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| 1 | Human bocavirus: Current knowledge and future challenges显示文摘Human bocavirus(HBoV) is a parvovirus isolated about a decade ago and found worldwide in both respiratory samples, mainly from early life and children of 6-24 mo of age with acute respiratory infection, and in stool samples, from patients with gastroenteritis. Since then, other viruses related to the first HBoV isolate(HBoV 1), namely HBoV 2, HBoV 3 and HBoV 4, have been detected principally in human faeces. HBo Vs are small nonenveloped single-stranded DNA viruses of about 5300 nucleotides, consisting of three open reading frames encoding the first two the non-structural protein 1(NS1) and nuclear phosphoprotein(NP1) and the third the viral capsid proteins 1 and 2(VP1 and VP2). HBoV pathogenicity remains to be fully clarified mainly due to the lack of animal models for the difficulties in replicating the virus in in vitro cell cultures, and the fact that HBo V infection is frequently accompanied by at least another viral and/or bacterial respiratory and/or gastroenteric pathogen infection. Current diagnostic methods to support HBoV detection include polymerase chain reaction, real-time PCR, enzymelinked immunosorbent assay and enzyme immunoassay using recombinant VP2 or virus-like particle capsid proteins, although sequence-independent amplification techniques combined with next-generation sequencing platforms promise rapid and simultaneous detection of the pathogens in the future. This review presents the current knowledge on HBoV genotypes with emphasis on taxonomy, phylogenetic relationship and genomic analysis, biology, epidemiology, pathogenesis and diagnostic methods. The emerging discussion on HBoV s as true pathogen or innocent bystander is also emphasized. | Marcello Guido Maria Rosaria Tumolo Tiziano Verri Alessandro Romano Francesca Serio Mattia De Giorgi Antonella De Donno Francesco Bagordo Antonella Zizza | 2016 | World Journal of Gastroenterology2016，22，39： | 11 |
| 2 | Integrated Computer Program for Simulation of Meshing and Contact of Gear Drives 显示文摘 | LITVIN F L DONNO M D PENG A | 2000 | Computer Methods in Applied Mechanics and Engineering2000，181，13： | 1 |
| 3 | The AIMAR recommendations for early diagnosis of chronic obstructive respiratory disease based on the WHO/GARD model显示文摘 | Nardini S Annesi-Maesano I De L Donno M | 2014 | Multidiscip Respir Med2014，9，1： | 1 |
| 4 | Integrated computer program for simulation of meshing and contact of gear drives显示文摘 | Litvin F L De Donno M Peng A | 2000 | Computer Methods in Applied Mechanics and Engineering2000，181，13： | 1 |
| 5 | Positional asphyxia:reflection on 2cases显示文摘 | Belviso M De Donno A Vitale L | 2003 | Am J Forensic Med Pathol2003，24，3： | 1 |
| 6 | Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial显示文摘 | Marc Decramer Maureen Rutten-van M?lken PN Richard Dekhuijzen Thierry Troosters Cees van Herwaarden Riccardo Pellegrino CP Onno van Schayck Dario Olivieri Mario Del Donno Wilfried De Backer Ida Lankhorst Alfredo Ardia | 2005 | The Lancet2005，，9470： | 1 |
| 7 | Effect of short-term treatment with low-dose in-haled flutieasone propionate on airway inflammation and remode-ling in mild asthma: a placebo-controlled study显示文摘 | Olivieri D Chetta A Del Donno M BertoreLli G Casalini A Pesci A | 1997 | Am J Respir Crit Care Med1997，155，6： | 1 |
| 8 | Computerized design and generation of modified spiroid worm-gear drive with low transmission errors and stabilized bearing contact显示文摘 | LITVIN F L DONNO M D | 1998 | Computer Methods in Applied Mechanics and Engineering1998，162，4： | 1 |
| 9 | Computerizied design and generation of worm gear drives with stable bearing contact and low transmission errors显示文摘 | Donno M D Litvu F L | 1999 | Journal of Mechanical Design1999，121，4： | 1 |
| 10 | Airways remodelling is a distinctive feature of asthma and is related to severity of disease显示文摘 | Chetta A Fores iA Del Donno M | 1997 | Chest1997，111，4： | 1 |
| 11 | Airways remodeling is a distinctive feature of asthma and is related to severity of disease 显示文摘 | Chetta A Foresi A Del Donno M | 1997 | Chest1997，111，4： | 1 |
| 12 | Evaluation of a new serological test using recombinant proteins and synthetic peptides for the diagnosis of tuberculosis显示文摘 | Amicosante M de Donno G Houde M | 1996 | Tuberc Lung Dis1996，，： | 1 |
| 13 | The effect of inflammation on mucociliary clearance in asthma: an overview 显示文摘 | Del Donno M Bittesnich D Chetta A | 2000 | Chest2000，118，4： | 1 |
| 14 | Computerized design and generation of modified spiroid worm-gear drive with low transmission errors and stabilized bearing contact显示文摘 | LITVIN F L DONNO M D | 1998 | Computer Methods in Applied Mechanics and Engineering1998，162，14： | 1 |
| 15 | Airways remodeling is a distinctive feature of asthma and is related to severity of disease显示文摘 | Chetta A Foresi A Del Donno M | 1997 | Chest1997，111，4： | 1 |
| 16 | Forensic age estimation of living individuals:a retrospective analysis显示文摘 | Santoro V De Donno A Marrone M | | 0，，1： | 1 |
| 17 | Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammtion and remodeling in mild asthma: A placebocontrolled study显示文摘 | Olivieri D Chetta A Del Donno M | 1997 | Am respir Crit Care Med1997，155，： | 1 |
| 18 | Airways remodeling is a distinctive feature of asthma and is related to severity of disease显示文摘 | Chetta A Foresi A Del Donno M | 1997 | Chest1997，111，： | 1 |
| 19 | Replica consistency in a data grid显示文摘 | Andrea Domenici Flavia Donno Gianni Pucciani | 2004 | Nuclear Instrument andMethods in Physics Research2004，534，： | 1 |
| 20 | Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis progxam : a pilot study显示文摘 | Girardis M Rinaldi L Donno L | 2009 | Crit Care2009，13，5： | 1 |
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