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| 1 | Fat:A matter of disturbance for the immune system显示文摘Obesity is increasingly being recognized as a risk factor for a number of benign and malignant gastrointestinal conditions. However, literature on the underlying pathophysiological mechanisms is sparse and ambiguous. There is compelling evidence that both overnutrition and undernutrition negatively interfere with the immune system. Overnutrition has been found to increase susceptibility to the development of inflammatory diseases, autoimmune diseases and cancer. In the regulation of immune and in? ammatory processes, white adipose tissue plays a critical role, not only as an energy store but also as an important endocrine organ. The obese state is characterised by a low-grade systemic in? ammation, mainly as a result of increased adipocytes as well as fat resident-and recruited-macrophage activity. In the past few years, various products of adipose tissue including adipokines and cytokines have been characterised and a number of pathways linking adipose tissue metabolism with the immune system have been identified. Activation of the innate immune system plays a major role in hepatic steatosis. Non-alcoholic fatty liver disease includes a wide spectrum of diseases, from pure steatosis to non-alcoholic steato-hepatitis in the absence of signif icant alcohol consumption. Although steatosis is considered a non-progressive disease, non-alcoholic steatohepatitis may deteriorate in advanced chronic liver diseases, cirrhosis, and hepatocellular carcinoma. An important parallel between obesityrelated pathology of adipose tissue and liver pertains to the emerging role of macrophages, and growing evidence suggests that Kupffer cells critically contribute to progression of non-alcoholic fatty liver disease. Moreover, a close link between specif ic immune activation and atherosclerosis has been well established, suggesting that fat can directly trigger immune responses. This review discusses the role of fat as 'a matter of disturbance for the immune system' with a focus on hepatic steatosis. | Alessandro Federico Elena D’Aiuto Francesco Borriello Giusi Barra Antonietta Gerarda Gravina Marco Romano Raffaele De Palma | 2010 | World Journal of Gastroenterology2010，16，38： | 12 |
| 2 | Chronic functional constipation is strongly linked to vitamin D deficiency显示文摘BACKGROUND Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined.AIM To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders.METHODS We performed a prospective case-control study, from May-June to November2017. Glucose/lactulose breath tests, radiopaque markers(multiple capsule techniques) and wireless motility capsule analysis were used to assess colonicand oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life(IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14(HADS-14 A and HADS-14 D).RESULTS We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels(P < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests(IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group(P < 0.001), which significantly correlated with low vitamin D levels(r =-0.57, P < 0.001; r = 0.21, P = 0.01; r =-0.48, P < 0.001; r =-0.57, P < 0.001; r =-0.29, P < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder(odds ratio = 1.19; 95% confidence interval: 1.14-1.26, P < 0.001).CONCLUSION Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients. | Alba Panarese Francesco Pesce Piero Porcelli Giuseppe Riezzo Palma Aurelia Iacovazzi Carla Maria Leone Massimo De Carne Caterina Mammone Rinaldi Endrit Shahini | 2019 | World Journal of Gastroenterology2019，25，14： | 8 |
| 3 | Adipose tissue and vascular inflammation in coronary artery disease显示文摘Obesity has become an important public health issue in Western and developing countries,with well known metabolic and cardiovascular complications.In the last decades,evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences.As a consequence of the expansion of fat depots,in obese subjects,adipose tissue cells develope a phenotypic modification,which turns into a change of the secretory output.Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling,vascular biology and,moreover,participate to the systemic inflammatory response,which characterizes obesity and metabolic syndrome.This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events.A great number of adipocytokines have been described recently,linking inflammatory mileu and vascular pathology.The understanding of these pathways is crucial not only from a pathophysiological point of view,but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets.The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. | Enrica Golia Giuseppe Limongelli Francesco Natale Fabio Fimiani Valeria Maddaloni Pina Elvira Russo Lucia Riegler Renatomaria Bianchi Mario Crisci Gaetano Di Palma Paolo Golino Maria Giovanna Russo Raffaele Calabrò Paolo Calabrò | 2014 | World Journal of Cardiology2014，6，7： | 8 |
