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| 1 | 羟乙基淀粉溶液在复苏肠缺血-再灌注休克中的作用显示文摘目的 比较不同剂量羟乙基淀粉溶液 ( HES)对兔肠缺血再灌注损伤所致休克的复苏作用。方法 32只新西兰白兔随机分为 4组 :模型对照、乳酸林格液复苏组 ( L RS,2 0 m l· kg- 1 · h- 1 ) ,小剂量 HES复苏组 ( HES2 ml· kg- 1· h- 1 + L RS18m l· kg- 1· h- 1 ) ,大剂量 HES复苏组 ( HES2 0 ml· kg- 1· h- 1 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠缺血再灌注休克模型 ,松夹再灌注时同步进行液体复苏。观测各时间点的血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 ) ,并通过测定肠黏膜CO2 分压和动脉血 CO2 分压的差值 (动脉二氧化碳间隙 )、肠黏膜 p H值、动脉血乳酸浓度和氧输送等指标间接评估组织氧合情况。实验结束后累计动物死亡数。结果 HES能明显提高肠缺血再灌注休克时的血流动力学参数 ,与对照组和 L RS组比较差异均有显著性 ( P均 <0 .0 5 ) ;小剂量 HES比大剂量 HES改善血流动力学参数的作用更平稳 ( P均 <0 .0 5 ) ,且较其他 3组能明显降低血乳酸浓度和动脉二氧化碳间隙 ,减轻 p Hi的降低 ( P均 <0 .0 5 ) ;而大剂量 HES对上述参数的影响不明显 ,并可见动物口鼻出血及死亡 ;小剂量或大剂量HES与其他两组比较均能使氧输送回升 ( P均 <0 .0 5 )。 | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo Daniel de Backer 肖献忠 Jean-Louis Vincent | 2004 | 中国危重病急救医学2004，16，8： | 6 |
| 2 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 3 | 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)显示文摘 | Giuseppe Mancia Guy De Backer Anna Dominiczak Renata Cifkova Robert Fagard Giuseppe Germano Guido Grassi Anthony M Heagerty Sverre E Kjeldsen Stephane Laurent Krzysztof Narkiewicz Luis Ruilope Andrzej Rynkiewicz Roland E Schmieder Harry AJ Struijker Boudi | 2007 | Journal of Hypertension2007，，6： | 2 |
| 4 | Oxygen supply dependency can characterize septic shock显示文摘 | Friedman G De Backer D Shahla M | 1998 | Intensive Care Med1998，24，2： | 1 |
| 5 | Imaging of gastro-intestinal and abdominaltuberculosis显示文摘 | VANHOENACKER F M DE BACKER A I Op deBB | 2004 | Eur Radiol2004，14，13： | 1 |
| 6 | Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial显示文摘 | Marc Decramer Maureen Rutten-van M?lken PN Richard Dekhuijzen Thierry Troosters Cees van Herwaarden Riccardo Pellegrino CP Onno van Schayck Dario Olivieri Mario Del Donno Wilfried De Backer Ida Lankhorst Alfredo Ardia | 2005 | The Lancet2005，，9470： | 1 |
| 7 | The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects显示文摘 | DE BACKER D CRETEUR J DUBOIS M J | 2006 | Crit Care Med2006，34，2： | 1 |
| 8 | Quantitative determina- tion of several toxicological important mycotoxins in pig plasma using multi-mycotoxin and analyte-specific high performance liquid chro- matography-tandem mass spectrometric methods 显示文摘 | Devreese M De Baere S De Backer P | 2012 | J Chromatogr A2012，1257，： | 1 |
| 9 | Quantitative determination of several toxicological importantmycotoxins in pig plasma using multi-mycotoxin andanalyte-specifichighperformanceliquidchromatography-tandem mass spectrometric methods 显示文摘 | Devreese M DEBAERE S DE BACKER P | 2012 | Journal of Chromatography A2012，1257，28： | 1 |
| 10 | How to treat arterial stiffness beyond blood pressure lowering?显示文摘 | Luc M Van Bortel Tine De Backer Marc De Buyzere | 2011 | Journal of Hypertension2011，，6： | 1 |
| 11 | Persistent microcirculato- ry alterations are associated with organ failure and death in patients with septic shock显示文摘 | Sakr Y Dubois M J De Backer D | 2004 | Crit Care Med2004，32，9： | 1 |
| 12 | Tailored echocardiographic interventricular delay programming further optimizes left ventricular performance after cardiac resynchronization therapy显示文摘 | Vanderheyden M De Backer T Rivero-Ayerza M | 2005 | Heart Rhythna2005，2，10： | 1 |
| 13 | Ant-Based ap- proach to the knowledge fusion problem 显示文摘 | Martens D De Backer M Haesen R | 2006 | Lecture Notes in Computer Science2006，，4150： | 1 |
| 14 | Classification with ant colony optimization 显示文摘 | Martens D de Backer M Haesen R | 2007 | IEEE Transactions on Evolutionary Computation2007，11，5： | 1 |
| 15 | A scenario-based verification technique to assess the compatibility of collaborative business processes显示文摘 | De BACKER M SNOECK M MONSIEUR G | 2009 | Data & Knowledge Engineering2009，68，6： | 1 |
| 16 | An overview oi the MAGE genefanily with the identification of all human members of the family显示文摘 | Chomez P De Backer O Bertrand M | 2001 | Cancer Res2001，61，14： | 1 |
| 17 | An overview of the MAGE gene family with the identification of all human members of the family 显示文摘 | Chomez P De Backer O Bertrand M | 2001 | Cancer Res2001，61，14： | 1 |
| 18 | Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock 显示文摘 | Sakr Y L Dubois M J De Backer D | 2004 | Crit Care Med2004，32，9： | 1 |
| 19 | The role of whole blood viscosity in premature coronary artery disease in women显示文摘 | De Backer TL De Buyzere M Segers P | 2002 | Atherosclerosis2002，165，2： | 1 |
| 20 | Quantitative determination of dexamethasone in bovine plasma and tissues by liquid chromatography –atmospheric pressure chemical ionization–tandemmass spectrometry to monitor residue depletion kinetics显示文摘 | CHERLET M CROUBELS S DE BACKER P | 2002 | J MassSpectrom2002，37，： | 1 |
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