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| 1 | Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study显示文摘AIM To determine the incidence of hepatocellular carcinoma(HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis. RESULTS Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients(16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10 th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients(P < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less(P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54(0.15-1.89), P = 0.33].CONCLUSION HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis. | Marcelo Campos Appel-da-Silva Suelen Aparecida da Silva Miozzo Isabella de Azevedo Dossin Cristiane Valle Tovo Fernanda Branco Angelo Alves de Mattos | 2016 | World Journal of Gastroenterology2016，22，46： | 7 |
| 2 | Use of paper capsules for cadmium determination in biological samples by solid sampling flame atomic absorption spectrometry显示文摘 | Adilson Ben da Costa Julio Cezar Paz de Mattos Edson Irineu Mü ller | | 0，，： | 1 |
| 3 | Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimerμs Disease显示文摘 | Maria Cecilia Rodrigues Simoes Flavia Pereira Dias Viegas Marcella Soares Moreira Matheus de Freitas Silva Mariana Maximo Riquiel Patricia Mattos da Rosa Maísa Rosa Castelli Marcelo Henrique dos Santos Marisi Gomes Soares Claudio Viegas | 2014 | Mini-Reviews in Medicinal Chemistry2014，，1： | 1 |
| 4 | Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database显示文摘AIM To evaluate the occurrence of resistant mutations in treatment-na?ve hepatitis C virus(HCV) sequences deposited in the European hepatitis C virus database(euH CVdb). METHODS The sequences were downloaded from the eu HCVdb(http://gffzzc7adb7d73a2545c0s5xn95cvp6f5f6fqx.ffgz.tsg.suse.edu.cn/eu HCVdb/). The search was performed for full-length NS3 protease, NS5 A and NS5 B polymerase sequences of HCV, separated by genotypes 1a, 1b, 2a, 2b and 3a, and resulted in 798 NS3, 708 NS5 A and 535 NS5 B sequences from HCV genotypes1a, 1b, 2a, 2b and 3a, after the exclusion of sequences containing errors and/or gaps or incomplete sequences, and sequences from patients previously treated with direct antiviral agents(DAA). The sequence alignment was performed with MEGA 6.06 MAC and the resulting protein sequences were then analyzed using the BioE dit 7.2.5. for mutations associated with resistance. Only positions that have been described as being associated with failure in treatment in in vivo studies, and/or as conferring a more than 2-fold change in replication in comparison to the wildtype reference strain in in vitro phenotypic assays were included in the analysis.RESULTS The Q80 K variant in the NS3 gene was the most prevalent mutation, being found in 44.66% of subtype 1a and 0.25% of subtype 1b. Other frequent mutations observed in more than 2% of the NS3 sequences were: I170V(3.21%) in genotype 1a, and Y56F(15.93%), V132I(23.28%) and I170V(65.20%) in genotype 1b. For the NS5 A, 2.21% of the genotype 1a sequences have the P58 S mutation, 5.95% of genotype 1b sequences have the R30 Q mutation, 15.79% of subtypes 2a sequences have the Q30 R mutation, 23.08% of subtype 2b sequences have a L31 M mutation, and in subtype 3a sequences, 23.08% have the M31 L resistant variants. For the NS5 B, the V321 L RAV was identified in 0.60% of genotype 1a and in 0.32% of genotype 1b sequences, and the N142 T variant was observed in 0.32% of subtype 1b sequences. The C316 Y, S556 G, D559 N RAV were identified in 0.33%, 7.82% and 0.32% of genotype 1b sequences, respectively, and were not observed in other genotypes.CONCLUSION HCV mutants resistant to DAAs are found in low frequency, nevertheless they could be selected and therapy could fail due resistance substitutions in HCV genome. | Dimas Alexandre Kliemann Cristiane Valle Tovo Ana Beatriz Gorini da Veiga Angelo Alves de Mattos Charles Wood | 2016 | World Journal of Gastroenterology2016，22，40： | 1 |
