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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Neural Mechanisms of Mental Fatigue Revisited: New Insights from the Brain Connectome显示文摘Maintaining sustained attention during a prolonged cognitive task often comes at a cost: high levels of mental fatigue. Heuristically, mental fatigue refers to a feeling of tiredness or exhaustion, and a disengagement from the task at hand;it manifests as impaired cognitive and behavioral performance. In order to effectively reduce the undesirable yet preventable consequences of mental fatigue in many real-world workspaces, a better understanding of the underlying neural mechanisms is needed, and continuous efforts have been devoted to this topic. In comparison with conventional univariate approaches, which are widely utilized in fatigue studies, convergent evidence has shown that multivariate functional connectivity analysis may lead to richer information about mental fatigue. In fact, mental fatigue is increasingly thought to be related to the deviated reorganization of functional connectivity among brain regions in recent studies. In addition, graph theoretical analysis has shed new light on quantitatively assessing the reorganization of the brain functional networks that are modulated by mental fatigue. This review article begins with a brief introduction to neuroimaging studies on mental fatigue and the brain connectome, followed by a thorough overview of connectome studies on mental fatigue. Although only a limited number of studies have been published thus far, it is believed that the brain connectome can be a useful approach not only for the elucidation of underlying neural mechanisms in the nascent field of neuroergonomics, but also for the automatic detection and classification of mental fatigue in order to address the prevention of fatigue-related human error in the near future. | Peng Qi Hua Ru Lingyun Gao Xiaobing Zhang Tianshu Zhou Yu Tian Nitish Thakor Anastasios Bezerianos Jinsong Li Yu Sun | 2019 | Engineering2019，5，2： | 5 |
| 3 | Transient acquisition of cross-species infectivity during the evolution of SARS-CoV-2显示文摘Since the coronavirus disease 2019(COVID-19)pandemic began,its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has spread worldwide.During the global transmission of SARS-CoV-2,mutations in the viral genome have gradually accumulated and have led to the emergence of variants.These emerging variants;including 501Y.V1,501Y.V2 and 501Y.V3(also called the alpha,beta and gamma variants,respectively),rapidly became the predominant epidemic strains and subsequently spread worldwide. | Qi Chen Xing-Yao Huang Meng-Xu Sun Rui-Ting Li Hongjing Gu Ying Tian Rong-Rong Zhang Dan Luo Chao Zhou Yifei Zhang Tianshu Cao Na-Na Zhang Yong-Qiang Deng Xiao-Feng Li Cheng-Feng Qin | 2021 | National Science Review2021，8，11： | 3 |
| 4 | Observational Study on the Supercooled Fog Droplet Spectrum Distribution and Icing Accumulation Mechanism in Lushan, Southeast China显示文摘A fog monitor, hotplate total precipitation sensor, weather identifier and visibility sensor, ultrasonic wind speed meter,an icing gradient observation frame, and an automated weather station were involved in the observations at the Lushan Meteorological Bureau of Jiangxi Province, China. In this study, for the icing process under a cold surge from 20–25 January2016, the duration, frequency, and spectrum distribution of agglomerate fog were analyzed. The effects of rain, snow, and supercooled fog on icing growth were studied and the icing and meteorological conditions at two heights(10 m and 1.5 m)were compared. There were 218 agglomerate fogs in this icing process, of which agglomerate fogs with durations less than and greater than 10 min accounted for 91.3% and 8.7%, respectively. The average time interval was 10.3 min. The fog droplet number concentration for sizes 2–15 μm and 30–50 μm increased during rainfall, and that for 2–27 μm decreased during snowfall. Icing grew rapidly(1.3 mm h-1) in the freezing rain phase but slowly(0.1 mm h-1) during the dry snow phase. Intensive supercooled fog, lower temperatures and increased wind speed all favored icing growth during dry snow(0.5 mm h-1). There were significant differences in the thickness, duration, density, and growth mechanism of icing at the heights of 10 m and 1.5 m. Differences in temperature and wind speed between the two heights were the main reasons for the differences in icing conditions, which indicated that icing was strongly affected by height. | Tianshu WANG Shengjie NIU Jingjing Lü Yue ZHOU | 2019 | Advances in Atmospheric Sciences2019，36，1： | 3 |
