|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Imaging of gastroenteropancreatic neuroendocrine tumors显示文摘Imaging of gastroenteropancreatic neuroendocrine tumors can be broadly divided into anatomic and functional techniques.Anatomic imaging determines the local extent of the primary lesion,providing crucial information required for surgical planning.Functional imaging,not only determines the extent of metastatic disease spread,but also provides important information with regard to the biologic behavior of the tumor,allowing clinicians to decide on the most appropriate forms of treatment.We review the current literature on this subject,with emphasis on the strengths of each imaging modality. | Eik Hock Tan Cher Heng Tan | 2011 | World Journal of Clinical Oncology2011，2，1： | 20 |
| 2 | Updates in the management of cranial dural arteriovenous fistula显示文摘Dural arteriovenous fistula(dAVF)accounts for approximately 10%of all intracranial vascular malformations.While they can be benign lesions,the presence of retrograde venous drainage and cortical venous reflux makes the natural course of these lesions aggressive high risk of haemorrhage,neurological injury and mortality.Endovascular treatment is often the first line of treatment for dAVF.Both transarterial and transvenous approaches are used to cure dAVF.The selection of treatment approach depends on the angioarchitecture of the dAVF,the location,the direction of venous flow.Surgery and,to a lesser extent,stereotactic radiosurgery are used when endovascular approaches are impossible or unsuccessful. | Humain Baharvahdat Yinn Cher Ooi Wi Jin Kim Ashkan Mowla Alexander L Coon Geoffrey P Colby | 2020 | Stroke & Vascular Neurology2020，5，1： | 10 |
| 3 | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers显示文摘OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers. | Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 4 |
| 4 | 2006、2008年新疆新源县哈萨克牧民卫生服务利用状况分析显示文摘目的:了解新农合实施前后新疆新源县哈萨克族牧民卫生服务利用现状,为卫生行政部门合理配置卫生资源,有效调控卫生服务供求关系,为制定深化医药卫生体制改革政策提供依据和实施效果评价提供基础信息。方法:分析2006年及2008年两次牧区居民卫生服务调查中有关卫生服务利用的相关数据并进行描述性统计分析。结果:2006年、2008年新源县哈萨克族牧民两周就诊率分别为9.0%、7.6%(X2=3.73,=0.053),未就诊率分别为83.0%、50.6%(X2=52.88,<0.01),住院率分别为3.0%、3.7%(X2=0.188,P>0.05)应住院而未住院的比例分别为50.8%、29.3%(X2=15.09,<0.01)。结论:哈萨克族牧民卫生服务利用不足。卫生主管部门应当针对牧民的特点,提供相应的卫生服务项目,以提高牧民卫生服务的有效利用。 | 芮东升 秦江梅 Susanne Weigelin-Schwiedrzik Sascha Klotzbücher 吴艳辉 聂绍发 | 2011 | 医学与社会2011，24，6： | 4 |
| 5 | 哈萨克族牧民2周患病率和慢性病患病率比较显示文摘目的比较新疆新源县新型农村合作医疗实施前后哈萨克族牧民健康状况和卫生服务需要的变化,为进一步的科学研究提供基础,为医药卫生体制改革提供相应的参考依据。方法利用2006年及2008年哈萨克牧区居民卫生服务调查中有关2周患病、半年慢性病的相关数据进行描述性统计分析。结果 2006年、2008年新源县哈萨克族牧民2周患病率分别为8.05%、11.78%,差异有统计学意义(χ2=21.02,P<0.05);慢性病患病率分别为15.97%、24.27%,差异有统计学意义(χ2=57.88,P<0.05);类风湿性关节炎、高血压病是影响哈萨克牧民健康的主要疾病。结论新疆新源县哈萨克牧民慢性疾病患病率有明显增加趋势,与其生产生活环境、民族习俗、膳食结构等有关,适宜的健康教育和提供适宜的卫生服务可提高牧民对健康的关注程度。 | 芮东升 秦江梅 Susanne Weigelin-Schwiedrzik Sascha Klotzbücher 吴艳辉 聂绍发 | 2012 | 中国公共卫生2012，28，8： | 4 |
| 6 | Restoration of HCV-specific CD8+ T-cell function by Interferon-free therapy显示文摘 | Bianca Martin Nadine Hennecke Volker Lohmann Antonin Kayser Christoph Neumann-Haefelin George Kukolj Wulf-Otto B?cher Robert Thimme | 2014 | Journal of Hepatology2014，，： | 3 |
| 7 | 18F-DOPAPET/CT对甲状腺髓样癌病人的价值:与18F-FDGPET/CT的比较显示文摘本研究前瞻性地比较^18F—DOPA PET/CT与FDG PET—CT在检测甲状腺髓样癌(MTC)恶性病变中的诊断价值。此前瞻性研究连续评估26例降钙素升高的病人[男10例,女16例;平均年龄(59±14)岁]。所有病人最长在4周内(中位数7d)行DOPA和FDG PET/CT检查。以病人和病变为基础进行数据分析。PET的阳性病变的确诊依据为组织病理学结果和(或)至少6个月(范围6~24个月)的影像随访检查,即DOPA和(或)FDG PET/CT。DOPA PET共检出21例(21/26)病人至少有1个恶性病灶; | M.Beheshti S.Pcher R.Vali P.Waldenberger G.Broinger M.Nader 钟进 | 2009 | 国际医学放射学杂志2009，32，4： | 3 |