| 5 | Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin induced clastogenesis in Balb/c mice显示文摘 | Resende FA Claudete Aparecida Mattos de Andrade Barcala Marcia Cristina da Silva Faria | 2006 | Life Sciences2006，79，2006： | 1 |
| 6 | Numerical simulation of airfoil thermal anti-Ice operation part 1: mathematical modeling显示文摘 | Guilherme Araajo Lima da Silva Otatvio de Mattos Silvares Euryale Jorge Godoy de Jesus Zerbini | 2007 | Journal of Aircraft2007，44，2： | 1 |
| 7 | A Systematic Review of Topical Treatments to Control the Odor of Malignant Fungating Wounds显示文摘 | Cristina Mamédio da Costa Santos Cibele Andrucioli de Mattos Pimenta Moacyr Roberto Cuce Nobre | 2010 | Journal of Pain and Symptom Management2010，，6： | 1 |
| 8 | Asystematic review of topical treatments to control the odor ofmalignant fungating wounds显示文摘 | da Costa Santos CM de Mattos Pimenta CA Nobre MR | 2010 | J Pain Symptom Manage2010，39，6： | 1 |
| 9 | Comparison of redox and D29 phage methods for detection of isoniazide and rifampicin resistance in Mycobacterium tuberculosis显示文摘 | da Silva PA Boffo MM de Mattos IG | 2006 | Clin Microbiol Infect2006，12，3： | 1 |
| 10 | Evaluation of the corrosion behavior of galvannealed steel in chloride aqueous solution and in tropical marine environment显示文摘 | Paulo S. G. da Silva Alberto N. C. Costa Oscar R. Mattos Adriana N. Correia P. de Lima-Neto | 2006 | Journal of Applied Electrochemistry2006，，3： | 1 |
| 11 | Hydrogen production through oxidative steam reforming of ethanol over Ni-based catalysts derived from La 1? x Ce x NiO 3 perovskite-type oxides显示文摘 | Sania M. de Lima Adriana M. da Silva Lídia O.O. da Costa José M. Assaf Lisiane V. Mattos Reema Sarkari A. Venugopal Fábio B. Noronha | 2012 | Applied Catalysis B Environmental2012，，： | 1 |
| 12 | Dermatan sulfate is the predominant antithrombotic glycosaminoglycan in vessel walls: implications for a possible physiological function of heparin cofactor II 显示文摘 | Tovar AM de Mattos DA Stelling MP | 2005 | Biochim Biophys Acta2005，1740，1： | 1 |
| 13 | Evaluation of the performance of Ni/La 2 O 3 catalyst prepared from LaNiO 3 perovskite-type oxides for the production of hydrogen through steam reforming and oxidative steam reforming of ethanol显示文摘 | Sania M. de Lima Adriana M. da Silva Lídia O.O. da Costa José M. Assaf Gary Jacobs Burtron H. Davis Lisiane V. Mattos Fábio B. Noronha | 2010 | Applied Catalysis A General2010，，1： | 1 |
| 14 | Automated determination of glucose in soluble coffee using Prussian Blue-glucoseoxidase-nafion modified electrode显示文摘 | Ivanildo Luiz de Mattos Madalena Carneiro da Cunha Areias | 2005 | Talanta2005，66，5： | 1 |
| 15 | Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics显示文摘Severe acute respiratory syndrome coronavirus(SARS-CoV)and SARS-CoV-2 are thought to transmit to humans via wild mammals,especially bats.However,evidence for direct bat-to-human transmission is lacking.Involvement of intermediate hosts is considered a reason for SARS-CoV-2 transmission to humans and emergence of outbreak.Large biodiversity is found in tropical territories,such as Brazil.On the similar line,this study aimed to predict potential coronavirus hosts among Brazilian wild mammals based on angiotensin-converting enzyme 2(ACE2)sequences