| 4 | Endoscopic approach to malignant strictures at the hepatic hilum显示文摘Hilar tumors have proven to be a challenge to treat and manage because of their poor sensitivity to conventional therapies and our inability to prevent or to detect early tumor formation. Endoscopic stent drainage has been proposed as an alternative to biliary-enteric bypass surgery and percutaneous drainage to palliate malignant biliary obstruction. Prosthetic palliation of patients with malignant hilar stenoses poses particular difficulties, especially in advanced lesions (type n lesions or higher). The risk of cholangitis after contrast injection into the biliary tree in cases where incomplete drainage is achieved is well known. The success rate of plastic stent insertion is around 80% in patients with proximal tumors. Relief of symptoms can be achieved in nearly all patients successfully stented. | Giovanni D De Palma Stefania Masone Maria Rega Immacolata Simeoli Francesca Salvatori Saverio Siciliano Francesco Maione Valerio Girardi Marta Celiento Giovanni Persico | 2007 | World Journal of Gastroenterology2007，13，30： | 8 |
| 5 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 6 | In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy显示文摘Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was reported.In this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in CUC.The study involved a patient presenting long-standing CUC.Confocal imaging of both the inflamed mucosa,a circumscribed lesion(dysplasiaassociated lesional mass),and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological images.Inflamed mucosa and dysplasia showed specific alteration of crypt architecture,cellular infiltration,and vessel architecture with an excellent correlation between CLE and standard histological examination. | Giovanni D De Palma Stefania Staibano Saverio Siciliano Francesco Maione Maria Siano Dario Esposito Giovanni Persico | 2011 | World Journal of Gastroenterology2011，17，5： | 3 |
| 7 | Exploring the Potentialities of Automatic Extraction of University Webometric Information显示文摘Purpose:The main objective of this work is to show the potentialities of recently developed approaches for automatic knowledge extraction directly from the universities’websites.The information automatically extracted can be potentially updated with a frequency higher than once per year,and be safe from manipulations or misinterpretations.Moreover,this approach allows us flexibility in collecting indicators about the efficiency of universities’websites and their effectiveness in disseminating key contents.These new indicators can complement traditional indicators of scientific research(e.g.number of articles and number of citations)and teaching(e.g.number of students and graduates)by introducing further dimensions to allow new insights for“profiling”the analyzed universities.Design/methodology/approach:Webometrics relies on web mining methods and techniques to perform quantitative analyses of the web.This study implements an advanced application of the webometric approach,exploiting all the three categories of web mining:web content mining;web structure mining;web usage mining.The information to compute our indicators has been extracted from the universities’websites by using web scraping and text mining techniques.The scraped information has been stored in a NoSQL DB according to a semistructured form to allow for retrieving information efficiently by text mining techniques.This provides increased flexibility in the design of new indicators,opening the door to new types of analyses.Some data have also been collected by means of batch interrogations of search engines(Bing,www.bing.com)or from a leading provider of Web analytics(SimilarWeb,http://gffzz7594f747c9634dbeh0vk660c6vfwx60bb.ffgz.tsg.suse.edu.cn).The information extracted from the Web has been combined with the University structural information taken from the European Tertiary Education Register(http://gffzzbd18f4732c3f4d63s0vk660c6vfwx60bb.ffgz.tsg.suse.edu.cn/#/home),a database collecting information on Higher Education Institutions(HEIs)at European level.All the above was used to perform a clusterization of 79 Italian universities based on structural and digital indicators.Findings:The main findings of this study concern the evaluation of the potential in digitalization of universities,in particular by presenting techniques for the automatic extraction of information from the web to build indicators of quality and impact of universities’websites.These indicators can complement traditional indicators and can be used to identify groups of universities with common features using clustering techniques working with the above indicators.Research limitations:The results reported in this study refers to Italian universities only,but the approach could be extended to other university systems abroad.Practical implications:The approach proposed in this