19 | First Pre‐Functionalised Polymeric Aromatic Framework from Mononitrotetrakis(iodophenyl)methane and its Applications显示文摘 | Ester Verde‐Sesto Mercedes Pintado‐Sierra Avelino Corma Eva M. Maya Jose G. de la Campa Marta Iglesias Felix Sánchez | 2014 | Chem. Eur. J2014，，17： | 2 |
| 20 | Selective effect of infliximab on the inflammatory component of a colonic stricture in Crohn’s disease显示文摘 | Dario Sorrentino Claudio Avellini Carlo Alberto Beltrami Enrico Pasqual Ester Zearo | 2006 | International Journal of Colorectal Disease2006，，3： | 2 |
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