using evolutionary bioinformatics.Cougar,maned wolf,and bush dogs were predicted as potential hosts for coronavirus.These indigenous carnivores are philogenetically closer to the known SARS-CoV/SARS-CoV-2 hosts and presented low ACE2 divergence.A new coronavirus transmission chain was developed in which white-tailed deer,a susceptible SARS-CoV-2 host,have the central position.Cougar play an important role because of its low divergent ACE2 level in deer and humans.The discovery of these potential coronavirus hosts will be useful for epidemiological surveillance and discovery of interventions that can contribute to break the transmission chain. | Luciano Rodrigo Lopes Giancarlo de Mattos Cardillo Natalia Carvalho de Lucca Pina Antonio Carlos da Silva Junior Silvana Kertzer Kasinski Paulo Bandiera-Paiva | 2022 | Animal Diseases2022，2，1： | 0 |
| 16 | 种植体螺丝连接处的预载荷丧失与时间及(螺丝)旋紧/旋松序列的关系显示文摘目的:本实验研究基台螺丝旋紧/旋松序列对3种不同种植体/基台接口及种植体的预载荷丧失的影响。材料和方法:定制纯钛机械加工种植体,分别配以相应基台,根据连接方式、螺丝类型和扭矩值不同分3组.每组5个。分别是外六角-纯钛螺丝/32Ncm、外六角-表面涂层螺丝/32Ncm、内六角/20Ncm、内锥度/20Ncm和内锥度/32Ncm。每个种植体进行5次旋紧/旋松序列并用两台应变测量仪检测预载荷值。结果:在种植体颈部1/3处,外六角连接方式的预载荷值最低(平均值27.75N).内连接方式的预载荷值最高(平均值219.61N)。结论:旋紧螺丝后各组预载荷不会迅速丧失。本实验中不论种植体/基台连接或螺丝类型相同与否,经过5次旋紧/旋松序列后,对早期预载荷值丧失没有显著影响。内锥度连接和内连接相比,具有更高的结构性固位力。 | Sergio Rocha Bernardes Maria da Gloria Chiarello de Mattos John Hobkirk Ricardo Faria Ribeiro 陈健 汤春波 | 2015 | 中国口腔医学继续教育杂志2015，0，5： | 0 |
| 17 | Serological evidence of Toxoplasma gondii infection as potential risk for the development of lepromatous leprosy in an endemic area for both neglected tropical diseases in Brazil显示文摘Background:Mycobacterium leprae and Toxoplasma gondii infections are both neglected tropical diseases highly prevalent in Brazil.Infection with certain parasite species can significantly alter susceptibility to other important pathogens,and/or influence the development of pathology.Here we investigated the possible influence of M.leprae/T.gondii co-parasitism on the manifestation of leprosy and its clinical forms.Methods:Participants(n=291)were recruited in Campos dos Goytacazes city,Rio de Janeiro state,southeast Brazil,from August 2015 to December 2019 and clinically diagnosed for leprosy.Participants were selected based on the presence(patients)or absence(healthy controls)of the leprosy disease.Contacts of patients were also recruited for this study.Serum samples from patients(n=199)with leprosy,contacts(n=40)and healthy controls(n=52)were investigated for levels of IgM and IgG anti-phenolic glycolipid-1(PGL-1)by ELISA.Additionally,IgG antibody against soluble Toxoplasma antigen(STAg)was measured in sera samples from leprosy patients,contacts and healthy controls for Toxoplasma gondii serology by ELISA.Anti-PGL-1 IgG and IgM levels were compared using one-way ANOVA Kruskal-Wallis or Mann-Whitney,while Spearman test was used to correlate levels of IgG anti-STAg and IgM/IgG anti-PGL-1 from seropositive and seronegative individuals for T.gondii infection.The risk of T.gondii infection for leprosy disease was assessed using Fisher’s test.Results:Levels of IgM anti-PGL-1 antibodies were significantly higher in multibacillary(MB)patients compared to paucibacillary(PB)patients(P=0.0068).Higher IgM and IgG levels anti-PGL-1 were detected in patients with the lepromatous forms.The serologic prevalence for T.gondii infection was 74.9%.We detected increased anti-STAg antibody levels in leprosy patients(79.4%),reaching 88.8%within those with lepromatous form of this disease.The leprosy risk increase in T.gondii seropositive individuals was two-fold(odds ratio[OR]=2.055;95% confidence intervals[95%CI]:1.18–3.51)higher