study and its illustration on Italian universities show the usefulness of recently introduced automatic data extraction and web scraping approaches and its practical relevance for characterizing and profiling the activities of universities on the basis of their websites.The approach could be applied to other university systems.Originality/value:This work applies for the first time to university websites some recently introduced techniques for automatic knowledge extraction based on web scraping,optical character recognition and nontrivial text mining operations(Bruni&Bianchi,2020). | Gianpiero Bianchi Renato Bruni Cinzia Daraio Antonio Laureti Palma Giulio Perani Francesco Scalfati | 2020 | Journal of Data and Information Science2020，5，4： | 2 |
| 8 | Contrast-free endoscopic stent insertion in malignant biliary obstruction显示文摘AIM: To present a case series of MRCP-guided endoscopic biliary stent placement, performed entirely without contrast injection. METHODS: Contrast-free endoscopic biliary drainage was attempted in 20 patients with malignant obstruction, unsuitable for resection on the basis of tumor extent or medical illness. MRCP images were used to confirm the diagnosis of tumor, to exclude other biliary diseases and to demonstrate the stenoses as well as dilation of proximal liver segments. The procedure was carried out under conscious sedation. Patients were placed in the left lateral decubitus position. The endoscope was inserted, the papilla identified and cannulated by a papillotome. A guide wire was inserted and guided deeply into the biliary tree, above the stenosis, by fluoroscopy. A papillotomy approximately 1 cm. long was performed and the papillotome was exchanged with a guiding-catheter. A 10 Fr, Amsterdam-type plastic stent, 7 to 15 cm long, was finally inserted over the guide wire/ guiding catheter by a pusher tube system. RESULTS: Successful stent insertion was achieved in all patients. There were no major complications. Successful drainage, with substantial reduction in bilirubin levels, was achieved in all patients. CONCLUSION: This new method of contrast-free endoscopic stenting in malignant biliary obstruction is a safe and effective method of palliation. However, a larger, randomized study comparing this new approach with the standard procedure is needed to confirm the findings of the present study. | Giovanni D De Palma Giovanni Lombardi Maria Rega Immacolata Simeoli Stefania Masone Saverio Siciliano Francesco Maione Francesca Salvatori Antonio Balzano Giovanni Persico | 2007 | World Journal of Gastroenterology2007，13，29： | 2 |
| 9 | Actively bleeding Dieulafoy's lesion of the small bowel identified by capsule endoscopy and treated by push enteroscopy显示文摘Dieulafoy 的损害是周期性的官方补给的流血的一个不平常的原因。这份报告描述活跃地为 Dieulafoy 诊断被囊内视镜检查法在做的小肠的损害放血的一个案例,与推肠寄生物的使用由治疗列在后面。案例说明那囊内视镜检查法,肠寄生物在有小肠疾病的病人是高度补足的。 | Giovanni D De Palma Francesco Patrone Maria Rega Immacolata Simeoli Stefania Masone Giovanni Persico | 2006 | World Journal of Gastroenterology2006，12，24： | 2 |
| 10 | Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years显示文摘 | Mauro Manno Calogero Cammà Filippo Schepis Fabio Bassi Roberta Gelmini Francesco Giannini Francesca Miselli Antonella Grottola Ilva Ferretti Chiara Vecchi Marisa De Palma Erica Villa | 2004 | Gastroenterology2004，，3： | 1 |
| 11 | Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis显示文摘 | Daniela Fenoglio Florinda Battaglia Alessia Parodi Silvia Stringara Simone Negrini Nicoletta Panico Marta Rizzi Francesca Kalli Giuseppina Conteduca Massimo Ghio Raffaele De Palma Francesco Indiveri Gilberto Filaci | 2011 | Clinical Immunology2011，，3： | 1 |
| 12 | Unilateral placement of metallic stents for malignant hilar obstruction: A prospective study显示文摘 | Giovanni D. De Palma Angelo Pezzullo Maria Rega Marcello Persico Francesco Patrone Luigi Mastantuono Giovanni Persico | 2003 | Gastrointestinal Endoscopy2003，，1： | 1 |
| 13 | HVAC dehumidification systems for thermal comfort: A critical review 显示文摘 | Mazzei Pietro Minichiello Francesco Palma Daniele | 2005 | Applied ThermalEngineering2005，25，56： | 1 |
| 14 | Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer显示文摘 | Pier Paolo Mainenti Luigi Carlo Cirillo Luigi Camera Francesco Persico Teresa Cantalupo Leonardo Pace Giovanni Domenico De Palma Giovanni Persico Marco Salvatore | 2006 | European Journal of Radiology2006，，3： | 1 |