| 5 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 6 | Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4显示文摘 | Jie He Wanyu Zhang Qiangqiang Zhou Tianshu Zhao Yuwen Song Li Chai Yu Li | 2013 | International Journal of Biochemistry and Cell Biology2013，，： | 1 |
| 7 | Experimental investigation on a novel liquid cooling device for a prismatic Li-ion battery module operating at high ambient temperature显示文摘A novel liquid cooling device for a prismatic LiFePO4 battery module was proposed and manufactured in this study in order to improve the thermal management performance of the battery module operating at high ambient temperature.A testing system was set up to experimentally measure temperatures in different locations of the battery module consisting of seven 60 Ah cells.Tests were conducted to investigate both the passive and active cooling performances of the proposed system at different ambient temperatures and discharging rates in regarding with the maximum temperature and difference between the maximum and minimum temperatures.The results clearly show that both the ambient temperature and discharging rate play important role on the maximum temperature of the battery module.Passive cooling cannot meet the cooling requirement of the battery module particularly at high ambient temperature of 40℃.In contrary,liquid cooling can successfully reduce the maximum temperature to the required temperature range of the battery module even in high temperature environment and relatively high discharging rate.The effect of water inlet temperature on the cooling performance was also experimentally studied.With the inlet temperature of 28℃,the active cooling device can reduce the maximum temperature of the battery module to about 34.8℃after discharging at 0.6℃for 1000 s.The temperature difference of only 3.8℃was also achieved which suggests a great uniform distribution of temperature in the battery module. | XU JiaWei ZHOU TianShu XU XinHai | 2020 | Science China(Technological Sciences)2020，63，10： | 1 |
| 8 | In-situ generation of gold nanoparticles on MnO_2 nanosheets for the enhanced oxidative degradation of basic dye(Methylene Blue)显示文摘In this work,the gold nanoparticles(Au-NPs)were in-situ generated on the surface of MnO_2nanosheets to form MnO_2/Au-NPs nanocomposite in a simple and cost-effective way.Multiple experiments were carried out to optimize the oxidation of basic dye(Methylene Blue(MB)),including the molar ratio of MnO_2to chloroauric acid(HAu Cl_4),the p H of the solution and the effect of initial material.Under the optimal condition,the highest degradation efficiency for MB achieved to 98.9%within 60 min,which was obviously better than commercial MnO_2powders(4.3%)and MnO_2nanosheets(74.2%).The enhanced oxidative degradation might attribute to the in-situ generation of ultra-small and highly-dispersed Au-NPs which enlarged the synergistic effect and/or interfacial effect between MnO_2nanosheets and Au-NPs and facilitated the uptake of electrons by MnO_2from MB during the oxidation,thus validating the application of MnO_2/Au-NPs nanocomposite for direct removal of organic dyes from wastewater in a simple and convenient fashion. | Xueqin Bao Zhen Qin Tianshu Zhou Jingjing Deng | 2018 | Journal of Environmental Sciences2018，30，3： | 1 |