| 8 | Efficacy of texture analysis of pre-operative magnetic resonance imaging in predicting microvascular invasion in hepatocellular carcinoma显示文摘BACKGROUND Presence of microvascular invasion(MVI)indicates poorer prognosis postcurative resection of hepatocellular carcinoma(HCC),with an increased chance of tumour recurrence.By present standards,MVI can only be diagnosed postoperatively on histopathology.Texture analysis potentially allows identification of patients who are considered‘high risk’through analysis of pre-operative magnetic resonance imaging(MRI)studies.This will allow for better patient selection,improved individualised therapy(such as extended surgical margins or adjuvant therapy)and pre-operative prognostication.AIM This study aims to evaluate the accuracy of texture analysis on pre-operative MRI in predicting MVI in HCC.METHODS Retrospective review of patients with new cases of HCC who underwent hepatectomy between 2007 and 2015 was performed.Exclusion criteria:No preoperative MRI,significant movement artefacts,loss-to-follow-up,ruptured HCCs,previous hepatectomy and adjuvant therapy.Fifty patients were divided into MVI(n=15)and non-MVI(n=35)groups based on tumour histology.Selected images of the tumour on post-contrast-enhanced T1-weighted MRI were analysed.Both qualitative(performed by radiologists)and quantitative data(performed by software)were obtained.Radiomics texture parameters were extracted based on the largest cross-sectional area of each tumor and analysed using MaZda software.Five separate methods were performed.Methods 1,2 and 3 exclusively made use of features derived from arterial,portovenous and equilibrium phases respectively.Methods 4 and 5 made use of the comparatively significant features to attain optimal performance.RESULTS Method 5 achieved the highest accuracy of 87.8%with sensitivity of 73%and specificity of 94%.CONCLUSION Texture analysis of tumours on pre-operative MRI can predict presence of MVI in HCC with accuracies of up to 87.8%and can potentially impact clinical management. | Jordan Zheng Ting Sim Terrence Chi Hong Hui Tong Kuan Chuah Hsien Min Low Cher Heng Tan Vishal GShelat | 2022 | World Journal of Clinical Oncology2022，13，11： | 3 |
| 9 | 新型变速恒频风力发电系统的非线性控制器设计显示文摘针对当前采用电力电子变流设备完成变速恒频风力发电的成本高及可靠性有待改善等问题,提出一种利用变量泵.变量马达组成的液压无级调速系统实现风力发电变速恒频的新方法。基于新型风力发电变速恒频液压无级调速系统的工作原理,建立该系统的风-机-液动力学模型,并针对其强非线性、多输入多输出特点,设计非线性精确反馈线性化的非线性控制器。以10kW风力发电系统运行的仿真结果显示,在湍流强度为12%的10rrds额定风速输入工况下,该非线性控制系统能有效的控制发电机输出频率为49.67.50.23Hz。 | 李富柱 Wen Cher 王存堂 郭玉琴 | 2015 | 太阳能学报2015，36，10： | 3 |
| 10 | 非小细胞肺癌联合治疗的现状与展望显示文摘对T1、T2期没有淋巴结受侵的NSCLC患者只要能耐受手术、肺叶切除术应作为首选。对Ⅰ、Ⅱ、ⅢA期符合手术指征的患者单纯手术是不够的,必须进行辅助化疗并从中受益,但辅助放疗因显著的副作用,使Ⅰ、Ⅱ期患者反而有害。对ⅢA期NSCLC患者术后使用放化疗,亦无益于改善局控率和延长生存期。关于可切除的Ⅰ、Ⅱ、ⅢA期NSCLC的新辅助化疗尚有争议。一项RTOG和SWOG的Ⅲ期随机对照临床试验(ⅢA期NSCLC患者先联合放化疗,后行手术和化疗)以评估ⅢANSCLC患者的预后已启动。本文综述了一系列重要文献及临床试验。讨论了各期NSCLC联合治疗的现状及展望未来的发展方向。 | John Wong Boon Cher Goh Jiade Lu 罗晓阳 | 2005 | 中国癌症杂志2005，15，3： | 2 |
| 11 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | 2011 (9806)2011，，9806： | 2 |
| 12 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 13 | Three-dimensional extension of non-linear shell formulation based on the enhanced assumed strain concept显示文摘 | Bücher N Ramm E Roehl D | 1994 | Inter J Numer Methods Engrg1994，37，： | 2 |
| 14 | Changes in Climate Extremes Over the Australian Region and New Zealand During the Twentieth Century显示文摘 | Neil Plummer M. James Salinger Neville Nicholls Ramasamy Suppiah Kevin J. Hennessy Robert M. Leighton Blair Trewin Cher M. Page Janice M. Lough | 1999 | Climatic Change1999，，1： | 2 |
| 15 | Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment显示文摘 | Nácher M Blázquez AB Shao B | | 0，，05： | 1 |
| 16 | Fractures in the proximal humerus:functional outcome and evaluation of 70 patients treated in hospital显示文摘 | Fjalestad T Str?ms?e K Blücher J | | 0，，05： | 1 |
| 17 | Microbial activity catalyzes oxygen transfer in membrane-aeratednitritating biofilm reactors 显示文摘 | Pellicer-N^cher C Domingo-F6lez C Lackner S | 2013 | Journal of Membrane Science2013，446，： | 1 |
| 18 | Isocyanic acid hydrolysis over Fe-ZSM5 in urea-SCR显示文摘 | Piazzesi Gaia Devadas Mukundan Krcher Oliver | 2006 | Catalysis Communications2006，7，8： | 1 |
| 19 | Manipulating redox and ATP balancing for improved production of sue- cinateinE, coli显示文摘 | Singh A Cher S Hatzimanikatis V | 2011 | Metab Eng2011，13，： | 1 |
| 20 | Fluid aecumu- lation, survival and recovery of kidney function in critically ill patients with acute kidney injury显示文摘 | Bouchard J Soroko SB Cher tow GM | 2009 | Kidney Int2009，76，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员