| 15 | Concentration and Preservation of Very Low Abundance Biomarkers in Urine, such as Human Growth Hormone (hGH), by Cibacron Blue F3G-A Loaded Hydrogel Particles显示文摘Urine is a potential source of diagnostic biomarkers for detection of diseases,and is a very attractive means of non-invasive biospecimen collection.Nonetheless,proteomic measurement in urine is very challenging because diagnostic biomarkers exist in very low concentration(usually below the sensitivity of common immunoassays)and may be subject to rapid degradation.Hydrogel nanoparticles functionalized with Cibacron Blue F3G-A(CB)have been applied to address these challenges for urine biomarker measurement.We chose one of the most difficult low abundance,but medically relevant,hormones in the urine:human growth hormone(hGH).The normal range of hGH in serum is 1 to 10 ng/mL but the urine concentration is suspected to be a thousand times less,well below the detection limit(50 pg/mL)of sensitive clinical hGH immunoassays.We demonstrate that CB particles can capture,preserve and concentrate hGH in urine at physiological salt and urea concentrations,so that hGH can be measured in the linear range of a clinical immunometric assay.Recombinant and cadaveric hGH were captured from synthetic and human urine,concentrated and measured with an Immulite chemiluminescent immunoassay.Values of hGH less than 0.05 ng/mL(the Immulite detection limit)were concentrated to 2 ng/mL,with a urine volume of 1 mL.Dose response studies using 10 mL of urine demonstrated that the concentration of hGH in the particle eluate was linearly dependent on the concentration of hGH in the starting solution,and that all hGH was removed from solution.Thus if the starting urine volume is 100 mL,the detection limit will be 0.1 pg/mL.Urine from a healthy donor whose serum hGH concentration was 1.34 ng/mL was studied in order detect endogenous hGH.Starting from a volume of 33 mL,the particle eluate had an hGH concentration of 58 pg/mL,giving an estimated initial concentration of hGH in urine of 0.175 pg/mL.The nanotechnology described here appears to have the desired precision,accuracy and sensitivity to support large scale clinical studies of urine hGH levels. | Claudia Fredolini Francesco Meani K.Alex Reeder Sally Rucker Alexis Patanarut Palma J.Botterell Barney Bishop Caterina Longo Virginia Espina Emanuel F.Petricoin III Lance A.Liotta Alessandra Luchini | 2008 | Nano Research2008，1，6： | 1 |
| 16 | HVAC dehumidification systems for thermal comfort: article review 显示文摘 | Pieter Massey Francesco Minichiello Daniele Palma | 2005 | Applied Thermal Engineering2005，25，： | 1 |
| 17 | Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years显示文摘 | Mauro Manno Calogero Cammà Filippo Schepis Fabio Bassi Roberta Gelmini Francesco Giannini Francesca Miselli Antonella Grottola Ilva Ferretti Chiara Vecchi Marisa De Palma Erica Villa | | Gastroenterology0，，： | 1 |
| 18 | Lower gastrointestinal bleeding secondary to a rectal leiomyoma显示文摘The occurrence of leiomyoma of the rectum is uncommon. Most of these lesions are clinically silent and are found incidentally during laparotomy or endoscopic procedures for unrelated conditions. Symptomatic leiomyomas of the rectum are encountered less frequently, with only sporadic reports in the literature. We describe a case of a leiomyoma of the rectum presenting as recurrent lower gastrointestinal hemorrhage and secondary anemia. | Giovanni D De Palma Maria Rega Stefania Masone Saverio Siciliano Marcello Persico Francesca Salvatori Francesco Maione Dario Esposito Antonio Bellino Giovanni Persico | 2009 | World Journal of Gastroenterology2009，15，14： | 1 |
| 19 | Endoscopic treatment of esophageal achalasia显示文摘Achalasia is a motility disorder of the esophagus characterized by dysphagia, regurgitation of undigested food, chest pain, weight loss and respiratory symptoms. The most common form of achalasia is the idiopathic one. Diagnosis largely relies upon endoscopy, barium swallow study, and high resolution esophageal manometry(HRM). Barium swallow and manometry after treatment are also good predictors of success of treatment as it is the residue symptomatology. Short term improvement in the symptomatology of achalasia can be achieved with medical therapy with calcium channel blockers or endoscopic botulin toxin injection. Even though few patients can be cured with only one treatment and repeat procedure might be needed, long term relief from dysphagia can be obtained in about 90% of cases with either surgical interventions such as laparoscopic Heller myotomy or with endoscopic techniques such pneumatic dilatation or, more recently, with per-oral endoscopic myotomy. Age, sex, and manometric type by HRM are also predictors of responsiveness to treatment. Older patients, females and type Ⅱ achalasia are better after treatment compared to younger patients, males and type Ⅲ achalasia. Self-expandable metallic stents are an alternative in patients non responding to conventional therapies. | Dario Esposito Francesco Maione Alessandra D’Alessandro Giovanni Sarnelli Giovanni D De Palma | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 1 |
| 20 | Natural history of chronic HBV carriers in northern Italy: Morbidity and mortality after 30 years显示文摘 | Mauro Manno Calogero Cammà Filippo Schepis Fabio Bassi Roberta Gelmini Francesco Giannini Francesca Miselli Antonella Grottola Ilva Ferretti Chiara Vecchi Marisa De Palma Erica Villa | 2004 | Gastroenterology2004，，3： | 1 |
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