| 9 | Robust,fluorine-free and superhydrophobic composite melamine sponge modified with dual silanized SiO_(2) microspheres for oil-water separation显示文摘Massive oily wastewater discharged from industrial production and human daily life have been an urgent environmental and ecological challenge.Superhydrophobic materials have attracted tremendous attention due to their unique properties and potential applications in the treatment of wastewater.In this study,a novel superhydrophobic/superoleophilic composite melamine sponge modified with dual silanized SiO_(2) microspheres was fabricated simply by a two-step sol-gel method using vinyltriethoxysilane and hexadecyltrimethoxysilane as functional agent,which exhibited a water contact angle of 153.2°and a water sliding contact angle of 4.8°.Furthermore,the composite sponge showed the excellent oil adsorption performance and the compressive elasticity reaching up to 130 g·g^(-1) of dichloromethane and 33.1 kPa of compressive stress.It was worth noting that the composite sponge presented the excellent separation efficiency(up to 99.5%)in the processes of continuous oil/water separation.The robust superhydrophobic composite melamine sponge provided the possibility with the practical application for oil-water separation. | Ruilong Zhang Zhiping Zhou Wenna Ge Yi Lu Tianshu Liu Wenming Yang Jiangdong Dai | 2021 | Chinese Journal of Chemical Engineering2021，34，5： | 1 |
| 10 | Solid-state pH ultramicrosensor based on a tungstic oxide film fabricated on a tungsten nanoelectrode and its application to the study of endothelial cells 显示文摘 | Guoyue Shi Tianshu Zhou | 2003 | Analytica Chimica Acta2003，480，： | 1 |
| 11 | SiGe HBTs Model Converting Technique From SGP to VBIC Model显示文摘 | Lin Fujiang Zhou Tianshu Chen Bo | 2002 | Microelectronics Journal2002，33，： | 1 |
| 12 | SiGe HBTs Model Converting Technique from SGP to VBIC Model显示文摘 | Lin Fujiang Zhou Tianshu | 2002 | Microelectronics Journal2002，，2002： | 1 |
| 13 | The effect of estrogen on the Restoration of bone mass and bone quality in ovariectomized rats显示文摘 | Chen Lulu Zeng Tianshu Xia Wenfang Li Huiqin Zhou Ming | 2000 | Journal of Tongji Medical University2000，，4： | 1 |
| 14 | Solid-state pH ultramicrosensor based on a tungstic oxide film fabricated on a tungsten nanoelectrode and its application to the study of endothelial cells显示文摘 | Yamamoto Katsunobu Shi Guoyue Zhou Tianshu | 2003 | Analytica Chimica Acta2003，480，： | 1 |
| 15 | A novel switchable dual-wavelength ring Erbium-doped fiber laser operating in single-longitudinal-mode 显示文摘 | Gongquan Liang Tianshu Wang Xuefang Zhou | 2011 | Electronics and Optoelectronics2011，29，31： | 1 |
| 16 | Electronic properties and tunability in graphene/3D-InP mixed-dimensional van der Waals heterostructure显示文摘InP solar cell is promising for space application due to its strong space radiation resistance and high power conversion efficient(PCE).Graphene/InP heterostructure solar cell is expected to have a higher PCE because strong near-infrared light can also be absorbed and converted additionally by graphene in this heterostructure.However,a low PCE was reported experimentally for Graphene/InP heterostructures.In this paper,electronic properties of graphene/InP heterostructures are calculated using density functional theory to understand the origin of the low PCE and propose possible improving ways.Our calculation results reveal that graphene contact with InP form a p-type Schottky heterostructure with a low Schottky barrier height(SBH).It is the low SBH that leads to the low PCE of graphene/InP heterostructure solar cells.A new heterostructure,graphene/insulating layer/InP solar cells,is proposed to raise SBH and PCE.Moreover,we also find that the opened bandgap of graphene and SBH in graphene/InP heterostructures can be tuned by exerting an electric field,which is useful for photodetector of graphene/InP heterostructures. | Qingyun Zhou Yusheng Hou Tianshu Lai | 2023 | Frontiers of physics2023，18，2： | 0 |