than those seronegative,and considering the lepromatous leprosy risk this increase was even dramatic(OR=4.33;95%CI:1.76–9.69)in T.gondii seropositive individuals.Moreover the leprosy risk in T.gondii seropositive individuals was weakly correlated to the levels of IgG anti-STAg and IgM/IgG anti-PGL-1.Conclusions:Altogether,our results suggest that T.gondii infection may exert immunomodulatory properties that influence to the susceptibility of leprosy,mainly on its more severe clinical form.A better understanding of parasite immunomodulation can ultimately contribute to the development of medical applications. | Luciana Regina Pereira Oliveira Lívia Mattos Martins Rebeka da Conceição Souza Yuri Scheidegger de Castro Letícia Silva Nascimento Juliana Azevedo da Silva Edilbert Pellegrini Nahn Junior Wilmar Dias da Silva Alba Lucínia Peixoto-Rangel | 2020 | Infectious Diseases of Poverty2020，9，1： | 0 |
| 18 | ANA-HEp2 pattern evaluation in pancreatic cancer:What can the autoantibodies tell us?显示文摘To the Editor:Pancreatic neoplasms are mainly diagnosed by imaging methods and confirmed by biopsies[1].Imaging techniques and the tumor markers carbohydrate antigen 19-9(CA19-9)or carcinoembryonic antigen(CEA)used for follow-up,are expensive and of low sensitivity and specificity[2]. | Amanda PB Albuquerque Amanda R Fernandes Angela LBP Duarte Henrique de Ataide Mariz José GCA Júnior Luiz A Mattos Maira Galdino da Rocha Pitta Moacyr JBM Rego | 2023 | Hepatobiliary & Pancreatic Diseases International2023，22，1： | 0 |
| 19 | Fraud investigation in commercial coffee by chromatography显示文摘Coffee is currently the second largest commodity on the world market today,and there is great concern about the quality of the beans exported from producer countries to Europe and USA.Practices such as using blends of different species and adding low-cost raw materials,such as chicory,corn,and soybean,impair the sensory and functional characteristics of the drink made from roasted and ground coffee beans.There is a need to adopt more efficient analytical methods than the microscopy technique currently used.The first chromatographic method used to determine fraud was reported in 1958.This method used paper chromatography to differentiate between coffee and chicory based on the free reducing sugars.As of the 1980s,different methods involving high-performance liquid chromatography and gas chromatography were developed in order to demonstrate geographic authenticity,distinction between species,occurrence of adulteration,and the presence of defective beans by determining the monosaccharides,oligosaccharides,tocopherols,fatty acids,volatiles,diterpenes,sterols,and phenolic substances,among others.As far as the authors know,there are no papers published in the literature that have compiled such an extensive set of information about these chromatographic methods as here.Over the last 2 years,there has been a trend to develop analytical methods for ultra-performance liquid chromatography coupled with tandem mass spectrometry to confirm fraud in coffee,due to high sensitivity and selectivity. | Víctor de Carvalho Martins Ronoel Luiz de Oliveira Godoy Ana Cristina Miranda Senna Gouvêa Manuela Cristina Pessanha de Araujo Santiago Renata Galhardo Borguini Elaine Cristina de Oliveira Braga Sidney Pacheco Luzimar da Silva de Mattos do Nascimento | 2018 | Food Quality and Safety2018，2，3： | 0 |
| 20 | Nanorobotics in Drug Delivery Systems for Treatment of Cancer: A Review显示文摘 | Glecia Virgolino da Silva LUZ | 2016 | 材料科学与工程(中英文A版)2016，6，3： | 0 |
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