| 17 | Effects of Bushen Zhuanggu Formul on interleukin-6 production and bone metabolism of the ovariectomized rats显示文摘Objective: To observe the effects of Bushen Zhuanggu Formul on interleukin 6(IL-6) level and bone metabolism of the ovariectomized rats, and to explore the possible mechanism of preventing and treating postmenopausal osteoporosis by traditional Chinese Formul. Methods: SD rats were randomly divided into 4 groups: normal control group(N), ovariectomized control group(OVX), estrogen-treated group(OVX+E) traditional and Chinese medicine-treated group(OVX+CM). After treatment, IL-6 levels in rat bone tissue media and serum were examined by ELISA. The proximal tibias(PTM) of rats were undecalcified for quantitative bone histomorphometry. Results: Compared with OVX group, both Bushen Zhuanggu medicine and estrogen decreased IL-6 level in rat bone tissue media. However, the effects of Bushen Zhuanggu Formul were weaker than those of estrogen. Furthermore, Bushen Zhuanggu Formul and estrogen produced a reduction in bone turnover by inhibiting bone formation and bone resorption at the same time. Conclusion: Bushen Zhuanggu Formul prevents ovariectomic bone loss by inhibiting IL-6 production in rat bone tissues. | Lulu Chen Huiqing Li Tianshu Zeng Wenfang Xia Juan Zheng Min Zhou | 2006 | Journal of Nanjing Medical University2006，20，4： | 0 |
| 18 | China enters CAR-T cell therapy era显示文摘The emerging individualized and living-cell-based genetic engineering chimeric antigen receptor T(CAR-T)therapy demonstrates great curative effects in some hematological tumor treatments,thus it is turning out to be a star immunotherapy method of the world.1 Recently,the China NationalMedical Products Administration(NMPA)approved launching applications of two CAR-T cell cancer products,Axicabtagene Ciloleucel(FKC876)and Relmacabtagene Autoleucel(Carteyva),which marked the beginning of the of CAR-T cell therapy era in China(Figure 1). | Xin Cao Wei Li Yiyi Yu Tianshu Liu Yuhong Zhou | 2022 | The Innovation2022，3，1： | 0 |
| 19 | PLC for In-Vehicle Network:A DRL-Based Algorithm of Diversity Combination of OFDM Subcarriers显示文摘For low latency communication service of vehicles,it is critical to improve the delay performance of power line communication(PLC)for in-vehicle network,which can decrease the weight and cost of the vehicle.In order to minimize the total time slots used in a transmission task,an orthogonal frequency-division multiplexing(OFDM)subcarrier diversity combination algorithm of PLC based on the deep reinforcement learning(DRL)is proposed herein.The short packet communication theory is used to develop an optimal combination model with constraints on short packet reliability,transmitting power and the amount of data.The state,action,and reward function of double deep Q-learning network(DDQN)are defined,and diversity combination for OFDM subcarriers is performed using DDQN.An adaptive power allocation algorithm based on the thresholds of error rate and the data amount is used.Simulation results show that the proposed algorithm can effectively improve the delay performance of PLC under the constraints of power and data amount. | CHEN Zhixiong ZHANG Zhikun CAO Tianshu ZHOU Zhenyu | 2023 | Chinese Journal of Electronics2023，32，6： | 0 |
| 20 | Accurate atomic scanning transmission electron microscopy analysis enabled by deep learning显示文摘Currently,the machine learning(ML)-based scanning transmission electron microscopy(STEM)analysis is limited in the simulative stage,its application in experimental STEM is needed but challenging.Herein,we built up a universal model to analyze the vacancy defects and single atoms accurately and rapidly in experimental STEM images using a full convolution network.In our model,the unavoidable interference factors of noise,aberration,and carbon contamination were fully considered during the training,which were difficult to be considered in the past.Even toward the simultaneous identification of various vacancy types and low-contrast single atoms in the low-quality STEM images,our model showed rapid process speed(45 images per second)and high accuracy(>95%).This work represents an improvement in experimental STEM image analysis by ML. | Tianshu Chu Lei Zhou Bowei Zhang Fu-Zhen Xuan | 2024 | Nano Research2024，17，4： | 0 |
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